메뉴 건너뛰기




Volumn 7, Issue JUL, 2015, Pages

Role of diffuse low-level heteroplasmy of mitochondrial DNA in Alzheimer's disease neurodegeneration

Author keywords

Aging; Allele; Alzheimer's disease; Heteroplasmy; MitoChip; mtDNA; Mutation

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

EID: 84938598693     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2015.00142     Document Type: Article
Times cited : (24)

References (59)
  • 2
    • 84866375516 scopus 로고    scopus 로고
    • Mitochondrial DNA heteroplasmy in diabetes and normal adults: role of acquired and inherited mutational patterns in twins
    • Avital, G., Buchshtav, M., Zhidkov, I., Tuval Feder, J., Dadon, S., Rubin, E., et al. (2012). Mitochondrial DNA heteroplasmy in diabetes and normal adults: role of acquired and inherited mutational patterns in twins. Hum. Mol. Genet. 21, 4214-4224. doi: 10.1093/hmg/dds245
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 4214-4224
    • Avital, G.1    Buchshtav, M.2    Zhidkov, I.3    Tuval Feder, J.4    Dadon, S.5    Rubin, E.6
  • 3
    • 84899019792 scopus 로고    scopus 로고
    • Amyloid-ß and tau: the trigger and bullet in Alzheimer disease pathogenesis
    • Bloom, G. S. (2014). Amyloid-ß and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol. 71, 505-508. doi: 10.1001/jamaneurol.2013.5847
    • (2014) JAMA Neurol. , vol.71 , pp. 505-508
    • Bloom, G.S.1
  • 4
    • 50649114611 scopus 로고    scopus 로고
    • Amyloid-beta dynamics correlate with neurological status in the injured human brain
    • Brody, D. L., Magnoni, S., Schwetye, K. E., Spinner, M. L., Esparza, T. J., Stocchetti, N., et al. (2008). Amyloid-beta dynamics correlate with neurological status in the injured human brain. Science 321, 1221-1224. doi: 10.1126/science.1161591
    • (2008) Science , vol.321 , pp. 1221-1224
    • Brody, D.L.1    Magnoni, S.2    Schwetye, K.E.3    Spinner, M.L.4    Esparza, T.J.5    Stocchetti, N.6
  • 6
    • 84989336819 scopus 로고    scopus 로고
    • The role of mitochondrial DNA mutation on neurodegenerative diseases
    • Cha, M. Y., Kim, D. K., and Mook-Jung, I. (2015). The role of mitochondrial DNA mutation on neurodegenerative diseases. Exp. Mol. Med. 47:e150. doi: 10.1038/emm.2014.122
    • (2015) Exp. Mol. Med , vol.47
    • Cha, M.Y.1    Kim, D.K.2    Mook-Jung, I.3
  • 7
    • 33748201067 scopus 로고    scopus 로고
    • Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing
    • Coon, K. D., Valla, J., Szelinger, S., Schneider, L. E., Niedzielko, T. L., Brown, K. M., et al. (2006). Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing. Mitochondrion 6, 194-210. doi: 10.1016/j.mito.2006.07.002
    • (2006) Mitochondrion , vol.6 , pp. 194-210
    • Coon, K.D.1    Valla, J.2    Szelinger, S.3    Schneider, L.E.4    Niedzielko, T.L.5    Brown, K.M.6
  • 8
    • 0027933135 scopus 로고
    • Marked changes in mitochondrial DNA deletion levels in Alzheimer brains
    • Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., McKee, A. C., Beal, M. F., et al. (1994). Marked changes in mitochondrial DNA deletion levels in Alzheimer brains. Genomics 23, 471-476. doi: 10.1006/geno.1994.1525
    • (1994) Genomics , vol.23 , pp. 471-476
    • Corral-Debrinski, M.1    Horton, T.2    Lott, M.T.3    Shoffner, J.M.4    McKee, A.C.5    Beal, M.F.6
  • 9
    • 3242668604 scopus 로고    scopus 로고
    • Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
    • Coskun, P. E., Beal, M. F., and Wallace, D. C. (2004). Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. Proc. Natl. Acad. Sci. U S A 101, 10726-10731. doi: 10.1073/pnas.0403649101
    • (2004) Proc. Natl. Acad. Sci. U S A , vol.101 , pp. 10726-10731
    • Coskun, P.E.1    Beal, M.F.2    Wallace, D.C.3
  • 11
    • 84855268661 scopus 로고    scopus 로고
    • Late-onset Alzheimer's disease is associated with mitochondrial DNA 7028C/haplogroup H and D310 poly-C tract heteroplasmy
    • Coto, E., Gómez, J., Alonso, B., Corao, A. I., Díaz, M., Menéndez, M., et al. (2011). Late-onset Alzheimer's disease is associated with mitochondrial DNA 7028C/haplogroup H and D310 poly-C tract heteroplasmy. Neurogenetics 12, 345-346. doi: 10.1007/s10048-011-0295-4
    • (2011) Neurogenetics , vol.12 , pp. 345-346
    • Coto, E.1    Gómez, J.2    Alonso, B.3    Corao, A.I.4    Díaz, M.5    Menéndez, M.6
  • 12
    • 77957130057 scopus 로고    scopus 로고
    • Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment
    • Fernández, M., Gobartt, A. L., Balañá, M., and COOPERA Study Group. (2010). Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment. BMC Neurol. 10:87. doi: 10.1186/1471-2377-10-87
    • (2010) BMC Neurol , vol.10 , pp. 87
    • Fernández, M.1    Gobartt, A.L.2    Balañá, M.3
  • 13
    • 33749633921 scopus 로고    scopus 로고
    • Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial
    • Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., et al. (2006). Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch. Neurol. 63, 1402-1408. doi: 10.1001/archneur.63.10.1402
    • (2006) Arch. Neurol. , vol.63 , pp. 1402-1408
    • Freund-Levi, Y.1    Eriksdotter-Jönhagen, M.2    Cederholm, T.3    Basun, H.4    Faxén-Irving, G.5    Garlind, A.6
  • 14
    • 33750463390 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer's disease
    • Frey, C., Bonert, A., Kratzsch, T., Rexroth, G., Rösch, W., Müller-Spahn, F., et al. (2006). Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer's disease. J. Neural Transm. 11, 1753-1761. doi: 10.1007/s00702-006-0481-y
    • (2006) J. Neural Transm. , vol.11 , pp. 1753-1761
    • Frey, C.1    Bonert, A.2    Kratzsch, T.3    Rexroth, G.4    Rösch, W.5    Müller-Spahn, F.6
  • 15
    • 0028200649 scopus 로고
    • Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
    • Gabuzda, D., Busciglio, J., Chen, L. B., Matsudaira, P., and Yankner, B. A. (1994). Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J. Biol. Chem. 269, 13623-13628.
    • (1994) J. Biol. Chem. , vol.269 , pp. 13623-13628
    • Gabuzda, D.1    Busciglio, J.2    Chen, L.B.3    Matsudaira, P.4    Yankner, B.A.5
  • 16
    • 77954755957 scopus 로고    scopus 로고
    • Mitochondrial biology in Alzheimer's disease pathogenesis
    • Galindo, M. F., Ikuta, I., Zhu, X., Casadesus, G., and Jordán, J. (2010). Mitochondrial biology in Alzheimer's disease pathogenesis. J. Neurochem. 114, 933-945. doi: 10.1111/j.1471-4159.2010.06814.x
    • (2010) J. Neurochem. , vol.114 , pp. 933-945
    • Galindo, M.F.1    Ikuta, I.2    Zhu, X.3    Casadesus, G.4    Jordán, J.5
  • 17
    • 0030930721 scopus 로고    scopus 로고
    • Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells
    • Gasparini, L., Racchi, M., Benussi, L., Curti, D., Binetti, G., Bianchetti, A., et al. (1997). Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells. Neurosci. Lett. 231, 113-117. doi: 10.1016/s0304-3940(97)00536-3
    • (1997) Neurosci. Lett. , vol.231 , pp. 113-117
    • Gasparini, L.1    Racchi, M.2    Benussi, L.3    Curti, D.4    Binetti, G.5    Bianchetti, A.6
  • 18
    • 0031737226 scopus 로고    scopus 로고
    • Abnormalities of mitochondrial enzymes in Alzheimer disease
    • Gibson, G. E., Sheu, K. F., and Blass, J. P. (1998). Abnormalities of mitochondrial enzymes in Alzheimer disease. J. Neural Transm. 105, 855-870. doi: 10.1007/s007020050099
    • (1998) J. Neural Transm. , vol.105 , pp. 855-870
    • Gibson, G.E.1    Sheu, K.F.2    Blass, J.P.3
  • 19
    • 84891044032 scopus 로고    scopus 로고
    • Very low-level heteroplasmy mtDNA variations are inherited in humans
    • Guo, Y., Li, C. I., Sheng, Q., Winther, J. F., Cai, Q., Boice, J. D., et al. (2013). Very low-level heteroplasmy mtDNA variations are inherited in humans. J. Genet. Genomics 40, 607-615. doi: 10.1016/j.jgg.2013.10.003
    • (2013) J. Genet. Genomics , vol.40 , pp. 607-615
    • Guo, Y.1    Li, C.I.2    Sheng, Q.3    Winther, J.F.4    Cai, Q.5    Boice, J.D.6
  • 20
    • 84929890412 scopus 로고    scopus 로고
    • The case for rejecting the amyloid cascade hypothesis
    • Herrup, K. (2015). The case for rejecting the amyloid cascade hypothesis. Nat. Neurosci. 18, 794-799. doi: 10.1038/nn.4017
    • (2015) Nat. Neurosci. , vol.18 , pp. 794-799
    • Herrup, K.1
  • 21
    • 84865581809 scopus 로고    scopus 로고
    • Alzheimer's disease neuroimaging initiative. maternal family history is associated with Alzheimer's disease biomarkers
    • Honea, R. A., Vidoni, E. D., Swerdlow, R. H., and Burns, J. M. (2012). Alzheimer's disease neuroimaging initiative. maternal family history is associated with Alzheimer's disease biomarkers. J. Alzheimers Dis. 31, 659-668. doi: 10.3233/JAD-2012-120676
    • (2012) J. Alzheimers Dis. , vol.31 , pp. 659-668
    • Honea, R.A.1    Vidoni, E.D.2    Swerdlow, R.H.3    Burns, J.M.4
  • 22
    • 84906815063 scopus 로고    scopus 로고
    • Mitochondrial flashes: new insights into mitochondrial ROS signaling and beyond
    • Hou, T., Wang, X., Ma, Q., and Cheng, H. (2014). Mitochondrial flashes: new insights into mitochondrial ROS signaling and beyond. J. Physiol. 592, 3703-3713. doi: 10.1113/jphysiol.2014.275735
    • (2014) J. Physiol. , vol.592 , pp. 3703-3713
    • Hou, T.1    Wang, X.2    Ma, Q.3    Cheng, H.4
  • 23
    • 84860770991 scopus 로고    scopus 로고
    • GERAD1 Consortium. No consistent evidence for association between mtDNA variants and Alzheimer disease
    • Hudson, G., Sims, R., Harold, D., Chapman, J., Hollingworth, P., Gerrish, A., et al. (2012). GERAD1 Consortium. No consistent evidence for association between mtDNA variants and Alzheimer disease. Neurology 78, 1038-1042. doi: 10.1212/WNL.0b013e31824e8f1d
    • (2012) Neurology , vol.78 , pp. 1038-1042
    • Hudson, G.1    Sims, R.2    Harold, D.3    Chapman, J.4    Hollingworth, P.5    Gerrish, A.6
  • 24
    • 0028296817 scopus 로고
    • Blood markers in Alzheimer disease: subnormal acetylcholinesterase and butyrylcholinesterase in lymphocytes and erythrocytes
    • Inestrosa, N. C., Alarcón, R., Arriagada, J., Donoso, A., Alvarez, J., and Campos, E. O. (1994). Blood markers in Alzheimer disease: subnormal acetylcholinesterase and butyrylcholinesterase in lymphocytes and erythrocytes. J. Neurol. Sci. 122, 1-5. doi: 10.1016/0022-510x(94)90044-2
    • (1994) J. Neurol. Sci. , vol.122 , pp. 1-5
    • Inestrosa, N.C.1    Alarcón, R.2    Arriagada, J.3    Donoso, A.4    Alvarez, J.5    Campos, E.O.6
  • 25
    • 84884686924 scopus 로고    scopus 로고
    • Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage
    • Kennedy, S. R., Salk, J. J., Schmitt, M. W., and Loeb, L. A. (2013). Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet. 9:e1003794. doi: 10.1371/journal.pgen.1003794
    • (2013) PLoS Genet , vol.9
    • Kennedy, S.R.1    Salk, J.J.2    Schmitt, M.W.3    Loeb, L.A.4
  • 26
    • 0033866833 scopus 로고    scopus 로고
    • Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways
    • Khan, S. M., Cassarino, D. S., Abramova, N. N., Keeney, P. M., Borland, M. K., Trimmer, P. A., et al. (2000). Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways. Ann. Neurol. 48, 148-155. doi: 10.1002/1531-8249(200008)48:2<148::aid-ana3>3.3.co;2-z
    • (2000) Ann. Neurol. , vol.48 , pp. 148-155
    • Khan, S.M.1    Cassarino, D.S.2    Abramova, N.N.3    Keeney, P.M.4    Borland, M.K.5    Trimmer, P.A.6
  • 28
    • 84901294948 scopus 로고    scopus 로고
    • Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease
    • Kukreja, L., Kujoth, G. C., Prolla, T. A., Van Leuven, F., and Vassar, R. (2014). Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Mol. Neurodegener. 9:16. doi: 10.1186/1750-1326-9-16
    • (2014) Mol. Neurodegener , vol.9 , pp. 16
    • Kukreja, L.1    Kujoth, G.C.2    Prolla, T.A.3    Van Leuven, F.4    Vassar, R.5
  • 29
    • 84877922143 scopus 로고    scopus 로고
    • The role of mitochondrial DNA mutations and free radicals in disease and ageing
    • Lagouge, M., and Larsson, N. G. (2013). The role of mitochondrial DNA mutations and free radicals in disease and ageing. J. Intern. Med. 273, 529-543. doi: 10.1111/joim.12055
    • (2013) J. Intern. Med. , vol.273 , pp. 529-543
    • Lagouge, M.1    Larsson, N.G.2
  • 30
    • 77953627194 scopus 로고    scopus 로고
    • Somatic mitochondrial DNA mutations in mammalian aging
    • Larsson, N. G. (2010). Somatic mitochondrial DNA mutations in mammalian aging. Annu. Rev. Biochem. 79, 683-706. doi: 10.1146/annurev-biochem-060408-093701
    • (2010) Annu. Rev. Biochem. , vol.79 , pp. 683-706
    • Larsson, N.G.1
  • 31
    • 84868097630 scopus 로고    scopus 로고
    • Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes
    • Leuner, K., Schulz, K., Schütt, T., Pantel, J., Prvulovic, D., Rhein, V., et al. (2012). Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes. Mol. Neurobiol. 46, 194-204. doi: 10.1007/s12035-012-8300-y
    • (2012) Mol. Neurobiol. , vol.46 , pp. 194-204
    • Leuner, K.1    Schulz, K.2    Schütt, T.3    Pantel, J.4    Prvulovic, D.5    Rhein, V.6
  • 32
    • 0037081814 scopus 로고    scopus 로고
    • High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
    • Lin, M. T., Simon, D. K., Ahn, C. H., Kim, L. M., and Beal, M. F. (2002). High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum. Mol. Genet. 11, 133-145. doi: 10.1093/hmg/11.2.133
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 133-145
    • Lin, M.T.1    Simon, D.K.2    Ahn, C.H.3    Kim, L.M.4    Beal, M.F.5
  • 33
    • 67650921433 scopus 로고    scopus 로고
    • Vitamin E paradox in Alzheimer's disease: it does not prevent loss of cognition and may even be detrimental
    • Lloret, A., Badía, M. C., Mora, N. J., Pallardó, F. V., Alonso, M. D., and Viña, J. (2009). Vitamin E paradox in Alzheimer's disease: it does not prevent loss of cognition and may even be detrimental. J. Alzheimers Dis. 17, 143-149. doi: 10.3233/JAD-2009-1033
    • (2009) J. Alzheimers Dis. , vol.17 , pp. 143-149
    • Lloret, A.1    Badía, M.C.2    Mora, N.J.3    Pallardó, F.V.4    Alonso, M.D.5    Viña, J.6
  • 34
    • 0034612075 scopus 로고    scopus 로고
    • A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients
    • Maurer, I., Zierz, S., and Möller, H. J. (2000). A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients. Neurobiol. Aging 21, 455-462. doi: 10.1016/s0197-4580(00)00112-3
    • (2000) Neurobiol. Aging , vol.21 , pp. 455-462
    • Maurer, I.1    Zierz, S.2    Möller, H.J.3
  • 35
    • 0030842414 scopus 로고    scopus 로고
    • Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain
    • Mecocci, P., Beal, M. F., Cecchetti, R., Polidori, M. C., Cherubini, A., Chionne, F., et al. (1997). Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain. Mol. Chem. Neuropathol. 31, 53-64. doi: 10.1007/bf02815160
    • (1997) Mol. Chem. Neuropathol. , vol.31 , pp. 53-64
    • Mecocci, P.1    Beal, M.F.2    Cecchetti, R.3    Polidori, M.C.4    Cherubini, A.5    Chionne, F.6
  • 36
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mtDNA mutations in the human mtDNA control region for replication
    • Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G., and Attardi, G. (1999). Aging-dependent large accumulation of point mtDNA mutations in the human mtDNA control region for replication. Science 286, 774-779. doi: 10.1126/science.286.5440.774
    • (1999) Science , vol.286 , pp. 774-779
    • Michikawa, Y.1    Mazzucchelli, F.2    Bresolin, N.3    Scarlato, G.4    Attardi, G.5
  • 37
    • 38949175007 scopus 로고    scopus 로고
    • A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
    • Miller, J. A., Oldham, M. C., and Geschwind, D. H. (2008). A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. J. Neurosci. 28, 1410-1420. doi: 10.1523/JNEUROSCI.4098-07.2008
    • (2008) J. Neurosci. , vol.28 , pp. 1410-1420
    • Miller, J.A.1    Oldham, M.C.2    Geschwind, D.H.3
  • 38
    • 24644443839 scopus 로고    scopus 로고
    • Oxidative stress: the old enemy in Alzheimer's disease pathophysiology
    • Moreira, P. I., Honda, K., Liu, Q., Santos, M. S., Oliveira, C. R., Aliev, G., et al. (2005). Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. Curr. Alzheimer Res. 2, 403-408. doi: 10.2174/156720505774330537
    • (2005) Curr. Alzheimer Res. , vol.2 , pp. 403-408
    • Moreira, P.I.1    Honda, K.2    Liu, Q.3    Santos, M.S.4    Oliveira, C.R.5    Aliev, G.6
  • 40
    • 80055088009 scopus 로고    scopus 로고
    • Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease
    • Mosconi, L., de Leon, M., Murray, J., E, L., Lu, J., Javier, E., et al. (2011). Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease. J. Alzheimers Dis. 27, 483-490. doi: 10.3233/JAD-2011-110866
    • (2011) J. Alzheimers Dis. , vol.27 , pp. 483-490
    • Mosconi, L.1    de Leon, M.2    Murray, J.3    Lu, J.4    Javier, E.5
  • 41
    • 84929938315 scopus 로고    scopus 로고
    • Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
    • Musiek, E. S., and Holtzman, D. M. (2015). Three dimensions of the amyloid hypothesis: time, space and 'wingmen'. Nat. Neurosci. 18, 800-806. doi: 10.1038/nn.4018
    • (2015) Nat. Neurosci. , vol.18 , pp. 800-806
    • Musiek, E.S.1    Holtzman, D.M.2
  • 42
    • 0028201012 scopus 로고
    • Reduced platelet cytochrome c oxidase activity in Alzheimer's disease
    • Parker, W. D. Jr., Mahr, N. J., Filley, C. M., Parks, J. K., Hughes, D., Young, D. A., et al. (1994). Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology 44, 1086-1090. doi: 10.1212/wnl.44.6.1086
    • (1994) Neurology , vol.44 , pp. 1086-1090
    • Parker, W.D.1    Mahr, N.J.2    Filley, C.M.3    Parks, J.K.4    Hughes, D.5    Young, D.A.6
  • 43
    • 75649135280 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease
    • Perl, D. P. (2010). Neuropathology of Alzheimer's disease. Mt. Sinai J. Med. 77, 32-42. doi: 10.1002/msj.20157
    • (2010) Mt. Sinai J. Med. , vol.77 , pp. 32-42
    • Perl, D.P.1
  • 44
    • 0022001659 scopus 로고
    • Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease
    • Peterson, C., Gibson, G. E., and Blass, J. P. (1985). Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease. N. Engl. J. Med. 312, 1063-1065. doi: 10.1056/nejm198504183121618
    • (1985) N. Engl. J. Med. , vol.312 , pp. 1063-1065
    • Peterson, C.1    Gibson, G.E.2    Blass, J.P.3
  • 45
    • 84887223586 scopus 로고    scopus 로고
    • Mitochondrial haplotypes associated with biomarkers for Alzheimer's disease
    • Ridge, P. G., Koop, A., Maxwell, T. J., Bailey, M. H., Swerdlow, R. H., Kauwe, J. S., et al. (2013). Mitochondrial haplotypes associated with biomarkers for Alzheimer's disease. PLoS One 8:e74158. doi: 10.1371/journal.pone.0074158
    • (2013) PLoS One , vol.8
    • Ridge, P.G.1    Koop, A.2    Maxwell, T.J.3    Bailey, M.H.4    Swerdlow, R.H.5    Kauwe, J.S.6
  • 46
    • 84884416043 scopus 로고    scopus 로고
    • Germline mitochondrial DNA mutations aggravate ageing and can impair brain development
    • Ross, J. M., Stewart, J. B., Hagström, E., Brené, S., Mourier, A., Coppotelli, G., et al. (2013). Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature 501, 412-415. doi: 10.1038/nature12474
    • (2013) Nature , vol.501 , pp. 412-415
    • Ross, J.M.1    Stewart, J.B.2    Hagström, E.3    Brené, S.4    Mourier, A.5    Coppotelli, G.6
  • 47
  • 48
    • 84869397441 scopus 로고    scopus 로고
    • Human mitochondrial DNA: roles of inherited and somatic mutations
    • Schon, E. A., DiMauro, S., and Hirano, M. (2012). Human mitochondrial DNA: roles of inherited and somatic mutations. Nat. Rev. Genet. 13, 878-890. doi: 10.1038/nrg3275
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 878-890
    • Schon, E.A.1    DiMauro, S.2    Hirano, M.3
  • 49
    • 84871417031 scopus 로고    scopus 로고
    • Role of mitochondrial homeostasis and dynamics in Alzheimer's disease
    • Selfridge, J. E., E, L., Lu, J., and Swerdlow, R. H. (2013). Role of mitochondrial homeostasis and dynamics in Alzheimer's disease. Neurobiol. Dis. 51, 3-12. doi: 10.1016/j.nbd.2011.12.057
    • (2013) Neurobiol. Dis. , vol.51 , pp. 3-12
    • Selfridge, J.E.1    Lu, J.2    Swerdlow, R.H.3
  • 50
    • 0030923869 scopus 로고    scopus 로고
    • Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease
    • Sheehan, J. P., Swerdlow, R. H., Miller, S. W., Davis, R. E., Parks, J. K., Parker, W. D., et al. (1997). Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J. Neurosci. 17, 4612-4622.
    • (1997) J. Neurosci. , vol.17 , pp. 4612-4622
    • Sheehan, J.P.1    Swerdlow, R.H.2    Miller, S.W.3    Davis, R.E.4    Parks, J.K.5    Parker, W.D.6
  • 51
    • 0025790342 scopus 로고
    • Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease
    • Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., et al. (1991). Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc. Natl. Acad. Sci. U S A 88, 10540-10543. doi: 10.1073/pnas.88.23.10540
    • (1991) Proc. Natl. Acad. Sci. U S A , vol.88 , pp. 10540-10543
    • Smith, C.D.1    Carney, J.M.2    Starke-Reed, P.E.3    Oliver, C.N.4    Stadtman, E.R.5    Floyd, R.A.6
  • 52
    • 77956220629 scopus 로고    scopus 로고
    • Neuronal calcium signaling, mitochondrial dysfunction and Alzheimer's disease
    • Supnet, C., and Bezprozvanny, I. (2010). Neuronal calcium signaling, mitochondrial dysfunction and Alzheimer's disease. J. Alzheimers Dis. 20, S487-S498. doi: 10.3233/JAD-2010-100306
    • (2010) J. Alzheimers Dis. , vol.20 , pp. S487-S498
    • Supnet, C.1    Bezprozvanny, I.2
  • 53
    • 84903304968 scopus 로고    scopus 로고
    • The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives
    • Swerdlow, R. H., Burns, J. M., and Khan, S. M. (2014). The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives. Biochim. Biophys. Acta 1842, 1219-1231. doi: 10.1016/j.bbadis.2013.09.010
    • (2014) Biochim. Biophys. Acta , vol.1842 , pp. 1219-1231
    • Swerdlow, R.H.1    Burns, J.M.2    Khan, S.M.3
  • 54
    • 5044220307 scopus 로고    scopus 로고
    • Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease
    • Tacconi, S., Perri, R., Balestrieri, E., Grelli, S., Bernardini, S., Annichiarico, R., et al. (2004). Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease. Exp. Neurol. 1, 254-262. doi: 10.1016/j.expneurol.2004.07.009
    • (2004) Exp. Neurol. , vol.1 , pp. 254-262
    • Tacconi, S.1    Perri, R.2    Balestrieri, E.3    Grelli, S.4    Bernardini, S.5    Annichiarico, R.6
  • 55
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., et al. (2004). Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429, 417-423. doi: 10.1038/nature02517
    • (2004) Nature , vol.429 , pp. 417-423
    • Trifunovic, A.1    Wredenberg, A.2    Falkenberg, M.3    Spelbrink, J.N.4    Rovio, A.T.5    Bruder, C.E.6
  • 56
    • 84862826227 scopus 로고    scopus 로고
    • Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer's disease
    • Wang, S., Song, J., Tan, M., Albers, K. M., and Jia, J. (2012). Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer's disease. Eur. J. Neurol. 19, 1015-1022. doi: 10.1111/j.1468-1331.2012.03670.x
    • (2012) Eur. J. Neurol. , vol.19 , pp. 1015-1022
    • Wang, S.1    Song, J.2    Tan, M.3    Albers, K.M.4    Jia, J.5
  • 57
    • 67650732998 scopus 로고    scopus 로고
    • Impaired balance of mitochondrial fission and fusion in Alzheimer's disease
    • Wang, X., Su, B., Lee, H. G., Li, X., Perry, G., Smith, M. A., et al. (2009). Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J. Neurosci. 29, 9090-9103. doi: 10.1523/JNEUROSCI.1357-09.2009
    • (2009) J. Neurosci. , vol.29 , pp. 9090-9103
    • Wang, X.1    Su, B.2    Lee, H.G.3    Li, X.4    Perry, G.5    Smith, M.A.6
  • 58
    • 23244442108 scopus 로고    scopus 로고
    • Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels
    • Ward, W. F., Qi, W., Van Remmen, H., Zackert, W. E., Roberts, J. L. IInd, and Richardson, A. (2005). Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J. Gerontol. A Biol. Sci. Med. Sci. 60, 845-847. doi: 10.1093/gerona/60.7.847
    • (2005) J. Gerontol. A Biol. Sci. Med. Sci. , vol.60 , pp. 845-847
    • Ward, W.F.1    Qi, W.2    Van Remmen, H.3    Zackert, W.E.4    Roberts, J.L.5    Richardson, A.6
  • 59
    • 78149485884 scopus 로고    scopus 로고
    • Lactic acid induces aberrant amyloid precursor protein processing by promoting its interaction with endoplasmic reticulum chaperone proteins
    • Xiang, Y., Xu, G., and Weigel-Van Aken, K. A. (2010). Lactic acid induces aberrant amyloid precursor protein processing by promoting its interaction with endoplasmic reticulum chaperone proteins. PLoS One 5:e13820. doi: 10.1371/journal.pone.0013820
    • (2010) PLoS One , vol.5
    • Xiang, Y.1    Xu, G.2    Weigel-Van Aken, K.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.