Contribution of nanotechnology to improved treatment of periodontal disease

Current Pharmaceutical Design

Volumn 21, Issue 22, 2015, Pages 3257-3271

  Zupančič, Špela ^a   Kocbek, Petra ^a   Baumgartner, Saša ^a   Kristl, Julijana ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Biofilm; Drug delivery; Liposomes; Nanofibers; Nanomedicine; Nanoparticles; Periodontal regeneration; Periodontitis

Indexed keywords

ANTIBIOTIC AGENT; CHITOSAN; DENDRIMER; DOXYCYCLINE HYCLATE; LIPOSOME; MOLECULAR SCAFFOLD; NANOCARRIER; NANOCRYSTAL; NANOFIBER; NANOPARTICLE; PHOTOSENSITIZING AGENT; ANTIINFECTIVE AGENT; DRUG CARRIER; NANOMATERIAL; NONSTEROID ANTIINFLAMMATORY AGENT;

AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ANTIBIOTIC THERAPY; ARTICLE; BIOFILM; DRUG EFFICACY; GINGIVITIS; HOST SUSCEPTIBILITY; IMMUNOMODULATION; LIPOSOMAL DELIVERY; MICROBIAL COMMUNITY; MOUTH FLORA; MOUTH HYGIENE; NANOPHARMACEUTICS; PATHOGENESIS; PERIODONTAL DISEASE; PERIODONTITIS; PERIODONTIUM; PHOTODYNAMIC THERAPY; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; RISK FACTOR; TANNERELLA FORSYTHIA; TISSUE REGENERATION; TOOTH PLAQUE; TREPONEMA; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; HUMAN; MICROBIOLOGY; NANOMEDICINE; PERIODONTAL DISEASES;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; NANOMEDICINE; NANOSTRUCTURES; PERIODONTAL DISEASES;

EID: 84938577032     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612821666150531171829     Document Type: Article

References (147)

1. Savage A, Eaton KA, Moles DR, Needleman I. A systematic review of definitions of periodontitis and methods that have been used to identify this disease. J Clin Periodontol 2009; 36: 458-67.
2. Dentino A, Lee S, Mailhot J, Hefti AF. Principles of periodontology. Periodontol 2000 2013; 61: 16-53.
3. Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res 2012; 91: 914-20.
4. Teughels W, Van Essche M, Sliepen I, Quirynen M. Probiotics and oral healthcare. Periodontol 2000 2008; 48: 111-47.
5. Hajishengallis G. Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol 2014; 35: 3-11.
6. Berezow AB, Darveau RP. Microbial shift and periodontitis. Periodontol 2000 2011; 55: 36-47.
7. Mombelli A, Cionca N, Almaghlouth A. Does adjunctive antimicrobial therapy reduce the perceived need for periodontal surgery? Periodontol 2000 2011; 55: 205-16.
8. Jain N, Jain GK, Javed S, et al. Recent approaches for the treatment of periodontitis. Drug Discov Today 2008; 13: 932-43.
9. Hau H, Rohanizadeh R, Ghadiri M, Chrzanowski W. A minireview on novel intraperiodontal pocket drug delivery materials for the treatment of periodontal diseases. Drug Deliv Transl Res 2014; 4: 295-301.
10. Sahoo SK, Parveen S, Panda JJ. The present and future of nanotechnology in human health care. Nanomedicine 2007; 3: 20-31.
11. Bogunia-Kubik K, Sugisaka M. From molecular biology to nanotechnology and nanomedicine. Biosystems 2002; 65: 123-38.
12. Pelipenko J, Kocbek P, Kristl J. Critical attributes of nanofibers: preparation, drug loading and tissue regeneration. Int J Pharm 2015; 1-2: 57-74.
13. Shi J, Votruba AR, Farokhzad OC, Langer R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett 2010; 10: 3223-30.
14. Petelin M, Pavlica Z, Ivanuaš T, Šentjurc M, Skalerič U. Local delivery of liposome-encapsulated superoxide dismutase and catalase suppress periodontal inflammation in beagles. J Clin Periodontol 2000; 27: 918-25.
15. Bottino MC, Arthur RA, Waeiss RA, Kamocki K, Gregson KS, Gregory RL. Biodegradable nanofibrous drug delivery systems: effects of metronidazole and ciprofloxacin on periodontopathogens and commensal oral bacteria. Clin Oral Investig 2014; 18: 2151-8.
16. Bottino MC, Thomas V, Janowski GM. A novel spatially designed and functionally graded electrospun membrane for periodontal regeneration. Acta Biomater 2011; 7: 216-24.
17. Phillips MA, Gran ML, Peppas NA. Targeted nanodelivery of drugs and diagnostics. Nano Today 2010; 5: 143-59.
18. Gao H, Zhang Q, Yu Z, He Q. Cell-penetrating peptide-based intelligent liposomal systems for enhanced drug delivery. Curr Pharm Biotechnol 2014; 15: 210-9.
19. Huh AJ, Kwon YJ. "Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. J Control Release 2011; 156: 128-45.
20. Martin C, Low WL, Gupta A, et al. Strategies for antimicrobial drug delivery to biofilm. Curr Pharm Des 2015; 21: 43-66.
21. Xiong MH, Bao Y, Yang XZ, Zhu YH, Wang J. Delivery of antibiotics with polymeric particles. Adv Drug Deliv Rev 2014; 78: 63-76.
22. Bottino MC, Thomas V, Schmidt G, et al. Recent advances in the development of GTR/GBR membranes for periodontal regeneration-- a materials perspective. Dent Mater 2012; 28: 703-21.
23. Wagner V, Dullaart A, Bock AK, Zweck A. The emerging nanomedicine landscape. Nat Biotechnol 2006; 24: 1211-7.
24. Prosecka E, Rampichova M, Litvinec A, et al. Collagen/ hydroxyapatite scaffold enriched with polycaprolactone nanofibers, thrombocyte-rich solution and mesenchymal stem cells promotes regeneration in large bone defect in vivo. J Biomed Mater Res A 2015; 103(2): 671-82.
25. Joshi D, Garg T, Goyal AK, Rath G. Advanced drug delivery approaches against periodontitis. Drug Deliv 2014;Epub ahead of print..
26. Kong LX, Peng Z, Li SD, Bartold PM. Nanotechnology and its role in the management of periodontal diseases. Periodontol 2000 2006; 40: 184-96.
27. Nanci A, Bosshardt DD. Structure of periodontal tissues in health and disease. Periodontol 2000 2006; 40: 11-28.
28. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005; 366: 1809-20.
29. Lindhe J, Lang NP, Karring T. Clinical Periodontology and Implant Dentistry. USA: Wiley 2009.
30. Parahitiyawa NB, Scully C, Leung WK, Yam WC, Jin LJ, Samaranayake LP. Exploring the oral bacterial flora: current status and future directions. Oral Dis 2010; 16: 136-45.
31. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 2005; 43: 5721-32.
32. Hojo K, Nagaoka S, Ohshima T, Maeda N. Bacterial interactions in dental biofilm development. J Dent Res 2009; 88: 982-90.
33. Zijnge V, Ammann T, Thurnheer T, Gmur R. Subgingival biofilm structure. Front Oral Biol 2012; 15: 1-16.
34. Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000 2002; 28: 12-55.
35. Genco RJ, Borgnakke WS. Risk factors for periodontal disease. Periodontol 2000 2013; 62: 59-94.
36. Bullon P, Newman HN, Battino M. Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a shared pathology via oxidative stress and mitochondrial dysfunction? Periodontol 2000 2014; 64: 139-53.
37. Slots J. Low-cost periodontal therapy. Periodontol 2000 2012; 60: 110-37.
38. Hanes PJ, Purvis JP. Local anti-infective therapy: pharmacological agents. A systematic review. Ann Periodontol 2003; 8: 79-98.
39. Bonito AJ, Lux L, Lohr KN. Impact of local adjuncts to scaling and root planing in periodontal disease therapy: a systematic review. J Periodontol 2005; 76: 1227-36.
40. Iqbal Z, Jain N, Jain GK, et al. Dental therapeutic systems. Rec Pat Drug Deliv Formul 2008; 2: 58-67.
41. Di Turi G, Riggio C, Vittorio O, et al. Sub-micrometric liposomes as drug delivery systems in the treatment of periodontitis. Int J Immunopathol Pharmacol 2012; 25: 657-70.
42. Sindhura RN, Sowmya S, Bumgardner JD, Chennazhi KP, Biswas R, Jayakumar R. Tetracycline nanoparticles loaded calcium sulfate composite beads for periodontal management. Biochim Biophys Acta 2014; 1840: 2080-90.
43. Kenawy el R, Bowlin GL, Mansfield K, et al. Release of tetracycline hydrochloride from electrospun poly(ethylene-covinylacetate), poly(lactic acid), and a blend. J Control Release 2002; 81: 57-64.
44. Khodir WWA, Guarino V, Alvarez-Perez M, Cafiero C, Ambrosio L. Trapping tetracycline-loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy. J Bioact Compat Polym 2013; 28: 258-73.
45. Wayakanon K, Thornhill MH, Douglas CW, et al. Polymersomemediated intracellular delivery of antibiotics to treat Porphyromonas gingivalis-infected oral epithelial cells. FASEB J 2013; 27: 4455-65.
46. Feng K, Sun H, Bradley MA, Dupler EJ, Giannobile WV, Ma PX. Novel antibacterial nanofibrous PLLA scaffolds. J Control Release 2010; 146: 363-9.
47. Liu D, Yang PS. Minocycline hydrochloride nanoliposomes inhibit the production of TNF-alpha in LPS-stimulated macrophages. Int J Nanomed 2012; 7: 4769-75.
48. Yao W, Xu P, Pang Z, et al. Local delivery of minocycline-loaded PEG-PLA nanoparticles for the enhanced treatment of periodontitis in dogs. Int J Nanomed 2014; 9: 3963-70.
49. Saboktakin MR, Tabatabaie RM, Maharramov A, Ramazanov MA. Development and in vitro evaluation of thiolated chitosan-- Poly(methacrylic acid) nanoparticles as a local mucoadhesive delivery system. Int J Biol Macromol 2011; 48: 403-7.
50. Chen DW, Lee FY, Liao JY, Liu SJ, Hsiao CY, Chen JK. Preclinical experiments on the release behavior of biodegradable nanofibrous multipharmaceutical membranes in a model of four-wall intrabony defect. Antimicrob Agents Chemother 2013; 57: 9-14.
51. Reise M, Wyrwa R, Muller U, et al. Release of metronidazole from electrospun poly(L-lactide-co-D/L-lactide) fibers for local periodontitis treatment. Dent Mater 2012; 28: 179-88.
52. Xue J, He M, Liang Y, et al. Fabrication and evaluation of electrospun PCL-gelatin micro-/nanofiber membranes for anti-infective GTR implants. J Mater Chem B 2014; 2: 6867-77.
53. Garcez AS, Nunez SC, Hamblim MR, Suzuki H, Ribeiro MS. Photodynamic therapy associated with conventional endodontic treatment in patients with antibiotic-resistant microflora: a preliminary report. J Endod 2010; 36: 1463-6.
54. Gupta A, Avci P, Sadasivam M, et al. Shining light on nanotechnology to help repair and regeneration. Biotechnol Adv 2013; 31: 607-31.
55. Kepczynski M, Dzieciuch M, Nowakowska M. Nanostructural hybrid sensitizers for photodynamic therapy. Curr Pharm Des 2012; 18: 2607-21.
56. Gulati M, Anand V, Govila V, Jain N. Host modulation therapy: An indispensable part of perioceutics. J Indian Soc Periodontol 2014; 18: 282-8.
57. Ciancio S, Ashley R. Safety and efficacy of sub-antimicrobial-dose doxycycline therapy in patients with adult periodontitis. Adv Dent Res 1998; 12: 27-31.
58. Preshaw PM, Hefti AF, Jepsen S, Etienne D, Walker C, Bradshaw MH. Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis. J Clin Periodontol 2004; 31: 697-707.
59. Reddy MS, Geurs NC, Gunsolley JC. Periodontal host modulation with antiproteinase, anti-inflammatory, and bone-sparing agents. Ann Periodontol 2003; 8: 12-37.
60. Hasturk H, Kantarci A, Goguet-Surmenian E, et al. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol 2007; 179: 7021-9.
61. Serhan CN, Brain SD, Buckley CD, et al. Resolution of inflammation: state of the art, definitions and terms. FASEB J 2007; 21: 325-32.
62. Rizzo A, Bevilacqua N, Guida L, Annunziata M, Romano Carratelli C, Paolillo R. Effect of resveratrol and modulation of cytokine production on human periodontal ligament cells. Cytokine 2012; 60: 197-204.
63. Gomez-Florit M, Ramis JM, Monjo M. Anti-fibrotic and antiinflammatory properties of melatonin on human gingival fibroblasts in vitro. Biochem Pharmacol 2013; 86: 1784-90.
64. Hasturk H, Kantarci A, Ebrahimi N, et al. Topical H2 antagonist prevents periodontitis in a rabbit model. Infect Immun 2006; 74: 2402-14.
65. Sowmya S, Bumgardener JD, Chennazhi KP, Nair SV, Jayakumar R. Role of nanostructured biopolymers and bioceramics in enamel, dentin and periodontal tissue regeneration. Prog Polym Sci 2013; 38: 1748-72.
66. Chen FM, An Y, Zhang R, Zhang M. New insights into and novel applications of release technology for periodontal reconstructive therapies. J Control Release 2011; 149: 92-110.
67. Ahlin-Grabnar P, Kristl J. The manufacturing techniques of drugloaded polymeric nanoparticles from preformed polymers. J Microencapsul 2011; 28: 323-35.
68. Rošic R, Pelipenko J, Kocbek P, Baumgartner S, Bešter-Rogač M, Kristl J. The role of rheology of polymer solutions in predicting nanofiber formation by electrospinning. Eur Polym J 2012; 48: 1374-84.
69. Felice B, Prabhakaran MP, Rodríguez AP, Ramakrishna S. Drug delivery vehicles on a nano-engineering perspective. Mater Sci Eng C Mater Biol Appl 2014; 41: 178-95.
70. Wade RJ, Burdick JA. Advances in nanofibrous scaffolds for biomedical applications: From electrospinning to self-assembly. Nano Today 2015 doi:10.1016/j.nantod.2014.10.002.
71. Ahlin P, Kristl J, Pečar S, Štrancar J, Šentjurc M. The effect of lipophilicity of spin-labeled compounds on their distribution in solid lipid nanoparticle dispersions studied by electron paramagnetic resonance. J Pharm Sci 2003; 92: 58-66.
72. Vrhovnik K, Kristl J, Šentjurc M, Šmid-Korbar J. Influence of Liposome Bilayer Fluidity on the Transport of Encapsulated Substance into the Skin as Evaluated by EPR. Pharm Res 1998; 15: 525-30.
73. Pelipenko J, Kristl J, Rosič R, Baumgartner S, Kocbek P. Interfacial rheology: an overview of measuring techniques and its role in dispersions and electrospinning. Acta Pharm 2012; 62: 123-40.
74. Peetla C, Labhasetwar V. Biophysical characterization of nanoparticle- endothelial model cell membrane interactions. Mol Pharm 2008; 5: 418-29.
75. Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005; 4: 145-60.
76. Nanjwade BK, Bechra HM, Derkar GK, Manvi FV, Nanjwade VK. Dendrimers: emerging polymers for drug-delivery systems. Eur J Pharm Sci 2009; 38: 185-96.
77. Bertoncelj V, Pelipenko J, Kristl J, Jeras M, Cukjati M, Kocbek P. Development and bioevaluation of nanofibers with blood-derived growth factors for dermal wound healing. Eur J Pharm Biopharm 2014; 88: 64-74.
78. Breunig M, Bauer S, Goepferich A. Polymers and nanoparticles: intelligent tools for intracellular targeting? Eur J Pharm Biopharm 2008; 68: 112-28.
79. Goyal G, Garg T, Rath G, Goyal AK. Current nanotechnological strategies for an effective delivery of drugs in treatment of periodontal disease. Crit Rev Ther Drug Carrier Syst 2014; 31: 89-119.
80. Pattnaik S, Panigrahi L, Murthy RS. Periodontal muco-adhesive formulations for the treatment of infectious periodontal diseases. Curr Drug Deliv 2007; 4: 303-23.
81. Kilicarslan M, Gumustas M, Yildiz S, Baykara T. Preparation and characterization of chitosan-based spray-dried microparticles for the delivery of clindamycin phosphate to periodontal pockets. Curr Drug Deliv 2014; 11: 98-111.
82. Vasir JK, Tambwekar K, Garg S. Bioadhesive microspheres as a controlled drug delivery system. Int J Pharm 2003; 255: 13-32.
83. Barat R, Srinatha A, Pandit JK, Anupurba S, Mittal N. Chitosan inserts for periodontitis: influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release. Acta Pharm 2007; 57: 469-77.
84. Zvonar A, Kristl J, Kerč J, Grabnar PA. High celecoxib-loaded nanoparticles prepared by a vibrating nozzle device. J Microencapsul 2009; 26: 748-59.
85. Teskač K, Kristl J. The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. Int J Pharm 2010; 390: 61-9.
86. Gardiner J, Freeman S, Leach M, Green A, Alcock J, D'Emanuele A. PAMAM dendrimers for the delivery of the antibacterial Triclosan. J Enzyme Inhib Med Chem 2008; 23: 623-8.
87. Arancibia R, Maturana C, Silva D, et al. Effects of chitosan particles in periodontal pathogens and gingival fibroblasts. J Dent Res 2013; 92: 740-5.
88. Kawazoe A, Inubushi T, Miyauchi M, et al. Orally administered liposomal lactoferrin inhibits inflammation-related bone breakdown without interrupting orthodontic tooth movement. J Periodontol 2013; 84: 1454-62.
89. Ishikado A, Uesaki S, Suido H, et al. Human trial of liposomal lactoferrin supplementation for periodontal disease. Biol Pharm Bull 2010; 33: 1758-62.
90. Sugano M, Negishi Y, Endo-Takahashi Y, et al. Gene delivery to periodontal tissue using Bubble liposomes and ultrasound. J Periodontal Res 2014; 49: 398-404.
91. Peng L, Cheng X, Zhuo R, et al. Novel gene-activated matrix with embedded chitosan/plasmid DNA nanoparticles encoding PDGF for periodontal tissue engineering. J Biomed Mater Res A 2009; 90: 564-76.
92. Ma Z, Dagnaes-Hansen F, Lovschall H, et al. Macrophagemediated nanoparticle delivery to the periodontal lesions in established murine model via Pg-LPS induction. J Oral Pathol Med 2014.
93. Honma K, Kato T, Okuda K. Salivary immunoglobulin A production against a synthetic oligopeptide antigen of Actinobacillus actinomycetemcomitans fimbriae. Oral Microbiol Immunol 1999; 14: 288-92.
94. Hamada S, Ogawa T, Shimauchi H, Kusumoto Y. Induction of mucosal and serum immune responses to a specific antigen of periodontal bacteria. Adv Exp Med Biol 1992; 327: 71-81.
95. Ko A, Yee M, Skupin-Mrugalska P, Duzgunes N. Photodynamic therapy of Porphyromonas gingivalis via liposome-encapsulated sensitizers. J Calif Dent Assoc 2013; 41: 827-30.
96. Klepac-Ceraj V, Patel N, Song X, et al. Photodynamic effects of methylene blue-loaded polymeric nanoparticles on dental plaque bacteria. Lasers Surg Med 2011; 43: 600-6.
97. Nagahara A, Mitani A, Fukuda M, et al. Antimicrobial photodynamic therapy using a diode laser with a potential new photosensitizer, indocyanine green-loaded nanospheres, may be effective for the clearance of Porphyromonas gingivalis. J Periodontal Res 2013; 48: 591-9.
98. Pinon-Segundo E, Ganem-Quintanar A, Alonso-Perez V, Quintanar- Guerrero D. Preparation and characterization of triclosan nanoparticles for periodontal treatment. Int J Pharm 2005; 294: 217-32.
99. Vargas-Reus MA, Memarzadeh K, Huang J, Ren GG, Allaker RP. Antimicrobial activity of nanoparticulate metal oxides against periimplantitis pathogens. Int J Antimicrob Agents 2012; 40: 135-9.
100. Lu Z, Rong K, Li J, Yang H, Chen R. Size-dependent antibacterial activities of silver nanoparticles against oral anaerobic pathogenic bacteria. J Mater Sci Mater Med 2013; 24: 1465-71.
101. Inanc B, Arslan YE, Seker S, Elcin AE, Elcin YM. Periodontal ligament cellular structures engineered with electrospun poly(DLlactide- co-glycolide) nanofibrous membrane scaffolds. J Biomed Mater Res A 2009; 90: 186-95.
102. Vanič Z, Hafner A, Bego M, Skalko-Basnet N. Characterization of various deformable liposomes with metronidazole. Drug Dev Ind Pharm 2013; 39: 481-8.
103. Filipovič-Grčič J, Skalko-Basnet N, Jalšenjak I. Mucoadhesive chitosan-coated liposomes: characteristics and stability. J Microencapsul 2001; 18: 3-12.
104. Chan JM, Valencia PM, Zhang L, Langer R, Farokhzad OC. Polymeric nanoparticles for drug delivery. Methods Mol Biol 2010; 624: 163-75.
105. Manke A, Luanpitpong S, Dong C, et al. Effect of fiber length on carbon nanotube-induced fibrogenesis. Int J Mol Sci 2014; 15: 7444-61.
106. Dong C, Kashon ML, Lowry D, et al. Exposure to carbon nanotubes leads to changes in the cellular biomechanics. Adv Healthc Mater 2013; 2: 945-51.
107. Liu Z, Zhang N. pH-Sensitive polymeric micelles for programmable drug and gene delivery. Curr Pharm Des 2012; 18: 3442-51.
108. Cevc G, Vierl U. Nanotechnology and the transdermal route: A state of the art review and critical appraisal. J Control Release 2010; 141: 277-99.
109. Mallick S, Choi JS. Liposomes: versatile and biocompatible nanovesicles for efficient biomolecules delivery. J Nanosci Nanotechnol 2014; 14: 755-65.
110. Love RM, Jenkinson HF. Invasion of dentinal tubules by oral bacteria. Crit Rev Oral Biol Med 2002; 13: 171-83.
111. Stone WL, Smith M. Therapeutic uses of antioxidant liposomes. Mol Biotechnol 2004; 27: 217-30.
112. Caddeo C, Teskač K, Sinico C, Kristl J. Effect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells. Int J Pharm 2008; 363: 183-91.
113. Kristl J, Teskač K, Caddeo C, Abramovič Z, Šentjurc M. Improvements of cellular stress response on resveratrol in liposomes. Eur J Pharm Biopharm 2009; 73: 253-9.
114. Seguier S, Souza SL, Sverzut AC, et al. Impact of photodynamic therapy on inflammatory cells during human chronic periodontitis. J Photochem Photobiol B 2010; 101: 348-54.
115. Drulis-Kawa Z, Dorotkiewicz-Jach A. Liposomes as delivery systems for antibiotics. Int J Pharm 2010; 387: 187-98.
116. Cevc G, Gebauer D, Stieber J, Schätzlein A, Blume G. Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim Biophys Acta 1998; 1368: 201-15.
117. Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release 2000; 65: 403-18.
118. Sinico C, Fadda AM. Vesicular carriers for dermal drug delivery. Expert Opin Drug Deliv 2009; 6: 813-25.
119. Zupančič Š, Kocbek P, Zariwala MG, et al. Design and development of novel mitochondrial targeted nanocarriers, DQAsomes for curcumin inhalation. Mol Pharm 2014; 11: 2334-45.
120. Šmid-Korbar J, Kristl J. Development of oral mucoadhesive formulations based on polymethyl methacrylate polymer. STP Pharma Sci 1997; 7: 452-6.
121. Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces 2010; 75: 1-18.
122. Chen W, Meng F, Cheng R, Deng C, Feijen J, Zhong Z. Advanced drug and gene delivery systems based on functional biodegradable polycarbonates and copolymers. J Control Release 2014; 190: 398-414.
123. Kristl J, Šmid-Korbar J, Štruc E, Schara M, Rupprecht H. Hydrocolloids and gels of chitosan as drug carriers. Int J Pharm 1993; 99: 13-9.
124. Kim T, Hyeon T. Applications of inorganic nanoparticles as therapeutic agents. Nanotechnology 2014; 25: 012001.
125. Beer C, Foldbjerg R, Hayashi Y, Sutherland DS, Autrup H. Toxicity of silver nanoparticles—Nanoparticle or silver ion? Toxicol Lett 2012; 208: 286-92.
126. Tamai N, Myoui A, Tomita T, et al. Novel hydroxyapatite ceramics with an interconnective porous structure exhibit superior osteoconduction in vivo. J Biomed Mater Res 2002; 59: 110-7.
127. Heinz B, Kasaj A, Teich M, Jepsen S. Clinical effects of nanocrystalline hydroxyapatite paste in the treatment of intrabony periodontal defects: a randomized controlled clinical study. Clin Oral Investig 2010; 14: 525-31.
128. Horvath A, Stavropoulos A, Windisch P, Lukacs L, Gera I, Sculean A. Histological evaluation of human intrabony periodontal defects treated with an unsintered nanocrystalline hydroxyapatite paste. Clin Oral Investig 2013; 17: 423-30.
129. Tomalia DA, Baker H, Dewald J, et al. A new class of polymers: starburst-dendritic macromolecules. Polym J 1985; 17: 117-32.
130. Oliveira JM, Salgado AJ, Sousa N, Mano JF, Reis RL. Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies. Prog Polym Sci 2010; 35: 1163-94.
131. Seiler M. Dendritic polymers – interdisciplinary research and emerging applications from unique structural properties. Chem Eng Technol 2002; 25: 237-53.
132. Backlund CJ, Sergesketter AR, Offenbacher S, Schoenfisch MH. Antibacterial efficacy of exogenous nitric oxide on periodontal pathogens. J Dent Res 2014; 93: 1089-94.
133. Bhardwaj N, Kundu SC. Electrospinning: a fascinating fiber fabrication technique. Biotechnol Adv 2010; 28: 325-47.
134. Beachley V, Wen X. Polymer nanofibrous structures: Fabrication, biofunctionalization, and cell interactions. Prog Polym Sci 2010; 35: 868-92.
135. Pelipenko J, Kocbek P, Kristl J. Nanofiber diameter as a critical parameter affecting skin cell response. Eur J Pharm Sci 2014; 66: 29-35.
136. Gandhi M, Srikar R, Yarin AL, Megaridis CM, Gemeinhart RA. Mechanistic examination of protein release from polymer nanofibers. Mol Pharm 2009; 6: 641-7.
137. Manning CN, Schwartz AG, Liu W, et al. Controlled delivery of mesenchymal stem cells and growth factors using a nanofiber scaffold for tendon repair. Acta Biomater 2013; 9: 6905-14.
138. Paaver U, Tamm I, Laidmae I, et al. Soluplus graft copolymer: potential novel carrier polymer in electrospinning of nanofibrous drug delivery systems for wound therapy. Biomed Res Int 2014; 2014: 789765.
139. Zamani M, Morshed M, Varshosaz J, Jannesari M. Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases. Eur J Pharm Biopharm 2010; 75: 179-85.
140. Ai J, Kiasat-Dolatabadi A, Ebrahimi-Barough S, et al. Polymeric scaffolds in neural tissue engineering. Arch Neurosci 2014; 1: 15-20.
141. Jang JH, Castano O, Kim HW. Electrospun materials as potential platforms for bone tissue engineering. Adv Drug Deliv Rev 2009; 61: 1065-83.
142. Zhang S, Huang Y, Yang X, et al. Gelatin nanofibrous membrane fabricated by electrospinning of aqueous gelatin solution for guided tissue regeneration. J Biomed Mater Res A 2009; 90: 671-9.
143. Ingber DE. Cellular mechanotransduction: putting all the pieces together again. FASEB J 2006; 20: 811-27.
144. Pelipenko J, Kocbek P, Govedarica B, Rosic R, Baumgartner S, Kristl J. The topography of electrospun nanofibers and its impact on the growth and mobility of keratinocytes. Eur J Pharm Biopharm 2013; 84: 401-11.
145. Jankovič B, Pelipenko J, Škarabot M, Muševič I, Kristl J. The design trend in tissue-engineering scaffolds based on nanomechanical properties of individual electrospun nanofibers. Int J Pharm 2013; 455: 338-47.
146. Matanovič MR, Kristl J, Grabnar PA. Thermoresponsive polymers: insights into decisive hydrogel characteristics, mechanisms of gelation, and promising biomedical applications. Int J Pharm 2014; 472: 262-75.
147. Hurler J, Žakelj S, Mravljak J, et al. The effect of lipid composition and liposome size on the release properties of liposomes-inhydrogel. Int J Pharm 2013; 456: 49-57.