Release of metronidazole from electrospun poly(l-lactide-co-d/l-lactide) fibers for local periodontitis treatment

Dental Materials

Volumn 28, Issue 2, 2012, Pages 179-188

  Reise, Markus ^a   Wyrwa, Ralf ^b   Müller, Ulrike ^b   Zylinski, Matthias ^a   Völpel, Andrea ^a   Schnabelrauch, Matthias ^b   Berg, Albrecht ^b   Jandt, Klaus D ^c   Watts, David C ^c,d   Sigusch, Bernd W ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b INNOVENT EV ^*  (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Biomaterials; Dental materials; Drug delivery system; Electrospun fibers; Metronidazole; Periodontitis; Polylactide; Polymeric fibers

Indexed keywords

DRUG DELIVERY SYSTEM; ELECTROSPUN FIBERS; METRONIDAZOLE; PERIODONTITIS; POLY LACTIDE; POLYMERIC FIBERS;

BIOLOGICAL MATERIALS; BIOMATERIALS; CELL CULTURE; DENTAL MATERIALS; DRUG DELIVERY; DRUG PRODUCTS; ELECTROSPINNING; SURFACE TESTING;

FIBERS;

ANTIINFECTIVE AGENT; BIOMATERIAL; METRONIDAZOLE; POLYESTER; POLYLACTIDE;

AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ARTICLE; BIODEGRADABLE IMPLANT; CELL ADHESION; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DELAYED RELEASE FORMULATION; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG EFFECT; ELECTROCHEMICAL ANALYSIS; FIBROBLAST; FUSOBACTERIUM NUCLEATUM; GINGIVA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INSTRUMENTATION; MATERIALS TESTING; MICROBIAL VIABILITY; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; SCANNING ELECTRON MICROSCOPY; SPECTROMETRY; SURFACE PROPERTY; SYNTHESIS; TIME;

ABSORBABLE IMPLANTS; ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANTI-INFECTIVE AGENTS; BIOCOMPATIBLE MATERIALS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL ADHESION; CELL SURVIVAL; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG DELIVERY SYSTEMS; ELECTROCHEMICAL TECHNIQUES; FIBROBLASTS; FUSOBACTERIUM NUCLEATUM; GINGIVA; HUMANS; MATERIALS TESTING; METRONIDAZOLE; MICROBIAL VIABILITY; MICROSCOPY, ELECTRON, SCANNING; PERIODONTITIS; POLYESTERS; PORPHYROMONAS GINGIVALIS; SPECTROMETRY, X-RAY EMISSION; SURFACE PROPERTIES; TIME FACTORS;

EID: 84855821695     PISSN: 01095641     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dental.2011.12.006     Document Type: Article

References (30)

1. K.D. Jandt, and B.W. Sigusch Future perspectives of resin-based dental materials Dent Mater 25 2009 1001
2. A. Balamurugan, G. Balossier, D. Laurent-Maquin, S. Pina, A.H. Rebelo, and J. Faure An in vitro biological and anti-bacterial study on a sol-gel derived silver-incorporated bioglass system Dent Mater 24 2008 1343
3. B.W. Sigusch, A. Güntsch, A. Pfitzner, and E. Glockmann Enhanced root planing and systemic metronidazole administration improve clinical and microbiological outcomes in a two-step treatment procedure J Periodontol 76 2005 991
4. B. Sigusch, M. Beier, G. Klinger, W. Pfister, and E. Glockmann A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis J Periodontol 72 2001 275
5. P.J. Hanes, and J.P. Purvis Local anti-infective therapy: pharmacological agents. A systematic review Ann Periodontol 8 2003 79
6. D.F. Kinane, and M. Radvar A six-month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets J Periodontol 70 1999 1
7. T.E. Rams, and J. Slots Local delivery of antimicrobial agents in the periodontal pocket Periodontol 2000 10 1996 139
8. T. Noguchi, K. Izumizawa, M. Fukuda, S. Kitamura, Y. Suzuki, and H. Ikura New method for local drug delivery using resorbable base material in periodontal therapy Bull Tokyo Med Dent Univ 31 1984 145
9. W.A. Soskolne Subgingival delivery of therapeutic agents in the treatment of periodontal diseases Crit Rev Oral Biol Med 8 1997 164
10. S.A. Al-Mubarak, T. Karring, and A. Ho Clinical evaluation of subgingival application of metronidazole 25%, and adjunctive therapy J Int Acad Periodontol 2 2000 64
11. S. Sato, M.J. Fonseca, J.O. Ciampo, J.R. Jabor, and V. Pedrazzi Metronidazole-containing gel for the treatment of periodontitis: an in vivo evaluation Braz Oral Res 22 2008 145
12. E. Stellini, A. Migliorato, S. Mazzoleni, A. Mottola, L. Lombardi, and G.A. Favero Topical treatment of peri-implantitis with metronidazole dental gel 25%. Clinical analysis and microbiological control Minerva Stomatol 49 2000 59
13. Y. Shifrovitch, I. Binderman, H. Bahar, I. Berdicevsky, and M. Zilberman Metronidazole-loaded bioabsorbable films as local antibacterial treatment of infected periodontal pockets J Periodontol 80 2009 330
14. M. Roccuzzo, M. Bunino, I. Needleman, and M. Sanz Periodontal plastic surgery for treatment of localized gingival recessions: a systematic review J Clin Periodontol 29 Suppl. 3 2002 178
15. P.J. Kluger, R. Wyrwa, J. Weisser, J. Maierle, M. Votteler, and C. Rode Electrospun poly(d/l-lactide-co-l-lactide) hybrid matrix: a novel scaffold material for soft tissue engineering J Mater Sci Mater Med 21 2010 2665
16. R. Wyrwa, B. Finke, H. Rebl, N. Mischner, M. Quaas, and J. Schäfer Design of plasma surface-activated, electrospun polylactide non-wovens with improved cell acceptance Adv Biomater 2011 B165
17. B.W. Sigusch, A. Völpel, I. Braun, A. Uhl, and K.D. Jandt Influence of different light curing units on the cytotoxicity of various dental composites Dent Mater 23 2007 1342
18. B.W. Sigusch, T. Pflaum, A. Völpel, M. Schinkel, and K.D. Jandt The influence of various light curing units on the cytotoxicity of dental adhesives Dent Mater 25 2009 1446
19. G. Greenstein, and A. Polson The role of local drug delivery in the management of periodontal diseases: a comprehensive review J Periodontol 69 1998 507
20. D. Soscia, N. Raof, Y. Xie, N.C. Cady, and A. Gadre Antibiotic-loaded PLGA nanofibers for wound healing applications Adv Biomater 2010 B83
21. M. Pavia, C.G. Nobile, A. Bianco, and I.F. Angelillo Meta-analysis of local metronidazole in the treatment of chronic periodontitis J Periodontol 75 2004 830
22. P.P. Poulet, D. Duffaut, and J.P. Lodter Metronidazole susceptibility testing of anaerobic bacteria associated with periodontal disease J Clin Periodontol 26 1999 261
23. M.P. Silva, M. Feres, T.A. Sirotto, G.M. Soares, J.A. Mendes, and M. Faveri Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: a randomized placebo-controlled clinical trial J Clin Periodontol 38 2011 828
24. E.M. Kulik, K. Lenkeit, S. Chenaux, and J. Meyer Antimicrobial susceptibility of periodontopathogenic bacteria J Antimicrob Chemother 61 2008 1087
25. S. Eick, and W. Pfister Efficacy of antibiotics against periodontopathogenic bacteria within epithelial cells: an in vitro study J Periodontol 75 2004 1327
26. S. Eick, T. Seltmann, and W. Pfister Efficacy of antibiotics to strains of periodontopathogenic bacteria within a single species biofilm - an in vitro study J Clin Periodontol 31 2004 376
27. G.E. Salvi, A. Mombelli, L. Mayfield, A. Rutar, J. Suvan, and S. Garrett Local antimicrobial therapy after initial periodontal treatment J Clin Periodontol 29 2002 540
28. M. Zamani, M. Morshed, J. Varshosaz, and M. Jannesari Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases Eur J Pharm Biopharm 75 2010 179
29. E.G. Winkel, A.J. Van Winkelhoff, M.F. Timmerman, U. Van der Velden, and G.A. Van der Weijden Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study J Clin Periodontol 28 2001 296
30. F. Sgolastra, A. Petrucci, R. Gatto, and A. Monaco Effectiveness of systemic amoxicillin/metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: a systematic review and meta-analysis J Periodontol 2011 10.1902/jop.2011.110432