Polymer nanofibrous structures: Fabrication, biofunctionalization, and cell interactions

Progress in Polymer Science (Oxford)

Volumn 35, Issue 7, 2010, Pages 868-892

  Beachley, Vince ^a   Wen, Xuejun ^a,b,c  

^a AMRL   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c TONGJI UNIVERSITY   (China)

Author keywords

Biomaterial; Electrospinning; Nanofiber; Phase Separation; Polymer; Regeneration; Scaffold; Self assembly; Tissue engineering

Indexed keywords

BIOFUNCTIONALIZATION; CELL ATTACHMENTS; CELL BEHAVIORS; CELL FATES; CELL INTERACTION; CLINICAL SETTINGS; EXTRACELLULAR MATRICES; FABRICATION TECHNIQUE; FIBER MATERIALS; FIBROUS STRUCTURES; FUNCTIONALIZATIONS; INDIVIDUAL FIBERS; MATERIAL COMPOSITIONS; ORGAN DEVELOPMENT; POLYMER NANOFIBERS; REGENERATION; SIZE SCALE; STRUCTURAL ARRANGEMENT; TISSUE ENGINEERING SCAFFOLD; TISSUE REGENERATION;

ELECTROSPINNING; ENGINEERING; FABRICATION; FIBERS; FUNCTIONAL POLYMERS; MOLECULAR BIOLOGY; NANOFIBERS; PHASE MODULATION; PHASE SEPARATION; POLYMERS; SCAFFOLDS; SELF ASSEMBLY; TISSUE;

TISSUE ENGINEERING;

EID: 77953723114     PISSN: 00796700     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.progpolymsci.2010.03.003     Document Type: Review

References (226)

1. Daley W.P., Peters S.B., and Larsen M. Extracellular matrix dynamics in development and regenerative medicine. J Cell Sci 121 (2008) 255-264
2. Roach M.R., and Burton A.C. The reason for the shape of the distensibility curves of arteries. Can J Biochem Physiol 35 (1957) 681-690
3. George E.L., Georges-Labouesse E.N., Patel-King R.S., Rayburn H., and Hynes R.O. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119 (1993) 1079-1091
4. Rebustini I.T., Patel V.N., Stewart J.S., Layvey A., Georges-Labouesse E., Miner J.H., and Hoffman M.P. Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling. Dev Biol 308 (2007) 15-29
5. Sakai T., Larsen M., and Yamada K.M. Fibronectin requirement in branching morphogenesis. Nature 423 (2003) 876-881
6. Fawcett J.W., and Keynes R.J. Peripheral nerve regeneration. Annu Rev Neurosci 13 (1990) 43-60
7. Zhang Y., Ouyang H., Lim C.T., Ramakrishna S., and Huang Z.M. Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds. J Biomed Mater Res B Appl Biomater 72 (2005) 156-165
8. Ellis-Behnke R.G., Liang Y.X., You S.W., Tay D.K., Zhang S., So K.F., and Schneider G.E. Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci U S A 103 (2006) 5054-5059
9. Venugopal J., Low S., Choon A.T., and Ramakrishna S. Interaction of cells and nanofiber scaffolds in tissue engineering. J Biomed Mater Res B Appl Biomater 84 (2008) 34-48
10. Ma Z., Kotaki M., Inai R., and Ramakrishna S. Potential of nanofiber matrix as tissue-engineering scaffolds. Tissue Eng 11 (2005) 101-109
11. Vasita R., and Katti D.S. Nanofibers and their applications in tissue engineering. Int J Nanomed 1 (2006) 15-30
12. Beachley V., and Wen X. Fabrication of nanofiber reinforced protein structures for tissue engineering. Mater Sci Eng C 29 (2009) 2448-2453
13. Berndt P., Fields G., and Tirrell M. Synthetic lipidation of peptides and amino acids: monolayer structure and properties. J Am Chem Soc 117 (1995) 9515-9522
14. Hartgerink J.D., Beniash E., and Stupp S.I. Self-assembly and mineralization of peptide-amphiphile nanofibers. Science 294 (2001) 1684-1688
15. Silva G.A., Czeisler C., Niece K.L., Beniash E., Harrington D.A., Kessler J.A., and Stupp S.I. Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science 303 (2004) 1352-1355
16. Zhang S. Fabrication of novel biomaterials through molecular self-assembly. Nat Biotechnol 21 (2003) 1171-1178
17. Hong Y., Legge R.L., Zhang S., and Chen P. Effect of amino acid sequence and pH on nanofiber formation of self-assembling peptides EAK16-II and EAK16-IV. Biomacromolecules 4 (2003) 1433-1442
18. Yokoi H., Kinoshita T., and Zhang S. Dynamic reassembly of peptide RADA16 nanofiber scaffold. Proc Natl Acad Sci U S A 102 (2005) 8414-8419
19. Liu G. Nanofibers. Adv Mater 9 (1997) 437-439
20. Liu D., De Feyter S., Cotlet M., Wiesler U.-M., Weil T., Herrmann A., et al. Flourescent self-assembled polyphenylene dendrimer nanofibers. Macromolecules 36 (2003) 8489-8498
21. Jun H.W., Yuwono V., Paramonov S.E., and Hartgerink J.D. Enzyme-mediated degradation of peptide-amphiphile nanofiber network. Adv Mater 17 (2005) 2612-2617
22. Ma P.X., and Zhang R. Synthetic nano-scale fibrous extracellular matrix. J Biomed Mater Res 46 (1999) 60-72
23. Ramakrishna S., Fujuhara K., Teo W.E., Lim T.C., and Ma Z. An introduction to electrospinning and nanofibers (2005), World Scientific Publishing Company, Singapore 396 pp
24. Czaja W.K., Young D.J., Kawecki M., and Brown Jr. R.M. The future prospects of microbial cellulose in biomedical applications. Biomacromolecules 8 (2007) 1-12
25. Brown E.E., and Laborie M.P. Bioengineering bacterial cellulose/poly(ethylene oxide) nanocomposites. Biomacromolecules 8 (2007) 3074-3081
26. Ciechanska D. Multifunctional bacterial cellulose/chitosan composite materials for medical applications. Fibres Textiles Eastern Europe 12 (2004) 69-72
27. Grimm S., Giesa R., Sklarek K., Langner A., Gosele U., Schmidt H.W., and Steinhart M. Nondestructive replication of self-ordered nanoporous alumina membranes via cross-linked polyacrylate nanofiber arrays. Nano Lett 8 (2008) 1954-1959
28. Porter J.R., Henson A., and Popat K.C. Biodegradable poly(epsilon-caprolactone) nanowires for bone tissue engineering applications. Biomaterials 30 (2009) 780-788
29. Tao S.L., and Desai T.A. Aligned arrays of biodegradable poly(epsilon-caprolactone) nanowires and nanofibers by template synthesis. Nano Lett 7 (2007) 1463-1468
30. Jeong H.E., Lee S.H., Kim P., and Suh K.Y. Stretched polymer nanohairs by nanodrawing. Nano Lett 6 (2006) 1508-1513
31. Xing X., Wang Y., and Li B. Nanofibers drawing and nanodevices assembly in poly(trimethylene terephthalate). Opt Express 16 (2008) 10815-10822
32. Nain A., Wong J., Amon C., and Sitti M. Drawing suspended polymer micro-/nanofibers using glass micropipettes. Appl Phys Lett 89 (2006) 1831051-1831053
33. Alemdar A., and Sain M. Isolation and characterization of nanofibers from agricultural residues: wheat straw and soy hulls. Bioresour Technol 99 (2008) 1664-1671
34. Fischer T.H., Valeri C.R., Smith C.J., Scull C.M., Merricks E.P., Nichols T.C., et al. Non-classical processes in surface hemostasis: mechanisms for the poly-N-acetyl glucosamine-induced alteration of red blood cell morphology and surface prothrombogenicity. Biomed Mater 3 (2008) 015009/1-9
35. Fan Y., Saito T., and Isogai A. Preparation of chitin nanofibers from squid pen beta-chitin by simple mechanical treatment under acid conditions. Biomacromolecules 9 (2008) 1919-1923
36. Aden Brook Farms Website. Large 3x3 bales of bright wheat straw; 2009 http://adenbrookfarms.com/order/index.php?main_page=index&cPath=2.
37. Rollings D.A., Tsoi S., Sit J.C., and Veinot J.G. Formation and aqueous surface wettability of polysiloxane nanofibers prepared via surface initiated, vapor-phase polymerization of organotrichlorosilanes. Langmuir 23 (2007) 5275-5278
38. Mankidy P., Rajagopalan R., and Foley H. Facile catalytic growth of cyanoacrylate nanofibers. Chem Commun (2006) 1139-1141
39. Jang J., Chang M., and Yoon H. Chemical sensors based on highly conductive Poly(3,4-ethylene-dioxythiophene) Nanorods. Adv Mater 17 (2005) 1616-1620
40. Kong H., and Jang J. One-step fabrication of silver nanoparticle embedded polymer nanofibers by radical-mediated dispersion polymerization. Chem Commun (2006) 3010-3012
41. Jing X., Wang Y., Wu D., and Qiang J. Sonochemical synthesis of polyaniline nanofibers. Ultrason Sonochem 14 (2007) 75-80
42. Li D., Huang J., and Kaner R.B. Polyaniline nanofibers: a unique polymer nanostructure for versatile applications. Acc Chem Res 42 (2009) 135-145
43. Chen F., Li X., Mo X., He C., Wang H., and Ikada Y. Electrospun chitosan-P(LLA-CL) nanofibers for biomimetic extracellular matrix. J Biomater Sci Polym Ed 19 (2008) 677-691
44. Jeong S.I., Lee A.Y., Lee Y.M., and Shin H. Electrospun gelatin/poly(L-lactide-co-epsilon-caprolactone) nanofibers for mechanically functional tissue-engineering scaffolds. J Biomater Sci Polym Ed 19 (2008) 339-357
45. Li M., Mondrinos M.J., Gandhi M.R., Ko F.K., Weiss A.S., and Lelkes P.I. Electrospun protein fibers as matrices for tissue engineering. Biomaterials 26 (2005) 5999-6008
46. Boland E.D., Matthews J.A., Pawlowski K.J., Simpson D.G., Wnek G.E., and Bowlin G.L. Electrospinning collagen and elastin: preliminary vascular tissue engineering. Front Biosci 9 (2004) 1422-1432
47. Rho K.S., Jeong L., Lee G., Seo B.M., Park Y.J., Hong S.D., et al. Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials 27 (2006) 1452-1461
48. Zhang Y.Z., Venugopal J., Huang Z.M., Lim C.T., and Ramakrishna S. Crosslinking of the electrospun gelatin nanofibers. Polymer 47 (2006) 2911-2917
49. Chen Z.C., Ekaputra A.K., Gauthaman K., Adaikan P.G., Yu H., and Hutmacher D.W. In vitro and in vivo analysis of co-electrospun scaffolds made of medical grade poly(epsilon-caprolactone) and porcine collagen. J Biomater Sci Polym Ed 19 (2008) 693-707
50. Kwon I.K., and Matsuda T. Co-electrospun nanofiber fabrics of poly(L-lactide-co-epsilon-caprolactone) with type I collagen or heparin. Biomacromolecules 6 (2005) 2096-2105
51. Han I., Shim K.J., Kim J.Y., Im S.U., Sung Y.K., Kim M., et al. Effect of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofiber matrices cocultured with hair follicular epithelial and dermal cells for biological wound dressing. Artif Organs 31 (2007) 801-808
52. Meng W., Kim S.Y., Yuan J., Kim J.C., Kwon O.H., Kawazoe N., et al. Electrospun PHBV/collagen composite nanofibrous scaffolds for tissue engineering. J Biomater Sci Polym Ed 18 (2007) 81-94
53. Zeugolis D.I., Khew S.T., Yew E.S., Ekaputra A.K., Tong Y.W., Yung L.Y., et al. Electro-spinning of pure collagen nano-fibres-just an expensive way to make gelatin?. Biomaterials 29 (2008) 2293-2305
54. Gauthaman K, Venugopal JR, Yee FC, Peh GS, Ramakrishna S, Bongso A. Nanofibrous substrates support colony formation and maintain stemness of human embryonic stem cells. J Cell Mol Med; in press.
55. Casper C.L., Yang W., Farach-Carson M.C., and Rabolt J.F. Coating electrospun collagen and gelatin fibers with perlecan domain I for increased growth factor binding. Biomacromolecules 8 (2007) 1116-1123
56. Song J.H., Kim H.E., and Kim H.W. Production of electrospun gelatin nanofiber by water-based co-solvent approach. J Mater Sci Mater Med 19 (2008) 95-102
57. Ghasemi-Mobarakeh L., Prabhakaran M.P., Morshed M., Nasr-Esfahani M.H., and Ramakrishna S. Electrospun poly(epsilon-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering. Biomaterials 29 (2008) 4532-4539
58. Kim H.W., Yu H.S., and Lee H.H. Nanofibrous matrices of poly(lactic acid) and gelatin polymeric blends for the improvement of cellular responses. J Biomed Mater Res A 87 (2008) 25-32
59. Meng W., Xing Z.C., Jung K.H., Kim S.Y., Yuan J., Kang I.K., et al. Synthesis of gelatin-containing PHBV nanofiber mats for biomedical application. J Mater Sci Mater Med 19 (2008) 2799-2807
60. Stitzel J., Liu J., Lee S.J., Komura M., Berry J., Soker S., et al. Controlled fabrication of a biological vascular substitute. Biomaterials 27 (2006) 1088-1094
61. Geng X., Kwon O.H., and Jang J. Electrospinning of chitosan dissolved in concentrated acetic acid solution. Biomaterials 26 (2005) 5427-5432
62. Ohkawa K., Cha D., Kim H., Nishida A., and Yamamoto H. Electrospinning of chitosan. Macromol Rapid Commun 25 (2004) 1600-1605
63. Ohkawa K., Minato K., Kumagai G., Hayashi S., and Yamamoto H. Chitosan nanofiber. Biomacromolecules 7 (2006) 3291-3294
64. Chu X.H., Shi X.L., Feng Z.Q., Gu Z.Z., and Ding Y.T. Chitosan nanofiber scaffold enhances hepatocyte adhesion and function. Biotechnol Lett 31 (2009) 347-352
65. Jiang H., Fang D., Hsiao B.S., Chu B., and Chen W. Optimization and characterization of dextran membranes prepared by electrospinning. Biomacromolecules 5 (2004) 326-333
66. Pan H., Jiang H., and Chen W. Interaction of dermal fibroblasts with electrospun composite polymer scaffolds prepared from dextran and poly lactide-co-glycolide. Biomaterials 27 (2006) 3209-3220
67. Wnek G., Carr M., Simpson D., and Bowlin G. Electrospinning of nanofiber fibrinogen structrures. Nano Lett 3 (2003) 213-216
68. McManus M.C., Boland E.D., Simpson D.G., Barnes C.P., and Bowlin G.L. Electrospun fibrinogen: feasibility as a tissue engineering scaffold in a rat cell culture model. J Biomed Mater Res A 81 (2007) 299-309
69. McManus M., Boland E., Sell S., Bowen W., Koo H., Simpson D., and Bowlin G. Electrospun nanofibre fibrinogen for urinary tract tissue reconstruction. Biomed Mater 2 (2007) 257-262
70. Neal R.A., McClugage S.G., Link M.C., Sefcik L.S., Ogle R.C., and Botchwey E.A. Laminin nanofiber meshes that mimic morphological properties and bioactivity of basement membranes. Tissue Eng Part C Methods 15 (2009) 11-21
71. Um I.C., Fang D., Hsiao B.S., Okamoto A., and Chu B. Electro-spinning and electro-blowing of hyaluronic acid. Biomacromolecules 5 (2004) 1428-1436
72. Ji Y., Ghosh K., Shu X.Z., Li B., Sokolov J.C., Prestwich G.D., Clark R.A., and Rafailovich M.H. Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Biomaterials 27 (2006) 3782-3792
73. Ji Y., Ghosh K., Li B., Sokolov J.C., Clark R.A., and Rafailovich M.H. Dual-syringe reactive electrospinning of cross-linked hyaluronic acid hydrogel nanofibers for tissue engineering applications. Macromol Biosci 6 (2006) 811-817
74. Ma Z., He W., Yong T., and Ramakrishna S. Grafting of gelatin on electrospun poly(caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell Orientation. Tissue Eng 11 (2005) 1149-1158
75. Duan Y., Wang Z., Yan W., Wang S., Zhang S., and Jia J. Preparation of collagen-coated electrospun nanofibers by remote plasma treatment and their biological properties. J Biomater Sci Polym Ed 18 (2007) 1153-1164
76. Koh H.S., Yong T., Chan C.K., and Ramakrishna S. Enhancement of neurite outgrowth using nano-structured scaffolds coupled with laminin. Biomaterials 29 (2008) 3574-3582
77. Chen J., Chu B., and Hsiao B.S. Mineralization of hydroxyapatite in electrospun nanofibrous poly(L-lactic acid) scaffolds. J Biomed Mater Res A 79 (2006) 307-317
78. Yu H.S., Jang J.H., Kim T.I., Lee H.H., and Kim H.W. Apatite-mineralized polycaprolactone nanofibrous web as a bone tissue regeneration substrate. J Biomed Mater Res A 88 (2009) 747-754
79. Zhu Y., Leong M.F., Ong W.F., Chan-Park M.B., and Chian K.S. Esophageal epithelium regeneration on fibronectin grafted poly(L-lactide-co-caprolactone) (PLLC) nanofiber scaffold. Biomaterials 28 (2007) 861-868
80. Nisbet D.R., Yu L.M., Zahir T., Forsythe J.S., and Shoichet M.S. Characterization of neural stem cells on electrospun poly(epsilon-caprolactone) submicron scaffolds: evaluating their potential in neural tissue engineering. J Biomater Sci Polym Ed 19 (2008) 623-634
81. Park K., Ju Y.M., Son J.S., Ahn K.D., and Han D.K. Surface modification of biodegradable electrospun nanofiber scaffolds and their interaction with fibroblasts. J Biomater Sci Polym Ed 18 (2007) 369-382
82. Patel S., Kurpinski K., Quigley R., Gao H., Hsiao B.S., Poo M.M., et al. Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Nano Lett 7 (2007) 2122-2128
83. Chua K.N., Chai C., Lee P.C., Ramakrishna S., Leong K.W., and Mao H.Q. Functional nanofiber scaffolds with different spacers modulate adhesion and expansion of cryopreserved umbilical cord blood hematopoietic stem/progenitor cells. Exp Hematol 35 (2007) 771-781
84. Bakowsky U., Schumacher G., Gege C., Schmidt R.R., Rothe U., and Bendas G. Cooperation between lateral ligand mobility and accessibility for receptor recognition in selectin-induced cell rolling. Biochemistry 41 (2002) 4704-4712
85. Houseman B.T., and Mrksich M. The microenvironment of immobilized Arg-Gly-Asp peptides is an important determinant of cell adhesion. Biomaterials 22 (2001) 943-955
86. Choi J.S., Leong K.W., and Yoo H.S. In vivo wound healing of diabetic ulcers using electrospun nanofibers immobilized with human epidermal growth factor (EGF). Biomaterials 29 (2008) 587-596
87. Li W., Guo Y., Wang H., Shi D., Liang C., Ye Z., Qing F., and Gong J. Electrospun nanofibers immobilized with collagen for neural stem cells culture. J Mater Sci Mater Med 19 (2008) 847-854
88. Kim T.G., and Park T.G. Biomimicking extracellular matrix: cell adhesive RGD peptide modified electrospun poly(D,L-lactic-co-glycolic acid) nanofiber mesh. Tissue Eng 12 (2006) 221-233
89. Zhang D., Chang J., and Zeng Y. Fabrication of fibrous poly(butylene succinate)/wollastonite/apatite composite scaffolds by electrospinning and biomimetic process. J Mater Sci Mater Med 19 (2008) 443-449
90. He W., Ma Z., Yong T., Teo W.E., and Ramakrishna S. Fabrication of collagen-coated biodegradable polymer nanofiber mesh and its potential for endothelial cells growth. Biomaterials 26 (2005) 7606-7615
91. Ma K., Chan C.K., Liao S., Hwang W.Y., Feng Q., and Ramakrishna S. Electrospun nanofiber scaffolds for rapid and rich capture of bone marrow-derived hematopoietic stem cells. Biomaterials 29 (2008) 2096-2103
92. Chew S.Y., Hufnagel T.C., Lim C.T., and Leong K.W. Mechanical properties of single electrospun drug-encapsulated nanofibres. Nanotechnology 17 (2006) 3880-3891
93. Kim K., Luu Y.K., Chang C., Fang D., Hsiao B.S., Chu B., et al. Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J Control Release 98 (2004) 47-56
94. Luu Y.K., Kim K., Hsiao B.S., Chu B., and Hadjiargyrou M. Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. J Control Release 89 (2003) 341-353
95. Chew S.Y., Wen J., Yim E.K., and Leong K.W. Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules 6 (2005) 2017-2024
96. Maretschek S., Greiner A., and Kissel T. Electrospun biodegradable nanofiber nonwovens for controlled release of proteins. J Control Release 127 (2008) 180-187
97. Sanders E., Kloefkorn R., Bowlin G., Simpson D., and Wnek G. Two-phase electrospinning from a single electrified jet: microencapsulation of aqueous reservoirs in poly(ethylene-co-vinylacetate) fibers. Macromolecules 36 (2003) 3803-3805
98. Luong-Van E., Grondahl L., Chua K.N., Leong K.W., Nurcombe V., and Cool S.M. Controlled release of heparin from poly(epsilon-caprolactone) electrospun fibers. Biomaterials 27 (2006) 2042-2050
99. Qi H., Hu P., Xu J., and Wang A. Encapsulation of drug reservoirs in fibers by emulsion electrospinning: morphology characterization and preliminary release assessment. Biomacromolecules 7 (2006) 2327-2330
100. Li X., Su Y., He C., Wang H., Fong H., and Mo X. Sorbitan monooleate and poly(L-lactide-co-epsilon-caprolactone) electrospun nanofibers for endothelial cell interactions. J Biomed Mater Res A 91 (2009) 878-885
101. Yang X., Shah J.D., and Wang H. Nanofiber enabled layer-by-layer approach toward three-dimensional Tissue formation. Tissue Eng Part A 15 (2009) 945-956
102. Taepaiboon P., Rungsardthong U., and Supaphol P. Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E. Eur J Pharm Biopharm 67 (2007) 387-397
103. Erisken C., Kalyon D.M., and Wang H. A hybrid twin screw extrusion/electrospinning method to process nanoparticle-incorporated electrospun nanofibers. Nanotechnology 19 (2008) 165302
104. Sun Z., Zussman E., Yarin A., Wendorff J., and Greiner A. Compound core-shell polymer nanofibers by co-electrospinning. Adv Mater 15 (2003) 1929-1932
105. Loscertales I.G., Barrero A., Marquez M., Spretz R., Velarde-Ortiz R., and Larsen G. Electrically forced coaxial nanojets for one-step hollow nanofiber design. J Am Chem Soc 126 (2004) 5376-5377
106. Zhang Y.Z., Wang X., Feng Y., Li J., Lim C.T., and Ramakrishna S. Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(epsilon-caprolactone) nanofibers for sustained release. Biomacromolecules 7 (2006) 1049-1057
107. Yi F., and LaVan D.A. Poly(glycerol sebacate) nanofiber scaffolds by core/shell electrospinning. Macromol Biosci 8 (2008) 803-806
108. Horii A., Wang X., Gelain F., and Zhang S. Biological designer self-assembling Peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration. PLoS ONE 2 (2007) e190
109. Segers V.F., Tokunou T., Higgins L.J., MacGillivray C., Gannon J., and Lee R.T. Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction. Circulation 116 (2007) 1683-1692
110. Gelain F., Bottai D., Vescovi A., and Zhang S. Designer self-assembling Peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. PLoS ONE 1 (2006) e119
111. Harrington D.A., Cheng E.Y., Guler M.O., Lee L.K., Donovan J.L., Claussen R.C., et al. Branched peptide-amphiphiles as self-assembling coatings for tissue engineering scaffolds. J Biomed Mater Res A 78 (2006) 157-167
112. Matsuzaka K., Walboomers X.F., de Ruijter J.E., and Jansen J.A. The effect of poly-L-lactic acid with parallel surface micro groove on osteoblast-like cells in vitro. Biomaterials 20 (1999) 1293-1301
113. Deligianni D.D., Katsala N., Ladas S., Sotiropoulou D., Amedee J., and Missirlis Y.F. Effect of surface roughness of the titanium alloy Ti-6Al-4 V on human bone marrow cell response and on protein adsorption. Biomaterials 22 (2001) 1241-1251
114. Curtis A., and Wilkinson C. Nanotechniques and approaches in biotechnology. Trends Biotechnol 19 (2001) 97-101
115. Badami A.S., Kreke M.R., Thompson M.S., Riffle J.S., and Goldstein A.S. Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substrates. Biomaterials 27 (2006) 596-606
116. Li W.J., Danielson K.G., Alexander P.G., and Tuan R.S. Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(epsilon-caprolactone) scaffolds. J Biomed Mater Res A 67 (2003) 1105-1114
117. Li W.J., Jiang Y.J., and Tuan R.S. Chondrocyte phenotype in engineered fibrous matrix is regulated by fiber size. Tissue Eng 12 (2006) 1775-1785
118. Liu Y., Ji Y., Ghosh K., Clark R.A., Huang L., and Rafailovich M.H. Effects of fiber orientation and diameter on the behavior of human dermal fibroblasts on electrospun PMMA scaffolds. J Biomed Mater Res A 90 (2009) 1092-1106
119. Rubenstein D., Han D., Goldgraben S., El-Gendi H., Gouma P.I., and Frame M.D. Bioassay chamber for angiogenesis with perfused explanted arteries and electrospun scaffolding. Microcirculation 14 (2007) 723-737
120. Li D., and Xia Y. Electrospinning of nanofibers: reinventing the wheel?. Adv Mater 16 (2004) 1151-1170
121. Huang Z.-M., Zhang Y.-Z., Kotaki M., and Ramakrishna S. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Composites Sci Technol 63 (2003) 2223-2253
122. Rockwood D.N., Akins Jr. R.E., Parrag I.C., Woodhouse K.A., and Rabolt J.F. Culture on electrospun polyurethane scaffolds decreases atrial natriuretic peptide expression by cardiomyocytes in vitro. Biomaterials 29 (2008) 4783-4791
123. Xu C.Y., Inai R., Kotaki M., and Ramakrishna S. Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering. Biomaterials 25 (2004) 877-886
124. Yang F., Murugan R., Wang S., and Ramakrishna S. Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 26 (2005) 2603-2610
125. Choi J.S., Lee S.J., Christ G.J., Atala A., and Yoo J.J. The influence of electrospun aligned poly(epsilon-caprolactone)/collagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes. Biomaterials 29 (2008) 2899-2906
126. Corey J.M., Lin D.Y., Mycek K.B., Chen Q., Samuel S., Feldman E.L., et al. Aligned electrospun nanofibers specify the direction of dorsal root ganglia neurite growth. J Biomed Mater Res A 83 (2007) 636-645
127. Chua K.N., Lim W.S., Zhang P., Lu H., Wen J., Ramakrishna S., et al. Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold. Biomaterials 26 (2005) 2537-2547
128. Meng J., Kong H., Han Z., Wang C., Zhu G., Xie S., et al. Enhancement of nanofibrous scaffold of multiwalled carbon nanotubes/polyurethane composite to the fibroblasts growth and biosynthesis. J Biomed Mater Res A 88 (2009) 105-116
129. Chua K.N., Chai C., Lee P.C., Tang Y.N., Ramakrishna S., Leong K.W., et al. Surface-aminated electrospun nanofibers enhance adhesion and expansion of human umbilical cord blood hematopoietic stem/progenitor cells. Biomaterials 27 (2006) 6043-6051
130. Finne-Wistrand A., Albertsson A.C., Kwon O.H., Kawazoe N., Chen G., Kang I.K., et al. Resorbable scaffolds from three different techniques: electrospun fabrics, salt-leaching porous films, and smooth flat surfaces. Macromol Biosci 8 (2008) 951-959
131. Chen M., Patra P.K., Warner S.B., and Bhowmick S. Role of fiber diameter in adhesion and proliferation of NIH 3T3 fibroblast on electrospun polycaprolactone scaffolds. Tissue Eng 13 (2007) 579-587
132. McKenzie J.L., Waid M.C., Shi R., and Webster T.J. Decreased functions of astrocytes on carbon nanofiber materials. Biomaterials 25 (2004) 1309-1317
133. Yuan Y., Cong C., Zhang J., Wei L., Li S., Chen Y., et al. Self-assembling peptide nanofiber as potential substrates in islet transplantation. Transplant Proc 40 (2008) 2571-2574
134. Sangsanoh P., Waleetorncheepsawat S., Suwantong O., Wutticharoenmongkol P., Weeranantanapan O., Chuenjitbuntaworn B., et al. In vitro biocompatibility of schwann cells on surfaces of biocompatible polymeric electrospun fibrous and solution-cast film scaffolds. Biomacromolecules 8 (2007) 1587-1594
135. Elias K.L., Price R.L., and Webster T.J. Enhanced functions of osteoblasts on nanometer diameter carbon fibers. Biomaterials 23 (2002) 3279-3287
136. Lee C.H., Shin H.J., Cho I.H., Kang Y.M., Kim I.A., Park K.D., et al. Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials 26 (2005) 1261-1270
137. Moffat K.L., Kwei A.S., Spalazzi J.P., Doty S.B., Levine W.N., and Lu H.H. Novel nanofiber-based scaffold for rotator cuff repair and augmentation. Tissue Eng Part A 15 (2009) 115-126
138. Baker B.M., and Mauck R.L. The effect of nanofiber alignment on the maturation of engineered meniscus constructs. Biomaterials 28 (2007) 1967-1977
139. Garreta E., Genove E., Borros S., and Semino C.E. Osteogenic differentiation of mouse embryonic stem cells and mouse embryonic fibroblasts in a three-dimensional self-assembling peptide scaffold. Tissue Eng 12 (2006) 2215-2227
140. Shih Y.R., Chen C.N., Tsai S.W., Wang Y.J., and Lee O.K. Growth of mesenchymal stem cells on electrospun type I collagen nanofibers. Stem Cells 24 (2006) 2391-2397
141. Nur E.K.A., Ahmed I., Kamal J., Schindler M., and Meiners S. Three-dimensional nanofibrillar surfaces promote self-renewal in mouse embryonic stem cells. Stem Cells 24 (2006) 426-433
142. Bashur C.A., Shaffer R.D., Dahlgren L.A., Guelcher S.A., and Goldstein A.S. Effect of fiber diameter and alignment of electrospun polyurethane meshes on mesenchymal progenitor cells. Tissue Eng Part A 15 (2009) 2435-2445
143. Leong M.F., Chian K.S., Mhaisalkar P.S., Ong W.F., and Ratner B.D. Effect of electrospun poly(D,L-lactide) fibrous scaffold with nanoporous surface on attachment of porcine esophageal epithelial cells and protein adsorption. J Biomed Mater Res A 89 (2009) 1040-1048
144. Baker B.M., Gee A.O., Metter R.B., Nathan A.S., Marklein R.A., Burdick J.A., and Mauck R.L. The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers. Biomaterials 29 (2008) 2348-2358
145. Li X., Gao H., Uo M., Sato Y., Akasaka T., Feng Q., et al. Effect of carbon nanotubes on cellular functions in vitro. J Biomed Mater Res A 91 (2009) 132-139
146. Maniotis A.J., Chen C.S., and Ingber D.E. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Natl Acad Sci U S A 94 (1997) 849-854
147. McBeath R., Pirone D.M., Nelson C.M., Bhadriraju K., and Chen C.S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6 (2004) 483-495
148. Spiegelman B.M., and Ginty C.A. Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes. Cell 35 (1983) 657-666
149. Thomas C.H., Collier J.H., Sfeir C.S., and Healy K.E. Engineering gene expression and protein synthesis by modulation of nuclear shape. Proc Natl Acad Sci U S A 99 (2002) 1972-1977
150. McBride S.H., and Knothe Tate M.L. Modulation of stem cell shape and fate A: the role of density and seeding protocol on nucleus shape and gene expression. Tissue Eng Part A 14 (2008) 1561-1572
151. Czaja W., Krystynowicz A., Bielecki S., and Brown Jr. R.M. Microbial cellulose-the natural power to heal wounds. Biomaterials 27 (2006) 145-151
152. Araujo J.V., Martins A., Leonor I.B., Pinho E.D., Reis R.L., and Neves N.M. Surface controlled biomimetic coating of polycaprolactone nanofiber meshes to be used as bone extracellular matrix analogues. J Biomater Sci Polym Ed 19 (2008) 1261-1278
153. Ito Y., Hasuda H., Kamitakahara M., Ohtsuki C., Tanihara M., Kang I.K., et al. A composite of hydroxyapatite with electrospun biodegradable nanofibers as a tissue engineering material. J Biosci Bioeng 100 (2005) 43-49
154. Deng X.L., Sui G., Zhao M.L., Chen G.Q., and Yang X.P. Poly(L-lactic acid)/hydroxyapatite hybrid nanofibrous scaffolds prepared by electrospinning. J Biomater Sci Polym Ed 18 (2007) 117-130
155. Jeong S.I., Ko E.K., Yum J., Jung C.H., Lee Y.M., and Shin H. Nanofibrous poly(lactic acid)/hydroxyapatite composite scaffolds for guided tissue regeneration. Macromol Biosci 8 (2008) 328-338
156. Venugopal J.R., Low S., Choon A.T., Kumar A.B., and Ramakrishna S. Nanobioengineered electrospun composite nanofibers and osteoblasts for bone regeneration. Artif Organs 32 (2008) 388-397
157. Li C., Vepari C., Jin H.J., Kim H.J., and Kaplan D.L. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 27 (2006) 3115-3124
158. Catledge S.A., Clem W.C., Shrikishen N., Chowdhury S., Stanishevsky A.V., Koopman M., et al. An electrospun triphasic nanofibrous scaffold for bone tissue engineering. Biomed Mater 2 (2007) 142-150
159. Kim H.W., Lee H.H., and Chun G.S. Bioactivity and osteoblast responses of novel biomedical nanocomposites of bioactive glass nanofiber filled poly(lactic acid). J Biomed Mater Res A 85 (2008) 651-663
160. Kim H.W., Song J.H., and Kim H.E. Bioactive glass nanofiber-collagen nanocomposite as a novel bone regeneration matrix. J Biomed Mater Res A 79 (2006) 698-705
161. Sargeant T.D., Oppenheimer S.M., Dunand D.C., and Stupp S.I. Titanium foam-bioactive nanofiber hybrids for bone regeneration. J Tissue Eng Regen Med 2 (2008) 455-462
162. Xin X., Hussain M., and Mao J.J. Continuing differentiation of human mesenchymal stem cells and induced chondrogenic and osteogenic lineages in electrospun PLGA nanofiber scaffold. Biomaterials 28 (2007) 316-325
163. Yoshimoto H., Shin Y.M., Terai H., and Vacanti J.P. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 24 (2003) 2077-2082
164. Nam J., Huang Y., Agarwal S., and Lannutti J. Improved cellular infiltration in electrospun fiber via engineered porosity. Tissue Eng 13 (2007) 2249-2257
165. Hosseinkhani H., Hosseinkhani M., Tian F., Kobayashi H., and Tabata Y. Bone regeneration on a collagen sponge self-assembled peptide-amphiphile nanofiber hybrid scaffold. Tissue Eng 13 (2007) 11-19
166. Wei G., Jin Q., Giannobile W.V., and Ma P.X. The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials 28 (2007) 2087-2096
167. Shin S.Y., Park H.N., Kim K.H., Lee M.H., Choi Y.S., Park Y.J., et al. Biological evaluation of chitosan nanofiber membrane for guided bone regeneration. J Periodontol 76 (2005) 1778-1784
168. Kim K.H., Jeong L., Park H.N., Shin S.Y., Park W.H., Lee S.C., et al. Biological efficacy of silk fibroin nanofiber membranes for guided bone regeneration. J Biotechnol 120 (2005) 327-339
169. Ko E.K., Jeong S.I., Rim N.G., Lee Y.M., Shin H., and Lee B.K. In vitro osteogenic differentiation of human mesenchymal stem cells and in vivo bone formation in composite nanofiber meshes. Tissue Eng Part A 14 (2008) 2105-2119
170. Sargeant T.D., Guler M.O., Oppenheimer S.M., Mata A., Satcher R.L., Dunand D.C., et al. Hybrid bone implants: self-assembly of peptide amphiphile nanofibers within porous titanium. Biomaterials 29 (2008) 161-171
171. da Silva M.A., Crawford A., Mundy J., Martins A., Araujo J.V., Hatton P.V., et al. Evaluation of extracellular matrix formation in polycaprolactone and starch-compounded polycaprolactone nanofiber meshes when seeded with bovine articular chondrocytes. Tissue Eng Part A 15 (2009) 377-385
172. Li W.J., Jiang Y.J., and Tuan R.S. Cell-nanofiber-based cartilage tissue engineering using improved cell seeding, growth factor, and bioreactor technologies. Tissue Eng Part A 14 (2008) 639-648
173. Li W.J., Tuli R., Okafor C., Derfoul A., Danielson K.G., Hall D.J., et al. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials 26 (2005) 599-609
174. Janjanin S., Li W.J., Morgan M.T., Shanti R.M., and Tuan R.S. Mold-shaped, nanofiber scaffold-based cartilage engineering using human mesenchymal stem cells and bioreactor. J Surg Res 149 (2008) 47-56
175. Shin H.J., Lee C.H., Cho I.H., Kim Y.J., Lee Y.J., Kim I.A., et al. Electrospun PLGA nanofiber scaffolds for articular cartilage reconstruction: mechanical stability, degradation and cellular responses under mechanical stimulation in vitro. J Biomater Sci Polym Ed 17 (2006) 103-119
176. Lee S.J., Yoo J.J., Lim G.J., Atala A., and Stitzel J. In vitro evaluation of electrospun nanofiber scaffolds for vascular graft application. J Biomed Mater Res A 83 (2007) 999-1008
177. He W., Yong T., Teo W.E., Ma Z., and Ramakrishna S. Fabrication and endothelialization of collagen-blended biodegradable polymer nanofibers: potential vascular graft for blood vessel tissue engineering. Tissue Eng 11 (2005) 1574-1588
178. Xu C., Inai R., Kotaki M., and Ramakrishna S. Electrospun nanofiber fabrication as synthetic extracellular matrix and its potential for vascular tissue engineering. Tissue Eng 10 (2004) 1160-1168
179. Jeong S.I., Kim S.Y., Cho S.K., Chong M.S., Kim K.S., Kim H., et al. Tissue-engineered vascular grafts composed of marine collagen and PLGA fibers using pulsatile perfusion bioreactors. Biomaterials 28 (2007) 1115-1122
180. Inoguchi H., Kwon I.K., Inoue E., Takamizawa K., Maehara Y., and Matsuda T. Mechanical responses of a compliant electrospun poly(L-lactide-co-epsilon-caprolactone) small-diameter vascular graft. Biomaterials 27 (2006) 1470-1478
181. Matsuda T., Ihara M., Inoguchi H., Kwon I.K., Takamizawa K., and Kidoaki S. Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane fabrics. J Biomed Mater Res A 73 (2005) 125-131
182. He W., Ma Z., Teo W.E., Dong Y.X., Robless P.A., Lim T.C., et al. Tubular nanofiber scaffolds for tissue engineered small-diameter vascular grafts. J Biomed Mater Res A 90 (2009) 205-216
183. Nottelet B., Pektok E., Mandracchia D., Tille J.C., Walpoth B., Gurny R., et al. Factorial design optimization and in vivo feasibility of poly(epsilon-caprolactone)-micro- and nanofiber-based small diameter vascular grafts. J Biomed Mater Res A 89 (2009) 865-875
184. Inanc B., Arslan Y.E., Seker S., Elcin A.E., and Elcin Y.M. Periodontal ligament cellular structures engineered with electrospun poly(DL-lactide-co-glycolide) nanofibrous membrane scaffolds. J Biomed Mater Res A 90 (2009) 186-195
185. Riboldi S.A., Sampaolesi M., Neuenschwander P., Cossu G., and Mantero S. Electrospun degradable polyesterurethane membranes: potential scaffolds for skeletal muscle tissue engineering. Biomaterials 26 (2005) 4606-4615
186. Wu Y., Zheng Q., Du J., Song Y., Wu B., and Guo X. Self-assembled IKVAV peptide nanofibers promote adherence of PC12 cells. J Huazhong Univ Sci Technol Med Sci 26 (2006) 594-596
187. Yang F., Murugan R., Ramakrishna S., Wang X., Ma Y.X., and Wang S. Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering. Biomaterials 25 (2004) 1891-1900
188. Corey J.M., Gertz C.C., Wang B.S., Birrell L.K., Johnson S.L., Martin D.C., et al. The design of electrospun PLLA nanofiber scaffolds compatible with serum-free growth of primary motor and sensory neurons. Acta Biomater 4 (2008) 863-875
189. Valmikinathan C.M., Tian J., Wang J., and Yu X. Novel nanofibrous spiral scaffolds for neural tissue engineering. J Neural Eng 5 (2008) 422-432
190. Guo J., Su H., Zeng Y., Liang Y.X., Wong W.M., Ellis-Behnke R.G., et al. Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold. Nanomedicine 3 (2007) 311-321
191. Panseri S., Cunha C., Lowery J., Del Carro U., Taraballi F., Amadio S., et al. Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections. BMC Biotechnol 8 (2008) 39
192. Wang W., Itoh S., Matsuda A., Ichinose S., Shinomiya K., Hata Y., et al. Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration. J Biomed Mater Res A 84 (2008) 557-566
193. Katti D.S., Robinson K.W., Ko F.K., and Laurencin C.T. Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters. J Biomed Mater Res B Appl Biomater 70 (2004) 286-296
194. Chong E.J., Phan T.T., Lim I.J., Zhang Y.Z., Bay B.H., Ramakrishna S., et al. Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution. Acta Biomater 3 (2007) 321-330
195. Venugopal J., and Ramakrishna S. Biocompatible nanofiber matrices for the engineering of a dermal substitute for skin regeneration. Tissue Eng 11 (2005) 847-854
196. Powell H.M., and Boyce S.T. Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes. J Biomed Mater Res A 84 (2008) 1078-1086
197. Sun T., Mai S., Norton D., Haycock J.W., Ryan A.J., and MacNeil S. Self-organization of skin cells in three-dimensional electrospun polystyrene scaffolds. Tissue Eng 11 (2005) 1023-1033
198. Schneider A., Garlick J.A., and Egles C. Self-assembling peptide nanofiber scaffolds accelerate wound healing. PLoS ONE 3 (2008) e1410
199. Pietramaggiori G., Yang H.J., Scherer S.S., Kaipainen A., Chan R.K., Alperovich M., et al. Effects of poly-N-acetyl glucosamine (pGlcNAc) patch on wound healing in db/db mouse. J Trauma 64 (2008) 803-808
200. Powell H.M., Supp D.M., and Boyce S.T. Influence of electrospun collagen on wound contraction of engineered skin substitutes. Biomaterials 29 (2008) 834-843
201. Meng H., Chen L., Ye Z., Wang S., and Zhao X. The effect of a self-assembling peptide nanofiber scaffold (peptide) when used as a wound dressing for the treatment of deep second degree burns in rats. J Biomed Mater Res B Appl Biomater 89B (2009) 379-391
202. Blackwood K.A., McKean R., Canton I., Freeman C.O., Franklin K.L., Cole D., et al. Development of biodegradable electrospun scaffolds for dermal replacement. Biomaterials 29 (2008) 3091-3104
203. Nerurkar N.L., Elliott D.M., and Mauck R.L. Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering. J Orthop Res 25 (2007) 1018-1028
204. Nesti L.J., Li W.J., Shanti R.M., Jiang Y.J., Jackson W., Freedman B.A., et al. Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam. Tissue Eng Part A 14 (2008) 1527-1537
205. Wang S., Nagrath D., Chen P.C., Berthiaume F., and Yarmush M.L. Three-dimensional primary hepatocyte culture in synthetic self-assembling peptide hydrogel. Tissue Eng Part A 14 (2008) 227-236
206. Navarro-Alvarez N., Soto-Gutierrez A., Rivas-Carrillo J.D., Chen Y., Yamamoto T., Yuasa T., et al. Self-assembling peptide nanofiber as a novel culture system for isolated porcine hepatocytes. Cell Transplant 15 (2006) 921-927
207. Hashemi S.M., Soleimani M., Zargarian S.S., Haddadi-Asl V., Ahmadbeigi N., Soudi S., et al. In vitro differentiation of human cord blood-derived unrestricted somatic stem cells into hepatocyte-like cells on poly(epsilon-caprolactone) nanofiber scaffolds. Cells Tissues Organs 190 (2009) 135-149
208. Navarro-Alvarez N., Rivas-Carrillo J.D., Soto-Gutierrez A., Yuasa T., Okitsu T., Noguchi H., et al. Reestablishment of microenvironment is necessary to maintain in vitro and in vivo human islet function. Cell Transplant 17 (2008) 111-119
209. Stankus J.J., Soletti L., Fujimoto K., Hong Y., Vorp D., and Wagner W.R. Fabrication of cell microintegrated blood vessel constructs through electrohydrodynamic atomization. Biomaterials 28 (2007) 2738-2746
210. van Aalst J.A., Reed C.R., Han L., Andrady T., Hromadka M., Bernacki S., et al. Cellular incorporation into electrospun nanofibers: retained viability, proliferation, and function in fibroblasts. Ann Plast Surg 60 (2008) 577-583
211. Pham Q.P., Sharma U., and Mikos A.G. Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration. Biomacromolecules 7 (2006) 2796-2805
212. Eichhorn S.J., and Sampson W.W. Statistical geometry of pores and statistics of porous nanofibrous assemblies. J R Soc Interface 2 (2005) 309-318
213. Balguid A., Mol A., van Marion M.H., Bank R.A., Bouten C.V., and Baaijens F.P. Tailoring fiber diameter in electrospun poly(epsilon-caprolactone) scaffolds for optimal cellular infiltration in cardiovascular tissue engineering. Tissue Eng Part A 15 (2009) 437-444
214. Tuzlakoglu K., Bolgen N., Salgado A.J., Gomes M.E., Piskin E., and Reis R.L. Nano- and micro-fiber combined scaffolds: a new architecture for bone tissue engineering. J Mater Sci Mater Med 16 (2005) 1099-1104
215. Santos M.I., Tuzlakoglu K., Fuchs S., Gomes M.E., Peters K., Unger R.E., et al. Endothelial cell colonization and angiogenic potential of combined nano- and micro-fibrous scaffolds for bone tissue engineering. Biomaterials 29 (2008) 4306-4313
216. Park S.H., Kim T.G., Kim H.C., Yang D.Y., and Park T.G. Development of dual scale scaffolds via direct polymer melt deposition and electrospinning for applications in tissue regeneration. Acta Biomater 4 (2008) 1198-1207
217. Thorvaldsson A., Stenhamre H., Gatenholm P., and Walkenstrom P. Electrospinning of highly porous scaffolds for cartilage regeneration. Biomacromolecules 9 (2008) 1044-1049
218. Yixiang D., Yong T., Liao S., Chan C.K., and Ramakrishna S. Degradation of electrospun nanofiber scaffold by short wave length ultraviolet radiation treatment and its potential applications in tissue engineering. Tissue Eng Part A 14 (2008) 1321-1329
219. Ki C.S., Park S.Y., Kim H.J., Jung H.M., Woo K.M., Lee J.W., et al. Development of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration. Biotechnol Lett 30 (2008) 405-410
220. Leong M.F., Rasheed M.Z., Lim T.C., and Chian K.S. In vitro cell infiltration and in vivo cell infiltration and vascularization in a fibrous, highly porous poly(D,L-lactide) scaffold fabricated by cryogenic electrospinning technique. J Biomed Mater Res A 91 (2009) 231-240
221. Ekaputra A.K., Prestwich G.D., Cool S.M., and Hutmacher D.W. Combining electrospun scaffolds with electrosprayed hydrogels leads to three-dimensional cellularization of hybrid constructs. Biomacromolecules 9 (2008) 2097-2103
222. Nair S., Kim J., Crawford B., and Kim S.H. Improving biocatalytic activity of enzyme-loaded nanofibers by dispersing entangled nanofiber structure. Biomacromolecules 8 (2007) 1266-1270
223. Ki C.S., Kim J.W., Hyun J.H., Lee K.H., Hattori M., Rah D.K., et al. Electrospun three-dimensional silk fibroin nanofibrous scaffold. J Appl Polym Sci 106 (2007) 3922-3928
224. Teo W.E., Liao S., Chan C.K., and Ramakrishna S. Remodeling of three-dimensional hierarchically organized nanofibrous assemblies. Curr Nanosci 4 (2008) 361-369
225. Srouji S., Kizhner T., Suss-Tobi E., Livne E., and Zussman E. 3-D Nanofibrous electrospun multilayered construct is an alternative ECM mimicking scaffold. J Mater Sci Mater Med 19 (2008) 1249-1255
226. Ishii O., Shin M., Sueda T., and Vacanti J.P. In vitro tissue engineering of a cardiac graft using a degradable scaffold with an extracellular matrix-like topography. J Thorac Cardiovasc Surg 130 (2005) 1358-1363