Preparation and characterization of chitosan-based spray-dried microparticles for the delivery of clindamycin phosphate to periodontal pockets

Current Drug Delivery

Volumn 11, Issue 1, 2014, Pages 98-111

  Kilicarslan, Muge ^a   Gumustas, Mehmet ^a   Yildiz, Sulhiye ^a   Baykara, Tamer ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Chitosan; Clindamycin phosphate; Microparticle; Periodontal drug delivery; Spray drying

Indexed keywords

CHITOSAN; CLINDAMYCIN PHOSPHATE; GLUTARALDEHYDE; WATER;

ARTICLE; DELAYED DRUG RELEASE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG SOLUBILITY; ENCAPSULATION; IN VITRO STUDY; MORPHOLOGY; NONHUMAN; PARTICLE SIZE; PERIODONTAL DISEASE; PERIODONTAL POCKET; PRIORITY JOURNAL; SPRAY DRYING; THERMAL ANALYSIS; THERMOGRAPHY; VISCOSITY;

ANTI-BACTERIAL AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CLINDAMYCIN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; GLUTARAL; KINETICS; MODELS, CHEMICAL; PARTICLE SIZE; PERIODONTAL POCKET; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY;

EID: 84894031158     PISSN: 15672018     EISSN: 18755704     Source Type: Journal    
DOI: 10.2174/15672018113109990055     Document Type: Article

References (59)

1. Perioli, L.; Ambrogi, V.; Rubini, D.; Giovagnoli, S.; Ricci, M.; Blasi, P.; Rossi, C. Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease. J. Control. Release, 2004, 95 (3), 521-533.
2. Jain, N.; Jain, G. K.; Javed, S.; Iqbal, Z.; Talegaonkar, S.; Ahmad, F. J.; Khar, R. K. Recent approaches for the treatment of periodontitis. Drug Discov. Today, 2008, 13 (21-22), 932-943.
3. Southard, G. L.; Godowski, K. C. Subgingival controlled release of antimicrobial agents in the treatment of periodontal disease. Int. J. Antimicrob. Agents, 1998, 9 (4), 239-253.
4. Jones, D. S.; Woolfson, A. D.; Brown, A. F.; Coulter, W. A.; McClelland, C.; Irwin, C. R. Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease. J. Control. Release, 2000, 67 (2-3), 357-368.
5. Vyas, S. P.; Sihorkar, V.; Mishra, V. Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases. J. Clin. Pharm. Ther., 2000, 25 (1), 21-42.
6. Medlicott, N. J.; Rathbone, M. J.; Tucker, I. G.; Holborow, D. W. Delivery Systems for the Administration of Drugs to the Periodontal Pocket. Adv. Drug Deliv. Rev., 1994, 13 (1-2), 181-203.
7. Pragati, S. A.S.; Kuldeep, S. Recent advances in periodontal drug delivery systems. Int. J. Drug Dev., 2009, 1, 1-14.
8. Seymour, R. A.; Heasman, P. A. Pharmacological control of periodontal disease. II. Antimicrobial agents. J. Dent., 1995, 23 (1), 5-14.
9. Schwach-Abdellaoui, K.; Vivien-Castioni, N.; Gurny, R. Local delivery of antimicrobial agents for the treatment of periodontal diseases. Eur. J. Pharm. Biopharm., 2000, 50 (1), 83-99.
10. Govender, S.; Lutchman, D.; Pillay, V.; Chetty, D. J.; Govender, T. Enhancing drug incorporation into tetracycline-loaded chitosan microspheres for periodontal therapy. J. Microencapsul., 2006, 23 (7), 750-761.
11. Pattnaik, S.; Panigrahi, L.; Murthy, R. S. Periodontal mucoadhesive formulations for the treatment of infectious periodontal diseases. Curr. Drug Deliv., 2007, 4 (4), 303-323.
12. Rawat, S. W. S.; Lahoti, S. In situ gel formulation of ornidazole for the treatment of periodontal disease. Curr. Pharm. Res., 2010, 1 (1), 60-69.
13. Kumari, N.; Pathak, K. Dual controlled release, in situ gelling periodontal sol of metronidazole benzoate and serratiopeptidase: statistical optimization and mechanistic evaluation. Curr. Drug Deliv., 2012, 9 (1), 74-84.
14. Barat, R.; Srinatha, A.; Pandit, J. K.; Anupurba, S.; Mittal, N. Chitosan inserts for periodontitis: influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release. Acta Pharm., 2007, 57 (4), 469-477.
15. El-Kamel, A. H.; Ashri, L. Y.; Alsarra, I. A. Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases. AAPS Pharm. Sci. Tech., 2007, 8 (3), E75.
16. Ikinci, G.; Senel, S.; Akincibay, H.; Kas, S.; Ercis, S.; Wilson, C. G.; Hincal, A. A. Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis. Int. J. Pharm., 2002, 235 (1-2), 121-127.
17. Akncbay, H.; Senel, S.; Ay, Z. Y. Application of chitosan gel in the treatment of chronic periodontitis. J. Biomed. Mater. Res. B. Appl. Biomater., 2007, 80 (2), 290-296.
18. Venkatesh, M. P.; Kumar, T. M.; Avinash, B. S.; Kumar, G. S. Development, in vitro and in vivo evaluation of novel injectable smart gels of azithromycin for chronic periodontitis. Curr. Drug Deliv., 2013, 10 (2), 188-197.
19. Mundargi, R. C.; Srirangarajan, S.; Agnihotri, S. A.; Patil, S. A.; Ravindra, S.; Setty, S. B.; Aminabhavi, T. M. Development and evaluation of novel biodegradable microspheres based on poly(d,llactide-co-glycolide) and poly(epsilon-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: in vitro and in vivo studies. J. Control. Release, 2007, 119 (1), 59-68.
20. Samati, Y.; Yuksel, N.; Tarimci, N. Preparation and characterization of poly(D,L-lactic-co-glycolic Acid) microspheres containing flurbiprofen sodium. Drug Deliv., 2006, 13 (2), 105-111.
21. Pichayakorn, W.; Boonme, P. Evaluation of cross-linked chitosan microparticles containing metronidazole for periodontitis treatment. Mater. Sci. Eng. C. Mater. Biol. Appl., 2013, 33 (3), 1197-1202.
22. Yue, I. C.; Poff, J.; Cortes, M. E.; Sinisterra, R. D.; Faris, C. B.; Hildgen, P.; Langer, R.; Shastri, V. P. A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease. Biomaterials, 2004, 25 (17), 3743-3750.
23. Tiwari, G. Biodegredable microspheres for controlled delivery of metronidazole in the treatment of periodontal diseases: Formulation consideration. Int. J. Phar. Bio. Sci., 2010, V1 (2), 1-13.
24. Govender, S.; Pillay, V.; Chetty, D. J.; Essack, S. Y.; Dangor, C. M.; Govender, T. Optimisation and characterisation of bioadhesive controlled release tetracycline microspheres. Int. J. Pharm., 2005, 306 (1-2), 24-40.
25. Jamal, T.; Rahman, M. A.; Mirza, M. A.; Panda, A. K.; Talegaonkar, S.; Iqbal, Z. Formulation, antimicrobial and toxicity evaluation of bioceramic based ofloxacin loaded biodegradable microspheres for periodontal infection. Curr. Drug Deliv., 2012, 9 (5), 515-526.
26. Saboktakin, M. R.; Tabatabaie, R. M.; Maharramov, A.; Ramazanov, M. A. Development and in vitro evaluation of thiolated chitosan- Poly(methacrylic acid) nanoparticles as a local mucoadhesive delivery system. Int. J. Biol. Macromol., 2011, 48 (3), 403-407.
27. Aimetti, M.; Romano, F.; Torta, I.; Cirillo, D.; Caposio, P.; Romagnoli, R. Debridement and local application of tetracyclineloaded fibres in the management of persistent periodontitis: results after 12 months. J. Clin. Periodontol., 2004, 31 (3), 166-172.
28. Reise, M.; Wyrwa, R.; Muller, U.; Zylinski, M.; Volpel, A.; Schnabelrauch, M.; Berg, A.; Jandt, K. D.; Watts, D. C.; Sigusch, B. W. Release of metronidazole from electrospun poly(L-lactideco-D/L-lactide) fibers for local periodontitis treatment. Dent. Mater., 2012, 28 (2), 179-188.
29. Zamani, M.; Morshed, M.; Varshosaz, J.; Jannesari, M. Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases. Eur. J. Pharm. Biopharm., 2010, 75 (2), 179-185.
30. Rinaudo, M. Chitin and chitosan: Properties and applications. Prog Polym. Sci., 2006, 31 (7), 603-632.
31. Senel, S.; McClure, S. J. Potential applications of chitosan in veterinary medicine. Adv. Drug Deliv. Rev., 2004, 56 (10), 1467-1480.
32. Anal, A. K.; Stevens, W. F.; Remunan-Lopez, C. Ionotropic crosslinked chitosan microspheres for controlled release of ampicillin. Int. J. Pharm., 2006, 312 (1-2), 166-173.
33. He, P.; Davis, S. S.; Illum, L. Chitosan microspheres prepared by spray drying. Int. J. Pharm., 1999, 187 (1), 53-65.
34. Desai, K. G.; Park, H. J. Preparation of cross-linked chitosan microspheres by spray drying: effect of cross-linking agent on the properties of spray dried microspheres. J. Microencapsul., 2005, 22 (4), 377-395.
35. He, P.; Davis, S. S.; Illum, L. In vitro evaluation of the mucoadhesive properties of chitosan microspheres. Int. J. Pharm., 1998, 166 (1), 75-88.
36. Gupta, K. C.; Jabrail, F. H. Effects of degree of deacetylation and cross-linking on physical characteristics, swelling and release behavior of chitosan microspheres. Carbohyd. Polym., 2006, 66 (1), 43-54.
37. Mi, F. L.; Tan, Y. C.; Liang, H. F.; Sung, H. W. In vivo biocompatibility and degradability of a novel injectable-chitosanbased implant. Biomaterials, 2002, 23 (1), 181-191.
38. Senel, S.; Kremer, M. J.; Kas, S.; Wertz, P. W.; Hincal, A. A.; Squier, C. A. Enhancing effect of chitosan on peptide drug delivery across buccal mucosa. Biomaterials, 2000, 21 (20), 2067-2071.
39. Martin, L.; Wilson, C. G.; Koosha, F.; Uchegbu, I. F. Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmitoyl glycol chitosan hydrogels. Eur. J. Pharm. Biopharm., 2003, 55 (1), 35-45.
40. Remunan-Lopez, C.; Portero, A.; Vila-Jato, J. L.; Alonso, M. J. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J. Control. Release, 1998, 55 (2-3), 143-152.
41. Grenha, A.; Seijo, B.; Remunan-Lopez, C. Microencapsulated chitosan nanoparticles for lung protein delivery. Eur. J. Pharm. Sci., 2005, 25 (4-5), 427-437.
42. Sandri, G.; Rossi, S.; Ferrari, F.; Bonferoni, M. C.; Muzzarelli, C.; Caramella, C. Assessment of chitosan derivatives as buccal and vaginal penetration enhancers. Eur. J. Pharm. Sci., 2004, 21 (2-3), 351-359.
43. Martinac, A.; Filipovic-Grcic, J.; Voinovich, D.; Perissutti, B.; Franceschinis, E. Development and bioadhesive properties of chitosan-ethylcellulose microspheres for nasal delivery. Int. J. Pharm., 2005, 291 (1-2), 69-77.
44. Uraz, A.; Bonuegri, D.; Özcan, G.; Karaduman, B.; Uç, D.; enel, S.; Pehlivan, S.; Öü, E.; Sultan, N. Two percent chitosan mouthwash: A microbiological and clinical comparative study. J. Dent. Sci., 2012, 7(4), 342-349.
45. Seyfarth, F.; Schliernann, S.; Elsner, P.; Hipler, U. C. Antifungal effect of highand low-molecular-weight chitosan hydrochloride, carboxymethyl chitosan, chitosan oligosaccharide and N-acetyl-Dglucosamine against Candida albicans, Candida krusei and Candida glabrata. Int. J. Pharm., 2008, 353 (1-2), 139-148.
46. Giunchedi, P.; Juliano, C.; Gavini, E.; Cossu, M.; Sorrenti, M. Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres. Eur. J. Pharm. Biopharm., 2002, 53 (2), 233-239.
47. Re, M. I. Formulating drug delivery systems by spray drying. Drying Technol., 2006, 24, 433-446.
48. Broadhead, J.; Rouan, S. K. E.; Rhodes, C. T. The Spray Drying of Pharmaceuticals. Drug Dev. Ind. Pharm., 1992, 18 (11-12), 1169-1206.
49. Desai, K. G.; Park, H. J. Effect of manufacturing parameters on the characteristics of vitamin C encapsulated tripolyphosphate-chitosan microspheres prepared by spray-drying. J. Microencapsul., 2006, 23 (1), 91-103.
50. Brook, I.; Lewis, M. A.; Sandor, G. K.; Jeffcoat, M.; Samaranayake, L. P.; Vera R.J. Clindamycin in dentistry: more than just effective prophylaxis for endocarditis? Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2005, 100 (5), 550-558.
51. Lin, S.; Levin, L.; Peled, M.; Weiss, E. I.; Fuss, Z. Reduction of viable bacteria in dentinal tubules treated with clindamycin or tetracycline. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 2003, 96 (6), 751-756.
52. Veloo, A. C.; Seme, K.; Raangs, E.; Rurenga, P.; Singadji, Z.; Wekema-Mulder, G.; van Winkelhoff, A. J. Antibiotic susceptibility profiles of oral pathogens. Int. J. Antimicrob. Agents, 2012, 40 (5), 450-454.
53. Kilicarslan, M.; Ozkan, S. A.; Baykara, T. LC Determination of Clindamycin Phosphate from Chitosan Microspheres. Chromatographia, 2010, 72 (9-10), 799-805.
54. Chung, T. W.; Chang, C. H.; Ho, C. W. Incorporating chitosan (CS) and TPP into silk fibroin (SF) in fabricating spray-dried microparticles prolongs the release of a hydrophilic drug. J. Taiwan Inst. Chem. E., 2011, 42 (4), 592-597.
55. Gavini, E.; Hegge, A. B.; Rassu, G.; Sanna, V.; Testa, C.; Pirisino, G.; Karlsen, J.; Giunchedi, P. Nasal administration of carbamazepine using chitosan microspheres: in vitro/in vivo studies. Int. J. Pharm., 2006, 307 (1), 9-15.
56. Learoyd, T. P.; Burrows, J. L.; French, E.; Seville, P. C. Chitosanbased spray-dried respirable powders for sustained delivery of terbutaline sulfate. Eur. J. Pharm. Biopharm., 2008, 68 (2), 224-234.
57. Cervera, M. F.; Heinamaki, J.; de la Paz, N.; Lopez, O.; Maunu, S. L.; Virtanen, T.; Hatanpaa, T.; Antikainen, O.; Nogueira, A.; Fundora, J.; Yliruusi, J. Effects of spray drying on physicochemical properties of chitosan acid salts. AAPS Pharm. Sci. Tech., 2011, 12 (2), 637-649.
58. Dash, S.; Murthy, P. N.; Nath, L.; Chowdhury, P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol. Pharm., 2010, 67 (3), 217-223.
59. Azab, A. K.; Orkin, B.; Doviner, V.; Nissan, A.; Klein, M.; Srebnik, M.; Rubinstein, A. Crosslinked chitosan implants as potential degradable devices for brachytherapy: in vitro and in vivo analysis. J. Control. Release, 2006, 111 (3), 281-289.