New insights into and novel applications of release technology for periodontal reconstructive therapies

Journal of Controlled Release

Volumn 149, Issue 2, 2011, Pages 92-110

  Chen, Fa Ming ^a   An, Ying ^a   Zhang, Rong ^a   Zhang, Min ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cell homing; Dual delivery; Gene therapy; Growth factors; Platelets; Tissue engineering

Indexed keywords

ADULT POPULATIONS; CELL ACTIVITY; CLINICAL TRANSLATION; CLINICAL USE; CURRENT LIMITATION; DELIVERY PROBLEMS; DUAL DELIVERY; EXPRESSION PATTERNS; FUNCTIONAL TISSUE; GROWTH FACTOR; IN-VIVO; LIMITED CAPACITY; NEW OPPORTUNITIES; NOVEL APPLICATIONS; PERIODONTAL TISSUE; PERIODONTIUM; PHYSIOLOGICAL LEVELS; RECENT PROGRESS; REGENERATIVE MEDICINE; SELF-REPAIR; SIGNALING MOLECULES; SPATIAL SEQUENCES; STEM CELL; WOUND HEALING;

GENE THERAPY; GENETIC ENGINEERING; HISTOLOGY; PEPTIDES; PLATELETS; ROBUST CONTROL; STEM CELLS; TISSUE;

TISSUE ENGINEERING;

BASIC FIBROBLAST GROWTH FACTOR; BIOMIMETIC MATERIAL; BONE MORPHOGENETIC PROTEIN 12; BONE MORPHOGENETIC PROTEIN 2; CALCIUM PHOSPHATE; CHITOSAN; COLLAGEN; COLLAGEN SPONGE; DEXTRAN; DRUG CARRIER; FIBRIN GLUE; GELATIN; GROWTH DIFFERENTIATION FACTOR 5; GROWTH FACTOR; MACROGOL; MICROSPHERE; MOLECULAR SCAFFOLD; OSTEOGENIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR B; POLYGLACTIN; POLYMER; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA1;

BONE GRAFT; BONE REGENERATION; CELL FATE; CELL HOMING; CELL MIGRATION; COMPOSITE MATERIAL; COVALENT BOND; CROSS LINKING; DENTAL EQUIPMENT; DRUG RELEASE; ENAMEL; HUMAN; HYDROGEL; IMPLANT; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PERIODONTAL DISEASE; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; STEM CELL; STEM CELL TRANSPLANTATION; THROMBOCYTE RICH PLASMA; TISSUE ENGINEERING; TRANSLATIONAL RESEARCH; WOUND HEALING;

CELL DIFFERENTIATION; GENE THERAPY; GUIDED TISSUE REGENERATION, PERIODONTAL; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PERIODONTITIS; STEM CELL TRANSPLANTATION;

EID: 78651346890     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.10.021     Document Type: Review

References (188)

1. B.L. Pihlstrom, B.S. Michalowicz, and N.W. Johnson Periodontal diseases Lancet 366 2005 1809 1820
2. G. Polimeni, A.V. Xiropaidis, and U.M. Wikesjö Biology and principles of periodontal wound healing/regeneration Periodontology 41 2006 2000 30 47
3. M.E. Aichelmann-Reidy, and M.A. Reynolds Predictability of clinical outcomes following regenerative therapy in intrabony defects J. Periodontol. 79 2008 387 393
4. Y.C. Liu, U.H. Lerner, and Y.T. Teng Cytokine responses against periodontal infection: protective and destructive roles Periodontology 2000 52 2010 163 206
5. M.A. Reynolds, M.E. Aichelmann-Reidy, and G.L. Branch-Mays Regeneration of periodontal tissue: bone replacement grafts Dent. Clin. North Am. 54 2010 55 71
6. C.C. Villar, and D.L. Cochran Regeneration of periodontal tissues: guided tissue regeneration Dent. Clin. North Am. 54 2010 73 92
7. F.M. Chen, J. Zhang, M. Zhang, Y. An, F. Chen, and Z.F. Wu A review on endogenous regenerative technology in periodontal regenerative medicine Biomaterials 31 2010 7892 7927
8. N.H. Lin, S. Gronthos, and P. Mark Bartold Stem cells and future periodontal regeneration Periodontology 2000 51 2009 239 251
9. D.E. Discher, D.J. Mooney, and P.W. Zandstra Growth factors, matrices, and forces combine and control stem cells Science 324 2009 1673 1677
10. F.M. Chen, and Y. Jin Periodontal tissue engineering and regeneration: current approaches and expanding opportunities Tissue Eng. B Rev. 16 2010 219 255
11. D. Kaigler, J.A. Cirelli, and W.V. Giannobile Growth factor delivery for oral and periodontal tissue engineering Expert Opin. Drug Deliv. 3 2006 647 662
12. M.P. Lutolf, P.M. Gilbert, and H.M. Blau Designing materials to direct stem-cell fate Nature 462 2009 433 441
13. F.M. Chen, R.M. Shelton, Y. Jin, and I.L. Chapple Localized delivery of growth factors for periodontal tissue regeneration: role, strategies, and perspectives Med. Res. Rev. 29 2009 472 513
14. P. Tayalia, and D.J. Mooney Controlled growth factor delivery for tissue engineering Adv. Mater. 21 2009 3269 3285
15. D.F. Williams To engineer is to create: the link between engineering and regeneration Trends Biotechnol. 24 2006 4 8
16. M. Zeichner-David Regeneration of periodontal tissues: cementogenesis revisited Periodontology 2000 41 2006 196 217
17. W.V. Giannobile, and M.J. Somerman Growth and amelogenin-like factors in periodontal wound healing. A systematic review Ann. Periodontol. 8 2003 193 204
18. F.J. Hughes, W. Turner, G. Belibasakis, and G. Martuscelli Effects of growth factors and cytokines on osteoblast differentiation Periodontology 2000 41 2006 48 72
19. J. Lee, A. Stavropoulos, C. Susin, and U.M. Wikesjö Periodontal regeneration: focus on growth and differentiation factors Dent. Clin. North Am. 54 2010 93 111
20. Y.H. Huang, G. Polimeni, M. Qahash, and U.M. Wikesjö Bone morphogenetic proteins and osseointegration: current knowledge - future possibilities Periodontology 2000 47 2008 206 223
21. R. Vasita, and D.S. Katti Growth factor-delivery systems for tissue engineering: a materials perspective Expert Rev. Med. Devices 3 2006 29 47
22. B. Inanc, A.E. Elcin, and Y.M. Elcin Osteogenic induction of human periodontal ligament fibroblasts under two- and three-dimensional culture conditions Tissue Eng. 12 2006 257 266
23. B.M. Seo, M. Miura, S. Gronthos, P.M. Bartold, S. Batouli, J. Brahim, M. Young, P.G. Robey, C.Y. Wang, and S. Shi Investigation of multipotent postnatal stem cells from human periodontal ligament Lancet 364 2004 149 155
24. S. Shi, P.M. Bartold, M. Miura, B.M. Seo, P.G. Robey, and S. Gronthos The efficacy of mesenchymal stem cells to regenerate and repair dental structures Orthod. Craniofac. Res. 8 2005 191 199
25. I.C. Gay, S. Chen, and M. MacDougall Isolation and characterization of multipotent human periodontal ligament stem cells Orthod. Craniofac. Res. 10 2007 149 160
26. S. Ohta, S. Yamada, K. Matuzaka, and T. Inoue The behavior of stem cells and progenitor cells in the periodontal ligament during wound healing as observed using immunohistochemical methods J. Periodontal Res. 43 2008 595 603
27. Y. Liu, Y. Zheng, G. Ding, D. Fang, C. Zhang, P.M. Bartold, S. Gronthos, S. Shi, and S. Wang Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine Stem Cells 26 2008 1065 1073
28. Z. Yang, F. Jin, X. Zhang, D. Ma, C. Han, N. Huo, Y. Wang, Y. Zhang, Z. Lin, and Y. Jin Tissue engineering of cementum/periodontal-ligament complex using a novel three-dimensional pellet cultivation system for human periodontal ligament stem cells Tissue Eng. C Meth. 15 2009 571 581
29. W. Techawattanawisal, K. Nakahama, M. Komaki, M. Abe, Y. Takagi, and I. Morita Isolation of multipotent stem cells from adult rat periodontal ligament by neurosphere forming culture system Biochem. Biophys. Res. Commun. 357 2007 917 923
30. G.S. Coura, R.C. Garcez, C.B. de Aguiar, M. Alvarez-Silva, R.S. Magini, and A.G. Trentin Human periodontal ligament: a niche of neural crest stem cells J. Periodontal Res. 43 2008 531 536
31. S. Gronthos, M. Mankani, J. Brahim, P.G. Robey, and S. Shi Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo Proc. Natl Acad. Sci. USA 97 2000 13625 13630
32. O. Trubiani, R. Di Primio, T. Traini, J. Pizzicannella, A. Scarano, A. Piattelli, and S. Caputi Morphological and cytofluorimetric analysis of adult mesenchymal stem cells expanded ex vivo from periodontal ligament Int. J. Immunopathol. Pharmacol. 18 2005 213 221
33. N. Kawanabe, S. Murata, K. Murakami, Y. Ishihara, S. Hayano, H. Kurosaka, H. Kamioka, T. Takano-Yamamoto, and T. Yamashiro Isolation of multipotent stem cells in human periodontal ligament using stage-specific embryonic antigen-4 Differentiation 79 2010 74 83
34. N. Smart, and P.R. Riley The stem cell movement Circ. Res. 102 2008 1155 1168
35. H.H. Sun, T. Jin, Q. Yu, F.M. Chen, Biological approaches toward dental pulp regeneration by tissue engineering, J. Tissue Eng. Regen. Med. 2011, doi:10.1002/term.369.
36. J.Y. Kim, X. Xin, E.K. Moioli, J. Chung, C.H. Lee, M. Chen, S.Y. Fu, P.D. Koch, and J.J. Mao Regeneration of dental-pulp-like tissue by chemotaxis-induced cell homing Tissue Eng. A 16 2010 3023 3031
37. K. Kim, C.H. Lee, B.K. Kim, and J.J. Mao Anatomically shaped tooth and periodontal regeneration by cell homing J. Dent. Res. 89 2010 842 847
38. C.H. Lee, J.L. Cook, A. Mendelson, E.K. Moioli, H. Yao, and J.J. Mao Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study Lancet 376 2010 440 448
39. J.J. Mao, M.S. Stosich, E.K. Moioli, C.H. Lee, S.Y. Fu, B. Bastian, S.B. Eisig, C. Zemnick, J. Ascherman, J. Wu, C. Rohde, and J. Ahn Facial reconstruction by biosurgery: cell transplantation versus cell homing Tissue Eng. B Rev. 16 2010 257 262
40. R.B. Rutherford, C.E. Niekrash, J.E. Kennedy, and M.F. Charette Platelet-derived and insulin-like growth factors stimulate regeneration of periodontal attachment in monkeys J. Periodontal Res. 27 1992 285 290
41. T.H. Howell, J.P. Fiorellini, D.W. Paquette, S. Offenbacher, W.V. Giannobile, and S.E. Lynch A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease J. Periodontol. 68 1997 1186 1193
42. W.V. Giannobile, S. Ryan, M.S. Shih, D.L. Su, P.L. Kaplan, and T.C. Chan Recombinant human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in class III furcation defects J. Periodontol. 69 1998 129 137
43. J.P. van den Bergh, C.M. ten Bruggenkate, H.H. Groeneveld, E.H. Burger, and D.B. Tuinzing Recombinant human bone morphogenetic protein-7 in maxillary sinus floor elevation surgery in 3 patients compared to autogenous bone grafts. A clinical pilot study J. Clin. Periodontol. 27 2000 627 636
44. N.M. Blumenthal, G. Koh-Kunst, M.E.D. Alves, R.G. Miranda, J.M. Sorensen, U.M. Wozney, and Wikesjö Effect of surgical implantation of recombinant human bone morphogenetic protein-2 in a bioabsorbable collagen sponge or calcium phosphate putty carrier in intrabony periodontal defects in the baboon J. Periodontol. 73 2002 1494 1506
45. J.P. Fiorellini, T.H. Howell, D. Cochran, J. Malmquist, L.C. Lilly, D. Spagnoli, J. Toljanic, A. Jones, and M. Nevins Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation J. Periodontol. 76 2005 605 613 (Pubitemid 40711289)
46. J.B. Park, M. Matsuura, K.Y. Han, O. Norderyd, W.L. Lin, R.J. Genco, and M.I. Cho Periodontal regeneration in class III furcation defects of beagle dogs using guided tissue regenerative therapy with platelet-derived growth factor J. Periodontol. 66 1995 462 477
47. M. Nevins, W.V. Giannobile, M.K. McGuire, R.T. Kao, J.T. Mellonig, J.E. Hinrichs, B.S. McAllister, K.S. Murphy, P.K. McClain, M.L. Nevins, D.W. Paquette, T.J. Han, M.S. Reddy, P.T. Lavin, R.J. Genco, and S.E. Lynch Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial J. Periodontol. 76 2005 2205 2215
48. S.A. Jovanovic, D.R. Hunt, G.W. Bernard, H. Spiekermann, J.M. Wozney, and U.M. Wikesjö Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects Clin. Oral Implants Res. 18 2007 224 230
49. U.M. Wikesjö, R.G. Sorensen, A. Kinoshita, X. Jian Li, and J.M. Wozney Periodontal repair in dogs: effect of recombinant human bone morphogenetic protein-12 (rhBMP-12) on regeneration of alveolar bone and periodontal attachment J. Clin. Periodontol. 31 2004 662 670 (Pubitemid 39092230)
50. Y. Oi, M. Ota, S. Yamamoto, Y. Shibukawa, and S. Yamada Beta-tricalcium phosphate and basic fibroblast growth factor combination enhances periodontal regeneration in intrabony defects in dogs Dent. Mater. J. 28 2009 162 169
51. A.C. Akman, R.S. Tiǧli, M. Gümüşderelioǧ lu, and R.M. Nohutcu bFGF-loaded HA-chitosan: a promising scaffold for periodontal tissue engineering J. Biomed. Mater. Res. A 92 2010 953 962
52. F.M. Chen, Y.M. Zhao, H. Wu, Z.H. Deng, Q.T. Wang, W. Zhou, Q. Liu, G.Y. Dong, K. Li, Z.F. Wu, and Y. Jin Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran-co-gelatin microspheres J. Control. Release 114 2006 209 222
53. S. Herberg, M. Siedler, S. Pippig, A. Schuetz, C. Dony, C.K. Kim, and U.M. Wikesjö Development of an injectable composite as a carrier for growth factor-enhanced periodontal regeneration J. Clin. Periodontol. 35 2008 976 984
54. F.M. Chen, Y.M. Zhao, H.H. Sun, T. Jin, Q.T. Wang, W. Zhou, Z.F. Wu, and Y. Jin Novel glycidyl methacrylated dextran (Dex-GMA)/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins: formulation and characteristics J. Control. Release 118 2007 65 77 (Pubitemid 46283098)
55. F.M. Chen, Y.M. Zhao, R. Zhang, T. Jin, H.H. Sun, Z.F. Wu, and Y. Jin Periodontal regeneration using novel glycidyl methacrylated dextran (Dex-GMA)/gelatin scaffolds containing microspheres loaded with bone morphogenetic proteins J. Control. Release 121 2007 81 90 (Pubitemid 47126066)
56. H.W. Liu, C.H. Chen, C.L. Tsai, and G.H. Hsiue Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation Bone 39 2006 825 836
57. Y. Zhang, Y. Wang, B. Shi, and X. Cheng A platelet-derived growth factor releasing chitosan/coral composite scaffold for periodontal tissue engineering Biomaterials 28 2007 1515 1522
58. P.C. Chang, J.A. Cirelli, Q. Jin, Y.J. Seol, J.V. Sugai, N.J. D'Silva, T.E. Danciu, L.A. Chandler, B.A. Sosnowski, and W.V. Giannobile Adenovirus encoding human platelet-derived growth factor-B delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use Hum. Gene Ther. 20 2009 486 496
59. S. Yilmaz, G. Cakar, B. Kuru, S. Dirikan, and B. Yildirim Platelet-rich plasma in combination with bovine derived xenograft in the treatment of deep intrabony periodontal defects: a report of 20 consecutively treated patients Platelets 20 2009 432 440
60. J. Sohier, T.J. Vlugt, N. Cabrol, C. Van Blitterswijk, K. de Groot, and J.M. Bezemer Dual release of proteins from porous polymeric scaffolds J. Control. Release 111 2006 95 106
61. Z.S. Patel, S. Young, Y. Tabata, J.A. Jansen, M.E. Wong, and A.G. Mikos Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model Bone 43 2008 931 940
62. T.A. Holland, Y. Tabata, and A.G. Mikos Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering J. Control. Release 101 2005 111 125
63. R.A. Peattie, E.R. Rieke, E.M. Hewett, R.J. Fisher, X.Z. Shu, and G.D. Prestwich Dual growth factor-induced angiogenesis in vivo using hyaluronan hydrogel implants Biomaterials 27 2006 1868 1875
64. T.A. Holland, E.W. Bodde, V.M. Cuijpers, L.S. Baggett, Y. Tabata, A.G. Mikos, and J.A. Jansen Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair Osteoarthritis Cartilage 15 2007 187 197
65. F.M. Chen, R. Chen, X.J. Wang, H.H. Sun, and Z.F. Wu In vitro cellular responses to scaffolds containing two microencapulated growth factors Biomaterials 30 2009 5215 5224
66. R.T. Franceschi Biological approaches to bone regeneration by gene therapy J. Dent. Res. 84 2005 1093 1103
67. K. Lee, E.A. Silva, D.J. Mooney, Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J. R. Soc. Interface 2011, doi:10.1098/rsif.2010.0223.
68. N. Matsuda, W.L. Lin, N.M. Kumar, M.I. Cho, and R.J. Genco Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro J. Periodontol. 63 1992 515 525
69. M. Kitamura, K. Nakashima, Y. Kowashi, T. Fujii, H. Shimauchi, T. Sasano, T. Furuuchi, M. Fukuda, T. Noguchi, T. Shibutani, Y. Iwayama, S. Takashiba, H. Kurihara, M. Ninomiya, J. Kido, T. Nagata, T. Hamachi, K. Maeda, Y. Hara, Y. Izumi, T. Hirofuji, E. Imai, M. Omae, M. Watanuki, and S. Murakami Periodontal tissue regeneration using fibroblast growth factor-2: randomized controlled phase II clinical trial PLoS ONE 3 2008 e2611
70. L.T. Hou, T.I. Li, C.M. Liu, B.Y. Liu, C.L. Liu, and H.W. Mi Modulation of osteogenic potential by recombinant human bone morphogenic protein-2 in human periodontal ligament cells: effect of serum, culture medium, and osteoinductive medium J. Periodontal Res. 42 2007 244 252
71. G.N. King, and D.L. Cochran Factors that modulate the effects of bone morphogenetic protein-induced periodontal regeneration: a critical review J. Periodontol. 73 2002 925 936
72. T.J. Stefonek-Puccinelli, and K.S. Masters Co-immobilization of gradient-patterned growth factors for directed cell migration Ann. Biomed. Eng. 36 2008 2121 2133
73. T.A. Kapur, and M.S. Shoichet Immobilized concentration gradients of nerve growth factor guide neurite outgrowth J. Biomed. Mater. Res. A 68 2004 235 243
74. R.R. Chen, E.A. Silva, W.W. Yuen, and D.J. Mooney Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation Pharm. Res. 24 2007 258 264
75. R.R. Chen, E.A. Silva, W.W. Yuen, A.A. Brock, C. Fischbach, A.S. Lin, R.E. Guldberg, and D.J. Mooney Integrated approach to designing growth factor delivery systems FASEB J. 21 2007 3896 3903
76. J.B. Gurdon, and P.Y. Bourillot Morphogen gradient interpretation Nature 413 2001 797 803
77. M. Ibañes, and J.C. Izpisúa Belmonte Theoretical and experimental approaches to understand morphogen gradients Mol. Syst. Biol. 4 2008 176
78. M. Singh, C.P. Morris, R.J. Ellis, M.S. Detamore, and C. Berkland Microsphere-based seamless scaffolds containing macroscopic gradients of encapsulated factors for tissue engineering Tissue Eng. C Meth. 14 2008 299 309
79. M. Singh, C. Berkland, and M.S. Detamore Strategies and applications for incorporating physical and chemical signal gradients in tissue engineering Tissue Eng. B Rev. 14 2008 341 366
80. X. Wang, E. Wenk, X. Zhang, L. Meinel, G. Vunjak-Novakovic, and D.L. Kaplan Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering J. Control. Release 134 2009 81 90
81. N.H. Dormer, M. Singh, L. Wang, C.J. Berkland, and M.S. Detamore Osteochondral interface tissue engineering using macroscopic gradients of bioactive signals Ann. Biomed. Eng. 38 2010 2167 2182
82. R.E. Guldberg Spatiotemporal delivery strategies for promoting musculoskeletal tissue regeneration J. Bone Miner. Res. 24 2009 1507 1511
83. B.V. Slaughter, S.S. Khurshid, O.Z. Fisher, A. Khademhosseini, and N.A. Peppas Hydrogels in regenerative medicine Adv. Mater. 21 2009 3307 3329
84. E. Anitua, M. Sánchez, G. Orive, and I. Andia Delivering growth factors for therapeutics Trends Pharmacol. Sci. 29 2008 37 41
85. F. Basmanav, G.T. Kose, and V. Hasirci Sequential growth factor delivery from complexed microspheres for bone tissue engineering Biomaterials 29 2008 4195 4204
86. A.B. Ennett, D. Kaigler, and D.J. Mooney Temporally regulated delivery of VEGF in vitro and in vivo J. Biomed. Mater. Res. A 79 2006 176 184
87. F. Chen, Z. Wu, Q. Wang, H. Wu, Y. Zhang, X. Nie, and Y. Jin Preparation and biological characteristics of recombinant human bone morphogenetic protein-2-loaded dextran-co-gelatin hydrogel microspheres, in vitro and in vivo studies Pharmacology 75 2005 133 144
88. F.M. Chen, Z.F. Wu, Q.T. Wang, H. Wu, Y.J. Zhang, X. Nie, and Y. Jin Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics Acta Pharmacol. Sin. 26 2005 1093 1103
89. F.M. Chen, Z.F. Wu, H.H. Sun, H. Wu, S.N. Xin, Q.T. Wang, G.Y. Dong, Z.W. Ma, S. Huang, Y.J. Zhang, and Y. Jin Release of bioactive BMP from dextran-derived microspheres: a novel delivery concept Int. J. Pharm. 307 2006 23 32
90. E.K. Moioli, P.A. Clark, X. Xin, S. Lal, and J.J. Mao Matrices and scaffolds for drug delivery in dental, oral and craniofacial tissue engineering Adv. Drug Deliv. Rev. 59 2007 308 324
91. F. Quaglia Bioinspired tissue engineering: the great promise of protein delivery technologies Int. J. Pharm. 364 2008 281 297
92. F.M. Chen, M. Zhang, and Z.F. Wu Toward delivery of multiple growth factors in tissue engineering Biomaterials 31 2010 6279 6308
93. T.A. Holland, Y. Tabata, and A.G. Mikos In vitro release of transforming growth factor-beta 1 from gelatin microparticles encapsulated in biodegradable, injectable oligo(poly(ethylene glycol) fumarate) hydrogels J. Control. Release 91 2003 299 313
94. T.A. Holland, J.K. Tessmar, Y. Tabata, and A.G. Mikos Transforming growth factor-beta 1 release from oligo(poly(ethylene glycol) fumarate) hydrogels in conditions that model the cartilage wound healing environment J. Control. Release 94 2004 101 114
95. A. Perets, Y. Baruch, F. Weisbuch, G. Shoshany, G. Neufeld, and S. Cohen Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres J. Biomed. Mater. Res. A 65 2003 489 497
96. A.J. DeFail, C.R. Chu, N. Izzo, and K.G. Marra Controlled release of bioactive TGF-beta 1 from microspheres embedded within biodegradable hydrogels Biomaterials 27 2006 1579 1585
97. K. Gavénis, D. Klee, R.M. Pereira-Paz, M. von Walter, J. Mollenhauer, U. Schneider, and B. Schmidt-Rohlfing BMP-7 loaded microspheres as a new delivery system for the cultivation of human chondrocytes in a collagen type-I gel J. Biomed. Mater. Res. B Appl. Biomater. 82 2007 275 283
98. K. Gavenis, U. Schneider, J. Groll, and B. Schmidt-Rohlfing BMP-7-loaded PGLA microspheres as a new delivery system for the cultivation of human chondrocytes in a collagen type I gel: the common nude mouse model Int. J. Artif. Organs 33 2010 45 53
99. B.I. Rosner, R.A. Siegel, A. Grosberg, and R.T. Tranquillo Rational design of contact guiding, neurotrophic matrices for peripheral nerve regeneration Ann. Biomed. Eng. 31 2003 1383 1401
100. V. Luginbuehl, E. Wenk, A. Koch, B. Gander, H.P. Merkle, and L. Meinel Insulin-like growth factor I-releasing alginate-tricalciumphosphate composites for bone regeneration Pharm. Res. 22 2005 940 950
101. U. Ripamonti, J. Crooks, J.C. Petit, and D.C. Rueger Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein-1 and bone morphogenetic protein-2. A pilot study in Chacma baboons (Papio ursinus) Eur. J. Oral Sci. 109 2001 241 248
102. A.T. Raiche, and D.A. Puleo Cell responses to BMP-2 and IGF-I released with different time-dependent profiles J. Biomed. Mater. Res. A 69 2004 342 350
103. A.B. Fleming, and W.M. Saltzman Simultaneous delivery of an active protein and neutralizing antibody: creation of separated regions of biological activity J. Control. Release 70 2001 29 36
104. T.P. Richardson, M.C. Peters, A.B. Ennett, and D.J. Mooney Polymeric system for dual growth factor delivery Nat. Biotechnol. 19 2001 1029 1034
105. B.B. Mandal, and S.C. Kundu Calcium alginate beads embedded in silk fibroin as 3D dual drug releasing scaffolds Biomaterials 30 2009 5170 5177
106. E. Anitua, M. Sánchez, and G. Orive Potential of endogenous regenerative technology for in situ regenerative medicine Adv. Drug Deliv. Rev. 62 2010 741 752
107. S. Elangovan, and N. Karimbux Review paper: DNA delivery strategies to promote periodontal regeneration J. Biomater. Appl. 25 2010 3 18
108. C.H. Evans, G.D. Palmer, A. Pascher, R. Porter, F.N. Kwong, E. Gouze, J.N. Gouze, F. Liu, A. Steinert, O. Betz, V. Betz, M. Vrahas, and S.C. Ghivizzani Facilitated endogenous repair: making tissue engineering simple, practical, and economical Tissue Eng. 13 2007 1987 1993
109. C.A. Ramseier, Z.R. Abramson, Q. Jin, and W.V. Giannobile Gene therapeutics for periodontal regenerative medicine Dent. Clin. North Am. 50 2006 245 263
110. F.M. Chen, Z.W. Ma, Q.T. Wang, and Z.F. Wu Gene delivery for periodontal tissue engineering: current knowledge - future possibilities Curr. Gene Ther. 8 2009 248 266
111. H. Peng, V. Wright, and A. Usas Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4 J. Clin. Invest. 110 2002 751 759
112. Y. Zhang, B. Shi, C. Li, Y. Wang, Y. Chen, W. Zhang, T. Luo, and X. Cheng The synergetic bone-forming effects of combinations of growth factors expressed by adenovirus vectors on chitosan/collagen scaffolds J. Control. Release 136 2009 172 178
113. A. Minimide, S.D. Boden, M. Viggeswarapu, G.A. Hair, C. Oliver, and L. Titus Mechanism of bone formation with gene transfer of the cDNA encoding for the Intracellular protein LMP-1 J. Bone Joint Surg. 85 2003 1030 1039
114. Z. Zhu, C.S. Lee, K.M. Tejeda, and W.V. Giannobile Gene transfer and expression of platelet-derived growth factors modulate periodontal cellular activity J. Dent. Res. 80 2001 892 897
115. W.V. Giannobile, C.S. Lee, M.P. Tomala, K.M. Tejeda, and Z. Zhu Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering J. Periodontol. 72 2001 815 823
116. O. Anusaksathien, S.A. Webb, Q.M. Jin, and W.V. Giannobile Platelet-derived growth factor gene delivery stimulates ex vivo gingival repair Tissue Eng. 9 2003 745 756
117. Q. Jin, O. Anusaksathien, S.A. Webb, M.A. Printz, and W.V. Giannobile Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors Mol. Ther. 9 2004 519 526
118. O. Anusaksathien, Q. Jin, M. Zhao, M.J. Somerman, and W.V. Giannobile Effect of sustained gene delivery of platelet-derived growth factor or its antagonist (PDGF-1308) on tissue-engineered cementum J. Periodontol. 75 2004 429 440
119. C.A. Dunn, Q. Jin, M. Jr, R.T. Franceschi Taba, R. Bruce Rutherford, and W.V. Giannobile BMP gene delivery for alveolar bone engineering at dental implant defects Mol. Ther. 11 2005 294 299
120. M. Jr, Q. Jin Taba, J.V. Sugai, and W.V. Giannobile Current concepts in periodontal bioengineering Orthod. Craniofac. Res. 8 2005 292 302
121. Y. Zhang, J. Song, B. Shi, Y. Wang, X. Chen, C. Huang, X. Yang, D. Xu, X. Cheng, and X. Chen Combination of scaffold and adenovirus vectors expressing bone morphogenetic protein-7 for alveolar bone regeneration at dental implant defects Biomaterials 28 2007 4635 4642
122. Z. Lin, J.V. Sugai, Q. Jin, L.A. Chandler, and W.V. Giannobile Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction J. Periodontal Res. 43 2008 440 449
123. Z. Tan, Q. Zhao, P. Gong, Y. Wu, N. Wei, Q. Yuan, C. Wang, D. Liao, and H. Tang Research on promoting periodontal regeneration with human basic fibroblast growth factor-modified bone marrow mesenchymal stromal cell gene therapy Cytotherapy 11 2009 317 325
124. L. Yang, Y. Zhang, R. Dong, L. Peng, X. Liu, Y. Wang, and X. Cheng Effects of adenoviral-mediated coexpression of bone morphogenetic protein-7 and insulin-like growth factor-1 on human periodontal ligament cells J. Periodontal Res. 45 2010 532 540
125. P.C. Chang, Y.J. Seol, J.A. Cirelli, G. Pellegrini, Q. Jin, L.M. Franco, S.A. Goldstein, L.A. Chandler, B. Sosnowski, and W.V. Giannobile PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration Gene Ther. 17 2010 95 104
126. Y. Zhang, X. Cheng, J. Wang, Y. Wang, B. Shi, C. Huang, X. Yang, and T. Liu Novel chitosan/collagen scaffold containing transforming growth factor-beta1 DNA for periodontal tissue engineering Biochem. Biophys. Res. Commun. 344 2006 362 369
127. L. Peng, X. Cheng, R. Zhuo, J. Lan, Y. Wang, B. Shi, and S. Li Novel gene-activated matrix with embedded chitosan/plasmid DNA nanoparticles encoding PDGF for periodontal tissue engineering J. Biomed. Mater. Res. A 90 2009 564 576
128. G. Intini Future approaches in periodontal regeneration: gene therapy, stem cells, and RNA interference Dent. Clin. North Am. 54 2010 141 155
129. D. Nikolidakis, and J.A. Jansen The biology of platelet-rich plasma and its application in oral surgery: literature review Tissue Eng. B Rev. 14 2008 249 258
130. G. Intini The use of platelet-rich plasma in bone reconstruction therapy Biomaterials 30 2009 4956 4966
131. E. Anitua, M. Sánchez, A.T. Nurden, P. Nurden, G. Orive, and I. Andía New insights into and novel applications for platelet-rich fibrin therapies Trends Biotechnol. 24 2006 227 234
132. E. Anitua, M. Sánchez, G. Orive, and I. Andía The potential impact of the preparation rich in growth factors (PRGF) in different medical fields Biomaterials 28 2007 4551 4560
133. E. Anitua, G. Orive, R. Pla, P. Roman, V. Serrano, and I. Andía The effects of PRGF on bone regeneration and on titanium implant osseointegration in goats: a histologic and histomorphometric study J. Biomed. Mater. Res. A 91 2009 158 165
134. S. Yilmaz, G. Cakar, B.E. Kuru, and B. Yildirim Platelet-rich plasma in combination with bovine derived xenograft in the treatment of generalized aggressive periodontitis: a case report with re-entry Platelets 18 2007 535 539
135. L. Boyapati, and H.L. Wang The role of platelet-rich plasma in sinus augmentation: a critical review Implant Dent. 15 2006 160 170
136. A.S. Plachokova, D. Nikolidakis, J. Mulder, J.A. Jansen, and N.H. Creugers Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review Clin. Oral Implants Res. 19 2008 539 545
137. J.P. Fréchette, I. Martineau, and G. Gagnon Platelet-rich plasmas: growth factor content and roles in wound healing J. Dent. Res. 84 2005 434 439
138. G.E. Friedlaender, C.R. Perry, J.D. Cole, S.D. Cook, G. Cierny, G.F. Muschler, G.A. Zych, J.H. Calhoun, A.J. LaForte, and S. Yin Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions J. Bone Joint Surg. 83 Suppl. 1 2001 151 158
139. J.K. Burkus, M.F. Gornet, C.A. Dickman, and T.A. Zdeblick Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages J. Spinal Disord. Tech. 15 2002 337 349
140. B. Nussenbaum, and P.H. Krebsbach The role of gene therapy for craniofacial and dental tissue engineering Adv. Drug Deliv. Rev. 58 2006 577 591
141. S.E. Sakiyama-Elbert, and J.A. Hubbell Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix J. Control. Release 69 2000 149 158
142. A. Sahni, T. Odrljin, and C.W. Francis Binding of basic fibroblast growth factor to fibrinogen and fibrin J. Biol. Chem. 273 1998 7554 7559
143. C. Wong, E. Inman, R. Spaethe, and S. Helgerson Fibrin-based biomaterials to deliver human growth factors Thromb. Haemost. 89 2003 573 582
144. A. Sahni, and C.W. Francis Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation Blood 96 2000 3772 3778
145. R. Mittermayr, T. Morton, M. Hofmann, S. Helgerson, M. van Griensven, and H. Redl Sustained (rh)VEGF165 release from a sprayed fibrin biomatrix induces angiogenesis, up-regulation of endogenous VEGF-R2, and reduces ischemic flap necrosis Wound Repair Regen. 16 2008 542 550
146. P. Giannoni, and E.B. Hunziker Release kinetics of transforming growth factor-beta1 from fibrin clots Biotechnol. Bioeng. 83 2003 121 123
147. P.P. Spicer, A.G. Mikos, Fibrin glue as a drug delivery system. J. Control. Release 2010, doi:10.1016/j.jconrel.2010.06.025.
148. O. Jeon, S.H. Ryu, J.H. Chung, and B. Kim Control of basic fibroblast growth factor release from fibrin gel with heparin and concentrations of fibrinogen and thrombin J. Control. Release 105 2005 249 259
149. Y.I. Chung, S.K. Kim, Y.K. Lee, S.J. Park, K.O. Cho, S.H. Yuk, G. Tae, and Y.H. Kim Efficient revascularization by VEGF administration via heparin-functionalized nanoparticle-fibrin complex J. Control. Release 143 2010 282 289
150. E. Briganti, D. Spiller, C. Mirtelli, S. Kull, C. Counoupas, P. Losi, S. Senesi, R. Di Stefano, and G. Soldani A composite fibrin-based scaffold for controlled delivery of bioactive pro-angiogenetic growth factors J. Control. Release 142 2010 14 21
151. C.T. Drinnan, G. Zhang, M.A. Alexander, A.S. Pulido, and L.J. Suggs Multimodal release of transforming growth factor-beta1 and the BB isoform of platelet derived growth factor from PEGylated fibrin gels J. Control. Release 147 2010 180 186
152. S. Young, M. Wong, Y. Tabata, and A.G. Mikos Gelatin as a delivery vehicle for the controlled release of bioactive molecules J. Control. Release 109 2005 256 274
153. M.M. Murray, K.P. Spindler, E. Abreu, J.A. Muller, A. Nedder, M. Kelly, J. Frino, D. Zurakowski, M. Valenza, B.D. Snyder, and S.A. Connolly Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament J. Orthop. Res. 25 2007 81 91
154. G. Intini, S. Andreana, F.E. Intini, R.J. Buhite, and L.A. Bobek Calcium sulfate and platelet-rich plasma make a novel osteoinductive biomaterial for bone regeneration J. Transl. Med. 5 2007 13
155. H.H. Lu, J.M. Vo, H.S. Chin, J. Lin, M. Cozin, R. Tsay, S. Eisig, and R. Landesberg Controlled delivery of platelet-rich plasma-derived growth factors for bone formation J. Biomed. Mater. Res. A 86 2008 1128 1136
156. L. Hammarstrom Enamel matrix, cementum development and regeneration J. Clin. Periodontol. 24 1997 658 668
157. L. Heijl, G. Heden, G. Svardstrom, and A. Ostgren Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects J. Clin. Periodontol. 24 1997 705 714 (Pubitemid 127731614)
158. E. Venezia, M. Goldstein, B.D. Boyan, and Z. Schwartz The use of enamel matrix derivative in the treatment of periodontal defects: a literature review and meta-analysis Crit. Rev. Oral Biol. Med. 15 2004 382 402
159. M. Esposito, P. Coulthard, P. Thomsen, and H.V. Worthington Enamel matrix derivative for periodontal tissue regeneration in treatment of intrabony defects: a Cochrane systematic review J. Dent. Educ. 68 2004 834 844
160. A. Sculean, A. Kiss, A. Miliauskaite, F. Schwarz, N.B. Arweiler, and M. Hannig Ten-year results following treatment of intrabony defects with enamel
161. S. Suzuki, T. Nagano, Y. Yamakoshi, K. Gomi, T. Arai, M. Fukae, T. Katagiri, and S. Oida Enamel matrix derivative gel stimulates signal transduction of BMP and TGF-{beta} J. Dent. Res. 84 2005 510 514
162. R.C. Casarin, E. Del Peloso Ribeiro, F.H. Jr, A.W. Sallum Nociti, E.A. Sallum, G.M. Ambrosano, and M.Z. Casati A double-blind randomized clinical evaluation of enamel matrix derivative proteins for the treatment of proximal class-II furcation involvements J. Clin. Periodontol. 35 2008 429 437
163. S. Gestrelius, S.P. Lyngstadaas, and L. Hammarström Emdogain - periodontal regeneration based on biomimicry Clin. Oral Investig. 4 2000 120 125
164. M. Nevins, W.V. Giannobile, M.K. McGuire, R.T. Kao, J.T. Mellonig, J.E. Hinrichs, B.S. McAllister, K.S. Murphy, P.K. McClain, M.L. Nevins, D.W. Paquette, T.J. Han, M.S. Reddy, P.T. Lavin, R.J. Genco, and S.E. Lynch Platelet derived growth factor (rhPDGF-BB) stimulates bone fill and rate of attachment level gain, results of a large, multicenter randomized controlled trial J. Periodontol. 76 2005 2205 2215
165. J.O. Hollinger, C.E. Hart, S.N. Hirsch, S. Lynch, and G.E. Friedlaender Recombinant human platelet-derived growth factor: biology and clinical applications J. Bone Joint Surg. Am. 90 2008 S48 S54
166. S. Govender, C. Csimma, H.K. Genant, A. Valentin-Opran, Y. Amit, R. Arbel, H. Aro, D. Atar, M. Bishay, M.G. Börner, P. Chiron, P. Choong, J. Cinats, B. Courtenay, R. Feibel, B. Geulette, C. Gravel, N. Haas, M. Raschke, E. Hammacher, D. van der Velde, P. Hardy, M. Holt, C. Josten, R.L. Ketterl, B. Lindeque, G. Lob, H. Mathevon, G. McCoy, D. Marsh, R. Miller, E. Munting, S. Oevre, L. Nordsletten, A. Patel, A. Pohl, W. Rennie, P. Reynders, P.M. Rommens, J. Rondia, W.C. Rossouw, P.J. Daneel, S. Ruff, A. Rüter, S. Santavirta, T.A. Schildhauer, C. Gekle, R. Schnettler, D. Segal, H. Seiler, R.B. Snowdowne, J. Stapert, G. Taglang, R. Verdonk, L. Vogels, A. Weckbach, A. Wentzensen, T. Wisniewski, and BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients J. Bone Joint Surg. Am. 84-A 2002 2123 2134
167. A.L. Jones, R.W. Bucholz, M.J. Bosse, S.K. Mirza, T.R. Lyon, L.X. Webb, A.N. Pollak, J.D. Golden, A. Valentin-Opran, and BMP-2 Evaluation in Surgery for Tibial Trauma-Allgraft (BESTT-ALL) Study Group Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial J. Bone Joint Surg. Am. 88 2006 1431 1441
168. H. Schliephake, A. Aref, D. Scharnweber, S. Bierbaum, S. Roessler, and A. Sewing Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation Clin. Oral Implants Res. 16 2005 563 569
169. R.E. Jung, S.I. Windisch, A.M. Eggenschwiler, D.S. Thoma, F.E. Weber, and C.H. Hämmerle A randomized-controlled clinical trial evaluating clinical and radiological outcomes after 3 and 5 years of dental implants placed in bone regenerated by means of GBR techniques with or without the addition of BMP-2 Clin. Oral Implants Res. 20 2009 660 666
170. J. Zhao, M. Shinkai, T. Takezawa, S. Ohba, U.I. Chung, and T. Nagamune Bone regeneration using collagen type I vitrigel with bone morphogenetic protein-2 J. Biosci. Bioeng. 107 2009 318 323
171. N.K. Kanakaris, G.M. Calori, R. Verdonk, P. Burssens, P. De Biase, R. Capanna, L.B. Vangosa, P. Cherubino, F. Baldo, J. Ristiniemi, G. Kontakis, and P.V. Giannoudis Application of BMP-7 to tibial non-unions: a 3-year multicenter experience Injury 39 2008 S83 S90
172. S. Desmyter, Y. Goubau, N. Benahmed, A. de Wever, and R. Verdonk The role of bone morphogenetic protein-7 (Osteogenic Protein-1) in the treatment of tibial fracture non-unions. An overview of the use in Belgium Acta Orthop. Belg. 74 2008 534 537
173. G.M. Calori, L. Tagliabue, L. Gala, M. d'Imporzano, G. Peretti, and W. Albisetti Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomised clinical study on 120 patients Injury 39 2008 1391 1402
174. M.P. Lutolf, and J.A. Hubbell Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering Nat. Biotechnol. 23 2005 47 55
175. N. Bhattarai, J. Gunn, and M. Zhang Chitosan-based hydrogels for controlled, localized drug delivery Adv. Drug Deliv. Rev. 62 2010 83 99
176. S.T. Andreadis, and D.J. Geer Biomimetic approaches to protein and gene delivery for tissue regeneration Trends Biotechnol. 24 2006 331 337
177. Q.M. Jin, O. Anusaksathien, S.A. Webb, R.B. Rutherford, and W.V. Giannobile Gene therapy of bone morphogenetic protein for periodontal tissue engineering J. Periodontol. 74 2003 202 213
178. C.H. Park, H.F. Rios, Q. Jin, M.E. Bland, C.L. Flanagan, S.J. Hollister, and W.V. Giannobile Biomimetic hybrid scaffolds for engineering human tooth-ligament interfaces Biomaterials 31 2010 5945 5952
179. A.F. Steinert, G.D. Palmer, C. Pilapil, U. Nöth, C.H. Evans, and S.C. Ghivizzani Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer Tissue Eng. A 15 2009 1127 1139
180. H.M. Atta, A. Al-Hendy, S.A. Salama, O.G. Shaker, and O.A. Hammam Low-dose simultaneous delivery of adenovirus encoding hepatocyte growth factor and vascular endothelial growth factor in dogs enhances liver proliferation without systemic growth factor elevation Liver Int. 29 2009 1022 1030
181. D. Cheng, and M.V. Sefton Dual delivery of placental growth factor and vascular endothelial growth factor from poly(hydroxyethyl methacrylate-co-methyl methacrylate) microcapsules containing doubly transfected luciferase-expressing l929 cells Tissue Eng. A 15 2009 1929 1939
182. M.G. Flores, M. Hasegawa, M. Yamato, R. Takagi, T. Okano, and I. Ishikawa Cementum-periodontal ligament complex regeneration using the cell sheet technique J. Periodontal Res. 43 2008 364 371
183. T. Iwata, M. Yamato, H. Tsuchioka, R. Takagi, S. Mukobata, K. Washio, T. Okano, and I. Ishikawa Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model Biomaterials 30 2009 2716 2723
184. S.H. Kim, K.H. Kim, B.M. Seo, K.T. Koo, T.I. Kim, Y.J. Seol, Y. Ku, I.C. Rhyu, C.P. Chung, and Y.M. Lee Alveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in a canine peri-implant defect model: a pilot study J. Periodontol. 80 2009 1815 1823
185. K. Washio, T. Iwata, M. Mizutani, T. Ando, M. Yamato, T. Okano, and I. Ishikawa Assessment of cell sheets derived from human periodontal ligament cells: a pre-clinical study Cell Tissue Res. 341 2010 397 404
186. N.H. Lin, S. Gronthos, and P. Mark Bartold Stem cells and future periodontal regeneration Periodontology 2000 51 2009 239 251
187. I. Ishikawa, T. Iwata, K. Washio, T. Okano, T. Nagasawa, K. Iwasaki, and T. Ando Cell sheet engineering and other novel cell-based approaches to periodontal regeneration Periodontology 2000 51 2009 220 238
188. H. He, J. Cao, D. Wang, B. Gu, H. Guo, and H. Liu Gene-modified stem cells combined with rapid prototyping techniques: a novel strategy for periodontal regeneration Stem Cell Rev. 6 2010 137 141