Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity

Journal of Inflammation (United Kingdom)

Volumn 9, Issue , 2012, Pages

  Klawitter, Marina ^a   Quero, Lilian ^a   Klasen, Juergen ^b   Gloess, Alexia N ^c   Klopprogge, Babette ^c   Hausmann, Oliver ^d   Boos, Norbert ^a,b,e   Wuertz, Karin ^a,e,f  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^c ZURICH UNIVERSITY OF APPLIED SCIENCES   (Switzerland)

^d Klinik St Anna   (Switzerland)

^e AOSpine Research Network   (Switzerland)

^f ETH ZURICH   (Switzerland)

Author keywords

Back pain; Curcuma; Curcumin; HPLC MS; Human intervertebral disc cells; MAP kinase; Matrix degrading enzymes; NF B; Proinflammatory cytokines; Toll like receptors

Indexed keywords

ALCOHOL; COLLAGENASE 3; CURCUMA LONGA EXTRACT; CURCUMIN; DIMETHYL SULFOXIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; TOLL LIKE RECEPTOR 2; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ANTICATABOLIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CELL VIABILITY; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTERVERTEBRAL DISK; MALE; MASS SPECTROMETRY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALIA; CURCUMA;

EID: 84865104998     PISSN: None     EISSN: 14769255     Source Type: Journal    
DOI: 10.1186/1476-9255-9-29     Document Type: Article

References (53)

1. 1997 Volvo Award winner in basic science studies. Immunohistologic markers for age-related changes of human lumbar intervertebral discs. Nerlich AG, Schleicher ED, Boos N, Spine (Phila Pa 1976) 1997 22 2781 2795 10.1097/00007632-199712150-00001 (Pubitemid 28070623)
2. Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Boos N, Weissbach S, Rohrbach H, Weiler C, Spratt KF, Nerlich AG, Spine (Phila Pa 1976) 2002 27 2631 2644 10.1097/00007632-200212010-00002 (Pubitemid 35425317)
3. The pathophysiology of the intervertebral disc. Bibby SR, Jones DA, Lee RB, Yu J, Urban JPG, Joint Bone Spine 2001 68 537 542 10.1016/S1297-319X(01) 00332-3 11808995 (Pubitemid 34037288)
4. Degeneration of the intervertebral disc. Urban JP, Roberts S, Arthritis Res Ther 2003 5 120 130 12723977 (Pubitemid 36849758)
5. Histology and pathology of the human intervertebral disc. Roberts S, Evans H, Trivedi J, Menage J, J Bone Joint Surg Am 2006 88 Suppl 2 10 14 17079362
6. Matrix synthesis and degradation in human intervertebral disc degeneration. Le Maitre CL, Pockert A, Buttle DJ, Freemont AJ, Hoyland JA, Biochem Soc Trans 2007 35 652 655 10.1042/BST0350652 17635113 (Pubitemid 47310333)
7. The cell biology of intervertebral disc aging and degeneration. Zhao CQ, Wang LM, Jiang LS, Dai LY, Ageing Res Rev 2007 6 247 261 10.1016/j.arr.2007.08. 001 17870673 (Pubitemid 47405307)
8. Analysis of tissue distribution of TNF-alpha, TNF-alpha-receptors, and the activating TNF-alpha-converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc. Bachmeier BE, Nerlich AG, Weiler C, Paesold G, Jochum M, Boos N, Ann N Y Acad Sci 2007 1096 44 54 10.1196/annals.1397.069 17405915 (Pubitemid 47092497)
9. Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Shamji MF, Setton LA, Jarvis W, So S, Chen J, Jing L, Bullock R, Isaacs RE, Brown C, Richardson WJ, Arthritis Rheum 2010 62 1974 1982 20222111
10. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Weiler C, Nerlich AG, Bachmeier BE, Boos N, Spine (Phila Pa 1976) 2005 30 44 53 discussion 54 10.1097/01.brs.0000174529.07959.c0 (Pubitemid 40209276)
11. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. Burke JG, Watson RW, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM, J Bone Joint Surg Br 2002 84 196 201 10.1302/0301-620X.84B2. 12511 11924650 (Pubitemid 34257682)
12. Nuclear factor-kappaB: its role in health and disease. Kumar A, Takada Y, Boriek AM, Aggarwal BB, J Mol Med 2004 82 434 448 15175863 (Pubitemid 39044283)
13. The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis. Andreakos E, Sacre S, Foxwell BM, Feldmann M, Front Biosci 2005 10 2478 2488 10.2741/1712 15970510 (Pubitemid 40905252)
14. Signaling transduction: target in osteoarthritis. Berenbaum F, Curr Opin Rheumatol 2004 16 616 622 10.1097/01.bor.0000133663.37352.4a 15314504 (Pubitemid 39128334)
15. MAP kinase pathways: the first twenty years. Avruch J, Biochim Biophys Acta 2007 1773 1150 1160 10.1016/j.bbamcr.2006.11.006 17229475 (Pubitemid 47125973)
16. Infectious risks of chronic pain treatments: injection therapy, surgical implants, and intradiscal techniques. Rathmell JP, Lake T, Ramundo MB, Reg Anesth Pain Med 2006 31 346 352 16857554 (Pubitemid 44081882)
17. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). Chainani-Wu N, J Altern Complement Med 2003 9 161 168 10.1089/107555303321223035 12676044 (Pubitemid 36297021)
18. Biological activities of Curcuma longa L. Araujo CC, Leon LL, Mem Inst Oswaldo Cruz 2001 96 723 728 10.1590/S0074-02762001000500026 11500779 (Pubitemid 33704182)
19. A simple isocratic HPLC method for the simultaneous determination of curcuminoids in commercial turmeric extracts. Wichitnithad W, Jongaroonngamsang N, Pummangura S, Rojsitthisak P, Phytochem Anal 2009 20 314 319 10.1002/pca.1129 19402187
20. Bupivacaine-the deadly friend of intervertebral disc cells? Quero L, Klawitter M, Nerlich AG, Leonardi M, Boos N, Wuertz K, Spine J 2011 11 46 53 10.1016/j.spinee.2010.11.001 21168098
21. Analysis of relative gene expression data using real-time quantitative PCR and the 2(Delta Delta C(T)) Method. Livak KJ, Schmittgen TD, Methods 2001 25 402 408 10.1006/meth.2001.1262 11846609 (Pubitemid 34164012)
22. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. Srimal RC, Dhawan BN, J Pharm Pharmacol 1973 25 447 452 4146582
23. Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells. Yu ZG, Xu N, Wang WB, Pan SH, Li KS, Liu JK, Chin Med J (Engl) 2009 122 2483 2488
24. Dimethyl sulfoxide (DMSO) attenuates the inflammatory response in the in vitro intestinal Caco-2 cell model. Hollebeeck S, Raas T, Piront N, Schneider YJ, Toussaint O, Larondelle Y, During A, Toxicol Lett 2011 206 268 275 10.1016/j.toxlet.2011.08.010 21878375
25. Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells. Reuter S, Charlet J, Juncker T, Teiten MH, Dicato M, Diederich M, Ann N Y Acad Sci 2009 1171 436 447 10.1111/j.1749-6632.2009.04731.x 19723087
26. Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Epstein J, Docena G, MacDonald TT, Sanderson IR, Br J Nutr 2010 103 824 832 10.1017/S0007114509992510 19878610
27. Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways. Chen M, Hu DN, Pan Z, Lu CW, Xue CY, Aass I, Exp Eye Res 2010 90 437 443 10.1016/j.exer.2009.12.004 20026325
28. Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. Wu SJ, Tam KW, Tsai YH, Chang CC, Chao JC, Am J Chin Med 2010 38 99 111 10.1142/S0192415X10007695 20128048
29. Curcumin inhibits the growth, induces apoptosis and modulates the function of pituitary folliculostellate cells. Schaaf C, Shan B, Onofri C, Stalla GK, Arzt E, Schilling T, Perone MJ, Renner U, Neuroendocrinology 2010 91 200 210 10.1159/000287236 20160430
30. Anti-ulcer activity of curcumin on experimental gastric ulcer in rats and its effect on oxidative stress/antioxidant, IL-6 and enzyme activities. Tuorkey M, Karolin K, Biomed Environ Sci 2009 22 488 495 10.1016/S0895-3988(10)60006-2 20337222
31. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB, J Immunol 1999 163 3474 3483 10477620 (Pubitemid 29431852)
32. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. Li WQ, Dehnade F, Zafarullah M, J Immunol 2001 166 3491 3498 11207308 (Pubitemid 33117353)
33. Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes. Schulze-Tanzil G, Mobasheri A, Sendzik J, John T, Shakibaei M, Ann N Y Acad Sci 2004 1030 578 586 10.1196/annals.1329.067 15659840 (Pubitemid 40378956)
34. Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M, Zafarullah M, Exp Cell Res 2003 288 208 217 10.1016/S0014-4827(03)00180-0 12878172 (Pubitemid 36871010)
35. Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells. Chen J, Wanming D, Zhang D, Liu Q, Kang J, Pharmazie 2005 60 57 61 15700780
36. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Ramirez-Tortosa MC, Ramirez-Tortosa CL, Mesa MD, Granados S, Gil A, Quiles JL, Free Radic Biol Med 2009 47 924 931 10.1016/j.freeradbiomed.2009.06.015 19539747
37. Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes. Toegel S, Wu SQ, Piana C, Unger FM, Wirth M, Goldring MB, Gabor F, Viernstein H, Osteoarthritis Cartilage 2008 16 1205 1212 10.1016/j.joca.2008.01.013 18321735
38. Curcumin decreases toll-like receptor-2 gene expression and function in human monocytes and neutrophils. Shuto T, Ono T, Ohira Y, Shimasaki S, Mizunoe S, Watanabe K, Suico MA, Koga T, Sato T, Morino S, et al. Biochem Biophys Res Commun 2010 398 4 647 52 Epub 2010 Jul 3 10.1016/j.bbrc.2010.06.126 20599422
39. The Targets of Curcumin. Zhou H, Beevers CS, Huang S, Curr Drug Targets 2011 12 3 332 47 Review 20955148
40. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Chen YR, Tan TH, Oncogene 1998 17 173 178 10.1038/sj.onc.1201941 9674701
41. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. Singh S, Aggarwal BB, J Biol Chem 1995 270 24995 25000 10.1074/jbc.270.42.24995 7559628
42. Biological actions of curcumin on articular chondrocytes. Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, Mathy-Hartert M, Shakibaei M, Mobasheri A, Osteoarthritis Cartilage 2010 18 141 149 10.1016/j.joca.2009.10.002 19836480
43. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Lubbad A, Oriowo MA, Khan I, Mol Cell Biochem 2009 322 127 135 10.1007/s11010-008-9949-4 19002562
44. Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway. Mun SH, Kim HS, Kim JW, Ko NY, do Kim K, Lee BY, Kim B, Won HS, Shin HS, Han JW, et al. J Pharmacol Sci 2009 111 13 21 10.1254/jphs.09134FP 19763044
45. Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration. Seguin CA, Bojarski M, Pilliar RM, Roughley PJ, Kandel RA, Matrix Biol 2006 25 409 418 10.1016/j.matbio.2006. 07.002 16934445 (Pubitemid 44512122)
46. Mechanism of signal transduction in tumor necrosis factor-like weak inducer of apoptosis-induced matrix degradation by MMP-3 upregulation in disc tissues. Wako M, Ohba T, Ando T, Arai Y, Koyama K, Hamada Y, Nakao A, Haro H, Spine (Phila Pa 1976) 2008 33 2489 2494 10.1097/BRS.0b013e318186b343
47. Inflammatory and catabolic signalling in intervertebral discs: the roles of NF-kappaB and MAP kinases. Wuertz K, Vo N, Kletsas D, Boos N, Eur Cell Mater 2012 23 103 119 discussion 119-120 22354461
48. Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway. Hu M, Du Q, Vancurova I, Lin X, Miller EJ, Simms HH, Wang P, Crit Care Med 2005 33 2571 2578 10.1097/01.CCM.0000186760.20502.C7 16276182 (Pubitemid 41682110)
49. Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. Watson JL, Greenshields A, Hill R, Hilchie A, Lee PW, Giacomantonio CA, Hoskin DW, Mol Carcinog 2010 49 13 24 19676105
50. Curcumin p38-dependently enhances the anticancer activity of valproic acid in human leukemia cells. Chen J, Wang G, Wang L, Kang J, Wang J, Eur J Pharm Sci 2010 41 210 218 10.1016/j.ejps.2010.06.011 20600877
51. ERK implication in cell cycle regulation. Chambard JC, Lefloch R, Pouyssegur J, Lenormand P, Biochim Biophys Acta 2007 1773 1299 1310 10.1016/j.bbamcr.2006.11.010 17188374 (Pubitemid 47125974)
52. The complexity of mitogen-activated protein kinases (MAPKs) made simple. Krishna M, Narang H, Cell Mol Life Sci 2008 65 3525 3544 10.1007/s00018-008- 8170-7 18668205
53. The Red Wine Polyphenol Resveratrol Shows Promising Potential for the Treatment of Nucleus Pulposus-Mediated Pain In Vitro and In Vivo. Wuertz K, Quero L, Sekiguchi M, Klawitter M, Nerlich A, Konno SI, Kikuchi SI, Boos N, Spine (Phila Pa 1976) 2011 36 1373 E1384 10.1097/BRS.0b013e318221e655