Is the interleukin-6 haplotype a prognostic factor for sciatica?

European Journal of Pain

Volumn 12, Issue 8, 2008, Pages 1018-1025

  Karppinen, Jaro ^a,b   Daavittila, Iita ^b   Noponen, Noora ^b   Haapea, Marianne ^c   Taimela, Simo ^d   Vanharanta, Heikki ^b   Ala Kokko, Leena ^b,e   Männikkö, Minna ^b  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c OULU UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e Helsinki University ^*  (United States)

Author keywords

Genetics; Haplotype; Interleukin 6; Prognosis; Prognostic factor; Sciatica; Workload

Indexed keywords

INTERLEUKIN 6;

ADULT; ARTICLE; BACKACHE; CONTROLLED STUDY; DISEASE DURATION; FEMALE; FOLLOW UP; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; INTERVERTEBRAL DISK DISEASE; ISCHIALGIA; LEG PAIN; MAJOR CLINICAL STUDY; MALE; MEDICAL LEAVE; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN FUNCTION; WORKLOAD;

ADULT; CHRONIC DISEASE; DISABILITY EVALUATION; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HAPLOTYPES; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; MUTATION; PAIN MEASUREMENT; PAIN THRESHOLD; POLYMORPHISM, GENETIC; PREVALENCE; PROGNOSIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SCIATICA; SICK LEAVE;

EID: 50849093185     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2008.01.009     Document Type: Article

References (63)

1. Ahn S.H., Ahn M.W., and Byun W.M. Effect of the transligamentous extension of lumbar disc herniations on their regression and the clinical outcome of sciatica. Spine 25 (2000) 475-480
2. Autio R.A., Karppinen J., Niinimäki J., Ojala R., Kurunlahti M., Haapea M., et al. Determinants of spontaneous resorption of intervertebral disc herniations. Spine 31 (2006) 1247-1252
3. Balague F., Nordin M., Sheikhzadeh A., Echegoyen A.C., Brisby H., Hoogewoud H.M., et al. Recovery of severe sciatica. Spine 24 (1999) 2516-2524
4. Battié M.C., Videman T., Gibbons L.E., Fisher L.D., Manninen H., and Gill K. Volvo Award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins. Spine 20 (1995) 2601-2612
5. Benoist M. The natural history of lumbar disc herniation and radiculopathy. Joint Bone Spine 69 (2000) 155-160
6. Brisby H., Olmarker K., Larsson K., Nutu M., and Rydevik B. Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. Eur Spine J 11 (2002) 62-66
7. Burke J., Watson R.W., McCormack D., Dowling F.E., Walsh M.G., and Fitzpatrick J.M. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg [Br] 84 (2002) 196-201
8. Cafferty W.B., Gardiner N.J., Das P., Qiu J., McMahon S.B., and Thompson S.W. Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice. J Neurosci 24 (2004) 4432-4443
9. Carp S.J., Barbe M.F., Winter K.A., Amin M., and Barr A.E. Inflammatory biomarkers increase with severity of upper extremity overuse disorders. Clin Sci (Lond) 112 (2007) 305-314
10. Choy E.H., and Panayi G.S. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 344 (2001) 907-916
11. Coghill R.C., McHaffie J.G., and Yen Y.F. Neural correlates of interindividual differences in the subjective experience of pain. Proc Natl Acad Sci USA 100 (2003) 8538-8542
12. Daavittila (née Virtanen) I. Genetic risk factors for lumbar intervertebral disc disease characterized by sciatica. (http://herkules.oulu.fi/isbn9789514283666/isbn9789514283666.pdf). Thesis, Oulu University, 2007.
13. DeLeo J.A., Colburn R.W., Nichols M., and Malhotra A. Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model. J Interferon Cytokine Res 16 (1996) 695-700
14. Demura S., Takahashi K., Kawahara N., Watanabe Y., and Tomita K. Serum interleukin-6 response after spinal surgery: estimation of surgical magnitude. J Orthop Sci 11 (2006) 241-247
15. Dendorfer U., Oettgen P., and Libermann T.A. Interleukin-6 gene expression by prostaglandins and cyclic AMP mediated by multiple regulatory elements. Am J Ther 2 (1995) 660-665
16. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102 (1998) 1369-1376
17. Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res Ther 8 Suppl. 2 (2006) S3
18. George A., Schmidt C., Weishaupt A., Toyka K.V., and Sommer C. Serial determination of tumor necrosis factor-alpha content in rat sciatic nerve after chronic constriction injury. Exp Neurol 160 (1999) 124-132
19. Heliövaara M., Impivaara K., Sievers K., Melkas T., Knekt P., Korpi J., et al. Lumbar disc syndrome in Finland. J Epidemiol Community Health 41 (1987) 251-258
20. Hestbaek L., Iachine I.A., Leboeuf-Yde C., Kyvik K.O., and Manniche C. Heredity of low back pain in a young population: a classical twin study. Twin Res 7 (2004) 16-26
21. Hurri H., and Karppinen J. Discogenic pain. Pain 112 (2004) 225-228
22. Igarashi T., Kikuchi S., Shubayev V., and Myers R.R. Volvo Award winner in basic science studies: exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine 25 (2000) 2975-2980
23. Kang J.D., Georgescu H.I., McIntyre-Larkin L., Stefanivic-Racic M., Donaldson III W.F., and Evan C.H. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine 21 (1996) 271-277
24. Karppinen J., Malmivaara A., Kurunlahti M., Kyllönen E., Pienimäki T., Nieminen P., et al. Periradicular infiltration for sciatica. A randomized controlled trial. Spine 26 (2001) 1059-1067
25. Karppinen J., Ohinmaa A., Malmivaara A., Kurunlahti M., Kyllönen E., Pienimäki T., et al. Cost effectiveness of periradicular infiltration for sciatica: subgroup analysis of a randomized controlled trial. Spine 26 (2001) 2587-2595
26. Karppinen J., Malmivaara A., Tervonen O., Pääkkö E., Kurunlahti M., Syrjälä P., et al. Severity of symptoms and signs in relation to magnetic resonance imaging findings among sciatic patients. Spine 26 (2001) E149-E154
27. Karppinen J., Pääkkö E., Räinä S., Tervonen O., Kurunlahti M., Nieminen P., et al. Magnetic resonance imaging findings in relation to the COL9A2 tryptophan allele among patients with sciatica. Spine 27 (2002) 78-83
28. Kishimoto T. Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res Ther 8 Suppl. 2 (2006) S2
29. Korhonen T., Karppinen J., Paimela L., Malmivaara A., Lindgren K.-A., Järvinen S., et al. The treatment of disc herniation-induced sciatica with infliximab. Results of a randomized, controlled, 3-month follow-up study. Spine 30 (2005) 2724-2728
30. Korhonen T., Karppinen J., Paimela L., Malmivaara A., Lindgren K.-A., Bowman C., et al. The treatment of disc herniation-induced sciatica with infliximab: one-year follow-up results of FIRST II, a randomized controlled trial. Spine 31 (2006) 2759-2766
31. Körkkö J., Annunen S., Pihlajamaa T., Prockop D.J., and Ala-Kokko L. Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: comparison with denaturing gradient gel electrophoresis and nucleotide sequencing. Proc Natl Acad Sci 95 (1998) 1681-1685
32. Kääriä S., Luukkonen R., Riihimäki H., Kirjonen J., and Leino-Arjas P. Persistence of low back pain reporting among a cohort of employees in a metal corporation: a study with 5-, 10-, and 28-year follow-ups. Pain 120 (2006) 131-137
33. Lee H.L., Lee K.M., Son S.J., Hwang S.H., and Cho H.J. Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model. Neuroreport 15 (2004) 2807-2811
34. Le Gars L., Borderie D., Kaplan G., and Berenbaum F. Systemic inflammatory response with plasma C-reactive protein elevation in disk-related lumbosciatic syndrome. Joint Bone Spine 67 (2000) 452-455
35. Leino-Arjas P., Kaila-Kangas L., Notkola V., Ilmo K., and Mutanen P. Inpatient hospital care for back disorders in relation to industry and occupation in Finland. Scand J Work Environ Health 28 (2002) 304-313
36. Masui T., Yakawa Y., Nakamura S., Kajino G., Matsubara Y., Kato F., et al. Natural history of patients with lumbar disc herniation observed by magnetic resonance imaging for minimum 7 years. J Spinal Disord Tech 18 (2005) 121-126
37. Matsusaka T., Fujikawa K., Nishio Y., Mukada N., Matsushima K., Kishimoto T., et al. Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci USA 90 (1993) 10193-10197
38. McCarron R.F., Wimpee M.W., Hudkins P.G., and Laros G.S. The inflammatory effect of nucleus pulposus. A possible element in the pathogenesis of low-back pain. Spine 12 (1987) 760-764
39. Miyamoto H., Doita M., Nishida K., Yamamoto T., Sumi M., and Kurosaka M. Effects of cyclic mechanical stress on the production of inflammatory agents by nucleus pulposus and annulus fibrosus derived cells in vitro. Spine 31 (2006) 4-9
40. Myers R.R., Campana W.M., and Shubayev V.I. The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets. Drug Discov Today 11 (2006) 8-20
41. Noponen-Hietala N., Virtanen I., Karttunen R., Schwenke S., Jakkula E., Lia H., et al. Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. Pain 114 (2005) 186-194
42. Oldenburg H.S., Rogy M.A., Lazarus D.D., van Zee K.J., Keeler B.P., Chizzonite R.A., et al. Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6. Eur J Immunol 23 (1993) 1889-1894
43. Olmarker K., and Myers R.R. Pathogenesis of sciatic pain: role of herniated nucleus pulposus and deformation of spinal nerve root and dorsal root ganglion. Pain 78 (1998) 99-105
44. Paassilta P., Lohiniva J., Göring H.H.H., Perälä M., Räinä S., Karppinen J., et al. Identification of a novel common genetic risk factor for lumbar disc disease. JAMA 285 (2001) 1843-1849
45. Ramer M.S., Murphy P.G., Richardson P.M., and Bisby M.A. Spinal nerve lesion-induced mechanoallodynia and adrenergic sprouting in sensory ganglia are attenuated in interleukin-6 knockout mice. Pain 78 (1998) 115-121
46. Riihimäki H., Viikari-Juntura E., Moneta G., Kuha J., Videman T., and Tola S. Incidence of sciatic pain among men in machine operating, dynamic physical work, and sedentary work. A three-year follow-up. Spine 19 (1994) 138-142
47. Seki S., Kawaguchi Y., Chiba K., Mikami Y., Kizawa H., Oya T., et al. A Functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet 37 (2005) 607-612
48. Shimizu H., Mitomo K., Watanabe T., Okamoto S., and Yamamoto K. Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Mol Cell Biol 10 (1990) 561-568
49. Shiri R, Karppinen J, Leino-Arjas P, Solovieva S, Varonen H, Kalso E, Ukkola O, Viikari-Juntura E. Cardiovascular and lifestyle risk factors in lumbar radicular pain or clinically defined sciatica: a systematic review. Eur Spine J 2007; May 25 [Epub ahead of print].
50. Solovieva S., Leino-Arjas P., Saarela J., Luoma K., Raininko E., and Riihimäki H. Possible association of interleukin 1 gene locus polymorphisms with low back pain. Pain 109 (2004) 8-19
51. Sturmer T., Raum E., Buchner M., Gebhardt K., Schiltenwolf M., Richter W., et al. Pain and high sensitivity C reactive protein in patients with chronic low back pain and acute sciatic pain. Ann Rheum Dis 64 (2005) 921-925
52. Takada T., Nishida K., Doita M., Miyamoto H., and Kurosaka M. Interleukin-6 production is upregulated by interaction between disc tissue and macrophages. Spine 29 (2004) 1089-1092
53. Takada T, Nishida K, Doita M, Shinomura T, Maeno K, Kurosaka M. TNFalpha is the trigger for IL-6 production in the interaction between intervertebral disc and macrophages. Presented at the Annual Meeting of the International Society for the Study of the Lumbar Spine, June 13-17 2006, Bergen, Norway.
54. Takahashi M., Suguro T., Okazima Y., Motegi M., Okada Y., and Kakiuchi T. Inflammatory cytokines in the herniated discs of the lumbar spine. Spine 21 (1996) 218-224
55. Takebayashi T., Cavanaugh J.M., Cuneyt Ozaktay A., Kallakuri S., and Chen C. Effect of nucleus pulposus on the neural activity of dorsal root ganglion. Spine 26 (2001) 940-945
56. Tegeder I., Costigan M., Griffin R.S., Abele A., Belfer I., Schmidt H., et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 12 (2006) 1269-1277
57. Terry C.F., Loukaci V., and Green F.R. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 275 (2000) 18138-18144
58. Tubach F., Leclerc A., Landre M.F., and Pietri-Taleb F. Risk factors for sick leave due to low back pain: a prospective study. J Occup Environ Med 44 (2002) 451-458
59. Tubach F., Beaute J., and Leclerc A. Natural history and prognostic indicators of sciatica. J Clin Epidemiol 57 (2004) 174-179
60. Virtanen I.M., Song Y.-Q., Cheung K.M.C., Ala-Kokko L., Karppinen J., Ho D.W.H., et al. Phenotypic and population differences in the association between CILP and lumbar disc disease. J Med Genet 44 (2007) 285-288
61. Wynne-Jones G., Dunn K.M., and Main C.J. The impact of low back pain on work: a study in primary care consulters. Eur J Pain 12 (2008) 180-188
62. Yang L., Jones N.R., Blumbergs P.C., Van Den Heuvel C., Moore E.J., Manavis J., et al. Severity-dependent expression of pro-inflammatory cytokines in traumatic spinal cord injury in the rat. J Clin Neurosci 12 (2005) 276-284
63. Younes M., Béjia I., Aguir Z., Letaief M., Hassen-Zrour S., Touzi M., et al. Prevalence and risk factors of disk-related sciatica in an urban population in Tunisia. Joint Bone Spine 73 (2006) 538-542