Human nucleus pulposus cells react to IL-6: Independent actions and amplification of response to IL-1 and TNF-α

Spine

Volumn 36, Issue 8, 2011, Pages 593-599

  Studer, Rebecca K ^a,b,d   Vo, Nam ^b   Sowa, Gwendolyn ^b,c   Ondeck, Courtney ^b   Kang, James ^a  

^a VA Pittsburgh ^*

^b Ferguson Laboratory for Orthopaedic Research   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d VAPHS   (United States)

Author keywords

disc degeneration; IL 6; matrix synthesis; nucleus pulposus cells

Indexed keywords

AGGRECAN; ALGINIC ACID; COLLAGEN; CYCLOOXYGENASE 2; DNA; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 8; PROSTAGLANDIN E2; RECOMBINANT INTERLEUKIN 1; RECOMBINANT INTERLEUKIN 6; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; VASCULOTROPIN;

ADOLESCENT; ADULT; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; INTERVERTEBRAL DISK DEGENERATION; MALE; NUCLEUS PULPOSUS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; AGED; AGGRECANS; CELLS, CULTURED; COLLAGEN; CYCLOOXYGENASE 2; DRUG SYNERGISM; FEMALE; GENE EXPRESSION; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; MALE; MATRIX METALLOPROTEINASE 3; MIDDLE AGED; PROTEOGLYCANS; RECEPTORS, INTERLEUKIN-6; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; YOUNG ADULT;

EID: 79955060109     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3181da38d5     Document Type: Article

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