-
1
-
-
84883312999
-
ATP-driven molecular chaperone machines
-
Clare DK, Saibil HR. ATP-driven molecular chaperone machines. Biopolymers. 2013;99(11):846-859.
-
(2013)
Biopolymers.
, vol.99
, Issue.11
, pp. 846-859
-
-
Clare, D.K.1
Saibil, H.R.2
-
2
-
-
0021708673
-
Quantitation and intracellular localization of the 85 K heat shock protein by using monoclonal and polyclonal antibodies
-
Lai BT, Chin NW, Stanek AE, Keh W, Lanks KW. Quantitation and intracellular localization of the 85 K heat shock protein by using monoclonal and polyclonal antibodies. Mol Cell Biol. 1984;4(12):2802-2810.
-
(1984)
Mol Cell Biol.
, vol.4
, Issue.12
, pp. 2802-2810
-
-
Lai, B.T.1
Chin, N.W.2
Stanek, A.E.3
Keh, W.4
Lanks, K.W.5
-
3
-
-
84898939969
-
Protein chaperones: A composition of matter review (2008-2013)
-
Taldone T, Patel HJ, Bolaender A, Patel MR, Chiosis G. Protein chaperones: a composition of matter review (2008-2013). Expert Opin Ther Pat. 2014;24(5):501-518.
-
(2014)
Expert Opin Ther Pat.
, vol.24
, Issue.5
, pp. 501-518
-
-
Taldone, T.1
Patel, H.J.2
Bolaender, A.3
Patel, M.R.4
Chiosis, G.5
-
4
-
-
62149135294
-
Discovery and development of heat shock protein 90 inhibitors
-
Taldone T, Sun W, Chiosis G. Discovery and development of heat shock protein 90 inhibitors. Bioorg Med Chem. 2009;17(6):2225-2235.
-
(2009)
Bioorg Med Chem.
, vol.17
, Issue.6
, pp. 2225-2235
-
-
Taldone, T.1
Sun, W.2
Chiosis, G.3
-
5
-
-
25844519550
-
HSP90 and the chaperoning of cancer
-
Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005;5(10):761-772.
-
(2005)
Nat Rev Cancer.
, vol.5
, Issue.10
, pp. 761-772
-
-
Whitesell, L.1
Lindquist, S.L.2
-
6
-
-
0031733457
-
Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas
-
Nanbu K, Konishi I, Mandai M, et al. Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Cancer Detect Prev. 1998;22(6):549-555.
-
(1998)
Cancer Detect Prev.
, vol.22
, Issue.6
, pp. 549-555
-
-
Nanbu, K.1
Konishi, I.2
Mandai, M.3
-
7
-
-
0033765238
-
Expression of heat shock proteins in osteosarcoma and its relationship to prognosis
-
Uozaki H, Ishida T, Kakiuchi C, et al. Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. Pathol Res Pract. 2000;196(10):665-673.
-
(2000)
Pathol Res Pract.
, vol.196
, Issue.10
, pp. 665-673
-
-
Uozaki, H.1
Ishida, T.2
Kakiuchi, C.3
-
8
-
-
33845302853
-
Tumor selectivity of Hsp90 inhibitors: The explanation remains elusive
-
Chiosis G, Neckers L. Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive. ACS Chem Biol. 2006;1(5):279-284.
-
(2006)
ACS Chem Biol.
, vol.1
, Issue.5
, pp. 279-284
-
-
Chiosis, G.1
Neckers, L.2
-
9
-
-
80054851888
-
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
-
Moulick K, Ahn JH, Zong H, et al. Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nat Chem Biol. 2011;7(11):818-826.
-
(2011)
Nat Chem Biol.
, vol.7
, Issue.11
, pp. 818-826
-
-
Moulick, K.1
Ahn, J.H.2
Zong, H.3
-
10
-
-
84880787644
-
Inhibition of HSP90 molecular chaperones: Moving into the clinic
-
Garcia-Carbonero R, Carnero A, Paz-Ares L. Inhibition of HSP90 molecular chaperones: moving into the clinic. Lancet Oncol. 2013;14(9):e358-e369.
-
(2013)
Lancet Oncol.
, vol.14
, Issue.9
, pp. e358-e369
-
-
Garcia-Carbonero, R.1
Carnero, A.2
Paz-Ares, L.3
-
11
-
-
4344674482
-
Targeting multiple signal transduction pathways through inhibition of Hsp90
-
Zhang H, Burrows F. Targeting multiple signal transduction pathways through inhibition of Hsp90. J Mol Med (Berl). 2004;82(8):488-499.
-
(2004)
J Mol Med (Berl).
, vol.82
, Issue.8
, pp. 488-499
-
-
Zhang, H.1
Burrows, F.2
-
12
-
-
84865839031
-
HSP90 inhibitors for cancer therapy and overcoming drug resistance
-
Jhaveri K, Modi S. HSP90 inhibitors for cancer therapy and overcoming drug resistance. Adv Pharmacol. 2012;65:471-517.
-
(2012)
Adv Pharmacol.
, vol.65
, pp. 471-517
-
-
Jhaveri, K.1
Modi, S.2
-
13
-
-
0034892432
-
Hsp90: Chaperoning signal transduction
-
Richter K, Buchner J. Hsp90: chaperoning signal transduction. J Cell Physiol. 2001;188(3):281-290.
-
(2001)
J Cell Physiol.
, vol.188
, Issue.3
, pp. 281-290
-
-
Richter, K.1
Buchner, J.2
-
14
-
-
0035718899
-
Structure, function, and mechanism of the Hsp90 molecular chaperone
-
Pearl LH, Prodromou C. Structure, function, and mechanism of the Hsp90 molecular chaperone. Adv Protein Chem. 2001;59:157-186.
-
(2001)
Adv Protein Chem.
, vol.59
, pp. 157-186
-
-
Pearl, L.H.1
Prodromou, C.2
-
15
-
-
0035989680
-
HSP90 as a new therapeutic target for cancer therapy: The story unfolds
-
Maloney A, Workman P. HSP90 as a new therapeutic target for cancer therapy: the story unfolds. Expert Opin Biol Ther. 2002;2(1):3-24.
-
(2002)
Expert Opin Biol Ther.
, vol.2
, Issue.1
, pp. 3-24
-
-
Maloney, A.1
Workman, P.2
-
16
-
-
84855457952
-
Hsp90 molecular chaperone inhibitors: Are we there yet?
-
Neckers L, Workman P. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res. 2012;18(1):64-76.
-
(2012)
Clin Cancer Res.
, vol.18
, Issue.1
, pp. 64-76
-
-
Neckers, L.1
Workman, P.2
-
17
-
-
0029812759
-
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin
-
Mimnaugh EG, Chavany C, Neckers L. Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin. J Biol Chem. 1996;271(37):22796-22801.
-
(1996)
J Biol Chem.
, vol.271
, Issue.37
, pp. 22796-22801
-
-
Mimnaugh, E.G.1
Chavany, C.2
Neckers, L.3
-
18
-
-
74849111762
-
Heat shock protein 90: Inhibitors in clinical trials
-
Biamonte MA, Van de Water R, Arndt JW, Scannevin RH, Perret D, Lee WC. Heat shock protein 90: inhibitors in clinical trials. J Med Chem. 2010;53(1):3-17.
-
(2010)
J Med Chem.
, vol.53
, Issue.1
, pp. 3-17
-
-
Biamonte, M.A.1
Van de Water, R.2
Arndt, J.W.3
Scannevin, R.H.4
Perret, D.5
Lee, W.C.6
-
19
-
-
33646176246
-
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex
-
Ali MM, Roe SM, Vaughan CK, et al. Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature. 2006;440(7087):1013-1017.
-
(2006)
Nature.
, vol.440
, Issue.7087
, pp. 1013-1017
-
-
Ali, M.M.1
Roe, S.M.2
Vaughan, C.K.3
-
20
-
-
0141596939
-
Structure and functional relationships of Hsp90
-
Prodromou C, Pearl LH. Structure and functional relationships of Hsp90. Curr Cancer Drug Targets. 2003;3(5):301-323.
-
(2003)
Curr Cancer Drug Targets.
, vol.3
, Issue.5
, pp. 301-323
-
-
Prodromou, C.1
Pearl, L.H.2
-
21
-
-
73949114912
-
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase
-
Ehrlich ES, Wang T, Luo K, et al. Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase. Proc Natl Acad Sci U S A. 2009;106(48):20330-20335.
-
(2009)
Proc Natl Acad Sci U S A.
, vol.106
, Issue.48
, pp. 20330-20335
-
-
Ehrlich, E.S.1
Wang, T.2
Luo, K.3
-
22
-
-
84857039457
-
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
-
Jhaveri K, Taldone T, Modi S, Chiosis G. Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers. Biochim Biophys Acta. 2012;1823(3):742-755.
-
(2012)
Biochim Biophys Acta.
, vol.1823
, Issue.3
, pp. 742-755
-
-
Jhaveri, K.1
Taldone, T.2
Modi, S.3
Chiosis, G.4
-
23
-
-
84898447762
-
Heat shock protein 90 inhibitors in the treatment of cancer: Current status and future directions
-
Jhaveri K, Ochiana SO, Dunphy MP, et al. Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions. Expert Opin Investig Drugs. 2014;23(5):611-628.
-
(2014)
Expert Opin Investig Drugs.
, vol.23
, Issue.5
, pp. 611-628
-
-
Jhaveri, K.1
Ochiana, S.O.2
Dunphy, M.P.3
-
24
-
-
84866375177
-
A phase I dose-escalation trial of trastuzumab and alvespimycin hydrochloride (KOS-1022; 17 DMAG) in the treatment of advanced solid tumors
-
Jhaveri K, Miller K, Rosen L, et al. A phase I dose-escalation trial of trastuzumab and alvespimycin hydrochloride (KOS-1022; 17 DMAG) in the treatment of advanced solid tumors. Clin Cancer Res. 2012;18(18):5090-5098.
-
(2012)
Clin Cancer Res.
, vol.18
, Issue.18
, pp. 5090-5098
-
-
Jhaveri, K.1
Miller, K.2
Rosen, L.3
-
25
-
-
79951885125
-
Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
-
Sequist LV, Gettinger S, Senzer NN, et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol. 2010;28(33):4953-4960.
-
(2010)
J Clin Oncol.
, vol.28
, Issue.33
, pp. 4953-4960
-
-
Sequist, L.V.1
Gettinger, S.2
Senzer, N.N.3
-
26
-
-
84887058257
-
A phase 1 study of the heat shock protein 90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft tissue sarcomas
-
Wagner AJ, Chugh R, Rosen LS, et al. A phase 1 study of the heat shock protein 90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft tissue sarcomas. Clin Cancer Res. 2013;19(21):6020-6029.
-
(2013)
Clin Cancer Res.
, vol.19
, Issue.21
, pp. 6020-6029
-
-
Wagner, A.J.1
Chugh, R.2
Rosen, L.S.3
-
27
-
-
84877581534
-
A multicenter trial evaluating retaspimycin HCL (IPI-504) plus trastuzumab in patients with advanced or metastatic HER2-positive breast cancer
-
Modi S, Saura C, Henderson C, et al. A multicenter trial evaluating retaspimycin HCL (IPI-504) plus trastuzumab in patients with advanced or metastatic HER2-positive breast cancer. Breast Cancer Res Treat. 2013;139(1):107-113.
-
(2013)
Breast Cancer Res Treat.
, vol.139
, Issue.1
, pp. 107-113
-
-
Modi, S.1
Saura, C.2
Henderson, C.3
-
28
-
-
84856832510
-
Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy
-
Ying W, Du Z, Sun L, et al. Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy. Mol Cancer Ther. 2012;11(2):475-484.
-
(2012)
Mol Cancer Ther.
, vol.11
, Issue.2
, pp. 475-484
-
-
Ying, W.1
Du, Z.2
Sun, L.3
-
29
-
-
79955044159
-
Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling
-
Proia DA, Foley KP, Korbut T, et al. Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling. PLoS One. 2011;6(4):e18552.
-
(2011)
PLoS One.
, vol.6
, Issue.4
-
-
Proia, D.A.1
Foley, K.P.2
Korbut, T.3
-
30
-
-
84866414082
-
Ganetespib (STA-9090), a non-geldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer
-
Shimamura T, Perera SA, Foley KP, et al. Ganetespib (STA-9090), a non-geldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. Clin Cancer Res. 2012;18(18):4973-4985.
-
(2012)
Clin Cancer Res.
, vol.18
, Issue.18
, pp. 4973-4985
-
-
Shimamura, T.1
Perera, S.A.2
Foley, K.P.3
-
31
-
-
84876315579
-
A critical role for the tissue distribution profile in heat shock protein (Hsp) 90 inhibitor-induced ocular toxicity in rats
-
Abstr C212
-
Zhou D, Liu Y, Ye J, et al. A critical role for the tissue distribution profile in heat shock protein (Hsp) 90 inhibitor-induced ocular toxicity in rats. Mol Cancer Ther. 2011;10(11 suppl):Abstr C212.
-
(2011)
Mol Cancer Ther.
, vol.10
, Issue.11
-
-
Zhou, D.1
Liu, Y.2
Ye, J.3
-
32
-
-
84899973398
-
A phase II open-label study of ganetespib, a novel heat shock protein 90 inhibitor for patients with metastatic breast cancer
-
Jhaveri K, Chandarlapaty S, Lake D, et al. A phase II open-label study of ganetespib, a novel heat shock protein 90 inhibitor for patients with metastatic breast cancer. Clin Breast Cancer. 2014;14(3):154-160.
-
(2014)
Clin Breast Cancer.
, vol.14
, Issue.3
, pp. 154-160
-
-
Jhaveri, K.1
Chandarlapaty, S.2
Lake, D.3
-
33
-
-
84875316604
-
A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies
-
Goldman JW, Raju RN, Gordon GA, et al. A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies. BMC Cancer. 2013;13:152.
-
(2013)
BMC Cancer.
, vol.13
, pp. 152
-
-
Goldman, J.W.1
Raju, R.N.2
Gordon, G.A.3
-
34
-
-
84938102559
-
-
General Poster Session, Developmental Therapeutics - Experimental Therapeutics, 2011 ASCO Annual Meeting, Abstract 3051; Chicago
-
Cho DC, Heath EI, Cleary JM, et al. A phase I dose-escalation study of the Hsp90 inhibitor ganetespib (STA-9090) administered twice weekly in patients with solid tumors: updated report. General Poster Session, Developmental Therapeutics - Experimental Therapeutics, 2011 ASCO Annual Meeting, Abstract 3051; 2011. Chicago.
-
(2011)
A phase I dose-escalation study of the Hsp90 inhibitor ganetespib (STA-9090) administered twice weekly in patients with solid tumors: Updated report.
-
-
Cho, D.C.1
Heath, E.I.2
Cleary, J.M.3
-
35
-
-
85006484740
-
A phase 1/2 study of the potent Hsp90 inhibitor STA-9090 administered once weekly in subjects with hematologic malignancies
-
Abstract 3294
-
Lancet JE, Smith BD, Bradley R, Komrokji RS, Teofilovici F, Rizzieri DA. A phase 1/2 study of the potent Hsp90 inhibitor STA-9090 administered once weekly in subjects with hematologic malignancies. Blood (ASH Annual Meeting Abstracts). 2010;116:Abstract 3294.
-
(2010)
Blood (ASH Annual Meeting Abstracts).
, vol.116
-
-
Lancet, J.E.1
Smith, B.D.2
Bradley, R.3
Komrokji, R.S.4
Teofilovici, F.5
Rizzieri, D.A.6
-
36
-
-
84857060831
-
A phase I study of the potent Hsp90 inhibitor STA-9090 administered twice weekly in subjects with hematologic malignancies
-
Abstract 2898
-
Padmanabhan S, Kelly K, Heaney M, et al. A phase I study of the potent Hsp90 inhibitor STA-9090 administered twice weekly in subjects with hematologic malignancies. Blood (ASH Annual Meeting Abstracts). 2010;116:Abstract 2898.
-
(2010)
Blood (ASH Annual Meeting Abstracts).
, vol.116
-
-
Padmanabhan, S.1
Kelly, K.2
Heaney, M.3
-
37
-
-
84892764962
-
Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer
-
Proia DA, Zhang C, Sequeira M, et al. Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer. Clin Cancer Res. 2014;20(2):413-424.
-
(2014)
Clin Cancer Res.
, vol.20
, Issue.2
, pp. 413-424
-
-
Proia, D.A.1
Zhang, C.2
Sequeira, M.3
-
38
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61-70.
-
(2012)
Nature.
, vol.490
, Issue.7418
, pp. 61-70
-
-
Cancer Genome Atlas Network1
-
39
-
-
84878971581
-
A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer
-
Socinski MA, Goldman J, El-Hariry I, et al. A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer. Clin Cancer Res. 2013;19(11):3068-3077.
-
(2013)
Clin Cancer Res.
, vol.19
, Issue.11
, pp. 3068-3077
-
-
Socinski, M.A.1
Goldman, J.2
El-Hariry, I.3
-
40
-
-
84874041489
-
An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) in patients (pts) with metastatic and/or unresectable GIST
-
(Vol 29, No 15_suppl (May 20 Supplement); 2011. Chicago
-
Demetri GD, Heinrich MC, Chmielowski B, et al. An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) in patients (pts) with metastatic and/or unresectable GIST. ASCO Annual Meeting, 2011 (Vol 29, No 15_suppl (May 20 Supplement); 2011. Chicago.
-
(2011)
ASCO Annual Meeting
-
-
Demetri, G.D.1
Heinrich, M.C.2
Chmielowski, B.3
-
41
-
-
0034902025
-
Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: In vitro and in vivo analysis
-
discussion 378-379
-
Nguyen DM, Lorang D, Chen GA, Stewart JH 4th, Tabibi E, Schrump DS. Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis. Ann Thorac Surg. 2001;72(2):371-378; discussion 378-379.
-
(2001)
Ann Thorac Surg.
, vol.72
, Issue.2
, pp. 371-378
-
-
Nguyen, D.M.1
Lorang, D.2
Chen, G.A.3
Stewart, J.H.4
Tabibi, E.5
Schrump, D.S.6
-
42
-
-
0034890377
-
Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner
-
See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters, Clin Cancer Res. 7:2155-2158, 2001
-
Munster PN, Basso A, Solit D, Norton L, Rosen N. Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters, Clin Cancer Res. 7:2155-2158, 2001. Clin Cancer Res. 2001;7(8):2228-2236.
-
(2001)
Clin Cancer Res.
, vol.7
, Issue.8
, pp. 2228-2236
-
-
Munster, P.N.1
Basso, A.2
Solit, D.3
Norton, L.4
Rosen, N.5
-
43
-
-
84896511103
-
Ganetespib and HSP90: Translating preclinical hypotheses into clinical promise
-
Proia DA, Bates RC. Ganetespib and HSP90: translating preclinical hypotheses into clinical promise. Cancer Res. 2014;74(5):1294-1300.
-
(2014)
Cancer Res.
, vol.74
, Issue.5
, pp. 1294-1300
-
-
Proia, D.A.1
Bates, R.C.2
-
44
-
-
0038404927
-
Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol
-
Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N. Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. Cancer Res. 2003;63(9):2139-2144.
-
(2003)
Cancer Res.
, vol.63
, Issue.9
, pp. 2139-2144
-
-
Solit, D.B.1
Basso, A.D.2
Olshen, A.B.3
Scher, H.I.4
Rosen, N.5
-
45
-
-
84875539014
-
Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models
-
Proia DA, Sang J, He S, et al. Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models. Invest New Drugs. 2012;30(6):2201-2209.
-
(2012)
Invest New Drugs.
, vol.30
, Issue.6
, pp. 2201-2209
-
-
Proia, D.A.1
Sang, J.2
He, S.3
-
46
-
-
84884580988
-
Network analysis identifies an HSP90-central hub susceptible in ovarian cancer
-
Liu H, Xiao F, Serebriiskii IG, et al. Network analysis identifies an HSP90-central hub susceptible in ovarian cancer. Clin Cancer Res. 2013;19(18):5053-5067.
-
(2013)
Clin Cancer Res.
, vol.19
, Issue.18
, pp. 5053-5067
-
-
Liu, H.1
Xiao, F.2
Serebriiskii, I.G.3
-
47
-
-
0036894746
-
BRAF and RAS mutations in human lung cancer and melanoma
-
Brose MS, Volpe P, Feldman M, et al. BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res. 2002;62(23):6997-7000.
-
(2002)
Cancer Res.
, vol.62
, Issue.23
, pp. 6997-7000
-
-
Brose, M.S.1
Volpe, P.2
Feldman, M.3
-
48
-
-
55949122976
-
KRAS mutations: An old oncogene becomes a new predictive biomarker
-
Riely GJ, Ladanyi M. KRAS mutations: an old oncogene becomes a new predictive biomarker. J Mol Diagn. 2008;10(6):493-495.
-
(2008)
J Mol Diagn.
, vol.10
, Issue.6
, pp. 493-495
-
-
Riely, G.J.1
Ladanyi, M.2
-
49
-
-
84938091360
-
Targeting KRAS mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib
-
Acquaviva J, Smith DL, Sang J, et al. Targeting KRAS mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib. Mol Cancer Ther. 2012;25:2012.
-
(2012)
Mol Cancer Ther.
, vol.25
, pp. 2012
-
-
Acquaviva, J.1
Smith, D.L.2
Sang, J.3
-
50
-
-
84877679409
-
Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer
-
Sang J, Acquaviva J, Friedland JC, et al. Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer. Cancer Discov. 2013;3(4):430-443.
-
(2013)
Cancer Discov.
, vol.3
, Issue.4
, pp. 430-443
-
-
Sang, J.1
Acquaviva, J.2
Friedland, J.C.3
-
51
-
-
79956318797
-
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
-
Katayama R, Khan TM, Benes C, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A. 2011;108(18):7535-7540.
-
(2011)
Proc Natl Acad Sci U S A.
, vol.108
, Issue.18
, pp. 7535-7540
-
-
Katayama, R.1
Khan, T.M.2
Benes, C.3
-
52
-
-
84894183166
-
Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib
-
Acquaviva J, Smith DL, Jimenez JP, et al. Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib. Mol Cancer Ther. 2014;13(2):353-363.
-
(2014)
Mol Cancer Ther.
, vol.13
, Issue.2
, pp. 353-363
-
-
Acquaviva, J.1
Smith, D.L.2
Jimenez, J.P.3
-
53
-
-
74049091229
-
BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy
-
Yin X, Zhang H, Lundgren K, Wilson L, Burrows F, Shores CG. BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int J Cancer. 2010;126(5):1216-1225.
-
(2010)
Int J Cancer.
, vol.126
, Issue.5
, pp. 1216-1225
-
-
Yin, X.1
Zhang, H.2
Lundgren, K.3
Wilson, L.4
Burrows, F.5
Shores, C.G.6
-
54
-
-
0141568014
-
Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin: A multitarget approach to radiosensitization
-
Russell JS, Burgan W, Oswald KA, Camphausen K, Tofilon PJ. Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin: a multitarget approach to radiosensitization. Clin Cancer Res. 2003;9(10 pt 1):3749-3755.
-
(2003)
Clin Cancer Res.
, vol.9
, Issue.10
, pp. 3749-3755
-
-
Russell, J.S.1
Burgan, W.2
Oswald, K.A.3
Camphausen, K.4
Tofilon, P.J.5
-
55
-
-
84865794941
-
Molecular pathways: Targeting hsp90 - who benefits and who does not
-
Scaltriti M, Dawood S, Cortes J. Molecular pathways: targeting hsp90 - who benefits and who does not. Clin Cancer Res. 2012;18(17):4508-4513.
-
(2012)
Clin Cancer Res.
, vol.18
, Issue.17
, pp. 4508-4513
-
-
Scaltriti, M.1
Dawood, S.2
Cortes, J.3
-
56
-
-
0242496212
-
Molecular sequelae of proteasome inhibition in human multiple myeloma cells
-
Mitsiades N, Mitsiades CS, Poulaki V, et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci U S A. 2002;99(22):14374-14379.
-
(2002)
Proc Natl Acad Sci U S A.
, vol.99
, Issue.22
, pp. 14374-14379
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
57
-
-
31544436323
-
Antimyeloma activity of heat shock protein-90 inhibition
-
Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Antimyeloma activity of heat shock protein-90 inhibition. Blood. 2006;107(3):1092-1100.
-
(2006)
Blood.
, vol.107
, Issue.3
, pp. 1092-1100
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
-
58
-
-
77955144862
-
Tanespimycin with bortezomib: Activity in relapsed/refractory patients with multiple myeloma
-
Richardson PG, Badros AZ, Jagannath S, et al. Tanespimycin with bortezomib: activity in relapsed/refractory patients with multiple myeloma. Br J Haematol. 2010;150(4):428-437.
-
(2010)
Br J Haematol.
, vol.150
, Issue.4
, pp. 428-437
-
-
Richardson, P.G.1
Badros, A.Z.2
Jagannath, S.3
-
59
-
-
79957539428
-
Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: Results of a phase 1/2 study
-
Richardson PG, Chanan-Khan AA, Lonial S, et al. Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study. Br J Haematol. 2011;153(6):729-740.
-
(2011)
Br J Haematol.
, vol.153
, Issue.6
, pp. 729-740
-
-
Richardson, P.G.1
Chanan-Khan, A.A.2
Lonial, S.3
-
60
-
-
84887029257
-
A randomized study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel versus docetaxel alone for second-line therapy of lung adenocarcinoma (GALAXY-1)
-
abstr CRA8007
-
Ramalingam S, Goss G, Rosell R, et al. A randomized study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel versus docetaxel alone for second-line therapy of lung adenocarcinoma (GALAXY-1). J Clin Oncol. 2013;31(suppl):abstr CRA8007.
-
(2013)
J Clin Oncol.
, vol.31
-
-
Ramalingam, S.1
Goss, G.2
Rosell, R.3
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