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Volumn 74, Issue 5, 2014, Pages 1294-1300

Ganetespib and HSP90: Translating preclinical hypotheses into clinical promise

Author keywords

[No Author keywords available]

Indexed keywords

GANETESPIB; HEAT SHOCK PROTEIN 90;

EID: 84896511103     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-3263     Document Type: Review
Times cited : (105)

References (44)
  • 1
    • 84855457952 scopus 로고    scopus 로고
    • Hsp90 molecular chaperone inhibitors: Are we there yet?
    • Neckers L, Workman P. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res 2012;18:64-76.
    • (2012) Clin Cancer Res , vol.18 , pp. 64-76
    • Neckers, L.1    Workman, P.2
  • 2
    • 77953916528 scopus 로고    scopus 로고
    • Hsp90 at the hub of protein homeostasis: Emerging mechanistic insights
    • Taipale M, Jarosz DF, Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 2010;11:515-28.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 515-528
    • Taipale, M.1    Jarosz, D.F.2    Lindquist, S.3
  • 3
    • 25844519550 scopus 로고    scopus 로고
    • Hsp90 and the chaperoning of cancer
    • Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer 2005;5:761-72.
    • (2005) Nat Rev Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 4
    • 33845302853 scopus 로고    scopus 로고
    • Tumor selectivity of hsp90 inhibitors: The explanation remains elusive
    • Chiosis G, Neckers L. Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive. ACS Chem Biol 2006;1:279-84.
    • (2006) ACS Chem Biol , vol.1 , pp. 279-284
    • Chiosis, G.1    Neckers, L.2
  • 6
    • 84856832510 scopus 로고    scopus 로고
    • Ganetespib, a unique triazolone-containing hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy
    • Ying W, Du Z, Sun L, Foley KP, Proia DA, Blackman RK, et al. Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy. Mol Cancer Ther 2012;11:475-84.
    • (2012) Mol Cancer Ther , vol.11 , pp. 475-484
    • Ying, W.1    Du, Z.2    Sun, L.3    Foley, K.P.4    Proia, D.A.5    Blackman, R.K.6
  • 7
    • 42349084306 scopus 로고    scopus 로고
    • Nvp-Auy922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
    • Eccles SA, Massey A, Raynaud FI, Sharp SY, Box G, Valenti M, et al. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res 2008;68:2850-60.
    • (2008) Cancer Res , vol.68 , pp. 2850-2860
    • Eccles, S.A.1    Massey, A.2    Raynaud, F.I.3    Sharp, S.Y.4    Box, G.5    Valenti, M.6
  • 8
    • 84866414082 scopus 로고    scopus 로고
    • Ganetespib (sta-9090), a nongeldanamycin hsp90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer
    • Shimamura T, Perera SA, Foley KP, Sang J, Rodig SJ, Inoue T, et al. Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. Clin Cancer Res 2012;18:4973-85.
    • (2012) Clin Cancer Res , vol.18 , pp. 4973-4985
    • Shimamura, T.1    Perera, S.A.2    Foley, K.P.3    Sang, J.4    Rodig, S.J.5    Inoue, T.6
  • 9
    • 26444482073 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-Allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models
    • Banerji U, Walton M, Raynaud F, Grimshaw R, Kelland L, Valenti M, et al. Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-Allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models. Clin Cancer Res 2005;11:7023-32.
    • (2005) Clin Cancer Res , vol.11 , pp. 7023-7032
    • Banerji, U.1    Walton, M.2    Raynaud, F.3    Grimshaw, R.4    Kelland, L.5    Valenti, M.6
  • 10
    • 11244337455 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17dmag,nsc707545) in c.B-17 scid mice bearing mda-mb-231 human breast cancer xenografts
    • Eiseman JL, Lan J, Lagattuta TF, Hamburger DR, Joseph E, Covey JM, et al. Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino) ethyl]amino]geldanamycin (17DMAG,NSC707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts. Cancer Chemo Pharm 2005;55:21-32.
    • (2005) Cancer Chemo Pharm , vol.55 , pp. 21-32
    • Eiseman, J.L.1    Lan, J.2    Lagattuta, T.F.3    Hamburger, D.R.4    Joseph, E.5    Covey, J.M.6
  • 11
    • 84888204057 scopus 로고    scopus 로고
    • A rat retinal damage model predicts for potential clinical visual disturbances induced by hsp90 inhibitors
    • Zhou D, Liu Y, Ye J, Ying W, Ogawa LS, Inoue T, et al. A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors. Toxicol Appl Pharmacol 2013;273: 401-9.
    • (2013) Toxicol Appl Pharmacol , vol.273 , pp. 401-409
    • Zhou, D.1    Liu, Y.2    Ye, J.3    Ying, W.4    Ogawa, L.S.5    Inoue, T.6
  • 12
    • 34248187981 scopus 로고    scopus 로고
    • Heat shock protein 90: The cancer chaperone
    • Neckers L. Heat shock protein 90: The cancer chaperone. J Biosci 2007;32:517-30.
    • (2007) J Biosci , vol.32 , pp. 517-530
    • Neckers, L.1
  • 13
    • 84877679409 scopus 로고    scopus 로고
    • Targeted inhibition of the molecular chaperone hsp90 overcomes alk inhibitor resistance in non-small cell lung cancer
    • Sang J, Acquaviva J, Friedland JC, Smith DL, Sequeira M, Zhang C, et al. Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer. Cancer Discov 2013;3:430-43.
    • (2013) Cancer Discov , vol.3 , pp. 430-443
    • Sang, J.1    Acquaviva, J.2    Friedland, J.C.3    Smith, D.L.4    Sequeira, M.5    Zhang, C.6
  • 15
    • 79957896979 scopus 로고    scopus 로고
    • The hsp90 inhibitor ipi-504 rapidly lowers eml4-Alk levels and induces tumor regression in alk-driven nsclc models
    • Normant E, Paez G, West KA, Lim AR, Slocum KL, Tunkey C, et al. The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models. Oncogene 2011; 30:2581-6.
    • (2011) Oncogene , vol.30 , pp. 2581-2586
    • Normant, E.1    Paez, G.2    West, K.A.3    Lim, A.R.4    Slocum, K.L.5    Tunkey, C.6
  • 16
    • 79951885125 scopus 로고    scopus 로고
    • Activity of ipi-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
    • Sequist LV, Gettinger S, Senzer NN, Martins RG, Janne PA, Lilenbaum R, et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol 2010;28:4953-60.
    • (2010) J Clin Oncol , vol.28 , pp. 4953-4960
    • Sequist, L.V.1    Gettinger, S.2    Senzer, N.N.3    Martins, R.G.4    Janne, P.A.5    Lilenbaum, R.6
  • 17
    • 84878971581 scopus 로고    scopus 로고
    • A multicenter phase ii study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer
    • Socinski MA, Goldman J, El-Hariry I, Koczywas M, Vukovic V, Horn L, et al. A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer. Clin Cancer Res 2013;19:3068-77.
    • (2013) Clin Cancer Res , vol.19 , pp. 3068-3077
    • Socinski, M.A.1    Goldman, J.2    El-Hariry, I.3    Koczywas, M.4    Vukovic, V.5    Horn, L.6
  • 19
    • 79960985354 scopus 로고    scopus 로고
    • Hsp90 inhibition is effective in breast cancer: A phase ii trial of tanespimycin (17-Aag) plus trastuzumab in patients with her2-positive metastatic breast cancer progressing on trastuzumab
    • Modi S, Stopeck A, Linden H, Solit D, Chandarlapaty S, Rosen N, et al. HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clin Cancer Res 2011;17:5132-9.
    • (2011) Clin Cancer Res , vol.17 , pp. 5132-5139
    • Modi, S.1    Stopeck, A.2    Linden, H.3    Solit, D.4    Chandarlapaty, S.5    Rosen, N.6
  • 20
    • 84899075777 scopus 로고    scopus 로고
    • Targeted inhibition of hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes
    • May 18, Epub ahead of print]
    • Friedland JC, Smith DL, Sang J, Acquaviva J, He S, Zhang C, et al. Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes. Invest New Drugs 2013 May 18.
    • (2013) Invest New Drugs
    • Friedland, J.C.1    Smith, D.L.2    Sang, J.3    Acquaviva, J.4    He, S.5    Zhang, C.6
  • 21
    • 66249138886 scopus 로고    scopus 로고
    • Hsp90 inhibitor pu-h71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
    • Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A 2009 106 8368-73.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 8368-8373
    • Caldas-Lopes, E.1    Cerchietti, L.2    Ahn, J.H.3    Clement, C.C.4    Robles, A.I.5    Rodina, A.6
  • 22
    • 80051706004 scopus 로고    scopus 로고
    • Effective targeting of triple-negative breast cancer cells by pf-4942847, a novel oral inhibitor of hsp 90
    • Mehta PP, Whalen P, BaxiSM, Kung PP, Yamazaki S, Yin MJ. Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90. Clin Cancer Res 2011;17:5432-42.
    • (2011) Clin Cancer Res , vol.17 , pp. 5432-5442
    • Mehta, P.P.1    Whalen, P.2    Baxi, S.M.3    Kung, P.P.4    Yamazaki, S.5    Yin, M.J.6
  • 23
    • 84892764962 scopus 로고    scopus 로고
    • Preclinical activity profile and therapeutic efficacy of the hsp90 inhibitor ganetespib in triple-negative breast cancer
    • Oct 30. [Epub ahead of print]
    • Proia DA, Zhang C, Sequeira M, Jimenez JP, He S, Spector NL, et al. Preclinical activity profile and therapeutic efficacy of the Hsp90 inhibitor ganetespib in triple-negative breast cancer. Clin Cancer Res 2013 Oct 30. [Epub ahead of print].
    • (2013) Clin Cancer Res
    • Proia, D.A.1    Zhang, C.2    Sequeira, M.3    Jimenez, J.P.4    He, S.5    Spector, N.L.6
  • 24
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012;490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 25
    • 84857055228 scopus 로고    scopus 로고
    • An open-label phase ii study of the hsp90 inhibitor ganetespib (sta-9090) in patients (pts) with metastatic and/or unresectable gist
    • (suppl; abstr 10011
    • Demetri GD, Heinrich MC, Chmielowski B, Morgan J, George S, Bradley R, et al. An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) in patients (pts) with metastatic and/or unresectable GIST. J Clin Oncol 29:15s, 2011 (suppl; abstr 10011).
    • (2011) J Clin Oncol , vol.29
    • Demetri, G.D.1    Heinrich, M.C.2    Chmielowski, B.3    Morgan, J.4    George, S.5    Bradley, R.6
  • 26
    • 0034902025 scopus 로고    scopus 로고
    • Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-Allylamino geldanamycin: In vitro and in vivo analysis
    • Nguyen DM, Lorang D, Chen GA, Stewart JH 4th, Tabibi E, Schrump DS. Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-Allylamino geldanamycin: in vitro and in vivo analysis. Ann Thorac Surg 2001;72:371-8.
    • (2001) Ann Thorac Surg , vol.72 , pp. 371-378
    • Nguyen, D.M.1    Lorang, D.2    Chen, G.A.3    Stewart IV, J.H.4    Tabibi, E.5    Schrump, D.S.6
  • 27
    • 0034890377 scopus 로고    scopus 로고
    • Modulation of hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an rb-And schedule-dependent manner
    • Munster PN, Basso A, Solit D, Norton L, Rosen N. Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB-And schedule-dependent manner. Clin Cancer Res 2001;7:2228-36.
    • (2001) Clin Cancer Res , Issue.7 , pp. 2228-2236
    • Munster, P.N.1    Basso, A.2    Solit, D.3    Norton, L.4    Rosen, N.5
  • 28
    • 33745071182 scopus 로고    scopus 로고
    • Potentiation of paclitaxel activity by the hsp90 inhibitor 17-Allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated akt
    • Sain N, Krishnan B, Ormerod MG, De Rienzo A, Liu WM, Kaye SB, et al. Potentiation of paclitaxel activity by the HSP90 inhibitor 17-Allylamino-17- demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT. Mol Cancer Ther 2006; 5:1197-208.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1197-1208
    • Sain, N.1    Krishnan, B.2    Ormerod, M.G.3    De Rienzo, A.4    Liu, W.M.5    Kaye, S.B.6
  • 29
    • 0038404927 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 function down-regulates akt kinase and sensitizes tumors to taxol
    • Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N. Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. Cancer Res 2003;63:2139-44.
    • (2003) Cancer Res , vol.63 , pp. 2139-2144
    • Solit, D.B.1    Basso, A.D.2    Olshen, A.B.3    Scher, H.I.4    Rosen, N.5
  • 30
    • 84875539014 scopus 로고    scopus 로고
    • Synergistic activity of the hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models
    • Proia DA, Sang J, He S, Smith DL, Sequeira M, Zhang C, et al. Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models. Invest New Drugs 2012;30: 2201-9.
    • (2012) Invest New Drugs , vol.30 , pp. 2201-2209
    • Proia, D.A.1    Sang, J.2    He, S.3    Smith, D.L.4    Sequeira, M.5    Zhang, C.6
  • 32
    • 84871391881 scopus 로고    scopus 로고
    • Targeting kras-mutant non-small cell lung cancer with the hsp90 inhibitor ganetespib
    • Acquaviva J, Smith DL, Sang J, Friedland JC, He S, Sequeira M, et al. Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib. Mol Cancer Ther 2012;11:2633-43.
    • (2012) Mol Cancer Ther , vol.11 , pp. 2633-2643
    • Acquaviva, J.1    Smith, D.L.2    Sang, J.3    Friedland, J.C.4    He, S.5    Sequeira, M.6
  • 33
    • 65349107082 scopus 로고    scopus 로고
    • Kras mutations in non-small cell lung cancer
    • Riely GJ, Marks J, Pao W. KRAS mutations in non-small cell lung cancer. Proc Am Thor Soc 2009;6:201-5.
    • (2009) Proc Am Thor Soc , vol.6 , pp. 201-205
    • Riely, G.J.1    Marks, J.2    Pao, W.3
  • 34
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of pi3k and mek inhibitors to treat mutant kras g12d and pik3ca h1047r murine lung cancers
    • Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008; 14:1351-6.
    • (2008) Nat Med , vol.14 , pp. 1351-1356
    • Engelman, J.A.1    Chen, L.2    Tan, X.3    Crosby, K.4    Guimaraes, A.R.5    Upadhyay, R.6
  • 35
    • 78649729548 scopus 로고    scopus 로고
    • Combination treatment with mek and akt inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo
    • Meng J, Dai B, Fang B, Bekele BN, Bornmann WG, Sun D, et al. Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo. PloS ONE 2010;5:e14124.
    • (2010) PloS ONE , vol.5
    • Meng, J.1    Dai, B.2    Fang, B.3    Bekele, B.N.4    Bornmann, W.G.5    Sun, D.6
  • 37
    • 84894183166 scopus 로고    scopus 로고
    • Overcoming acquired braf inhibitor resistance in melanoma via targeted inhibition of hspp90 with ganetespib
    • Jan 7. [Epub ahead of print]
    • Acquaviva J, Smith DL, Jimenez JP, Zhang C, Sequeira M, He S, et al. Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of HspP90 with ganetespib. Mol Cancer Ther 2014 Jan 7. [Epub ahead of print].
    • (2014) Mol Cancer Ther
    • Acquaviva, J.1    Smith, D.L.2    Jimenez, J.P.3    Zhang, C.4    Sequeira, M.5    He, S.6
  • 38
    • 80053307869 scopus 로고    scopus 로고
    • Potential therapeutic strategies to overcome acquired resistance to braf or mek inhibitors in braf mutant cancers
    • Corcoran RB, Settleman J, Engelman JA. Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers. Oncotarget 2011;2:336-46.
    • (2011) Oncotarget , vol.2 , pp. 336-346
    • Corcoran, R.B.1    Settleman, J.2    Engelman, J.A.3
  • 39
    • 56449089812 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-Activating mutations
    • Yano S, Wang W, Li Q, Matsumoto K, Sakurama H, Nakamura T, et al. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-Activating mutations. Cancer Res 2008;68:9479-87.
    • (2008) Cancer Res , vol.68 , pp. 9479-9487
    • Yano, S.1    Wang, W.2    Li, Q.3    Matsumoto, K.4    Sakurama, H.5    Nakamura, T.6
  • 40
    • 84860352732 scopus 로고    scopus 로고
    • Treating alk-positive lung cancer-early successes and future challenges
    • Camidge DR, Doebele RC. Treating ALK-positive lung cancer-early successes and future challenges. Nature Rev Clin Oncol 2012;9: 268-77.
    • (2012) Nature Rev Clin Oncol , vol.9 , pp. 268-277
    • Camidge, D.R.1    Doebele, R.C.2
  • 41
    • 79956318797 scopus 로고    scopus 로고
    • Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene eml4-Alk
    • Katayama R, Khan TM, Benes C, Lifshits E, Ebi H, Rivera VM, et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A 2011;108:7535-40.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 7535-7540
    • Katayama, R.1    Khan, T.M.2    Benes, C.3    Lifshits, E.4    Ebi, H.5    Rivera, V.M.6
  • 42
    • 84860533156 scopus 로고    scopus 로고
    • The hsp90 inhibitor xl888 overcomes braf inhibitor resistance mediated through diverse mechanisms
    • Paraiso KH, Haarberg HE, Wood E, Rebecca VW, Chen YA, Xiang Y, et al. The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms. Clin Cancer Res 2012;18: 2502-14.
    • (2012) Clin Cancer Res , vol.18 , pp. 2502-2514
    • Paraiso, K.H.1    Haarberg, H.E.2    Wood, E.3    Rebecca, V.W.4    Chen, Y.A.5    Xiang, Y.6
  • 43
    • 84864012288 scopus 로고    scopus 로고
    • Negative feedback and adaptive resistance to the targeted therapy of cancer
    • Chandarlapaty S. Negative feedback and adaptive resistance to the targeted therapy of cancer. Cancer Discov 2012;2:311-9.
    • (2012) Cancer Discov , vol.2 , pp. 311-319
    • Chandarlapaty, S.1
  • 44
    • 84887029257 scopus 로고    scopus 로고
    • A randomized study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel versus docetaxel alone for second-line therapy of lung adenomacarcinoma (galaxy-1
    • (suppl; abstr CRA8007
    • Ramalingam S, Goss GD, Andric ZG, Bondarenko I, Zaric B, Ceric T, et al. A randomized study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel versus docetaxel alone for second-line therapy of lung adenomacarcinoma (GALAXY-1). J Clin Oncol 31:18s, 2013 (suppl; abstr CRA8007).
    • (2013) J Clin Oncol , vol.31
    • Ramalingam, S.1    Goss, G.D.2    Andric, Z.G.3    Bondarenko, I.4    Zaric, B.5    Ceric, T.6


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