Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway

Cellular Physiology and Biochemistry

Volumn 36, Issue 5, 2015, Pages 1991-2002

  Song, Bao Quan ^a   Chi, Ying ^a   Li, Xue ^a   Du, Wen Jing ^a   Han, Zhi Bo ^a   Tian, Jian Jian ^a   Li, Juan Juan ^a   Chen, Fang ^a   Wu, He He ^a   Han, Li Xin ^a   Lu, Shi Hong ^a   Zheng, Yi Zhou ^a   Han, Zhong Chao ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

Adipogenesis; Akt; Autophagy; Mesenchymal stem cells; mTOR; Notch signaling; Phosphoinositide 3 kinase

Indexed keywords

3 METHYLADENINE; CHLOROQUINE; GAMMA SECRETASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; N [ N ( 3,5 DIFLUOROPHENACETYL LEVO ALANYL)]PHENYLGLYCINE TERT BUTYL ESTER; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; DIPEPTIDE; MTOR PROTEIN, HUMAN; N-(N-(3,5-DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT-BUTYL ESTER; PTEN PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; AUTOPHAGY; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; ADIPOSE TISSUE; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOLOGY; MESENCHYMAL STROMA CELL; METABOLISM;

ADIPOSE TISSUE; AUTOPHAGY; CELL DIFFERENTIATION; CELLS, CULTURED; DIPEPTIDES; HUMANS; MESENCHYMAL STROMAL CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84937838193     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430167     Document Type: Article

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