Decreased MicroRNA-221 is associated with high levels of TNF-α in human adipose tissue-derived mesenchymal stem cells from obese woman

Cellular Physiology and Biochemistry

Volumn 32, Issue 1, 2013, Pages 127-137

  Chou, Wen Wen ^a,b   Wang, Yu Ting ^a   Liao, Yi Chu ^e,f   Chuang, Shih Chang ^c,d   Wang, Shen Nien ^c,d   Juo, Suh Hang Hank ^a,c,g  

^a Department of Medical Research ^*  (Taiwan)

^b Hepatobiliary Division   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^f NATIONAL YANG MING UNIVERSITY   (Taiwan)

^g KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Adipocytes; hASCs; miR 221; Obesity; TNF

Indexed keywords

FATTY ACID BINDING PROTEIN 4; GLUCOSE TRANSPORTER 4; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; MICRORNA 221; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; THROMBOSPONDIN 1; TUMOR NECROSIS FACTOR ALPHA; MESSENGER RNA;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ADIPOSE TISSUE DERIVED MESENCHYMAL STEM CELL; ADULT; ARTICLE; BODY MASS; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPID STORAGE; MESENCHYMAL STEM CELL; OBESITY; PRIORITY JOURNAL; ADIPOSE DERIVED STEM CELL; CLINICAL ARTICLE; CORRELATIONAL STUDY; DISEASE ASSOCIATION; HUMAN ADIPOSE TISSUE DERIVED MESENCHYMAL STEM CELL; HUMAN TISSUE; INFLAMMATION; LEAN BODY WEIGHT; MIDDLE AGED; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DIFFERENTIATION;

ADIPOGENESIS; ADIPOKINES; ADIPOSE TISSUE; ADULT; CYTOKINES; DOWN-REGULATION; FEMALE; HUMANS; LIPID METABOLISM; MESENCHYMAL STROMAL CELLS; MICRORNAS; MIDDLE AGED; OBESITY; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84880181397     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000350131     Document Type: Article

References (40)

1. Schickel R, Boyerinas B, Park SM, Peter ME: Micrornas: Key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 2008;27:5959-5974.
2. Nelson P, Kiriakidou M, Sharma A, Maniataki E, Mourelatos Z: The microrna world: Small is mighty. Trends Biochem Sci 2003;28:534-540.
3. Alvarez-Garcia I, Miska EA: Microrna functions in animal development and human disease. Development 2005;132:4653-4662.
4. Chen KC, Hank Juo SH: Micrornas in atherosclerosis. Kaohsiung J Med Sci 2012;28:631-640.
5. Chen KC, Hsieh IC, Hsi E, Wang YS, Dai CY, Chou WW, Juo SH: Negative feedback regulation between microrna let-7g and the oxldl receptor lox-1. J Cell Sci 2011;124:4115-4124.
6. Dehwah MA, Xu A, Huang Q: Micrornas and type 2 diabetes/obesity. J Genet Genomics 2012;39:11-18.
7. Frost RJ, Olson EN: Control of glucose homeostasis and insulin sensitivity by the let-7 family of micrornas. Proc Natl Acad Sci U S A 2011;108:21075-21080.
8. Romao JM, Jin W, Dodson MV, Hausman GJ, Moore SS, Guan LL: Microrna regulation in mammalian adipogenesis. Exp Biol Med 2011;236:997-1004.
9. Kajimoto K, Naraba H, Iwai N: Microrna and 3t3-l1 pre-adipocyte differentiation. RNA 2006;12:1626-1632.
10. Xie H, Lim B, Lodish HF: Micrornas induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 2009;58:1050-1057.
11. Ono K: Microrna links obesity and impaired glucose metabolism. Cell Res 2011;21:864-866.
12. Martinelli R, Nardelli C, Pilone V, Buonomo T, Liguori R, Castano I, Buono P, Masone S, Persico G, Forestieri P, Pastore L, Sacchetti L: Mir-519d overexpression is associated with human obesity. Obesity 2010;18:2170-2176.
13. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH: Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-4295.
14. Rodriguez AM, Elabd C, Amri EZ, Ailhaud G, Dani C: The human adipose tissue is a source of multipotent stem cells. Biochimie 2005;87:125-128.
15. Esau C, Kang X, Peralta E, Hanson E, Marcusson EG, Ravichandran LV, Sun Y, Koo S, Perera RJ, Jain R, Dean NM, Freier SM, Bennett CF, Lollo B, Griffey R: Microrna-143 regulates adipocyte differentiation. J Biol Chem 2004;279:52361-52365.
16. Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS: Microrna-145 regulates oct4, sox2, and klf4 and represses pluripotency in human embryonic stem cells. Cell 2009;137:647-658.
17. Lee EK, Lee MJ, Abdelmohsen K, Kim W, Kim MM, Srikantan S, Martindale JL, Hutchison ER, Kim HH, Marasa BS, Selimyan R, Egan JM, Smith SR, Fried SK, Gorospe M: Mir-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol 2011;31:626-638.
18. Schenk S, Saberi M, Olefsky JM: Insulin sensitivity: Modulation by nutrients and inflammation. J Clin Invest 2008;118:2992-3002.
19. Neels JG, Olefsky JM: Inflamed fat: What starts the fire? J Clin Invest 2006;116:33-35.
20. Cawthorn WP, Sethi JK: Tnf-alpha and adipocyte biology. FEBS Lett 2008;582:117-131.
21. Katsuki A, Sumida Y, Murashima S, Murata K, Takarada Y, Ito K, Fujii M, Tsuchihashi K, Goto H, Nakatani K, Yano Y: Serum levels of tumor necrosis factor-alpha are increased in obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1998;83:859-862.
22. Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H, Hainque B: Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 2000;85:3338-3342.
23. Straczkowski M, Dzienis-Straczkowska S, Stepien A, Kowalska I, Szelachowska M, Kinalska I: Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-alpha system. J Clin Endocrinol Metab 2002;87:4602-4606.
24. Sato M, Miyazaki T, Nagaya T, Murata Y, Ida N, Maeda K, Seo H: Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells. J Rheumatol 1996;23:432-438.
25. Hu CJ, Lee YL, Shih NY, Yang YY, Charoenfuprasert S, Dai YS, Chang SM, Tsai YH, Tseng H, Liu CY, Leu SJ: Reduction of monocyte chemoattractant protein-1 and interleukin-8 levels by ticlopidine in tnf-alpha stimulated human umbilical vein endothelial cells. J Biomed Biotechnol 2009;2009:917837.
26. Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS: Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest 1997;100:2777-2782.
27. Finck BN, Johnson RW: Tumor necrosis factor (tnf)-alpha induces leptin production through the p55 tnf receptor. Am J Physiol Regul Integr Comp Physiol 2000;278:R537-543.
28. Salajegheh M, Raju R, Schmidt J, Dalakas MC: Upregulation of thrombospondin-1(tsp-1) and its binding partners, cd36 and cd47, in sporadic inclusion body myositis. J Neuroimmunol 2007;187:166-174.
29. Narizhneva NV, Razorenova OV, Podrez EA, Chen J, Chandrasekharan UM, DiCorleto PE, Plow EF, Topol EJ, Byzova TV: Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium. FASEB J 2005;19:1158-1160.
30. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al.: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-295.
31. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, et al.: Leptin levels in human and rodent: Measurement of plasma leptin and ob rna in obese and weight-reduced subjects. Nat Med 1995;1:1155-1161.
32. Varma V, Yao-Borengasser A, Bodles AM, Rasouli N, Phanavanh B, Nolen GT, Kern EM, Nagarajan R, Spencer HJ 3rd, Lee MJ, Fried SK, McGehee RE Jr, Peterson CA, Kern PA: Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance. Diabetes 2008;57:432-439.
33. El Gazzar M, McCall CE: Micrornas distinguish translational from transcriptional silencing during endotoxin tolerance. J Biol Chem 2010;285:20940-20951.
34. Dweep H, Sticht C, Pandey P, Gretz N: Mirwalk-database: Prediction of possible mirna binding sites by "walking" the genes of three genomes. J Biomed Inform 2011;44:839-847.
35. Ortega FJ, Moreno-Navarrete JM, Pardo G, Sabater M, Hummel M, Ferrer A, Rodriguez-Hermosa JI, Ruiz B, Ricart W, Peral B, Fernandez-Real JM: Mirna expression profile of human subcutaneous adipose and during adipocyte differentiation. PloS one 2010;5:e9022.
36. Liao YC, Chou WW, Li YN, Chuang SC, Lin WY, Lakkakula BV, Yu ML, Juo SH: Apelin gene polymorphism influences apelin expression and obesity phenotypes in chinese women. Am J Clin Nutr 2011;94:921-928.
37. Ruan H, Lodish HF: Insulin resistance in adipose tissue: Direct and indirect effects of tumor necrosis factor-alpha. Cytokine Growth Factor Rev 2003;14:447-455.
38. Lorenzo M, Fernandez-Veledo S, Vila-Bedmar R, Garcia-Guerra L, De Alvaro C, Nieto-Vazquez I: Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes. J Anim Sci 2008;86:E94-104.
39. Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G: Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 2001;280:E745-751.
40. Li Y, Tong X, Rumala C, Clemons K, Wang S: Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model. PloS One 2011;6:e26656.