Inhibition of Notch signalling ameliorates experimental inflammatory arthritis

Annals of the Rheumatic Diseases

Volumn 74, Issue 1, 2015, Pages 267-274

  Park, Jong Sung ^a   Kim, Seol Hee ^a   Kim, Kwangmeyung ^b   Jin, Cheng Hao ^c   Choi, Ki Young ^d   Jang, Jiyeon ^a   Choi, Yuri ^a   Gwon, A Ryeong ^a   Baik, Sang Ha ^a   Yun, Ui Jeong ^a   Chae, Su Young ^a   Lee, Seulki ^e   Kang, Young Mo ^f   Lee, Kang Choon ^a   Arumugam, Thiruma V ^a,g   Mattson, Mark P ^h,i   Park, Jae Hyung ^a   Jo, Dong Gyu ^a  

^a Sungkyunkwan University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY   (China)

^d NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f Kyungpook National University School of Medicine   (South Korea)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^h NATIONAL INSTITUTE ON AGING   (United States)

ⁱ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN ANTIBODY; COLLAGEN TYPE 2; COLLAGEN TYPE 2 ANTIBODY; CYTOKINE; CYTOKINE ANTIBODY; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERCELLULAR ADHESION MOLECULE 1; N [N (3,5 DIFLUOROPHENACETYL LEVO ALANYL)] S PHENYLGLYCINE T BUTYL ESTER; NOTCH RECEPTOR; STROMELYSIN; UNCLASSIFIED DRUG; DIPEPTIDE; N-(N-(3,5-DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT-BUTYL ESTER; SECRETASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MONITORING; C57BL 6 MOUSE; CELL STIMULATION; CLINICAL ASSESSMENT; COLLAGEN-INDUCED ARTHRITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL DISEASE; FIBROBLAST; FLUORESCENCE IMAGING; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOREGULATION; IN VIVO STUDY; JOINT DESTRUCTION; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PAW EDEMA; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RECEPTOR BLOCKING; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYMPTOM; SYNOVIOCYTE; TISSUE INJURY; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; EXPERIMENTAL ARTHRITIS; IMMUNOLOGY; SEVERITY OF ILLNESS INDEX; SYNOVIUM;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CYTOKINES; DIPEPTIDES; DISEASE MODELS, ANIMAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, NOTCH; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE;

EID: 84918502975     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2013-203467     Document Type: Article

References (49)

1. Fiuza UM, Arias AM. Cell and molecular biology of Notch. J Endocrinol 2007;194:459-74.
2. Bray S, Bernard F. Notch targets and their regulation. Curr Top Dev Biol 2010;92:253-75.
3. Selkoe D, Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci 2003;26:565-97.
4. Woo HN, Park JS, Gwon AR, et al. Alzheimer's disease and Notch signaling. Biochem Biophys Res Commun 2009;390:1093-7.
5. McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007;7:429-42.
6. Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 1996;14:397-440.
7. Khan IM, Palmer EA, Archer CW. Fibroblast growth factor-2 induced chondrocyte cluster formation in experimentally wounded articular cartilage is blocked by soluble Jagged-1. Osteoarthritis Cartilage 2010;18:208-19.
8. Nakazawa M, Ishii H, Aono H, et al. Role of Notch-1 intracellular domain in activation of rheumatoid synoviocytes. Arthritis Rheum 2001;44:1545-54.
9. Ishii H, Nakazawa M, Yoshino S, et al. Expression of notch homologues in the synovium of rheumatoid arthritis and osteoarthritis patients. Rheumatol Int 2001;21:10-14.
10. Ando K, Kanazawa S, Tetsuka T, et al. Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts. Oncogene 2003;22:7796-803.
11. Kijima M, Iwata A, Maekawa Y, et al. Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells. J Immunol 2009;182:3566-72.
12. Jiao Z, Wang W, Guo M, et al. Expression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis. Scand J Rheumatol 2010;39:26-32.
13. Gao W, Sweeney C, Connolly M, et al. Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum 2012;64:2104-13.
14. Gao W, Sweeney C, Walsh C, et al. Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2. Ann Rheum Dis 2013;72:1080-8.
15. Minter LM, Turley DM, Das P, et al. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol 2005;6:680-8.
16. Niranjan T, Bielesz B, Gruenwald A, et al. The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med 2008;14:290-8.
17. Arumugam TV, Chan SL, Jo DG, et al. Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med 2006;12:621-3.
18. Arumugam TV, Cheng YL, Choi Y, et al. Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke. Mol Pharmacol 2011;80:23-31.
19. Wei Z, Chigurupati S, Arumugam TV, et al. Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia. Stroke 2011;42:2589-94.
20. Cheng P, Zlobin A, Volgina V, et al. Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells. J Immunol 2001;167:4458-67.
21. Inglis JJ, Simelyte E, McCann FE, et al. Protocol for the induction of arthritis in C57BL/6 mice. Nat Protoc 2008;3:612-18.
22. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
23. Park JH, Kwon S, Nam JO, et al. Self-assembled nanoparticles based on glycol chitosan bearing 5beta-cholanic acid for RGD peptide delivery. J Control Release 2004;95:579-88.
24. Feldmann M, Maini RN. Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med 2003;9:1245-50.
25. Metselaar JM, Wauben MH, Wagenaar-Hilbers JP, et al. Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes. Arthritis Rheum 2003;48:2059-66.
26. Boerman OC, Oyen WJ, Storm G, et al. Technetium-99 m labelled liposomes to image experimental arthritis. Ann Rheum Dis 1997;56:369-73.
27. Dams ET, Reijnen MM, Oyen WJ, et al. Imaging experimental intraabdominal abscesses with 99mTc-PEG liposomes and 99mTc-HYNIC IgG. Ann Surg 1999;229:551-7.
28. Paleolog EM, Fava RA. Angiogenesis in rheumatoid arthritis: implications for future therapeutic strategies. Springer Semin Immunopathol 1998;20:73-94.
29. Park K, Kim JH, Nam YS, et al. Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles. J Control Release 2007;122:305-14.
30. Koo H, Huh MS, Sun IC, et al. In Vivo Targeted Delivery of Nanoparticles for Theranosis. Acc Chem Res 2011;44:1018-28.
31. Lee S, Cha EJ, Park K, et al. A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination. Angew Chem Int Ed Engl 2008;47:2804-7.
32. Sandanaraj BS, Gremlich HU, Kneuer R, et al. Fluorescent nanoprobes as a biomarker for increased vascular permeability: implications in diagnosis and treatment of cancer and inflammation. Bioconjug Chem 2010;21:93-101.
33. Kevorkian L, Young DA, Darrah C, et al. Expression profiling of metalloproteinases and their inhibitors in cartilage. Arthritis Rheum 2004;50:131-41.
34. Eguchi T, Kubota S, Kawata K, et al. Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene. Mol Cell Biol 2008;28:2391-413.
35. Ryu JH, Lee A, Chu JU, et al. Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic matrix metalloproteinase 3-specific polymeric probe. Arthritis Rheum 2011;63:3824-32.
36. Woo HN, Baik SH, Park JS, et al. Secretases as therapeutic targets for Alzheimer's disease. Biochem Biophys Res Commun 2011;404:10-5.
37. Espinosa L, Cathelin S, D'Altri T, et al. The Notch/Hes1 pathway sustains NF-kappaB activation through CYLD repression in T cell leukemia. Cancer Cell 2010;18:268-81.
38. Shin HM, Minter LM, Cho OH, et al. Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J 2006;25:129-38.
39. Maillard I, Fang T, Pear WS. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol 2005;23:945-74.
40. Yang CM, Luo SF, Hsieh HL, et al. Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: involvement of ERK, JNK, AP-1, and NF-kappaB. J Cell Physiol 2010;224:516-26.
41. Yabe Y, Matsumoto T, Tsurumoto T, et al. Immunohistological localization of Notch receptors and their ligands Delta and Jagged in synovial tissues of rheumatoid arthritis. J Orthop Sci 2005;10:589-94.
42. Elyaman W, Bradshaw EM, Wang Y, et al. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J Immunol 2007;179:5990-8.
43. Sekine C, Koyanagi A, Koyama N, et al. Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes. Arthritis Res Ther 2012;14:R45.
44. Benedito R, Roca C, Sorensen I, et al. The notch ligands D114 and Jagged1 have opposing effects on angiogenesis. Cell 2009;137:1124-35.
45. Hellstrom M, Phng LK, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007;445:776-80.
46. Ridgway J, Zhang G, Wu Y, et al. Inhibition of D114 signalling inhibits tumour growth by deregulating angiogenesis. Nature 2006;444:1083-7.
47. Shawber CJ, Das I, Francisco E, et al. Notch signaling in primary endothelial cells. Ann N Y Acad Sci 2003;995:162-70.
48. Sainson RC, Johnston DA, Chu HC, et al. TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood 2008;111:4997-5007.
49. Radtke F, Wilson A, Mancini SJ, et al. Notch regulation of lymphocyte development and function. Nat Immunol 2004;5:247-53.