메뉴 건너뛰기




Volumn 759, Issue , 2015, Pages 221-230

Validity of animal models of type 1 diabetes, and strategies to enhance their utility in translational research

Author keywords

Animal models; Cell therapy; Immunosuppressives; Nonhuman primate; Rodent; Type 1 diabetes

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

EID: 84937761242     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.02.054     Document Type: Review
Times cited : (52)

References (141)
  • 2
    • 84973276003 scopus 로고    scopus 로고
    • The role of T regulatory cells (Tregs) in the development and prevention of type 1 diabetes
    • T. Agathocles The role of T regulatory cells (Tregs) in the development and prevention of type 1 diabetes J. Clin. Cell. Immunol. S2 2012 003
    • (2012) J. Clin. Cell. Immunol. , vol.2 S , pp. 003
    • Agathocles, T.1
  • 3
    • 84877054560 scopus 로고    scopus 로고
    • Low C-peptide levels and decreased expression of TNF and CD45 in children with high risk of type 1 diabetes
    • L. Åkerman, J. Ludvigsson, and R. Casas Low C-peptide levels and decreased expression of TNF and CD45 in children with high risk of type 1 diabetes Clin. Immunol. 148 2013 4 15
    • (2013) Clin. Immunol. , vol.148 , pp. 4-15
    • Åkerman, L.1    Ludvigsson, J.2    Casas, R.3
  • 4
    • 58849102225 scopus 로고    scopus 로고
    • 2008 Update from the Collaborative Islet Transplant Registry
    • Collaborative Islet Transplant Registry Investigators
    • R. Alejandro, F.B. Barton, B.J. Hering, and S. Wease 2008 Update from the Collaborative Islet Transplant Registry Collaborative Islet Transplant Registry Investigators Transplantation 86 2008 1783 1788
    • (2008) Transplantation , vol.86 , pp. 1783-1788
    • Alejandro, R.1    Barton, F.B.2    Hering, B.J.3    Wease, S.4
  • 5
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: a model of immune dysregulation
    • M.S. Anderson, and J.A. Bluestone The NOD mouse: a model of immune dysregulation Annu. Rev. Immunol. 23 2005 447 485
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 447-485
    • Anderson, M.S.1    Bluestone, J.A.2
  • 6
    • 0242609973 scopus 로고    scopus 로고
    • Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus
    • E. Araki, S. Oyadomari, and M. Mori Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus Exp. Biol. Med. (Maywood) 228 2003 1213 1217
    • (2003) Exp. Biol. Med. (Maywood) , vol.228 , pp. 1213-1217
    • Araki, E.1    Oyadomari, S.2    Mori, M.3
  • 9
    • 0037094032 scopus 로고    scopus 로고
    • Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice
    • M. Bao, Y. Yang, H.S. Jun, and J.W. Yoon Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice J. Immunol. 168 2002 5369 5375
    • (2002) J. Immunol. , vol.168 , pp. 5369-5375
    • Bao, M.1    Yang, Y.2    Jun, H.S.3    Yoon, J.W.4
  • 11
    • 80755128378 scopus 로고    scopus 로고
    • Impact of islet transplantation on diabetes complications and quality of life
    • R. Bassi, and P. Fiorina Impact of islet transplantation on diabetes complications and quality of life Curr. Diab. Rep. 11 2011 355 363
    • (2011) Curr. Diab. Rep. , vol.11 , pp. 355-363
    • Bassi, R.1    Fiorina, P.2
  • 15
    • 0028931246 scopus 로고
    • A simulation model for glucose kinetics and estimates of glucose utilization rate in type 1 diabetic patients
    • M. Boroujerdi, A. Umpleby, R. Jones, and P. Sonksen A simulation model for glucose kinetics and estimates of glucose utilization rate in type 1 diabetic patients Am. J. Physiol. 31 1995 E766 E774
    • (1995) Am. J. Physiol. , vol.31 , pp. E766-E774
    • Boroujerdi, M.1    Umpleby, A.2    Jones, R.3    Sonksen, P.4
  • 18
    • 0018698403 scopus 로고
    • Acute effects of streptozotocin diabetes on rat renal function
    • S.L. Carney, N.L. Wong, and J.H. Dirks Acute effects of streptozotocin diabetes on rat renal function J. Lab. Clin. Med. 93 1979 950 961
    • (1979) J. Lab. Clin. Med. , vol.93 , pp. 950-961
    • Carney, S.L.1    Wong, N.L.2    Dirks, J.H.3
  • 20
    • 0023753771 scopus 로고
    • Effect of prolonged administration of cyclosporin A on (pro) insulin biosynthesis and insulin release by rat islets of Langerhans
    • B. Chandrasekar, and S. Mukherjee Effect of prolonged administration of cyclosporin A on (pro) insulin biosynthesis and insulin release by rat islets of Langerhans Biochem. Pharmacol. 37 1988 3609 3611
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 3609-3611
    • Chandrasekar, B.1    Mukherjee, S.2
  • 21
    • 84934440597 scopus 로고    scopus 로고
    • Assessment of diabetic nephropathy in the Akita mouse
    • H.G. Joost, H. Al-Hasani, A. Schürmann, Springer Science+Business Media
    • J. Chang, and S.B. Gurley Assessment of diabetic nephropathy in the Akita mouse H.G. Joost, H. Al-Hasani, A. Schürmann, Animal Models in Diabetes Research. Methods in Molecular Biology vol. 933 2012 Springer Science+Business Media 17 29
    • (2012) Animal Models in Diabetes Research. Methods in Molecular Biology , vol.933 , pp. 17-29
    • Chang, J.1    Gurley, S.B.2
  • 22
    • 33947587491 scopus 로고    scopus 로고
    • Preclinical safety testing of monoclonal antibodies: the significance of species relevance
    • K. Chapman, N. Pullen, M. Graham, and I. Ragan Preclinical safety testing of monoclonal antibodies: the significance of species relevance Nat. Rev. Drug Discovery 6 2007 120 126
    • (2007) Nat. Rev. Drug Discovery , vol.6 , pp. 120-126
    • Chapman, K.1    Pullen, N.2    Graham, M.3    Ragan, I.4
  • 23
    • 0020564729 scopus 로고
    • The discovery and development of the BB rat colony: an animal model of spontaneous diabetes mellitus
    • C. Chappel, and W. Chappel The discovery and development of the BB rat colony: an animal model of spontaneous diabetes mellitus Metab. Clin. Exp. 32 1983 8 10
    • (1983) Metab. Clin. Exp. , vol.32 , pp. 8-10
    • Chappel, C.1    Chappel, W.2
  • 24
    • 0033693585 scopus 로고    scopus 로고
    • Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells
    • R. Chen, M. Meseck, R.C. McEvoy, and S.L. Woo Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells Gene Ther. 7 2000 1802 1809
    • (2000) Gene Ther. , vol.7 , pp. 1802-1809
    • Chen, R.1    Meseck, M.2    Mcevoy, R.C.3    Woo, S.L.4
  • 25
    • 0031937692 scopus 로고    scopus 로고
    • Animal models of type I (insulin-dependent) diabetes mellitus
    • D. Cheţa Animal models of type I (insulin-dependent) diabetes mellitus J. Pediatr. Endocrinol. Metab. 11 1998 11 19
    • (1998) J. Pediatr. Endocrinol. Metab. , vol.11 , pp. 11-19
    • Cheţa, D.1
  • 27
    • 70349597644 scopus 로고    scopus 로고
    • The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial
    • D.K.C. Cooper, and A. Casu The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial Xenotransplantation 16 2009 229 238
    • (2009) Xenotransplantation , vol.16 , pp. 229-238
    • Cooper, D.K.C.1    Casu, A.2
  • 29
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group
    • DCCT The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus The Diabetes Control and Complications Trial Research Group N. Engl. J. Med. 329 1993 977 986
    • (1993) N. Engl. J. Med. , vol.329 , pp. 977-986
    • Dcct1
  • 31
    • 84876380021 scopus 로고    scopus 로고
    • Real-world factors affecting adherence to insulin therapy in patients with Type 1 or Type 2 diabetes mellitus: a systematic review
    • M. Davies, J. Gagliardino, L. Gray, K. Khunti, V. Mohan, and R. Hughes Real-world factors affecting adherence to insulin therapy in patients with Type 1 or Type 2 diabetes mellitus: a systematic review Diabet. Med. 30 2013 512 524
    • (2013) Diabet. Med. , vol.30 , pp. 512-524
    • Davies, M.1    Gagliardino, J.2    Gray, L.3    Khunti, K.4    Mohan, V.5    Hughes, R.6
  • 33
    • 84921911047 scopus 로고    scopus 로고
    • Animal models in translational medicine: validation and prediction
    • T. Denayer, T. Stöhr, and M. Van Roy Animal models in translational medicine: validation and prediction New Horiz. Transl. Med. 2 2014 5 11
    • (2014) New Horiz. Transl. Med. , vol.2 , pp. 5-11
    • Denayer, T.1    Stöhr, T.2    Van Roy, M.3
  • 34
    • 79251621206 scopus 로고    scopus 로고
    • Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease
    • J.P. Driver, D.V. Serreze, and Y. Chen Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease Semin. Immunopathol. 33 2011 67 87
    • (2011) Semin. Immunopathol. , vol.33 , pp. 67-87
    • Driver, J.P.1    Serreze, D.V.2    Chen, Y.3
  • 35
    • 33744496021 scopus 로고    scopus 로고
    • Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates: proof of concept
    • D. Dufrane, R.M. Goebbels, A. Saliez, Y. Guiot, and P. Gianello Six-month survival of microencapsulated pig islets and alginate biocompatibility in primates: proof of concept Transplantation 81 2006 1345 1353
    • (2006) Transplantation , vol.81 , pp. 1345-1353
    • Dufrane, D.1    Goebbels, R.M.2    Saliez, A.3    Guiot, Y.4    Gianello, P.5
  • 36
    • 84908504693 scopus 로고    scopus 로고
    • Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans
    • C.O. Eleazu, K.C. Eleazu, S. Chukwuma, and U.N. Essien Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans J. Diabetes Metab. Disord. 23 60 2013 6581-12-60
    • (2013) J. Diabetes Metab. Disord. , vol.23 , Issue.60
    • Eleazu, C.O.1    Eleazu, K.C.2    Chukwuma, S.3    Essien, U.N.4
  • 39
    • 0035885180 scopus 로고    scopus 로고
    • The pig: a new model of diabetic atherosclerosis
    • J. Fricker The pig: a new model of diabetic atherosclerosis Drug Discovery Today 6 2001 921 922
    • (2001) Drug Discovery Today , vol.6 , pp. 921-922
    • Fricker, J.1
  • 40
    • 22944476837 scopus 로고    scopus 로고
    • The α-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy
    • U. Galili The α-gal epitope and the anti-Gal antibody in xenotransplantation and in cancer immunotherapy Immunol. Cell Biol. 83 2005 674 686
    • (2005) Immunol. Cell Biol. , vol.83 , pp. 674-686
    • Galili, U.1
  • 41
    • 54749140900 scopus 로고    scopus 로고
    • Absence of transmission of potentially xenotic viruses in a prospective pig to primate islet xenotransplantation study
    • O. Garkavenko, B. Dieckhoff, S. Wynyard, J. Denner, R.B. Elliott, P.L. Tan, and M.C. Croxson Absence of transmission of potentially xenotic viruses in a prospective pig to primate islet xenotransplantation study J. Med. Virol. 80 2008 2046 2052
    • (2008) J. Med. Virol. , vol.80 , pp. 2046-2052
    • Garkavenko, O.1    Dieckhoff, B.2    Wynyard, S.3    Denner, J.4    Elliott, R.B.5    Tan, P.L.6    Croxson, M.C.7
  • 42
    • 21644490074 scopus 로고    scopus 로고
    • Nonhuman primate models for islet transplantation in type 1 diabetes research
    • L.K. Gaur Nonhuman primate models for islet transplantation in type 1 diabetes research ILAR J. 45 2004 324 333
    • (2004) ILAR J. , vol.45 , pp. 324-333
    • Gaur, L.K.1
  • 44
    • 0035405575 scopus 로고    scopus 로고
    • Diabetes-induced accelerated atherosclerosis in swine
    • R.G. Gerrity, R. Natarajan, J.L. Nadler, and T. Kimsey Diabetes-induced accelerated atherosclerosis in swine Diabetes 50 2001 1654 1665
    • (2001) Diabetes , vol.50 , pp. 1654-1665
    • Gerrity, R.G.1    Natarajan, R.2    Nadler, J.L.3    Kimsey, T.4
  • 45
    • 84873468988 scopus 로고    scopus 로고
    • The usefulness and limitations of the diabetic macaque model in evaluating long-term porcine islet xenograft survival
    • M.L. Graham, and H.-J. Schuurman The usefulness and limitations of the diabetic macaque model in evaluating long-term porcine islet xenograft survival Xenotransplantation 20 2013 5 17
    • (2013) Xenotransplantation , vol.20 , pp. 5-17
    • Graham, M.L.1    Schuurman, H.-J.2
  • 48
    • 83755206323 scopus 로고    scopus 로고
    • Species incompatibilities in the pig-to-macaque islet xenotransplant model affect transplant outcome: a comparison with allotransplantation
    • M.L. Graham, M.D. Bellin, K.K. Papas, B.J. Hering, and H.-J. Schuurman Species incompatibilities in the pig-to-macaque islet xenotransplant model affect transplant outcome: a comparison with allotransplantation Xenotransplantation 18 2011 328 342
    • (2011) Xenotransplantation , vol.18 , pp. 328-342
    • Graham, M.L.1    Bellin, M.D.2    Papas, K.K.3    Hering, B.J.4    Schuurman, H.-J.5
  • 49
    • 84857480181 scopus 로고    scopus 로고
    • The streptozotocin-induced diabetic nude mouse model: differences between animals from different sources
    • M.L. Graham, J.L. Janecek, J.A. Kittredge, B.J. Hering, and H.-J. Schuurman The streptozotocin-induced diabetic nude mouse model: differences between animals from different sources Comp. Med. 61 2011 356 360
    • (2011) Comp. Med. , vol.61 , pp. 356-360
    • Graham, M.L.1    Janecek, J.L.2    Kittredge, J.A.3    Hering, B.J.4    Schuurman, H.-J.5
  • 55
    • 0034909162 scopus 로고    scopus 로고
    • Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere
    • D.L. Greiner, A.A. Rossini, and J.P. Mordes Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere Clin. Immunol. 100 2001 134 143
    • (2001) Clin. Immunol. , vol.100 , pp. 134-143
    • Greiner, D.L.1    Rossini, A.A.2    Mordes, J.P.3
  • 58
    • 59249088016 scopus 로고    scopus 로고
    • Non-human primate models in allo-transplantation research: a short review
    • K.G. Haanstra, and M. Jonker Non-human primate models in allo-transplantation research: a short review Drug Discovery Today Dis. Models 5 2008 73 79
    • (2008) Drug Discovery Today Dis. Models , vol.5 , pp. 73-79
    • Haanstra, K.G.1    Jonker, M.2
  • 59
    • 0035491791 scopus 로고    scopus 로고
    • Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set?
    • P.A. Halban, S.E. Kahn, A. Lernmark, and C.J. Rhodes Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set? Diabetes 50 2001 2181 2191
    • (2001) Diabetes , vol.50 , pp. 2181-2191
    • Halban, P.A.1    Kahn, S.E.2    Lernmark, A.3    Rhodes, C.J.4
  • 61
    • 0020044140 scopus 로고
    • Nonhuman primates as models for the study of human diabetes mellitus
    • C.F. Howard Jr Nonhuman primates as models for the study of human diabetes mellitus Diabetes 31 1982 37 42
    • (1982) Diabetes , vol.31 , pp. 37-42
    • Howard, C.F.1
  • 62
    • 0028325527 scopus 로고
    • Irreversible loss of normal beta-cell regulation by glucose in neonatally streptozotocin diabetic rats
    • K. Inoue, M. Cetkovic-Cvrlje, D.L. Eizirik, and V. Grill Irreversible loss of normal beta-cell regulation by glucose in neonatally streptozotocin diabetic rats Diabetologia 37 1994 351 357
    • (1994) Diabetologia , vol.37 , pp. 351-357
    • Inoue, K.1    Cetkovic-Cvrlje, M.2    Eizirik, D.L.3    Grill, V.4
  • 64
    • 84889006121 scopus 로고    scopus 로고
    • The long-term effects of type 1 diabetes treatment and complications on health-related quality of life: a 23-year follow-up of the Diabetes Control and Complications/Epidemiology of Diabetes Interventions and Complications cohort
    • A.M. Jacobson, B.H. Braffett, P.A. Cleary, R.A. Gubitosi-Klug, and M.E. Larkin The long-term effects of type 1 diabetes treatment and complications on health-related quality of life: a 23-year follow-up of the Diabetes Control and Complications/Epidemiology of Diabetes Interventions and Complications cohort Diabetes Care 36 2013 3131 3138
    • (2013) Diabetes Care , vol.36 , pp. 3131-3138
    • Jacobson, A.M.1    Braffett, B.H.2    Cleary, P.A.3    Gubitosi-Klug, R.A.4    Larkin, M.E.5
  • 65
    • 0035076588 scopus 로고    scopus 로고
    • The role of viruses in type 1 diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals
    • H. Jun, and J. Yoon The role of viruses in type 1 diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals Diabetologia 44 2001 271 285
    • (2001) Diabetologia , vol.44 , pp. 271-285
    • Jun, H.1    Yoon, J.2
  • 66
    • 0014606996 scopus 로고
    • Diabetogenic action of streptozotocin: relationship of dose to metabolic response
    • A. Junod, A.E. Lambert, W. Stauffacher, and A.E. Renold Diabetogenic action of streptozotocin: relationship of dose to metabolic response J. Clin. Invest. 48 1969 2129 2139
    • (1969) J. Clin. Invest. , vol.48 , pp. 2129-2139
    • Junod, A.1    Lambert, A.E.2    Stauffacher, W.3    Renold, A.E.4
  • 67
    • 0025987029 scopus 로고
    • Low dose streptozotocin causes stimulation of the immune system and of anti-islet cytotoxicity in mice
    • G. Kantwerk-Funke, V. Burkart, and H. Kolb Low dose streptozotocin causes stimulation of the immune system and of anti-islet cytotoxicity in mice Clin. Exp. Immunol. 86 1991 266 270
    • (1991) Clin. Exp. Immunol. , vol.86 , pp. 266-270
    • Kantwerk-Funke, G.1    Burkart, V.2    Kolb, H.3
  • 68
    • 0019982401 scopus 로고
    • Low-dose streptozotocin-induced autoimmune diabetes is under the genetic control of the major histocompatibility complex in mice
    • U. Kiesel, and H. Kolb Low-dose streptozotocin-induced autoimmune diabetes is under the genetic control of the major histocompatibility complex in mice Diabetologia 23 1982 69 71
    • (1982) Diabetologia , vol.23 , pp. 69-71
    • Kiesel, U.1    Kolb, H.2
  • 69
    • 84860845827 scopus 로고    scopus 로고
    • The use of animal models in diabetes research
    • A.J. King The use of animal models in diabetes research Br. J. Pharmacol. 166 2012 877 894
    • (2012) Br. J. Pharmacol. , vol.166 , pp. 877-894
    • King, A.J.1
  • 70
    • 0033382193 scopus 로고    scopus 로고
    • Transplantation tolerance: a look at the nonhuman primate literature in the light of modern tolerance theories
    • A.D. Kirk Transplantation tolerance: a look at the nonhuman primate literature in the light of modern tolerance theories Crit. Rev. Immunol. 19 1999 349 388
    • (1999) Crit. Rev. Immunol. , vol.19 , pp. 349-388
    • Kirk, A.D.1
  • 71
    • 33746821137 scopus 로고    scopus 로고
    • Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model
    • S.J. Koopmans, Z. Mroz, R. Dekker, H. Corbijn, M. Ackermans, and H. Sauerwein Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model Metab. Clin. Exp. 55 2006 960 971
    • (2006) Metab. Clin. Exp. , vol.55 , pp. 960-971
    • Koopmans, S.J.1    Mroz, Z.2    Dekker, R.3    Corbijn, H.4    Ackermans, M.5    Sauerwein, H.6
  • 72
    • 79956190438 scopus 로고    scopus 로고
    • The existence of an insulin-stimulated glucose and non-essential but not essential amino acid substrate interaction in diabetic pigs
    • S.J. Koopmans, J. VanderMeulen, J. Wijdenes, H. Corbijn, and R. Dekker The existence of an insulin-stimulated glucose and non-essential but not essential amino acid substrate interaction in diabetic pigs BMC Biochem. 12 2011 25 2091-12-25
    • (2011) BMC Biochem. , vol.12
    • Koopmans, S.J.1    Vandermeulen, J.2    Wijdenes, J.3    Corbijn, H.4    Dekker, R.5
  • 73
    • 0037355040 scopus 로고    scopus 로고
    • The effect of low versus high dose of streptozotocin in cynomolgus monkeys (Macaca fascilularis)
    • M. Koulmanda, A. Qipo, S. Chebrolu, J. O'Neil, H. Auchincloss, and R.N. Smith The effect of low versus high dose of streptozotocin in cynomolgus monkeys (Macaca fascilularis) Am. J. Transplant. 3 2003 267 272
    • (2003) Am. J. Transplant. , vol.3 , pp. 267-272
    • Koulmanda, M.1    Qipo, A.2    Chebrolu, S.3    O'neil, J.4    Auchincloss, H.5    Smith, R.N.6
  • 74
    • 69949146908 scopus 로고    scopus 로고
    • In silico preclinical trials: a proof of concept in closed-loop control of type 1 diabetes
    • B.P. Kovatchev, M. Breton, C.D. Man, and C. Cobelli In silico preclinical trials: a proof of concept in closed-loop control of type 1 diabetes J. Diabetes Sci. Technol. 3 2009 44 55
    • (2009) J. Diabetes Sci. Technol. , vol.3 , pp. 44-55
    • Kovatchev, B.P.1    Breton, M.2    Man, C.D.3    Cobelli, C.4
  • 75
    • 0029128706 scopus 로고
    • Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins
    • K.O. Kyvik, A. Green, and H. Beck-Nielsen Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins BMJ 311 1995 913 917
    • (1995) BMJ , vol.311 , pp. 913-917
    • Kyvik, K.O.1    Green, A.2    Beck-Nielsen, H.3
  • 76
    • 0024450546 scopus 로고
    • Lessons from the NOD mouse for the pathogenesis and immunotherapy of human type 1 (insulin-dependent) diabetes mellitus
    • E. Lampeter, A. Signore, E. Gale, and P. Pozzilli Lessons from the NOD mouse for the pathogenesis and immunotherapy of human type 1 (insulin-dependent) diabetes mellitus Diabetologia 32 1989 703 708
    • (1989) Diabetologia , vol.32 , pp. 703-708
    • Lampeter, E.1    Signore, A.2    Gale, E.3    Pozzilli, P.4
  • 77
    • 84878870797 scopus 로고    scopus 로고
    • Blood glucose levels in rhesus monkeys (Macaca mulatta) and cynomolgus macaques (Macaca fascicularis) under moderate stress and after recovery
    • B. Lapin, T. Gvozdik, and I. Klots Blood glucose levels in rhesus monkeys (Macaca mulatta) and cynomolgus macaques (Macaca fascicularis) under moderate stress and after recovery Bull. Exp. Biol. Med. 154 2013 497 500
    • (2013) Bull. Exp. Biol. Med. , vol.154 , pp. 497-500
    • Lapin, B.1    Gvozdik, T.2    Klots, I.3
  • 79
    • 21644473153 scopus 로고    scopus 로고
    • Use of the Göttingen minipig as a model of diabetes, with special focus on type 1 diabetes research
    • M.O. Larsen, and B. Rolin Use of the Göttingen minipig as a model of diabetes, with special focus on type 1 diabetes research ILAR J. 45 2004 303 313
    • (2004) ILAR J. , vol.45 , pp. 303-313
    • Larsen, M.O.1    Rolin, B.2
  • 80
    • 0034707028 scopus 로고    scopus 로고
    • Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
    • H.C. Lee, S. Kim, K. Kim, H. Shin, and J. Yoon Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue Nature 408 2000 483 488
    • (2000) Nature , vol.408 , pp. 483-488
    • Lee, H.C.1    Kim, S.2    Kim, K.3    Shin, H.4    Yoon, J.5
  • 81
    • 84879195102 scopus 로고    scopus 로고
    • Porcine islet adaptation to metabolic need of monkeys in pig-to-monkey intraportal islet xenotransplantation
    • J. Lee, J. Shin, W. Jung, G. Lee, M. Kim, Y. Kim, J. Choi, C. Park, and S. Kim Porcine islet adaptation to metabolic need of monkeys in pig-to-monkey intraportal islet xenotransplantation Transplant. Proc. 45 2013 1866 1868
    • (2013) Transplant. Proc. , vol.45 , pp. 1866-1868
    • Lee, J.1    Shin, J.2    Jung, W.3    Lee, G.4    Kim, M.5    Kim, Y.6    Choi, J.7    Park, C.8    Kim, S.9
  • 83
    • 0020024396 scopus 로고
    • Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: influence of inbred background, sex, and thymus
    • E.H. Leiter Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: influence of inbred background, sex, and thymus Proc. Natl. Acad. Sci. U.S.A. 79 1982 630 634
    • (1982) Proc. Natl. Acad. Sci. U.S.A. , vol.79 , pp. 630-634
    • Leiter, E.H.1
  • 85
    • 37549029242 scopus 로고    scopus 로고
    • The mechanisms of alloxan- and streptozotocin-induced diabetes
    • S. Lenzen The mechanisms of alloxan- and streptozotocin-induced diabetes Diabetologia 51 2008 216 226
    • (2008) Diabetologia , vol.51 , pp. 216-226
    • Lenzen, S.1
  • 91
    • 84892372344 scopus 로고    scopus 로고
    • Animal models of human disease: challenges in enabling translation
    • P. McGonigle, and B. Ruggeri Animal models of human disease: challenges in enabling translation Biochem. Pharmacol. 87 2014 162 171
    • (2014) Biochem. Pharmacol. , vol.87 , pp. 162-171
    • Mcgonigle, P.1    Ruggeri, B.2
  • 92
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: differences between mouse and human immunology
    • J. Mestas, and C.C. Hughes Of mice and not men: differences between mouse and human immunology J. Immunol. 172 2004 2731 2738
    • (2004) J. Immunol. , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 93
    • 84880874176 scopus 로고    scopus 로고
    • Measuring the global burden of disease
    • C.J. Murray, and A.D. Lopez Measuring the global burden of disease N. Engl. J. Med. 369 2013 448 457
    • (2013) N. Engl. J. Med. , vol.369 , pp. 448-457
    • Murray, C.J.1    Lopez, A.D.2
  • 94
    • 0034663422 scopus 로고    scopus 로고
    • Cell receptors involved in adenovirus entry
    • G.R. Nemerow Cell receptors involved in adenovirus entry Virology 274 2000 1 4
    • (2000) Virology , vol.274 , pp. 1-4
    • Nemerow, G.R.1
  • 95
    • 70349584375 scopus 로고    scopus 로고
    • The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 6: patient selection for pilot clinical trials of islet xenotransplantation
    • P.J. O'Connell The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 6: patient selection for pilot clinical trials of islet xenotransplantation Xenotransplantation 16 2009 249 254
    • (2009) Xenotransplantation , vol.16 , pp. 249-254
    • O'connell, P.J.1
  • 97
    • 11144280131 scopus 로고    scopus 로고
    • Differentiating between effects of streptozotocin per se and subsequent hyperglycemia on renal function and metabolism in the streptozotocin-diabetic rat model
    • F. Palm, H. Ortsäter, P. Hansell, P. Liss, and P.O. Carlsson Differentiating between effects of streptozotocin per se and subsequent hyperglycemia on renal function and metabolism in the streptozotocin-diabetic rat model Diabetes Metab. Res. Rev. 20 2004 452 459
    • (2004) Diabetes Metab. Res. Rev. , vol.20 , pp. 452-459
    • Palm, F.1    Ortsäter, H.2    Hansell, P.3    Liss, P.4    Carlsson, P.O.5
  • 98
    • 73449118597 scopus 로고    scopus 로고
    • Diabetic rats and mice are resistant to porcine and human insulin: flawed experimental models for testing islet xenografts
    • A.R. Pepper, C. Gall, D.M. Mazzuca, C.W.J. Melling, and D.J. White Diabetic rats and mice are resistant to porcine and human insulin: flawed experimental models for testing islet xenografts Xenotransplantation 16 2009 502 510
    • (2009) Xenotransplantation , vol.16 , pp. 502-510
    • Pepper, A.R.1    Gall, C.2    Mazzuca, D.M.3    Melling, C.W.J.4    White, D.J.5
  • 100
  • 105
    • 10244255039 scopus 로고    scopus 로고
    • Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes
    • B.O. Roep, M. Atkinson, and M. von Herrath Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes Nat. Rev. Immunol. 4 2004 989 997
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 989-997
    • Roep, B.O.1    Atkinson, M.2    Von Herrath, M.3
  • 107
    • 0033978827 scopus 로고    scopus 로고
    • Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes
    • J.G. Rosmalen, T. Martin, C. Dobbs, J.S. Voerman, H.A. Drexhage, K. Haskins, and P.J. Leenen Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes Lab. Invest. 80 2000 23 30
    • (2000) Lab. Invest. , vol.80 , pp. 23-30
    • Rosmalen, J.G.1    Martin, T.2    Dobbs, C.3    Voerman, J.S.4    Drexhage, H.A.5    Haskins, K.6    Leenen, P.J.7
  • 109
    • 84876711566 scopus 로고    scopus 로고
    • Altered immune profile from pre-diabetes to manifestation of type 1 diabetes
    • A. Rydén, and M. Faresjö Altered immune profile from pre-diabetes to manifestation of type 1 diabetes Diabetes Res. Clin. Pract. 100 2013 74 84
    • (2013) Diabetes Res. Clin. Pract. , vol.100 , pp. 74-84
    • Rydén, A.1    Faresjö, M.2
  • 110
    • 33646467664 scopus 로고    scopus 로고
    • Strategies to optimize the validity of disease models in the drug discovery process
    • F. Sams-Dodd Strategies to optimize the validity of disease models in the drug discovery process Drug Discovery Today 11 2006 355 363
    • (2006) Drug Discovery Today , vol.11 , pp. 355-363
    • Sams-Dodd, F.1
  • 111
  • 118
    • 0035938721 scopus 로고    scopus 로고
    • Studies illuminate cause of fatal reaction in gene-therapy trial
    • J. Stephenson Studies illuminate cause of fatal reaction in gene-therapy trial JAMA 285 2001 2570-2570
    • (2001) JAMA , vol.285 , pp. 2570-2570
    • Stephenson, J.1
  • 120
    • 79951508861 scopus 로고    scopus 로고
    • Reduced progression of diabetic microvascular complications with islet cell transplantation compared with intensive medical therapy
    • D.M. Thompson, M. Meloche, Z. Ao, B. Paty, P. Keown, R.J. Shapiro, S. Ho, D. Worsley, M. Fung, and G. Meneilly Reduced progression of diabetic microvascular complications with islet cell transplantation compared with intensive medical therapy Transplantation 91 2011 373 378
    • (2011) Transplantation , vol.91 , pp. 373-378
    • Thompson, D.M.1    Meloche, M.2    Ao, Z.3    Paty, B.4    Keown, P.5    Shapiro, R.J.6    Ho, S.7    Worsley, D.8    Fung, M.9    Meneilly, G.10
  • 122
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • R. Tisch, and H. McDevitt Insulin-dependent diabetes mellitus Cell 85 1996 291 297
    • (1996) Cell , vol.85 , pp. 291-297
    • Tisch, R.1    Mcdevitt, H.2
  • 123
    • 0037198427 scopus 로고    scopus 로고
    • Effects of insulin in relatives of patients with type 1 diabetes mellitus
    • Type 1 Diabetes Study Group, Diabetes Prevention Trial Effects of insulin in relatives of patients with type 1 diabetes mellitus N. Engl. J. Med. 346 2002 1685 1691
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1685-1691
    • Type 1 Diabetes Study Group Diabetes Prevention Trial1
  • 124
  • 127
    • 84884587742 scopus 로고    scopus 로고
    • The changing landscape of type 1 diabetes: recent developments and future frontiers
    • K. Vehik, N.J. Ajami, D. Hadley, J.F. Petrosino, and B.R. Burkhardt The changing landscape of type 1 diabetes: recent developments and future frontiers Curr. Diab. Rep. 13 2013 642 650
    • (2013) Curr. Diab. Rep. , vol.13 , pp. 642-650
    • Vehik, K.1    Ajami, N.J.2    Hadley, D.3    Petrosino, J.F.4    Burkhardt, B.R.5
  • 128
    • 28844481889 scopus 로고    scopus 로고
    • Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injury
    • A.M. Vincent, M.J. Stevens, C. Backus, L.L. Mclean, and E.L. Feldman Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injury Antioxid. Redox Signal. 7 2005 1494 1506
    • (2005) Antioxid. Redox Signal. , vol.7 , pp. 1494-1506
    • Vincent, A.M.1    Stevens, M.J.2    Backus, C.3    Mclean, L.L.4    Feldman, E.L.5
  • 130
    • 58449085511 scopus 로고    scopus 로고
    • Animal models of human type 1 diabetes
    • M. Von Herrath, and G.T. Nepom Animal models of human type 1 diabetes Nat. Immunol. 10 2009 129 132
    • (2009) Nat. Immunol. , vol.10 , pp. 129-132
    • Von Herrath, M.1    Nepom, G.T.2
  • 131
    • 0027286787 scopus 로고
    • Meta-analysis of effects of intensive blood-glucose control on late complications of type I diabetes
    • P. Wang, J. Lau, and T. Chalmers Meta-analysis of effects of intensive blood-glucose control on late complications of type I diabetes Lancet 341 1993 1306 1309
    • (1993) Lancet , vol.341 , pp. 1306-1309
    • Wang, P.1    Lau, J.2    Chalmers, T.3
  • 133
  • 135
    • 84873467019 scopus 로고    scopus 로고
    • Limitations of the pig-to-non-human primate islet transplantation model
    • M. Wijkstrom, R. Bottino, and D.K. Cooper Limitations of the pig-to-non-human primate islet transplantation model Xenotransplantation 20 2013 2 4
    • (2013) Xenotransplantation , vol.20 , pp. 2-4
    • Wijkstrom, M.1    Bottino, R.2    Cooper, D.K.3
  • 136
    • 0032748135 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus and its animal models
    • F.S. Wong, and C.A. Janeway Jr Insulin-dependent diabetes mellitus and its animal models Curr. Opin. Immunol. 11 1999 643 647
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 643-647
    • Wong, F.S.1    Janeway, C.A.2
  • 137
    • 58549110474 scopus 로고    scopus 로고
    • The effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on cynomolgus (Macaca fascicularis) monkeys
    • D. Wu, C. Zou, F. Yue, X. Li, S. Li, and Y.A. Zhang The effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on cynomolgus (Macaca fascicularis) monkeys J. Med. Primatol. 38 2009 15 22
    • (2009) J. Med. Primatol. , vol.38 , pp. 15-22
    • Wu, D.1    Zou, C.2    Yue, F.3    Li, X.4    Li, S.5    Zhang, Y.A.6
  • 140
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Q. Zhou, J. Brown, A. Kanarek, J. Rajagopal, and D.A. Melton In vivo reprogramming of adult pancreatic exocrine cells to beta-cells Nature 455 2008 627 632
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 141
    • 84911191809 scopus 로고    scopus 로고
    • Nonhuman primate models of type 1 diabetes mellitus for islet transplantation
    • H. Zhu, L. Yu, Y. He, and B. Wang Nonhuman primate models of type 1 diabetes mellitus for islet transplantation J. Diabetes Res. 2014 2014 785948
    • (2014) J. Diabetes Res. , vol.2014 , pp. 785948
    • Zhu, H.1    Yu, L.2    He, Y.3    Wang, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.