Diabetic rats and mice are resistant to porcine and human insulin: Flawed experimental models for testing islet xenografts

Xenotransplantation

Volumn 16, Issue 6, 2009, Pages 502-510

  Pepper, Andrew R ^a,b,c   Gall, Chris ^b,c   Mazzuca, Delfina M ^b,c   Melling, Christopher William James ^a,b   White, David J G ^a,b,c  

^a WESTERN UNIVERSITY   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Blood glucose; Diabetes; Human insulin; Insulin resistant; Islets; Mouse; Porcine insulin; Rat; Stem cells; Xenotransplantation

Indexed keywords

GLUCOSE; HUMAN INSULIN; HYPURIN REGULAR; PIG INSULIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; DRUG DOSE ESCALATION; DRUG EFFICACY; EXPERIMENTAL MODEL; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; IMMUNOCOMPETENCE; INSULIN BLOOD LEVEL; LEWIS RAT; MALE; MONITORING; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TREATMENT RESPONSE; XENOGRAFT;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MODELS, ANIMAL; RATS; RATS, INBRED LEW; SUS SCROFA; TRANSPLANTATION, HETEROLOGOUS;

EID: 73449118597     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2009.00548.x     Document Type: Article

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