Impact of islet transplantation on diabetes complications and quality of life

Current Diabetes Reports

Volumn 11, Issue 5, 2011, Pages 355-363

  Bassi, Roberto ^a,b   Fiorina, Paolo ^a,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF SALENTO   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Diabetes complications; Islet transplantation; Quality of life

Indexed keywords

AZATHIOPRINE; C PEPTIDE; CYCLOSPORIN A; DACLIZUMAB; EFALIZUMAB; ETANERCEPT; EVEROLIMUS; EXENDIN 4; IMMUNOSUPPRESSIVE AGENT; INSULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ARTICLE; BRAIN DISEASE; CARDIOVASCULAR RISK; CLINICAL PROTOCOL; DIABETIC ENCEPHATOPATHY; DIABETIC MICROANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; GLYCEMIC CONTROL; GLYCEMIC LABILITY INDEX; HUMAN; HYPOGLYCEMIA; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; LONG TERM CARE; OUTCOMES RESEARCH; PANCREAS ISLET TRANSPLANTATION; PATIENT SATISFACTION; PATIENT SELECTION; PROTEIN SECRETION; QUALITY OF LIFE;

DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 1; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS TRANSPLANTATION; QUALITY OF LIFE;

EID: 80755128378     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-011-0211-1     Document Type: Article

References (80)

1. Bloomgarden ZT. Diabetes complications. Diabetes Care. 2004;27:1506-14. (Pubitemid 38680004)
2. Kemp CB, Knight MJ, Scharp DW, Ballinger WF, Lacy PE. Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats. Diabetologia. 1973;9:486-91.
3. Najarian JS, Sutherland DE, Matas AJ, Steffes MW, Simmons RL, Goetz FC. Human islet transplantation: a preliminary report. Transplant Proc. 1977;9:233-6.
4. Largiader F, Kolb E, Binswanger U, Illig R. Successful allotransplantation of an island of Langerhans. Schweiz Med Wochenschr. 1979;109:1733-6.
5. Scharp DW, Lacy PE, Santiago JV, et al. Insulin independence after islet transplantation into type I diabetic patient. Diabetes. 1990;39:515-8. (Pubitemid 20111437)
6. Pileggi A, Ricordi C, Kenyon NS, et al. Twenty years of clinical islet transplantation at the Diabetes Research Institute-University of Miami. Clin Transpl. 2004:177-204.
7. Pyzdrowski KL, Kendall DM, Halter JB, Nakhleh RE, Sutherland DE, Robertson RP. Preserved insulin secretion and insulin independence in recipients of islet autografts. N Engl J Med. 1992;327:220-6.
8. Tzakis AG, Ricordi C, Alejandro R, et al. Pancreatic islet transplantation after upper abdominal exenteration and liver replacement. Lancet. 1990;336:402-5. (Pubitemid 20252439)
9. Ricordi C, Tzakis AG, Carroll PB, et al. Human islet isolation and allotransplantation in 22 consecutive cases. Transplantation. 1992;53:407-14.
10. Brendel M. International islet transplant registry newsletter No.9. Volume 8. Number 1. 2001.
11. Oberholzer J, Triponez F, Mage R, et al. Human islet transplantation: lessons from 13 autologous and 13 allogeneic transplantations. Transplantation. 2000;69:1115-23. (Pubitemid 30217595)
12. Oberholzer J, Toso C, Triponez F, et al. Human islet allotransplantation with Basiliximab in type I diabetic patients with endstage renal failure. Transplant Proc. 2002;34:823-5. (Pubitemid 34556817)
13. Benhamou PY, Oberholzer J, Toso C, et al. Human islet transplantation network for the treatment of Type I diabetes: first data from the Swiss-French GRAGIL consortium (1999-2000). Groupe de Recherche Rhin Rhjne Alpes Geneve pour la transplantation d'Ilots de Langerhans. Diabetologia. 2001;44:859-64. (Pubitemid 32642458)
14. Hering BJ, Bretzel RG, Hopt UT, et al. New protocol toward prevention of early human islet allograft failure. Transplant Proc. 1994;26:570-1. (Pubitemid 24143603)
15. Bretzel RG, Brandhorst D, Brandhorst H, et al. Improved survival of intraportal pancreatic islet cell allografts in patients with type-1 diabetes mellitus by refined peritransplant management. J Mol Med. 1999;77:140-3. (Pubitemid 29146204)
16. Secchi A, Socci C, Maffi P, et al. Islet transplantation in IDDM patients. Diabetologia. 1997;40:225-31. (Pubitemid 27060297)
17. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343:230-8. (Pubitemid 30490390)
18. Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006;355:1318-30. (Pubitemid 44465460)
19. Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes. 2005;54:2060-9. (Pubitemid 40911269)
20. Lee TC, Barshes NR, Brunicardi FC, et al. Procurement of the human pancreas for pancreatic islet transplantation. Transplantation. 2004;78:481-3. (Pubitemid 39095418)
21. Venturini M, Angeli E, Maffi P, et al. Technique, complications, and therapeutic efficacy of percutaneous transplantation of human pancreatic islet cells in type 1 diabetes: the role of US. Radiology. 2005;234:617-24. (Pubitemid 40139939)
22. Robertson RP. Islet transplantation a decade later and strategies for filling a half-full glass. Diabetes. 2010;59:1285-91.
23. Hafiz MM, Faradji RN, Froud T, et al. Immunosuppression and procedure-related complications in 26 patients with type 1 diabetes mellitus receiving allogeneic islet cell transplantation. Transplantation. 2005;80:1718-28. (Pubitemid 43053997)
24. Lakey JR, Mirbolooki M, Shapiro AM. Current status of clinical islet cell transplantation. Methods Mol Biol. 2006;333:47-104.
25. Berney T, Toso C. Monitoring of the islet graft. Diabetes Metab. 2006;32:503-12. (Pubitemid 44836981)
26. Vantyghem MC, Kerr-Conte J, Arnalsteen L, et al. Primary graft function, metabolic control, and graft survival after islet transplantation. Diabetes Care. 2009;32:1473-8.
27. Naftanel MA, Harlan DM. Pancreatic islet transplantation. PLoS Med. 2004;1:e58; quiz e75.
28. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329:977-86.
29. Fiorina P, Shapiro AM, Ricordi C, Secchi A. The clinical impact of islet transplantation. Am J Transplant. 2008;8:1990-7. This work comprehensively reviews the state of the art of islet transplantation, immunosuppression, outcomes, and their impact on patients'survival and long-term diabetic complications.
30. Hering BJ, Browatzki CC, Schultz A, Bretzel RG, Federlin KF. Clinical islet transplantation-registry report, accomplishments in the past and future research needs. Cell Transplant. 1993;2:269-82. discussion 83-305. (Pubitemid 23183566)
31. Gaston RS, Basadonna G, Cosio FG, et al. Transplantation in the diabetic patient with advanced chronic kidney disease: a task force report. Am J Kidney Dis. 2004;44:529-42. (Pubitemid 39164629)
32. Robertson RP. Update on transplanting beta cells for reversing type 1 diabetes. Endocrinol Metab Clin North Am. 2010;39:655-67.
33. Maffi P, Bertuzzi F, De Taddeo F, et al. Kidney function after islet transplant alone in type 1 diabetes: impact of immunosuppressive therapy on progression of diabetic nephropathy. Diabetes Care. 2007;30:1150-5. (Pubitemid 46684640)
34. Robertson RP. Islet transplantation as a treatment for diabetes-a work in progress. N Engl J Med. 2004;350:694-705. (Pubitemid 38364628)
35. Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by beta cell regeneration. J Clin Invest. 2007;117:2553-61. (Pubitemid 47494356)
36. Brunicardi FC, Atiya A, Stock P, et al. Clinical islet transplantation experience of the University of California Islet Transplant Consortium. Surgery. 1995;118:967-71. discussion 71-2.
37. Goss JA, Goodpastor SE, Brunicardi FC, et al. Development of a human pancreatic islet-transplant program through a collaborative relationship with a remote islet-isolation center. Transplantation. 2004;77:462-6. (Pubitemid 38209753)
38. Shapiro AM, Ricordi C, Hering B. Edmonton's islet success has indeed been replicated elsewhere. Lancet. 2003;362:1242. (Pubitemid 37255361)
39. Toso C, Baertschiger R, Morel P, et al. Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol. Am J Transplant: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2006;6:1049-58. (Pubitemid 44356657)
40. Gerber PA, Pavlicek V,DemartinesN, et al. Simultaneous islet-kidney vs pancreas-kidney transplantation in type 1 diabetes mellitus: a 5 year single centre follow-up. Diabetologia. 2008;51:110-9. (Pubitemid 50000367)
41. Froud T, Ricordi C, Baidal DA, et al. Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am J Transplant: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2005;5:2037-46. (Pubitemid 41039883)
42. Hering BJ, Kandaswamy R, Harmon JV, et al. Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody. Am J Transplant: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2004;4:390-401. (Pubitemid 38282295)
43. Bellin MD, Kandaswamy R, Parkey J, et al. Prolonged insulin independence after islet allotransplants in recipients with type 1 diabetes. Am J Transplant. 2008;8:2463-70.
44. Gangemi A, Salehi P, Hatipoglu B, et al. Islet transplantation for brittle type 1 diabetes: the UIC protocol. Am J Transplant. 2008;8:1250-61. (Pubitemid 351763686)
45. Skyler JS, Greenbaum CJ, Lachin JM, et al. Type 1 Diabetes TrialNet-an international collaborative clinical trials network. Ann N YAcad Sci. 2008;1150:14-24.
46. Oberholzer J, Kinzer K, Fiorina P. The anti-LFA-1 trial in islet transplantation. Am J Transplant. 2010;10:1725-6.
47. Alejandro R, Barton FB, Hering BJ, Wease S. 2008 Update from the Collaborative Islet Transplant Registry. Transplantation 2008;86:1783-8. This paper summarizes the most recent update from the CITR and represents the most complete collection of information on islet transplantation.
48. Davalli AM, Maffi P, Socci C, et al. Insights from a successful case of intrahepatic islet transplantation into a type 1 diabetic patient. J Clin Endocrinol Metab. 2000;85:3847-52.
49. Berney T, Ferrari-Lacraz S, Buhler L, et al. Long-term insulinindependence after allogeneic islet transplantation for type 1 diabetes: over the 10-year mark. Am J Transplant. 2009;9:419-23.
50. Alejandro R, Lehmann R, RicordiC, et al. Long-term function (6 years) of islet allografts in type 1 diabetes. Diabetes. 1997;46:1983-9. (Pubitemid 27512084)
51. Luzi L, Perseghin G, Brendel MD, et al. Metabolic effects of restoring partial beta-cell function after islet allotransplantation in type 1 diabetic patients. Diabetes. 2001;50:277-82. (Pubitemid 32127283)
52. Rickels MR, Schutta MH, Markmann JF, Barker CF, Naji A, Teff KL. {beta}-Cell function following human islet transplantation for type 1 diabetes. Diabetes. 2005;54:100-6. (Pubitemid 40105100)
53. Poggioli R, Faradji RN, Ponte G, et al. Quality of life after islet transplantation. Am J Transplant: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2006;6:371-8. (Pubitemid 43382174)
54. Geiger MC, Ferreira JV, Hafiz MM, et al. Evaluation of metabolic control using a continuous subcutaneous glucose monitoring system in patients with type 1 diabetes mellitus who achieved insulin independence after islet cell transplantation. Cell Transplant. 2005;14:77-84. (Pubitemid 40604951)
55. Ryan EA, Shandro T, Green K, et al. Assessment of the severity of hypoglycemia and glycemic lability in type 1 diabetic subjects undergoing islet transplantation. Diabetes. 2004;53:955-62. (Pubitemid 38436607)
56. Poggioli R, Faradji RN, Ponte G, et al. Quality of life after islet transplantation. Am J Transplant. 2006;6:371-8. (Pubitemid 43382174)
57. Barshes NR, Vanatta JM, Mote A, et al. Health-related quality of life after pancreatic islet transplantation: a longitudinal study. Transplantation. 2005;79:1727-30. (Pubitemid 40885272)
58. Johnson JA, Kotovych M, Ryan EA, Shapiro AM. Reduced fear of hypoglycemia in successful islet transplantation. Diabetes Care. 2004;27:624-5. (Pubitemid 38174102)
59. Endicott J, Nee J, Harrison W, Blumenthal R. Quality of life enjoyment and satisfaction questionnaire: a new measure. Psychopharmacol Bull. 1993;29:321-6. (Pubitemid 23311543)
60. Teran-Escandon D, Teran-Ortiz L, Ormsby-Jenkins C, Evia- Viscarra ML, White DJ, Valdes-Gonzalez-Salas R. Psychosocial aspects of xenotransplantation: survey in adolescent recipients of porcine islet cells. Transplant Proc. 2005;37:521-4. (Pubitemid 40459839)
61. Reliability and validity of a diabetes quality-of-life measure for the diabetes control and complications trial (DCCT). The DCCT Research Group. Diabetes Care 1988;11:725-32.
62. Toso C, Shapiro AM, Bowker S, et al. Quality of life after islet transplant: impact of the number of islet infusions and metabolic outcome. Transplantation. 2007;84:664-6. (Pubitemid 47429051)
63. Cure P, Pileggi A, Froud T, et al. Improved metabolic control and quality of life in seven patients with type 1 diabetes following islet after kidney transplantation. Transplantation. 2008;85:801-12. (Pubitemid 351440744)
64. Tharavanij T, Betancourt A, Messinger S, et al. Improved longterm health-related quality of life after islet transplantation. Transplantation. 2008;86:1161-7.
65. Melton 3rd LJ, Macken KM, Palumbo PJ, Elveback LR. Incidence and prevalence of clinical peripheral vascular disease in a populationbased cohort of diabetic patients. Diabetes Care. 1980;3:650-4. (Pubitemid 11165002)
66. Fiorina P, Gremizzi C,Maffi P, et al. Islet transplantation is associated with an improvement of cardiovascular function in type 1 diabetic kidney transplant patients. Diabetes Care. 2005;28:1358-65. (Pubitemid 40756697)
67. Nathan DM. Long-term complications of diabetes mellitus. N Engl J Med. 1993;328:1676-85. (Pubitemid 23157351)
68. Fiorina P, Folli F, D'Angelo A, et al. Normalization of multiple hemostatic abnormalities in uremic type 1 diabetic patients after kidney-pancreas transplantation. Diabetes. 2004;53:2291-300. (Pubitemid 39145582)
69. Fiorina P, Folli F, Zerbini G, et al. Islet transplantation is associated with improvement of renal function among uremic patients with type I diabetes mellitus and kidney transplants. J Am Soc Nephrol. 2003;14:2150-8. (Pubitemid 36909924)
70. Fiorina P, Venturini M, Folli F, et al. Natural history of kidney graft survival, hypertrophy, and vascular function in end-stage renal disease type 1 diabetic kidney-transplanted patients: beneficial impact of pancreas and successful islet cotransplantation. Diabetes Care. 2005;28:1303-10. (Pubitemid 40756688)
71. Fung MA, Warnock GL, Ao Z, et al. The effect of medical therapy and islet cell transplantation on diabetic nephropathy: an interim report. Transplantation. 2007;84:17-22. (Pubitemid 47094636)
72. Leitao CB, Cure P, Messinger S, et al. Stable renal function after islet transplantation: importance of patient selection and aggressive clinical management. Transplantation. 2009;87:681-8.
73. Senior PA, Zeman M, Paty BW, Ryan EA, Shapiro AM. Changes in renal function after clinical islet transplantation: four-year observational study. Am J Transplant. 2007;7:91-8. (Pubitemid 44952860)
74. Vinik AI, Park TS, Stansberry KB, Pittenger GL. Diabetic neuropathies. Diabetologia. 2000;43:957-73. (Pubitemid 30655714)
75. Lee TC, Barshes NR, O'Mahony CA, et al. The effect of pancreatic islet transplantation on progression of diabetic retinopathy and neuropathy. Transplant Proc. 2005;37:2263-5. (Pubitemid 40956427)
76. Del Carro U, Fiorina P, Amadio S, et al. Evaluation of polyneuropathy markers in type 1 diabetic kidney transplant patients and effects of islet transplantation: neurophysiological and skin biopsy longitudinal analysis. Diabetes Care. 2007;30:3063-9. (Pubitemid 350255247)
77. McCall AL. Diabetes mellitus and the central nervous system. Int Rev Neurobiol. 2002;51:415-53.
78. Franceschi M, Cecchetto R, Minicucci F, Smizne S, Baio G, Canal N. Cognitive processes in insulin-dependent diabetes. Diabetes Care. 1984;7:228-31. (Pubitemid 14105302)
79. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376:124-36.
80. Venturini M, Fiorina P, Maffi P, et al. Early increase of retinal arterial and venous blood flow velocities at color Doppler imaging in brittle type 1 diabetes after islet transplant alone. Transplantation. 2006;81:1274-7. (Pubitemid 43804546)