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Volumn 100, Issue 1, 2013, Pages 74-84

Altered immune profile from pre-diabetes to manifestation of type 1 diabetes

Author keywords

Chemokines; Cytokines; Pre diabetes; Th1; Th2; Type 1 diabetes

Indexed keywords

AUTOANTIGEN; CHAPERONIN 60; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUTAMATE DECARBOXYLASE 65; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 7; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINAMIDE; PLACEBO; RANTES; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84876711566     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2013.01.014     Document Type: Article
Times cited : (17)

References (50)
  • 1
    • 0035257102 scopus 로고    scopus 로고
    • The discovery of type 1 diabetes
    • Gale E.A. The discovery of type 1 diabetes. Diabetes 2001, 50(2):217-226.
    • (2001) Diabetes , vol.50 , Issue.2 , pp. 217-226
    • Gale, E.A.1
  • 2
    • 79960088916 scopus 로고    scopus 로고
    • Insulitis in human type 1 diabetes: the quest for an elusive lesion
    • In't Veld P. Insulitis in human type 1 diabetes: the quest for an elusive lesion. Islets 2011, 3(4).
    • (2011) Islets , vol.3 , Issue.4
    • In't Veld, P.1
  • 3
    • 0022617990 scopus 로고
    • Type I diabetes mellitus. A chronic autoimmune disease
    • Eisenbarth G.S. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 1986, 314(21):1360-1368.
    • (1986) N Engl J Med , vol.314 , Issue.21 , pp. 1360-1368
    • Eisenbarth, G.S.1
  • 4
    • 0036333860 scopus 로고    scopus 로고
    • Autoreactive CD8T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention
    • Liblau R.S., Wong F.S., Mars L.T., Santamaria P. Autoreactive CD8T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention. Immunity 2002, 17(1):1-6.
    • (2002) Immunity , vol.17 , Issue.1 , pp. 1-6
    • Liblau, R.S.1    Wong, F.S.2    Mars, L.T.3    Santamaria, P.4
  • 5
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
    • Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989, 7:145-173.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 6
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets: Th1, Th2 and more
    • Mosmann T.R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996, 17(3):138-146.
    • (1996) Immunol Today , vol.17 , Issue.3 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 7
    • 33645023639 scopus 로고    scopus 로고
    • Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells
    • Taylor A., Verhagen J., Blaser K., Akdis M., Akdis C.A. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. Immunology 2006, 117(4):433-442.
    • (2006) Immunology , vol.117 , Issue.4 , pp. 433-442
    • Taylor, A.1    Verhagen, J.2    Blaser, K.3    Akdis, M.4    Akdis, C.A.5
  • 8
    • 0036894536 scopus 로고    scopus 로고
    • Fatal attraction: chemokines and type 1 diabetes
    • Atkinson M.A., Wilson S.B. Fatal attraction: chemokines and type 1 diabetes. J Clin Invest 2002, 110(11):1611-1613.
    • (2002) J Clin Invest , vol.110 , Issue.11 , pp. 1611-1613
    • Atkinson, M.A.1    Wilson, S.B.2
  • 9
    • 0030587869 scopus 로고    scopus 로고
    • Synthesis of the CC-chemokines MIP-1alpha: MIP-1beta, and RANTES is associated with a type 1 immune response
    • Schrum S., Probst P., Fleischer B., Zipfel P.F. Synthesis of the CC-chemokines MIP-1alpha: MIP-1beta, and RANTES is associated with a type 1 immune response. J Immunol 1996, 157(8):3598-3604.
    • (1996) J Immunol , vol.157 , Issue.8 , pp. 3598-3604
    • Schrum, S.1    Probst, P.2    Fleischer, B.3    Zipfel, P.F.4
  • 10
    • 0032504982 scopus 로고    scopus 로고
    • T-cell subsets: chemokine receptors guide the way
    • O'Garra A., McEvoy L.M., Zlotnik A. T-cell subsets: chemokine receptors guide the way. Curr Biol 1998, 8(18):R646-R649.
    • (1998) Curr Biol , vol.8 , Issue.18
    • O'Garra, A.1    McEvoy, L.M.2    Zlotnik, A.3
  • 11
    • 0033104725 scopus 로고    scopus 로고
    • Islet-specific Th1: but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes
    • Bradley L.M., Asensio V.C., Schioetz L.K., Harbertson J., Krahl T., Patstone G., et al. Islet-specific Th1: but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J Immunol 1999, 162(5):2511-2520.
    • (1999) J Immunol , vol.162 , Issue.5 , pp. 2511-2520
    • Bradley, L.M.1    Asensio, V.C.2    Schioetz, L.K.3    Harbertson, J.4    Krahl, T.5    Patstone, G.6
  • 12
    • 22644437303 scopus 로고    scopus 로고
    • CD4+ CD25+-regulatory T cells from mouse to man
    • Wing K., Suri-Payer E., Rudin A. CD4+ CD25+-regulatory T cells from mouse to man. Scand J Immunol 2005, 62(1):1-15.
    • (2005) Scand J Immunol , vol.62 , Issue.1 , pp. 1-15
    • Wing, K.1    Suri-Payer, E.2    Rudin, A.3
  • 14
    • 0032964798 scopus 로고    scopus 로고
    • Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes
    • Leslie R.D., Atkinson M.A., Notkins A.L. Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes. Diabetologia 1999, 42(1):3-14.
    • (1999) Diabetologia , vol.42 , Issue.1 , pp. 3-14
    • Leslie, R.D.1    Atkinson, M.A.2    Notkins, A.L.3
  • 15
    • 0027953701 scopus 로고
    • Autoimmune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin
    • Elias D., Prigozin H., Polak N., Rapoport M., Lohse A.W., Cohen I.R. Autoimmune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin. Diabetes 1994, 43(8):992-998.
    • (1994) Diabetes , vol.43 , Issue.8 , pp. 992-998
    • Elias, D.1    Prigozin, H.2    Polak, N.3    Rapoport, M.4    Lohse, A.W.5    Cohen, I.R.6
  • 16
    • 1642277657 scopus 로고    scopus 로고
    • European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes
    • Gale E.A., Bingley P.J., Emmett C.L., Collier T. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 2004, 363(9413):925-931.
    • (2004) Lancet , vol.363 , Issue.9413 , pp. 925-931
    • Gale, E.A.1    Bingley, P.J.2    Emmett, C.L.3    Collier, T.4
  • 17
    • 0034089590 scopus 로고    scopus 로고
    • Th1-like dominance in high-risk first-degree relatives of type I diabetic patients
    • Karlsson M.G., Lawesson S.S., Ludvigsson J. Th1-like dominance in high-risk first-degree relatives of type I diabetic patients. Diabetologia 2000, 43(6):742-749.
    • (2000) Diabetologia , vol.43 , Issue.6 , pp. 742-749
    • Karlsson, M.G.1    Lawesson, S.S.2    Ludvigsson, J.3
  • 18
    • 24344447802 scopus 로고    scopus 로고
    • The immunological effect of photopheresis in children with newly diagnosed type 1 diabetes
    • Faresjo M.K., Ernerudh J., Berlin G., Garcia J., Ludvigsson J. The immunological effect of photopheresis in children with newly diagnosed type 1 diabetes. Pediatr Res 2005, 58(3):459-466.
    • (2005) Pediatr Res , vol.58 , Issue.3 , pp. 459-466
    • Faresjo, M.K.1    Ernerudh, J.2    Berlin, G.3    Garcia, J.4    Ludvigsson, J.5
  • 19
    • 67349091253 scopus 로고    scopus 로고
    • How and when to pick up the best signals from markers associated with T-regulatory cells?
    • Kivling A., Nilsson L., Faresjo M. How and when to pick up the best signals from markers associated with T-regulatory cells?. J Immunol Methods 2009, 345(1-2):29-39.
    • (2009) J Immunol Methods , vol.345 , Issue.1-2 , pp. 29-39
    • Kivling, A.1    Nilsson, L.2    Faresjo, M.3
  • 20
    • 47249122232 scopus 로고    scopus 로고
    • Regulatory T cell-associated activity in photopheresis-induced immune tolerance in recent onset type 1 diabetes children
    • Jonson C.O., Pihl M., Nyholm C., Cilio C.M., Ludvigsson J., Faresjo M. Regulatory T cell-associated activity in photopheresis-induced immune tolerance in recent onset type 1 diabetes children. Clin Exp Immunol 2008, 153(2):174-181.
    • (2008) Clin Exp Immunol , vol.153 , Issue.2 , pp. 174-181
    • Jonson, C.O.1    Pihl, M.2    Nyholm, C.3    Cilio, C.M.4    Ludvigsson, J.5    Faresjo, M.6
  • 21
    • 13844297163 scopus 로고    scopus 로고
    • Diminished Th1-like response to autoantigens in children with a high risk of developing type 1 diabetes
    • Karlsson Faresjo M.G., Ludvigsson J. Diminished Th1-like response to autoantigens in children with a high risk of developing type 1 diabetes. Scand J Immunol 2005, 61(2):173-179.
    • (2005) Scand J Immunol , vol.61 , Issue.2 , pp. 173-179
    • Karlsson Faresjo, M.G.1    Ludvigsson, J.2
  • 22
    • 33646352455 scopus 로고    scopus 로고
    • Nicotinamide reduces high secretion of IFN-gamma in high-risk relatives even though it does not prevent type 1 diabetes
    • Hedman M., Ludvigsson J., Faresjo M.K. Nicotinamide reduces high secretion of IFN-gamma in high-risk relatives even though it does not prevent type 1 diabetes. J Interferon Cytokine Res 2006, 26(4):207-213.
    • (2006) J Interferon Cytokine Res , vol.26 , Issue.4 , pp. 207-213
    • Hedman, M.1    Ludvigsson, J.2    Faresjo, M.K.3
  • 23
    • 84862315128 scopus 로고    scopus 로고
    • Immunotherapies in diabetes mellitus type 1
    • xi
    • Gupta S. Immunotherapies in diabetes mellitus type 1. Med Clin North Am 2012, 96(3):621-34. xi.
    • (2012) Med Clin North Am , vol.96 , Issue.3 , pp. 621-34
    • Gupta, S.1
  • 24
    • 0842291575 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes
    • Chen W., Salojin K.V., Mi Q.S., Grattan M., Meagher T.C., Zucker P., et al. Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes. Endocrinology 2004, 145(2):627-638.
    • (2004) Endocrinology , vol.145 , Issue.2 , pp. 627-638
    • Chen, W.1    Salojin, K.V.2    Mi, Q.S.3    Grattan, M.4    Meagher, T.C.5    Zucker, P.6
  • 25
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • Katz J.D., Wang B., Haskins K., Benoist C., Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993, 74(6):1089-1100.
    • (1993) Cell , vol.74 , Issue.6 , pp. 1089-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3    Benoist, C.4    Mathis, D.5
  • 26
    • 0035856952 scopus 로고    scopus 로고
    • Beta-Cell death during progression to diabetes
    • Mathis D., Vence L., Benoist C. Beta-Cell death during progression to diabetes. Nature 2001, 414(6865):792-798.
    • (2001) Nature , vol.414 , Issue.6865 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 27
    • 0027990811 scopus 로고
    • Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process
    • Yang X.D., Tisch R., Singer S.M., Cao Z.A., Liblau R.S., Schreiber R.D., et al. Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process. J Exp Med 1994, 180(3):995-1004.
    • (1994) J Exp Med , vol.180 , Issue.3 , pp. 995-1004
    • Yang, X.D.1    Tisch, R.2    Singer, S.M.3    Cao, Z.A.4    Liblau, R.S.5    Schreiber, R.D.6
  • 28
    • 78651345190 scopus 로고    scopus 로고
    • Altered toll-like receptor signaling pathways in human type 1 diabetes
    • Meyers A.J., Shah R.R., Gottlieb P.A., Zipris D. Altered toll-like receptor signaling pathways in human type 1 diabetes. J Mol Med 2010, 88(12):1221-1231.
    • (2010) J Mol Med , vol.88 , Issue.12 , pp. 1221-1231
    • Meyers, A.J.1    Shah, R.R.2    Gottlieb, P.A.3    Zipris, D.4
  • 29
    • 33645222743 scopus 로고    scopus 로고
    • Serum IL-1beta, IL-2, and IL-6 in insulin-dependent diabetic children
    • Dogan Y., Akarsu S., Ustundag B., Yilmaz E., Gurgoze M.K. Serum IL-1beta, IL-2, and IL-6 in insulin-dependent diabetic children. Mediators Inflamm 2006, 2006(1):59206.
    • (2006) Mediators Inflamm , vol.2006 , Issue.1 , pp. 59206
    • Dogan, Y.1    Akarsu, S.2    Ustundag, B.3    Yilmaz, E.4    Gurgoze, M.K.5
  • 30
    • 33644810737 scopus 로고    scopus 로고
    • Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis
    • Pohlers D., Siegling A., Buchner E., Schmidt-Weber C.B., Palombo-Kinne E., Emmrich F., et al. Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis. Arthritis Res Ther 2005, 7(3):R445-R457.
    • (2005) Arthritis Res Ther , vol.7 , Issue.3
    • Pohlers, D.1    Siegling, A.2    Buchner, E.3    Schmidt-Weber, C.B.4    Palombo-Kinne, E.5    Emmrich, F.6
  • 31
  • 32
    • 0030856428 scopus 로고    scopus 로고
    • Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia
    • van der Poll T., Keogh C.V., Guirao X., Buurman W.A., Kopf M., Lowry S.F. Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. J Infect Dis 1997, 176(2):439-444.
    • (1997) J Infect Dis , vol.176 , Issue.2 , pp. 439-444
    • van der Poll, T.1    Keogh, C.V.2    Guirao, X.3    Buurman, W.A.4    Kopf, M.5    Lowry, S.F.6
  • 33
    • 33644755633 scopus 로고    scopus 로고
    • Interleukin-6 and diabetes: the good, the bad, or the indifferent?
    • Kristiansen O.P., Mandrup-Poulsen T. Interleukin-6 and diabetes: the good, the bad, or the indifferent?. Diabetes 2005, 54(Suppl 2):S114-S124.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Kristiansen, O.P.1    Mandrup-Poulsen, T.2
  • 34
    • 69249202525 scopus 로고    scopus 로고
    • Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes
    • Ryden A., Stechova K., Durilova M., Faresjo M. Switch from a dominant Th1-associated immune profile during the pre-diabetic phase in favour of a temporary increase of a Th3-associated and inflammatory immune profile at the onset of type 1 diabetes. Diabetes Metab Res Rev 2009, 25(4):335-343.
    • (2009) Diabetes Metab Res Rev , vol.25 , Issue.4 , pp. 335-343
    • Ryden, A.1    Stechova, K.2    Durilova, M.3    Faresjo, M.4
  • 35
    • 33751184869 scopus 로고    scopus 로고
    • Diminished IFN-gamma response to diabetes-associated autoantigens in children at diagnosis and during follow up of type 1 diabetes
    • Faresjo M.K., Vaarala O., Thuswaldner S., Ilonen J., Hinkkanen A., Ludvigsson J. Diminished IFN-gamma response to diabetes-associated autoantigens in children at diagnosis and during follow up of type 1 diabetes. Diabetes Metab Res Rev 2006, 22(6):462-470.
    • (2006) Diabetes Metab Res Rev , vol.22 , Issue.6 , pp. 462-470
    • Faresjo, M.K.1    Vaarala, O.2    Thuswaldner, S.3    Ilonen, J.4    Hinkkanen, A.5    Ludvigsson, J.6
  • 36
    • 2642523756 scopus 로고    scopus 로고
    • Cytokine profile in children during the first 3 months after the diagnosis of type 1 diabetes
    • Karlsson Faresjo M.G., Ernerudh J., Ludvigsson J. Cytokine profile in children during the first 3 months after the diagnosis of type 1 diabetes. Scand J Immunol 2004, 59(5):517-526.
    • (2004) Scand J Immunol , vol.59 , Issue.5 , pp. 517-526
    • Karlsson Faresjo, M.G.1    Ernerudh, J.2    Ludvigsson, J.3
  • 38
    • 0034662271 scopus 로고    scopus 로고
    • Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes
    • Cameron M.J., Arreaza G.A., Grattan M., Meagher C., Sharif S., Burdick M.D., et al. Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes. J Immunol 2000, 165(2):1102-1110.
    • (2000) J Immunol , vol.165 , Issue.2 , pp. 1102-1110
    • Cameron, M.J.1    Arreaza, G.A.2    Grattan, M.3    Meagher, C.4    Sharif, S.5    Burdick, M.D.6
  • 39
    • 33750365601 scopus 로고    scopus 로고
    • Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes
    • Zhernakova A., Alizadeh B.Z., Eerligh P., Hanifi-Moghaddam P., Schloot N.C., Diosdado B., et al. Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes. Genes Immun 2006, 7(7):544-549.
    • (2006) Genes Immun , vol.7 , Issue.7 , pp. 544-549
    • Zhernakova, A.1    Alizadeh, B.Z.2    Eerligh, P.3    Hanifi-Moghaddam, P.4    Schloot, N.C.5    Diosdado, B.6
  • 41
    • 0033653644 scopus 로고    scopus 로고
    • Transcriptional regulation of RANTES expression in T lymphocytes
    • Song A., Nikolcheva T., Krensky A.M. Transcriptional regulation of RANTES expression in T lymphocytes. Immunol Rev 2000, 177:236-245.
    • (2000) Immunol Rev , vol.177 , pp. 236-245
    • Song, A.1    Nikolcheva, T.2    Krensky, A.M.3
  • 42
    • 0027492915 scopus 로고
    • Effects of IL-13 on phenotype: cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10
    • de Waal Malefyt R., Figdor C.G., Huijbens R., Mohan-Peterson S., Bennett B., Culpepper J., et al. Effects of IL-13 on phenotype: cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10. J Immunol 1993, 151(11):6370-6381.
    • (1993) J Immunol , vol.151 , Issue.11 , pp. 6370-6381
    • de Waal Malefyt, R.1    Figdor, C.G.2    Huijbens, R.3    Mohan-Peterson, S.4    Bennett, B.5    Culpepper, J.6
  • 43
    • 77949907464 scopus 로고    scopus 로고
    • IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma
    • Deepak P., Kumar S., Kishore D., Acharya A. IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma. Int Immunol 2010, 22(1):53-63.
    • (2010) Int Immunol , vol.22 , Issue.1 , pp. 53-63
    • Deepak, P.1    Kumar, S.2    Kishore, D.3    Acharya, A.4
  • 44
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1
    • Skyler J.S., Krischer J.P., Wolfsdorf J., Cowie C., Palmer J.P., Greenbaum C., et al. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1. Diabetes Care 2005, 28(5):1068-1076.
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1068-1076
    • Skyler, J.S.1    Krischer, J.P.2    Wolfsdorf, J.3    Cowie, C.4    Palmer, J.P.5    Greenbaum, C.6
  • 45
    • 55749104546 scopus 로고    scopus 로고
    • Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial
    • Nanto-Salonen K., Kupila A., Simell S., Siljander H., Salonsaari T., Hekkala A., et al. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial. Lancet 2008, 372(9651):1746-1755.
    • (2008) Lancet , vol.372 , Issue.9651 , pp. 1746-1755
    • Nanto-Salonen, K.1    Kupila, A.2    Simell, S.3    Siljander, H.4    Salonsaari, T.5    Hekkala, A.6
  • 46
    • 0035944844 scopus 로고    scopus 로고
    • Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial
    • Raz I., Elias D., Avron A., Tamir M., Metzger M., Cohen I.R. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 2001, 358(9295):1749-1753.
    • (2001) Lancet , vol.358 , Issue.9295 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3    Tamir, M.4    Metzger, M.5    Cohen, I.R.6
  • 47
    • 43349090939 scopus 로고    scopus 로고
    • Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes
    • Huurman V.A., van der Meide P.E., Duinkerken G., Willemen S., Cohen I.R., Elias D., et al. Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes. Clin Exp Immunol 2008, 152(3):488-497.
    • (2008) Clin Exp Immunol , vol.152 , Issue.3 , pp. 488-497
    • Huurman, V.A.1    van der Meide, P.E.2    Duinkerken, G.3    Willemen, S.4    Cohen, I.R.5    Elias, D.6
  • 48
    • 69249212422 scopus 로고    scopus 로고
    • Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results
    • Eldor R., Kassem S., Raz I. Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results. Diabetes Metab Res Rev 2009, 25(4):316-320.
    • (2009) Diabetes Metab Res Rev , vol.25 , Issue.4 , pp. 316-320
    • Eldor, R.1    Kassem, S.2    Raz, I.3
  • 49
    • 21344461521 scopus 로고    scopus 로고
    • Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes
    • Agardh C.D., Cilio C.M., Lethagen A., Lynch K., Leslie R.D., Palmer M., et al. Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes. J Diabetes Complications 2005, 19(4):238-246.
    • (2005) J Diabetes Complications , vol.19 , Issue.4 , pp. 238-246
    • Agardh, C.D.1    Cilio, C.M.2    Lethagen, A.3    Lynch, K.4    Leslie, R.D.5    Palmer, M.6
  • 50
    • 55249110198 scopus 로고    scopus 로고
    • GAD treatment and insulin secretion in recent-onset type 1 diabetes
    • Ludvigsson J., Faresjo M., Hjorth M., Axelsson S., Cheramy M., Pihl M., et al. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N Engl J Med 2008, 359(18):1909-1920.
    • (2008) N Engl J Med , vol.359 , Issue.18 , pp. 1909-1920
    • Ludvigsson, J.1    Faresjo, M.2    Hjorth, M.3    Axelsson, S.4    Cheramy, M.5    Pihl, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.