Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6

Cancer Letters

Volumn 365, Issue 2, 2015, Pages 229-239

  Chiu, Hui Wen ^a,b   Lin, Shu Wen ^c   Lin, Li Ching ^d,e   Hsu, Yung Ho ^a   Lin, Yuh Feng ^a,b   Ho, Sheng Yow ^d,f   Wu, Yuan Hua ^c,g   Wang, Ying Jan ^c,h,i  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d CHI MEI MEDICAL CENTER   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^f CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^g NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^h ASIA UNIVERSITY   (Taiwan)

ⁱ CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Autophagy; Endoplasmic reticulum stress; Pancreatic cancer; Proteasome inhibitor; Radiation

Indexed keywords

3 METHYLADENINE; BAFILOMYCIN A1; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CARRIER PROTEINS AND BINDING PROTEINS; CYCLINE; LC3 PROTEIN; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; LEUPEPTIN; PROTEASOME INHIBITOR; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CANCER CELL LINE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; MIA PACA 2 CELL LINE; MONOTHERAPY; NONHUMAN; PANC 1 CELL LINE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; SCID MOUSE; ANIMAL; APOPTOSIS; BIOSYNTHESIS; CANCER TRANSPLANTATION; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; GENETICS; MOUSE; MULTIMODALITY CANCER THERAPY; PANCREATIC NEOPLASMS; RADIATION RESPONSE; RNA INTERFERENCE; TUMOR CELL LINE; XENOGRAFT;

AGOUTI PACA; MUS;

ANIMALS; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COMBINED MODALITY THERAPY; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; HUMANS; LEUPEPTINS; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; PROTEASOME INHIBITORS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSPLANTATION, HETEROLOGOUS;

EID: 84937643293     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2015.05.025     Document Type: Article

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