Role of autophagy in apoptotic regulation by Akt in pancreatic cancer

Anticancer Research

Volumn 34, Issue 2, 2014, Pages 631-638

  Muilenburg, Diego ^a   Parsons, Colin ^a   Coates, Jodi ^a   Virudachalam, Subbulakshmi ^a   Bold, Richard J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AKT; Autophagy; mTOR; Pancreatic cancer

Indexed keywords

3 METHYLADENINE; A 443654; CASPASE 3; CHLOROQUINE; MAMMALIAN TARGET OF RAPAMYCIN; PACLITAXEL; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; RAPAMYCIN; UNCLASSIFIED DRUG; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASPASE; INDAZOLE DERIVATIVE; INDOLE DERIVATIVE; MTOR PROTEIN, HUMAN; PEPTIDE CHLOROMETHYL KETONE; PROTEIN KINASE INHIBITOR; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; REGULATORY MECHANISM; AKT; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; MTOR; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

AKT; AUTOPHAGY; MTOR; PANCREATIC CANCER;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; AUTOPHAGY; CASPASES; CELL LINE, TUMOR; ENZYME ACTIVATION; HUMANS; INDAZOLES; INDOLES; MICROSCOPY, FLUORESCENCE; PANCREATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84897098337     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Boya P, Reggiori F and Codogno P: Emerging regulation and functions of autophagy. Nat Cell Biol 15(7): 713-720, 2013.
2. Yang ZJ, Chee CE, Huang S and Sinicrope FA: The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther 10(9): 1533-1541, 2012.
3. Hu YL, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS and Aghi MK: Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res 72(7): 1773-1783, 2012.
4. Altman BJ and Rathmell JC: Metabolic stress in autophagy and cell death pathways. Cold Spring Harb Perspect Biol 4(9): a008763, 2012.
5. Sridhar S, Botbol Y, Macian F and Cuervo AM: Autophagy and disease: always two sides to a problem. J Pathol 226(2): 255-273, 2012.
6. Gibson SB: A matter of balance between life and death: targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy. Autophagy 6(7): 835-837, 2010.
7. Schlieman MG, Fahy BN, Ramsamooj R, Beckett L and Bold RJ: Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br J Cancer 89(11): 2110-2115, 2003.
8. Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL and Reddy SA: The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. Oncogene 23(53): 8571-8580, 2004.
9. Altomare DA, Tanno S, De Rienzo A, Klein-Szanto AJ, Tanno S, Skele KL, Hoffman JP and Testa JR: Frequent activation of AKT2 kinase in human pancreatic carcinomas. J Cell Biochem 87(4): 470-476, 2002.
10. Fahy BN, Schlieman M, Virudachalam S and Bold RJ: AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2. Br J Cancer 89(2): 391-397, 2003.
11. Arlt A, Gehrz A, Müerköster S, Vorndamm J, Kruse ML, Fölsch UR and Schäfer H: Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 22(21): 3243-3251, 2003.
12. Ng SSW, Tsao MS, Chow S and Hedley DW: Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Res 60(19): 5451-5455, 2000.
13. Wang SY, Yu QJ, Zhang RD and Liu B: Core signaling pathways of survival/death in autophagy-related cancer networks. Int J Biochem Cell Biol 43(9): 1263-1266, 2011.
14. Janku F, McConkey DJ, Hong DS and Kurzrock R: Autophagy as a target for anticancer therapy. Nat Rev Clin Oncol 8(9): 528-39, 2011.
15. Fujiwara K, Iwado E, Mills GB, Sawaya R, Kondo S and Kondo Y: Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. Int J Oncol 31(4): 753-760, 2007.
16. Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB and Kondo S: Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3- kinase/protein kinase B inhibitors. Cancer Res 65(8): 3336-3346, 2005.
17. Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB and Kondo Y: Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol 72(1): 29-39, 2007.
18. Luo Y, Shoemaker AR, Liu X, Woods KW, Thomas SA, de Jong R, Han EK, Li T, Stoll VS, Powlas JA, Oleksijew A, Mitten MJ, Shi Y, Guan R, McGonigal TP, Klinghofer V, Johnson EF, Leverson JD, Bouska JJ, Mamo M, Smith RA, Gramling-Evans EE, Zinker BA, Mika AK, Nguyen PT, Oltersdorf T, Rosenberg SH, Li Q and Giranda VL: Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo . Mol Cancer Ther 4(6): 977-986, 2005.
19. Kim RH, Coates JM, Bowles TL, McNerney GP, Sutcliffe J, Jung JU, Gandour-Edwards R, Chuang FY, Bold RJ and Kung HJ: Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res 69(2): 700-708, 2009.
20. Yang W, Ju JH, Lee KM, Nam K, Oh S and Shin I: Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression. Exp Cell Res 319(3): 122-133, 2013.
21. Degtyarev M, De Mazière A, Klumperman J and Lin K: Autophagy, an Achilles' heel AKTing against cancer? Autophagy 5(3): 415-418, 2009.
22. Dai ZJ, Gao J, Ma XB, Kang HF, Wang BF, Lu WF, Lin S, Wang XJ and Wu WY: Antitumor effects of rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy. Int J Mol Sci 14(1): 273-285, 2012.
23. Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL and Reddy SA: The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation. Biochem Biophys Res Commun 331(1): 295-302, 2005.
24. Javle MM, Shroff RT, Xiong H, Varadhachary GA, Fogelman D, Reddy SA, Davis D, Zhang Y, Wolff RA and Abbruzzese JL: Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies. BMC Cancer 10: 368, 2010.
25. Jeong EH, Choi HS, Lee TG, Kim HR and Kim CH: Dual Inhibition of PI3K/Akt/mTOR Pathway and Role of Autophagy in Non-Small Cell Lung Cancer Cells. Tuberc Respir Dis (Seoul) 72(4): 343-351, 2012.
26. Lamoureux F and Zoubeidi A: Dual inhibition of autophagy and the AKT pathway in prostate cancer. Autophagy 9(7): 1119-1120, 2013.
27. Singh BN, Kumar D, Shankar S and Srivastava RK: Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. Biochem Pharmacol 84(9): 1154-1163, 2012.
28. Mujumdar N, Mackenzie TN, Dudeja V, Chugh R, Antonoff MB, Borja-Cacho D, Sangwan V, Dawra R, Vickers SM and Saluja AK: Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways. Gastroenterology 139(2): 598-608, 2010.
29. Ling YH, Aracil M, Zou Y, Yuan Z, Lu B, Jimeno J, Cuervo AM and Perez-Soler R: PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase. Clin Cancer Res 17(16): 5353-5366, 2011.