TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers

Cell

Volumn 148, Issue 4, 2012, Pages 639-650

  Singh, Anurag ^a,c   Sweeney, Michael F ^a   Yu, Min ^a   Burger, Alexa ^a   Greninger, Patricia ^a   Benes, Cyril ^a   Haber, Daniel A ^a,b   Settleman, Jeff ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; K RAS PROTEIN; OSTEOGENIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; RNA INTERFERENCE;

EID: 84863419728     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2011.12.033     Document Type: Article

References (36)

1. D.A. Barbie, P. Tamayo, J.S. Boehm, S.Y. Kim, S.E. Moody, I.F. Dunn, A.C. Schinzel, P. Sandy, E. Meylan, and C. Scholl Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 Nature 462 2009 108 112
2. J. Behrens, J.P. von Kries, M. Kühl, L. Bruhn, D. Wedlich, R. Grosschedl, and W. Birchmeier Functional interaction of beta-catenin with the transcription factor LEF-1 Nature 382 1996 638 642 (Pubitemid 26268958)
3. B.M. Bolstad, R.A. Irizarry, M. Astrand, and T.P. Speed A comparison of normalization methods for high density oligonucleotide array data based on variance and bias Bioinformatics 19 2003 185 193 (Pubitemid 36181903)
4. E. Campeau, V.E. Ruhl, F. Rodier, C.L. Smith, B.L. Rahmberg, J.O. Fuss, J. Campisi, P. Yaswen, P.K. Cooper, and P.D. Kaufman A versatile viral system for expression and depletion of proteins in mammalian cells PLoS ONE 4 2009 e6529
5. G. Dennis Jr., B.T. Sherman, D.A. Hosack, J. Yang, W. Gao, H.C. Lane, and R.A. Lempicki DAVID: Database for Annotation, Visualization, and Integrated Discovery Genome Biol. 4 2003 3
6. J. Downward Targeting RAS signalling pathways in cancer therapy Nat. Rev. Cancer 3 2003 11 22 (Pubitemid 37328883)
7. H. Ebi, R.B. Corcoran, A. Singh, Z. Chen, Y. Song, E. Lifshits, D.P. Ryan, J.A. Meyerhardt, C. Benes, and J. Settleman Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers J. Clin. Invest. 121 2011 4311 4321
8. M.B. Eisen, P.T. Spellman, P.O. Brown, and D. Botstein Cluster analysis and display of genome-wide expression patterns Proc. Natl. Acad. Sci. USA 95 1998 14863 14868 (Pubitemid 29003722)
9. C. Fuerer, and R. Nusse Lentiviral vectors to probe and manipulate the Wnt signaling pathway PLoS ONE 5 2010 e9370
10. A.P. Gasch, and M.B. Eisen Exploring the conditional coregulation of yeast gene expression through fuzzy k-means clustering Genome Biol. 3 2002 RESEARCH0059
11. D.A. Haber, N.S. Gray, and J. Baselga The evolving war on cancer Cell 145 2011 19 24
12. P. Hatzis, L.G. van der Flier, M.A. van Driel, V. Guryev, F. Nielsen, S. Denissov, I.J. Nijman, J. Koster, E.E. Santo, and W. Welboren Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells Mol. Cell. Biol. 28 2008 2732 2744 (Pubitemid 351542371)
13. K.P. Janssen, P. Alberici, H. Fsihi, C. Gaspar, C. Breukel, P. Franken, C. Rosty, M. Abal, F. El Marjou, and R. Smits APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression Gastroenterology 131 2006 1096 1109 (Pubitemid 44498698)
14. Z. Lin, C. Gao, Y. Ning, X. He, W. Wu, and Y.G. Chen The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling J. Biol. Chem. 283 2008 33053 33058
15. J. Luo, M.J. Emanuele, D. Li, C.J. Creighton, M.R. Schlabach, T.F. Westbrook, K.K. Wong, and S.J. Elledge A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene Cell 137 2009 835 848
16. J. Luo, N.L. Solimini, and S.J. Elledge Principles of cancer therapy: oncogene and non-oncogene addiction Cell 136 2009 823 837
17. B. Lustig, B. Jerchow, M. Sachs, S. Weiler, T. Pietsch, U. Karsten, M. van de Wetering, H. Clevers, P.M. Schlag, W. Birchmeier, and J. Behrens Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors Mol. Cell. Biol. 22 2002 1184 1193 (Pubitemid 34094854)
18. D. Melisi, Q. Xia, G. Paradiso, J. Ling, T. Moccia, C. Carbone, A. Budillon, J.L. Abbruzzese, and P.J. Chiao Modulation of pancreatic cancer chemoresistance by inhibition of TAK1 J. Natl. Cancer Inst. 103 2011 1190 1204
19. E. Meylan, A.L. Dooley, D.M. Feldser, L. Shen, E. Turk, C. Ouyang, and T. Jacks Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma Nature 462 2009 104 107
20. J. Moffat, D.A. Grueneberg, X. Yang, S.Y. Kim, A.M. Kloepfer, G. Hinkle, B. Piqani, T.M. Eisenhaure, B. Luo, and J.K. Grenier A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen Cell 124 2006 1283 1298
21. K. Nakamura, S. Kim, T. Ishidate, Y. Bei, K. Pang, M. Shirayama, C. Trzepacz, D.R. Brownell, and C.C. Mello Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos Genes Dev. 19 2005 1749 1754 (Pubitemid 41126912)
22. L. Naldini, U. Blömer, P. Gallay, D. Ory, R. Mulligan, F.H. Gage, I.M. Verma, and D. Trono In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector Science 272 1996 263 267 (Pubitemid 26119138)
23. N. Normanno, S. Tejpar, F. Morgillo, A. De Luca, E. Van Cutsem, and F. Ciardiello Implications for KRAS status and EGFR-targeted therapies in metastatic CRC Nat. Rev. Clin. Oncol. 6 2009 519 527
24. T.V. Petrova, A. Nykänen, C. Norrmén, K.I. Ivanov, L.C. Andersson, C. Haglund, P. Puolakkainen, F. Wempe, H. von Melchner, and G. Gradwohl Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype Cancer Cell 13 2008 407 419 (Pubitemid 351609440)
25. R.A. Phelps, S. Chidester, S. Dehghanizadeh, J. Phelps, I.T. Sandoval, K. Rai, T. Broadbent, S. Sarkar, R.W. Burt, and D.A. Jones A two-step model for colon adenoma initiation and progression caused by APC loss Cell 137 2009 623 634
26. P. Rawlins, T. Mander, R. Sadeghi, S. Hill, G. Gammon, B. Foxwell, S. Wrigley, and M. Moore Inhibition of endotoxin-induced TNF-alpha production in macrophages by 5Z-7-oxo-zeaenol and other fungal resorcylic acid lactones Int. J. Immunopharmacol. 21 1999 799 814 (Pubitemid 29512322)
27. J.F. Reid, M. Gariboldi, V. Sokolova, P. Capobianco, A. Lampis, F. Perrone, S. Signoroni, A. Costa, E. Leo, S. Pilotti, and M.A. Pierotti Integrative approach for prioritizing cancer genes in sporadic colon cancer Genes Chromosomes Cancer 48 2009 953 962
28. C. Scholl, S. Fröhling, I.F. Dunn, A.C. Schinzel, D.A. Barbie, S.Y. Kim, S.J. Silver, P. Tamayo, R.C. Wadlow, and S. Ramaswamy Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells Cell 137 2009 821 834
29. T. Sekiya, S. Adachi, K. Kohu, T. Yamada, O. Higuchi, Y. Furukawa, Y. Nakamura, T. Nakamura, K. Tashiro, and S. Kuhara Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells J. Biol. Chem. 279 2004 6840 6846 (Pubitemid 38248826)
30. T.H. Shin, J. Yasuda, C.E. Rocheleau, R. Lin, M. Soto, Y. Bei, R.J. Davis, and C.C. Mello MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans Mol. Cell 4 1999 275 280 (Pubitemid 29456896)
31. A. Singh, P. Greninger, D. Rhodes, L. Koopman, S. Violette, N. Bardeesy, and J. Settleman A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival Cancer Cell 15 2009 489 500
32. D.T. Starczynowski, W.W. Lockwood, S. Deléhouzée, R. Chari, J. Wegrzyn, M. Fuller, M.S. Tsao, S. Lam, A.F. Gazdar, W.L. Lam, and A. Karsan TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer J. Clin. Invest. 121 2011 4095 4105
33. B. Vogelstein, E.R. Fearon, S.R. Hamilton, S.E. Kern, A.C. Preisinger, M. Leppert, Y. Nakamura, R. White, A.M. Smits, and J.L. Bos Genetic alterations during colorectal-tumor development N. Engl. J. Med. 319 1988 525 532
34. D.B. Whyte, P. Kirschmeier, T.N. Hockenberry, I. Nunez-Oliva, L. James, J.J. Catino, W.R. Bishop, and J.K. Pai K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors J. Biol. Chem. 272 1997 14459 14464 (Pubitemid 27232866)
35. M. Xie, D. Zhang, J.R. Dyck, Y. Li, H. Zhang, M. Morishima, D.L. Mann, G.E. Taffet, A. Baldini, D.S. Khoury, and M.D. Schneider A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway Proc. Natl. Acad. Sci. USA 103 2006 17378 17383 (Pubitemid 44788977)
36. H. Zou, R. Wieser, J. Massagué, and L. Niswander Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage Genes Dev. 11 1997 2191 2203 (Pubitemid 27387970)