Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma

Science Signaling

Volumn 8, Issue 367, 2015, Pages

  Wengrod, Jordan ^a   Wang, Ding ^a   Weiss, Sarah ^a   Zhong, Hua ^a   Osman, Iman ^a   Gardner, Lawrence B ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENERAL CONTROL NONREPRESSED 2 KINASE; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MUTANT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT; UNCLASSIFIED DRUG; AMINO ACID; EIF2AK4 PROTEIN, HUMAN; INITIATION FACTOR 2; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PROTEIN PHOSPHATASE 6; PROTEIN SERINE THREONINE KINASE; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; TUNICAMYCIN;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME STABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MELANOMA; MUTATION; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANTAGONISTS AND INHIBITORS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DEFICIENCY; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENE TARGETING; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MASS SPECTROMETRY; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE;

EUKARYOTA; MAMMALIA;

AMINO ACIDS; AUTOPHAGY; CELL LINE, TUMOR; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; ENZYME ACTIVATION; EUKARYOTIC INITIATION FACTOR-2; GENE KNOCK-IN TECHNIQUES; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MELANOMA; MICROSCOPY, FLUORESCENCE; MULTIPROTEIN COMPLEXES; MUTATION; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIROLIMUS; TOR SERINE-THREONINE KINASES; TUNICAMYCIN;

EID: 84937634397     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aaa0899     Document Type: Article

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