Analysis of a lung defect in autophagy-deficient mouse strains

Autophagy

Volumn 10, Issue 1, 2014, Pages 45-56

  Cheong, Heesun ^a   Wu, Junmin ^b   Gonzales, Linda K ^b   Guttentag, Susan H ^b   Thompson, Craig B ^a   Lindsten, Tullia ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Atg5 KO mice; Glycogen; Lung development; Perinatal mortality; Ulk1 2 DKO mice

Indexed keywords

ATG5KO MICE; GLYCOGEN; LUNG DEVELOPMENT; PERINATAL MORTALITY; ULK1/2DKO MICE;

ANIMALS; ANIMALS, NEWBORN; AUTOPHAGY; GLYCOGEN; IMMUNOHISTOCHEMISTRY; LUNG; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHOLIPIDS; PNEUMOCYTES; PROTEIN-SERINE-THREONINE KINASES; STAINING AND LABELING;

EID: 84893564445     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.26505     Document Type: Article

References (44)

1. Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004; 306:990-5; PMID:15528435; http://dx.doi.org/10.1126/ science.1099993 (Pubitemid 39482894)
2. Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol 2010; 12:81422; PMID:20811353; http://dx.doi.org/10.1038/ncb0910-814
3. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069-75; PMID:18305538; http://dx.doi.org/10.1038/nature06639 (Pubitemid 351317450)
4. Rabinowitz JD, White E. Autophagy and metabolism. Science 2010; 330:1344-8; PMID:21127245; http://dx.doi.org/10.1126/science.1193497
5. Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol 2010; 12:823-30; PMID:20811354; http://dx.doi.org/10.1038/ncb0910-823
6. Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 2003; 100:1507782; PMID:14657337; http://dx.doi.org/10.1073/pnas.2436255100
7. Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112:1809-20; PMID:14638851 (Pubitemid 38063704)
8. Sou YS, Waguri S, Iwata J, Ueno T, Fujimura T, Hara T, Sawada N, Yamada A, Mizushima N, Uchiyama Y, et al. The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell 2008; 19:4762-75; PMID:18768753; http://dx.doi.org/10.1091/mbc.E08-03-0309
9. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. The role of autophagy during the early neonatal starvation period. Nature 2004; 432:10326; PMID:15525940; http://dx.doi.org/10. 1038/nature03029
10. Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169:425-34; PMID:15866887; http://dx.doi.org/10.1083/jcb.200412022 (Pubitemid 40686693)
11. Saitoh T, Fujita N, Hayashi T, Takahara K, Satoh T, Lee H, Matsunaga K, Kageyama S, Omori H, Noda T, et al. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A 2009; 106:208426; PMID:19926846; http://dx.doi.org/10.1073/pnas.0911267106
12. Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008; 456:264-8; PMID:18849965; http://dx.doi.org/10.1038/nature07383
13. Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008; 456:259-63; PMID:18849966; http://dx.doi.org/10.1038/nature07416
14. Kotoulas OB, Kalamidas SA, Kondomerkos DJ. Glycogen autophagy in glucose homeostasis. Pathol Res Pract 2006; 202:631-8; PMID:16781826; http://dx.doi.org/10.1016/j.prp.2006.04.001
15. Kalamidas SA, Kondomerkos DJ. The administration of nonmetabolizable glucose analogues fails to suppress the development of glycogen autophagy in newborn rat hepatocytes. Microsc Res Tech 2010; 73:1009-14; PMID:20146348; http://dx.doi.org/10.1002/jemt.20825
16. Kundu M, Lindsten T, Yang CY, Wu J, Zhao F, Zhang J, Selak MA, Ney PA, Thompson CB. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 2008; 112:1493-502; PMID:18539900; http://dx.doi.org/10.1182/blood-2008-02-137398
17. Cheong H, Lindsten T, Wu J, Lu C, Thompson CB. Ammonia-induced autophagy is independent of ULK1/ULK2 kinases. Proc Natl Acad Sci U S A 2011; 108:11121-6; PMID:21690395; http://dx.doi.org/10.1073/pnas.1107969108
18. Melton KR, Nesslein LL, Ikegami M, Tichelaar JW, Clark JC, Whitsett JA, Weaver TE. SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol 2003; 285:L543-9; PMID:12639841 (Pubitemid 37022854)
19. Ten Have-Opbroek AA, De Vries EC. Clara cell differentiation in the mouse: ultrastructural morphology and cytochemistry for surfactant protein A and Clara cell 10 kD protein. Microsc Res Tech 1993; 26:40011; PMID:8286786; http://dx.doi.org/10.1002/jemt.1070260508
20. Brehier A, Rooney SA. Phosphatidylcholine synthesis and glycogen depletion in fetal mouse lung: developmental changes and the effects of dexamethasone. Exp Lung Res 1981; 2:273-87; PMID:6274629; http://dx.doi.org/10. 3109/01902148109052323 (Pubitemid 12253149)
21. Rinaudo MT, Curto M, Bruno R, Ponzetto C. Some aspects of carbohydrate metabolism in rat lung during the period of growth. Int J Biochem 1981; 13:571-5; PMID:7238988; http://dx.doi.org/10.1016/0020-711X(81)90182-8 (Pubitemid 11089329)
22. Bourbon JR, Rieutort M, Engle MJ, Farrell PM. Utilization of glycogen for phospholipid synthesis in fetal rat lung. Biochim Biophys Acta 1982; 712:382-9; PMID:7126612; http://dx.doi.org/10.1016/0005-2760(82)90356-3 (Pubitemid 13227601)
23. Carlson KS, Davies P, Smith BT, Post M. Temporal linkage of glycogen and saturated phosphatidylcholine in fetal lung type II cells. Pediatr Res 1987; 22:79-82; PMID:3627877; http://dx.doi.org/10.1203/00006450-198707000-00018 (Pubitemid 17087234)
24. Ridsdale R, Post M. Surfactant lipid synthesis and lamellar body formation in glycogen-laden type II cells. Am J Physiol Lung Cell Mol Physiol 2004; 287:L743-51; PMID:15169678; http://dx.doi.org/10.1152/ajplung.00146.2004 (Pubitemid 39249387)
25. Clark DG, Topping DL, Illman RJ, Trimble RP, Malthus RS. A glycogen storage disease (gsd/gsd) rat: studies on lipid metabolism, lipogenesis, plasma metabolites, and bile acid secretion. Metabolism 1980; 29:415-20; PMID:6929400; http://dx.doi.org/10.1016/0026-0495(80)90165-1 (Pubitemid 10095952)
26. Rannels SR, Rannels SL, Sneyd JG, Loten EG. Fetal lung development in rats with a glycogen storage disorder. Am J Physiol 1991; 260:L419-27; PMID:2058687
27. Rannels SR. Impaired surfactant synthesis in fetal type II lung cells from gsd/gsd rats. Exp Lung Res 1996; 22:213-29; PMID:8706637; http://dx.doi.org/10.3109/01902149609050848 (Pubitemid 26097946)
28. Liu L, Rannels SR, Falconieri M, Phillips KS, Wolpert EB, Weaver TE. The testis isoform of the phosphorylase kinase catalytic subunit (PhK-gammaT) plays a critical role in regulation of glycogen mobilization in developing lung. J Biol Chem 1996; 271:117616; PMID:8662648; http://dx.doi.org/10.1074/jbc.271.20. 11761
29. Dimauro S, Garone C. Metabolic disorders of fetal life: glycogenoses and mitochondrial defects of the mitochondrial respiratory chain. Semin Fetal Neonatal Med 2011; 16:181-9; PMID:21620786; http://dx.doi.org/10.1016/j.siny. 2011.04.010
30. Scott RC, Juhász G, Neufeld TP. Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol 2007; 17:111; PMID:17208179; http://dx.doi.org/10.1016/j.cub.2006.10.053
31. Jung CH, Seo M, Otto NM, Kim DH. ULK1 inhibits the kinase activity of mTORC1 and cell proliferation. Autophagy 2011; 7:1212-21; PMID:21795849; http://dx.doi.org/10.4161/auto.7.10.16660
32. Dunlop EA, Hunt DK, Acosta-Jaquez HA, Fingar DC, Tee AR. ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy 2011; 7:73747; PMID:21460630; http://dx.doi.org/10. 4161/auto.7.7.15491
33. Gammoh N, Florey O, Overholtzer M, Jiang X. Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy. Nat Struct Mol Biol 2013; 20:144-9; PMID:23262492; http://dx.doi.org/10.1038/nsmb. 2475
34. Beaulaton J, Lockshin RA. Ultrastructural study of the normal degeneration of the intersegmental muscles of Anthereae polyphemus and Manduca sexta (Insecta, Lepidoptera) with particular reference of cellular autophagy. J Morphol 1977; 154:3957; PMID:915948; http://dx.doi.org/10.1002/jmor.1051540104
35. Scharrer B. Ultrastructural study of the regressing prothoracic glands of blattarian insects. Z Zellforsch Mikrosk Anat 1966; 69:1-21; PMID:5973090; http://dx.doi.org/10.1007/BF00406264
36. Schin KS, Clever U. Lysosomal and free acid phosphatase in salivary glands of chironomus tentans. Science 1965; 150:1053-5; PMID:5843621; http://dx.doi.org/10.1126/science.150.3699.1053
37. Schin K, Laufer H. Studies of programmed salivary gland regression during larval-pupal transformation in Chironomus thummi. I. Acid hydrolase activity. Exp Cell Res 1973; 82:335-40; PMID:4765248; http://dx.doi.org/10.1016/0014- 4827(73)90350-9
38. Holt SV, Wyspianska B, Randall KJ, James D, Foster JR, Wilkinson RW. The development of an immunohistochemical method to detect the autophagy-associated protein LC3-II in human tumor xenografts. Toxicol Pathol 2011; 39:516-23; PMID:21441228; http://dx.doi.org/10.1177/0192623310396903
39. Foster C, Aktar A, Kopf D, Zhang P, Guttentag S. Pepsinogen C: a type 2 cell-specific protease. Am J Physiol Lung Cell Mol Physiol 2004; 286:L3827; PMID:14578117; http://dx.doi.org/10.1152/ajplung.00310.2003
40. Beers MF, Bates SR, Fisher AB. Differential extraction for the rapid purification of bovine surfactant protein B. Am J Physiol 1992; 262:L773-8; PMID:1616060
41. Korimilli A, Gonzales LW, Guttentag SH. Intracellular localization of processing events in human surfactant protein B biosynthesis. J Biol Chem 2000; 275:8672-9; PMID:10722708; http://dx.doi.org/10.1074/jbc.275.12.8672 (Pubitemid 30180218)
42. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37:911-7; PMID:13671378; http://dx.doi.org/10.1139/o59-099
43. Bartlett GR. Phosphorus assay in column chromatography. J Biol Chem 1959; 234:466-8; PMID:13641241
44. Gonzales LW, Ballard PL, Ertsey R, Williams MC. Glucocorticoids and thyroid hormones stimulate biochemical and morphological differentiation of human fetal lung in organ culture. J Clin Endocrinol Metab 1986; 62:678-91; PMID:3949950; http://dx.doi.org/10.1210/jcem-62-4-678 (Pubitemid 16138139)