Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2α protein kinase GCN2

Journal of Biological Chemistry

Volumn 280, Issue 32, 2005, Pages 29289-29299

  Padyana, Anil K ^a,b   Qiu, Hongfang ^c   Roll Mecak, Antonina ^b,d   Hinnebusch, Alan G ^c   Burley, Stephen K ^a,b  

^a ELI LILLY AND COMPANY   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; CELLS; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYMES; HYDROLYSIS; MUTAGENESIS; RNA;

AUTOINHIBITION; INTRAMOLECULAR INTERACTIONS; MUTATIONAL ACTIVATION; PROTEIN KINASE;

PROTEINS;

ADENOSINE TRIPHOSPHATE; ARGININE; GLYCINE; HISTIDINE TRANSFER RNA LIGASE; MUTANT PROTEIN; PROTEIN GCN2; PROTEIN KINASE R; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RNA BINDING; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ARGININE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; EIF-2 KINASE; ESCHERICHIA COLI; HISTIDINE; HYDROLYSIS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RNA, TRANSFER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EUKARYOTA;

EID: 23844554840     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504096200     Document Type: Article

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