Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A

Journal of Cell Science

Volumn 126, Issue 15, 2013, Pages 3429-3440

  Hammond, Dean ^a,c   Zeng, Kang ^a,d   Espert, Antonio ^b   Bastos, Ricardo Nunes ^a   Baron, Ryan D ^a   Gruneberg, Ulrike ^b   Barr, Francis A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Aurora A; Chromothripsis; Protein phosphatase 6

Indexed keywords

AURORA A KINASE; DNA; PHOSPHOPROTEIN PHOSPHATASE; PROTEASOME; PROTEIN PHOSPHATASE 6; UNCLASSIFIED DRUG;

ARTICLE; CENTROSOME; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; FEMALE; GAIN OF FUNCTION MUTATION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MASS SPECTROMETRY; MELANOMA; MITOSIS; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

AURORA-A; CHROMOTHRIPSIS; PROTEIN PHOSPHATASE 6;

AMINO ACID SEQUENCE; AURORA KINASE A; CELL LINE, TUMOR; CHROMOSOMAL INSTABILITY; DNA DAMAGE; HELA CELLS; HUMANS; MELANOMA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION;

EID: 84883368399     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.128397     Document Type: Article

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