Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors

British Journal of Pharmacology

Volumn 172, Issue 13, 2015, Pages 3326-3340

  Helliwell, R M ^a   Shioukhuey, C O ^a   Dhuna, K ^a   Molero, J C ^a   Ye, J M ^a   Xue, C C ^a   Stokes, Leanne ^a,b  

^a RMIT UNIVERSITY   (Australia)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CHEMICAL COMPOUND; GINSENOSIDE; GLUCOPYRANOSIDE; PROTOPANAXDIOL; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG; BENZOXAZOLE DERIVATIVE; CALCIUM; FLUORESCENT DYE; PROTOPANAXADIOL; QUINOLINE DERIVATIVE; SAPOGENIN; YO-PRO 1;

ADULT; ALLOSTERISM; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; EC50; EMBRYO; EVOKED RESPONSE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; MACROPHAGE; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; WHOLE CELL PATCH CLAMP; ANIMAL; C57BL MOUSE; CELL LINE; HEK293 CELL LINE; METABOLISM; PATCH CLAMP TECHNIQUE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BENZOXAZOLES; CALCIUM; CELL LINE; FLUORESCENT DYES; GINSENOSIDES; HEK293 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; PATCH-CLAMP TECHNIQUES; QUINOLINIUM COMPOUNDS; RECEPTORS, PURINERGIC P2X7; SAPOGENINS;

EID: 84937556673     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13123     Document Type: Article

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