메뉴 건너뛰기




Volumn 5, Issue 1, 2013, Pages 72-83

Involvement of the P2X7 purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E2 induction by LL-37

Author keywords

Cathelicidin; Cyclooxygenase 2; LL 37; Mitogen activated protein kinase; P2X7; Prostaglandin E2; Purinergic receptors

Indexed keywords

BETA DEFENSIN 3; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NEUTRALIZING ANTIBODY; PROSTAGLANDIN E2; PROTEIN P46; PURINERGIC P2X7 RECEPTOR; PROTEIN C JUN; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE BINDING PROTEIN; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, HUMAN; STRESS ACTIVATED PROTEIN KINASE; SULFONAMIDE;

EID: 84872276132     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000342928     Document Type: Article
Times cited : (33)

References (40)
  • 1
    • 22944435825 scopus 로고    scopus 로고
    • Antimicrobial peptides in the oral environment: Expression and function in health and disease
    • Dale BA, Fredericks LP: Antimicrobial peptides in the oral environment: expression and function in health and disease. Curr Issues Mol Biol 2005; 7: 119-133.
    • (2005) Curr Issues Mol Biol , vol.7 , pp. 119-133
    • Dale, B.A.1    Fredericks, L.P.2
  • 3
    • 22944458199 scopus 로고    scopus 로고
    • The role of cathelicidins in the innate host defenses of mammals
    • Zanetti M: The role of cathelicidins in the innate host defenses of mammals. Curr Issues Mol Biol 2005; 7: 179-196. (Pubitemid 41051685)
    • (2005) Current Issues in Molecular Biology , vol.7 , Issue.2 , pp. 179-196
    • Zanetti, M.1
  • 4
    • 0032903987 scopus 로고    scopus 로고
    • The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6
    • Frohm Nilsson M, Sandstedt B, Sørensen O, Weber G, Borregaard N, Ståhle-Bäckdahl M: The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6. Infect Immun 1999; 67: 2561-2566. (Pubitemid 29200519)
    • (1999) Infection and Immunity , vol.67 , Issue.5 , pp. 2561-2566
    • Nilsson, M.F.1    Sandstedt, B.2    Sorensen, O.3    Weber, G.4    Borregaard, N.5    Stahle-Backdahl, M.6
  • 5
    • 0036891933 scopus 로고    scopus 로고
    • Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva
    • Murakami M, Ohtake T, Dorschner RA, Gallo RL: Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva. J Dent Res 2002; 81: 845-850.
    • (2002) J Dent Res , vol.81 , pp. 845-850
    • Murakami, M.1    Ohtake, T.2    Dorschner, R.A.3    Gallo, R.L.4
  • 6
    • 45149091570 scopus 로고    scopus 로고
    • Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria
    • DOI 10.1111/j.1399-302X.2008.00433.x
    • Puklo M, Guentsch A, Hiemstra PS, Eick S, Potempa J: Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria. Oral Microbiol Immunol 2008; 23: 328-335. (Pubitemid 351832179)
    • (2008) Oral Microbiology and Immunology , vol.23 , Issue.4 , pp. 328-335
    • Puklo, M.1    Guentsch, A.2    Hiemstra, P.S.3    Eick, S.4    Potempa, J.5
  • 8
    • 78650144259 scopus 로고    scopus 로고
    • Antimicrobial peptide hCAP- 18/LL-37 protein and mRNA expressions in different periodontal diseases
    • Türkoǧlu O, Kandiloǧlu G, Berdeli A, Emingil G, Atilla G: Antimicrobial peptide hCAP- 18/LL-37 protein and mRNA expressions in different periodontal diseases. Oral Dis 2011; 17: 60-67.
    • (2011) Oral Dis , vol.17 , pp. 60-67
    • Türkoǧlu, O.1    Kandiloǧlu, G.2    Berdeli, A.3    Emingil, G.4    Atilla, G.5
  • 9
    • 67649964706 scopus 로고    scopus 로고
    • Gingival crevicular fluid levels of cathelicidin LL-37 and interleukin-18 in patients with chronic periodontitis
    • Türkoǧlu O, Emingil G, Kütükçüler N, Atilla G: Gingival crevicular fluid levels of cathelicidin LL-37 and interleukin-18 in patients with chronic periodontitis. J Periodontol 2009; 80: 969-976.
    • (2009) J Periodontol , vol.80 , pp. 969-976
    • Türkoǧlu, O.1    Emingil, G.2    Kütükçüler, N.3    Atilla, G.4
  • 11
    • 33746467932 scopus 로고    scopus 로고
    • Prostaglandins in health and disease: An Overview
    • DOI 10.1016/j.semarthrit.2006.03.005, PII S0049017206000497
    • Miller SB: Prostaglandins in health and disease: an overview. Semin Arthritis Rheum 2006; 36: 37-49. (Pubitemid 44128595)
    • (2006) Seminars in Arthritis and Rheumatism , vol.36 , Issue.1 , pp. 37-49
    • Miller, S.B.1
  • 13
    • 0029825727 scopus 로고    scopus 로고
    • Prostaglandin production via induction of cyclooxygenase-2 by human gingival fibroblasts stimulated with lipopolysaccharides
    • DOI 10.1007/BF01487046
    • Noguchi K, Shitashige M, Yanai M, Morita I, Nishihara T, Murota S, Ishikawa I: Prostaglandin production via induction of cyclooxygenase-2 by human gingival fibroblasts stimulated with lipopolysaccharides. Inflammation 1996; 20: 555-568. (Pubitemid 26361657)
    • (1996) Inflammation , vol.20 , Issue.5 , pp. 555-568
    • Noguchi, K.1    Shitashige, M.2    Yanai, M.3    Morita, I.4    Nishihara, T.5    Murota, S.6    Ishikawa, I.7
  • 14
    • 0035318704 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is upregulated in inflamed gingival tissues
    • DOI 10.1902/jop.2001.72.4.461
    • Morton RS, Dongari-Bagtzoglou AI: Cyclooxygenase-2 is upregulated in inflamed gingival tissues. J Periodontol 2001; 72: 461-469. (Pubitemid 33664492)
    • (2001) Journal of Periodontology , vol.72 , Issue.4 , pp. 461-469
    • Morton, R.S.1    Dongari-Bagtzoglou, A.I.2
  • 15
    • 0028981966 scopus 로고
    • Interleukin-1 beta induces expression of cyclooxygenase-2 mRNA in human gingival fibroblasts
    • Yucel-Lindberg T, Ahola H, Nilsson S, Carlstedt- Duke J, Modéer T: Interleukin-1 beta induces expression of cyclooxygenase-2 mRNA in human gingival fibroblasts. Inflammation 1995; 19: 549-560.
    • (1995) Inflammation , vol.19 , pp. 549-560
    • Yucel-Lindberg, T.1    Ahola, H.2    Nilsson, S.3    Carlstedt- Duke, J.4    Modéer, T.5
  • 17
    • 77954859999 scopus 로고    scopus 로고
    • Human beta-defensin-3 up-regulates cyclooxygenase-2 expression and prostaglandin E2 synthesis in human gingival fibroblasts
    • Chotjumlong P, Khongkhunthian S, Ongchai S, Reutrakul V, Krisanaprakornkit S: Human beta-defensin-3 up-regulates cyclooxygenase-2 expression and prostaglandin E2 synthesis in human gingival fibroblasts. J Periodontal Res 2010; 45: 464-470.
    • (2010) J Periodontal Res , vol.45 , pp. 464-470
    • Chotjumlong, P.1    Khongkhunthian, S.2    Ongchai, S.3    Reutrakul, V.4    Krisanaprakornkit, S.5
  • 19
    • 20544447535 scopus 로고    scopus 로고
    • Candidacidal effects of two antimicrobial peptides: Histatin 5 causes small membrane defects, but LL-37 causes massive disruption of the cell membrane
    • DOI 10.1042/BJ20042099
    • den Hertog AL, van Marle J, van Veen HA, Van't Hof W, Bolscher JG, Veerman EC, Nieuw Amerongen AV: Candidacidal effects of two antimicrobial peptides: histatin 5 causes small membrane defects, but LL-37 causes massive disruption of the cell membrane. Biochem J 2005; 388: 689-695. (Pubitemid 40839946)
    • (2005) Biochemical Journal , vol.388 , Issue.2 , pp. 689-695
    • Den Hertog, A.L.1    Van Marle, J.2    Van Veen, H.A.3    Van't Hof, W.4    Bolscher, J.G.M.5    Veerman, E.C.I.6    Nieuw Amerongen, A.V.7
  • 20
    • 0034020351 scopus 로고    scopus 로고
    • Inducible expression of human β-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: Multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier
    • DOI 10.1128/IAI.68.5.2907-2915.2000
    • Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA: Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000; 68: 2907-2915. (Pubitemid 30253871)
    • (2000) Infection and Immunity , vol.68 , Issue.5 , pp. 2907-2915
    • Krisanaprakornkit, S.1    Kimball, J.R.2    Weinberg, A.3    Darveau, R.P.4    Bainbridge, B.W.5    Dale, B.A.6
  • 23
    • 0036136328 scopus 로고    scopus 로고
    • Regulation of human β-defensin-2 in gingival epithelial cells: The involvement of mitogen-activated protein kinase pathways, but not the NF-κB transcription factor family
    • Krisanaprakornkit S, Kimball JR, Dale BA: Regulation of human beta-defensin-2 in gingival epithelial cells: the involvement of mitogen- activated protein kinase pathways, but not the NF- - B transcription factor family. J Immunol 2002; 168: 316-324. (Pubitemid 34014132)
    • (2002) Journal of Immunology , vol.168 , Issue.1 , pp. 316-324
    • Krisanaprakornkit, S.1    Kimball, J.R.2    Dale, B.A.3
  • 24
    • 33646949280 scopus 로고    scopus 로고
    • The antimicrobial peptide LL-37 enhances IL-8 release by human airway smooth muscle cells
    • DOI 10.1016/j.jaci.2006.03.022, PII S0091674906007275
    • Zuyderduyn S, Ninaber DK, Hiemstra PS, Rabe KF: The antimicrobial peptide LL-37 enhances IL-8 release by human airway smooth muscle cells. J Allergy Clin Immunol 2006; 117: 1328-1335. (Pubitemid 43795721)
    • (2006) Journal of Allergy and Clinical Immunology , vol.117 , Issue.6 , pp. 1328-1335
    • Zuyderduyn, S.1    Ninaber, D.K.2    Hiemstra, P.S.3    Rabe, K.F.4
  • 27
    • 0036370736 scopus 로고    scopus 로고
    • 2 concentrations in gingival crevicular fluid: Observations in untreated chronic periodontitis
    • DOI 10.1034/j.1600-051x.2002.290103.x
    • Preshaw PM, Heasman PA: Prostaglandin E2 concentrations in gingival crevicular fluid: observations in untreated chronic periodontitis. J Clin Periodontol 2002; 29: 15-20. (Pubitemid 41697729)
    • (2002) Journal of Clinical Periodontology , vol.29 , Issue.1 , pp. 15-20
    • Preshaw, P.M.1    Heasman, P.A.2
  • 28
    • 80052968673 scopus 로고    scopus 로고
    • LL-37 suppresses sodium nitroprusside-induced apoptosis of systemic sclerosis dermal fibroblasts
    • Kim HJ, Cho DH, Lee KJ, Cho CS, Bang SI, Cho BK, Park HJ: LL-37 suppresses sodium nitroprusside-induced apoptosis of systemic sclerosis dermal fibroblasts. Exp Dermatol 2011; 20: 843-845.
    • (2011) Exp Dermatol , vol.20 , pp. 843-845
    • Kim, H.J.1    Cho, D.H.2    Lee, K.J.3    Cho, C.S.4    Bang, S.I.5    Cho, B.K.6    Park, H.J.7
  • 29
    • 33744512882 scopus 로고    scopus 로고
    • Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells
    • DOI 10.1016/j.jdermsci.2006.03.001, PII S0923181106000697
    • Chen X, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells. J Dermatol Sci 2006; 43: 63-66. (Pubitemid 43817496)
    • (2006) Journal of Dermatological Science , vol.43 , Issue.1 , pp. 63-66
    • Chen, X.1    Niyonsaba, F.2    Ushio, H.3    Nagaoka, I.4    Ikeda, S.5    Okumura, K.6    Ogawa, H.7
  • 30
    • 77952541658 scopus 로고    scopus 로고
    • Antimicrobial peptide rCRAMP induced glial cell activation through P2Y receptor signalling pathways
    • Brandenburg LO, Jansen S, Wruck CJ, Lucius R, Pufe T: Antimicrobial peptide rCRAMP induced glial cell activation through P2Y receptor signalling pathways. Mol Immunol 2010; 47: 1905-1913.
    • (2010) Mol Immunol , vol.47 , pp. 1905-1913
    • Brandenburg, L.O.1    Jansen, S.2    Wruck, C.J.3    Lucius, R.4    Pufe, T.5
  • 31
    • 77951249574 scopus 로고    scopus 로고
    • LL-37 via EGFR transactivation to promote high glucose-attenuated epithelial wound healing in organ-cultured corneas
    • Yin J, Yu FS: LL-37 via EGFR transactivation to promote high glucose-attenuated epithelial wound healing in organ-cultured corneas. Invest Ophthalmol Vis Sci 2010; 51: 1891-1897.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 1891-1897
    • Yin, J.1    Yu, F.S.2
  • 33
    • 77950833537 scopus 로고    scopus 로고
    • Signal pathways JNK and NF- - B, identified by global gene expression profiling, are involved in regulation of TNF - -induced mPGES-1 and COX-2 expression in gingival fibroblasts
    • Båge T, Lindberg J, Lundeberg J, Modéer T, Yucel-Lindberg T: Signal pathways JNK and NF- - B, identified by global gene expression profiling, are involved in regulation of TNF - -induced mPGES-1 and COX-2 expression in gingival fibroblasts. BMC Genomics 2010; 11: 241.
    • (2010) BMC Genomics , vol.11 , pp. 241
    • Båge, T.1    Lindberg, J.2    Lundeberg, J.3    Modéer, T.4    Yucel-Lindberg, T.5
  • 34
    • 11144348648 scopus 로고    scopus 로고
    • Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells
    • DOI 10.1128/IAI.73.1.583-591.2005
    • Lau YE, Rozek A, Scott MG, Goosney DL, Davidson DJ, Hancock RE: Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells. Infect Immun 2005; 73: 583-591. (Pubitemid 40041153)
    • (2005) Infection and Immunity , vol.73 , Issue.1 , pp. 583-591
    • Lau, Y.E.1    Rozek, A.2    Scott, M.G.3    Goosney, D.L.4    Davidson, D.J.5    Hancock, R.E.W.6
  • 36
    • 0034596945 scopus 로고    scopus 로고
    • LL-37, the neutrophil granuleand epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells
    • De Yang, Chen Q, Schmidt AP, Anderson GM, Wang JM, Wooters J, Oppenheim JJ, Chertov O: LL-37, the neutrophil granuleand epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 2000; 192: 1069-1074.
    • (2000) J Exp Med , vol.192 , pp. 1069-1074
    • De Yang Chen, Q.1    Schmidt, A.P.2    Anderson, G.M.3    Wang, J.M.4    Wooters, J.5    Oppenheim, J.J.6    Chertov, O.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.