Cathelicidin antimicrobial peptide inhibits fibroblast migration via P2X7 receptor signaling

Biochemical and Biophysical Research Communications

Volumn 437, Issue 4, 2013, Pages 609-614

  Kumagai, Shohei ^a   Matsui, Kazuki ^a   Kawaguchi, Haruyo ^a   Yamashita, Tomomi ^a   Mohri, Tomomi ^a   Fujio, Yasushi ^a   Nakayama, Hiroyuki ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

CAMP; Cardiac fibroblast; Fibrosis; Myocarditis; P2X7 purinergic receptor

Indexed keywords

CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; PURINERGIC P2X7 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FIBROBLAST; HEALING; HEART MUSCLE FIBROSIS; INFLAMMATION; MALE; MICROARRAY ANALYSIS; MOUSE; MYOCARDITIS; NONHUMAN; PRIORITY JOURNAL; STIMULATION; UPREGULATION;

MUS;

EID: 84881548113     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.07.010     Document Type: Article

References (33)

1. Qaseem A., Fihn S.D., Dallas P., et al. Management of stable ischemic heart disease: summary of a clinical practice guideline from the American College of Physicians/American College of Cardiology Foundation/American Heart Association/American Association for Thoracic Surgery/Preventive Cardiovascular Nurses Association/Society of Thoracic Surgeons. Ann. Intern. Med. 2012, 157:735-743.
2. Mensah G.A., Brown D.W. An overview of cardiovascular disease burden in the United States. Health Aff. (Millwood) 2007, 26:38-48.
3. Hobbs R.E. Guidelines for the diagnosis and management of heart failure. Am. J. Ther. 2004, 11:467-472.
4. Pfeffer M.A., Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990, 81:1161-1172.
5. Segura A.M., Frazier O.H., Buja L.M. Fibrosis and heart failure. Heart Fail. Rev. 2012.
6. Zeisberg E.M., Kalluri R. Origins of cardiac fibroblasts. Circ. Res. 2010, 107:1304-1312.
7. Carnevale D., Cifelli G., Mascio G., et al. Placental growth factor regulates cardiac inflammation through the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-alpha-converting enzyme axis: crucial role for adaptive cardiac remodeling during cardiac pressure overload. Circulation 2011, 124:1337-1350.
8. Frangogiannis N.G. Regulation of the inflammatory response in cardiac repair. Circ. Res. 2012, 110:159-173.
9. Mann D.L. The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls. Circ. Res. 2011, 108:1133-1145.
10. Frangogiannis N.G. Chemokines in the ischemic myocardium: from inflammation to fibrosis. Inflamm. Res. 2004, 53:585-595.
11. Bujak M., Frangogiannis N.G. The role of tgf-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc. Res. 2007, 74:184-195.
12. Valaperti A., Marty R.R., Kania G., et al. Cd11b+ monocytes abrogate th17 cd4+ t cell-mediated experimental autoimmune myocarditis. J. Immunol. 2008, 180:2686-2695.
13. Neu N., Rose N.R., Beisel K.W., et al. Cardiac myosin induces myocarditis in genetically predisposed mice. J. Immunol. 1987, 139:3630-3636.
14. Yamashita T., Iwakura T., Matsui K., et al. Il-6-mediated th17 differentiation through rorgammat is essential for the initiation of experimental autoimmune myocarditis. Cardiovasc. Res. 2011, 91:640-648.
15. Suzuki J., Ogawa M., Watanabe R., et al. Autoimmune giant cell myocarditis: clinical characteristics, experimental models and future treatments. Expert Opin. Ther. Targets 2011, 15:1163-1172.
16. Burton M.F., Steel P.G. The chemistry and biology of ll-37. Nat. Prod. Rep. 2009, 26:1572-1584.
17. Agerberth B., Charo J., Werr J., et al. The human antimicrobial and chemotactic peptides ll-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 2000, 96:3086-3093.
18. Henzler Wildman K.A., Lee D.K., Ramamoorthy A. Mechanism of lipid bilayer disruption by the human antimicrobial peptide, ll-37. Biochemistry 2003, 42:6545-6558.
19. Mookherjee N., Brown K.L., Bowdish D.M., et al. Modulation of the tlr-mediated inflammatory response by the endogenous human host defense peptide ll-37. J. Immunol. 2006, 176:2455-2464.
20. Koczulla R., von Degenfeld G., Kupatt C., et al. An angiogenic role for the human peptide antibiotic ll-37/hcap-18. J. Clin. Invest. 2003, 111:1665-1672.
21. Yamauchi-Takihara K., Ihara Y., Ogata A., et al. Hypoxic stress induces cardiac myocyte-derived interleukin-6. Circulation 1995, 91:1520-1524.
22. Liang C.C., Park A.Y., Guan J.L. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat. Protoc. 2007, 2:329-333.
23. Manso A.M., Kang S.M., Plotnikov S.V., et al. Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration. Am. J. Physiol. Heart Circ. Physiol. 2009, 296:H627-H638.
24. Park H.J., Cho D.H., Kim H.J., et al. Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide ll-37. J. Invest. Dermatol. 2009, 129:843-850.
25. Okura Y., Yamamoto T., Goto S., et al. Characterization of cytokine and inos mrna expression in situ during the course of experimental autoimmune myocarditis in rats. J. Mol. Cell. Cardiol. 1997, 29:491-502.
26. Blyszczuk P., Kania G., Dieterle T., et al. Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. Circ. Res. 2009, 105:912-920.
27. Doring Y., Drechsler M., Wantha S., et al. Lack of neutrophil-derived cramp reduces atherosclerosis in mice. Circ. Res. 2012, 110:1052-1056.
28. Oudhoff M.J., Blaauboer M.E., Nazmi K., et al. The role of salivary histatin and the human cathelicidin ll-37 in wound healing and innate immunity. Biol. Chem. 2010, 391:541-548.
29. Park H.J., Ock S.M., Kim H.J., et al. Vitamin C attenuates ERK signalling to inhibit the regulation of collagen production by ll-37 in human dermal fibroblasts. Exp. Dermatol. 2010, 19:e258-e264.
30. Tokumaru S., Sayama K., Shirakata Y., et al. Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide ll-37. J. Immunol. 2005, 175:4662-4668.
31. Yin J., Yu F.S. Ll-37 via EGFR transactivation to promote high glucose-attenuated epithelial wound healing in organ-cultured corneas. Invest. Ophthalmol. Vis. Sci. 2010, 51:1891-1897.
32. Otte J.M., Zdebik A.E., Brand S., et al. Effects of the cathelicidin ll-37 on intestinal epithelial barrier integrity. Regul. Pept. 2009, 156:104-117.
33. Chen J.B., Liu W.J., Che H., et al. Adenosine-5'-triphosphate up-regulates proliferation of human cardiac fibroblasts. Br. J. Pharmacol. 2012, 166:1140-1150.