20(S)-protopanaxadiol triggers mitochondrial-mediated apoptosis in human lung adenocarcinoma A549 cells via inhibiting the PI3K/Akt signaling pathway

American Journal of Chinese Medicine

Volumn 41, Issue 5, 2013, Pages 1137-1152

  Zhang, Yun Long ^a   Zhang, Rui ^b   Xu, Hua Li ^c   Yu, Xiao Feng ^c   Qu, Shao Chun ^c   Sui, Da Yuan ^c  

^a DONGHUA UNIVERSITY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c JILIN UNIVERSITY   (China)

Author keywords

20(S) Protopanaxadiol; Apoptosis; Lung Cancer; Mitochondria; PI3K Akt Pathway

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE; CASPASE 3; CASPASE 9; CASPASE INHIBITOR; CYTOCHROME C; GINSENOSIDE; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL; PROTOPANAXADIOL; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL LINE; DOWN REGULATION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LUNG CANCER; MITOCHONDRION;

ADENOCARCINOMA; APOPTOSIS; CASPASES; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; ONCOGENE PROTEIN V-AKT; PANAX; PHOSPHATIDYLINOSITOL 3-KINASES; PHYTOTHERAPY; SAPOGENINS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84885907483     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X13500778     Document Type: Article

References (36)

1. Agarwal, C., R.P. Singh and R. Agarwal. Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis 23: 1869-1876, 2002.
2. Attele, A.S., J.A. Wu and C.S. Yuan. Ginseng pharmacology: Multiple constituents and multiple actions. Biochem. Pharmacol. 58: 1685-1693, 1999.
3. Brunet, A., J. Park, H. Tran, L.S. Hu, B.A. Hemmings and M.E. Greenberg. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol. Cell Biol. 21: 952-965, 2001.
4. Cheng, Y.L., W.L. Chang, S.C. Lee, Y.G. Liu, C.J. Chen, S.Z. Lin, N.M. Tsai, D.S. Yu, C.Y. Yen and H.J. Harn. Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis. Life Sci. 75: 1579-1594, 2004.
5. Chipuk, J.E. and D.R. Green. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol. 18: 157-164, 2008.
6. Cho, S.H., K.S. Chung, J.H. Choi, D.H. Kim and K.T. Lee. Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells. BMC Cancer 9: 449, 2009.
7. Choi, Y.H., S.J. Lee, P. Nguyen, J.S. Jang, J. Lee, M.L. Wu, E. Takano, M. Maki, P.A. Henkart and J.B. Trepel. Regulation of cyclin D1 by calpain protease. J. Biol. Chem. 272: 28479-28484, 1997.
8. Gillis, C.N. Panax ginseng pharmacology: A nitric oxide link?. Biochem. Pharmacol. 54: 1-8, 1997.
9. Hail, N.J., B.Z. Carter, M. Konopleva and M. Andreeff. Apoptosis effector mechanisms: A requiem performed in different keys. Apoptosis 11: 889-904, 2006.
10. Hasegawa, H., J.H. Sung, S. Matsumiya and M. Uchiyama. Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 62: 453-457, 1996.
11. Hoffman, P.C., A.M. Mauer and E.F. Vokes. Lung cancer. Lancet 355: 479-485, 2000.
12. Jemal, A., R. Siegel, J. Xu and E. Ward. Cancer statistics. CA. Cancer J. Clin. 60: 277-300, 2010.
13. Jin, S., R.P. Pang, J.N. Shen, G. Huang, J. Wang and J.G. Zhou. Grifolin induces apoptosis via inhibition of PI3K/AKT signaling pathway in human osteosarcoma cells. Apoptosis 12: 1317-1326, 2007.
14. Jung, F., J. Haendeler, C. Goebel, A.M. Zeiher and S. Dimmeler. Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: Induction of cell proliferation and inhibition of cell death. Cardiovasc. Res. 48: 148-157, 2000.
15. Kitts, D.D., A.N. Wijewickreme and C. Hu. Antixidant properties of a North American ginseng extract. Mol. Cell. Biolchem. 203: 1-10, 2000.
16. Kuo, H.M., H.C. Tsai, Y.L. Lin, J.S. Yang, A.C. Huang, M.D. Yang, S.C. Hsu, M.C. Chung, W. Gibson-Wood and J.G. Chung. Mitochondrial-dependent caspase activation pathway is involved in baicalein-induced apoptosis in human hepatoma J5 cells. Int. J. Oncol. 35: 717-724, 2005.
17. Lee, J.S., H.S. Choi, S.W. Kang, J.H. Chung, H.K. Park, J.Y. Ban, O.Y. Kwon, H.P. Hong and Y.G. Ko. Therapeutic effect of Korean red ginseng on inflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Am. J. Chin. Med. 39: 83-94, 2011.
18. Lin, X., A.S. Böhle, P. Dohrmann, I. Leuschner, A. Schulz, B. Kremer and F. Fändrich. Overexpression of phosphatidylinositol 3-kinase in human lung cancer. Langenbecks Arch. Surg. 386: 293-301, 2001.
19. Lu, H.F., Y.S. Chen, J.S. Yang, J.C. Chen, K.W. Lu, T.H. Chiu, K.C. Liu, C.C. Yeh, G.W. Chen, H. J. Lin and J.G. Chung. Gypenosides induced G0/G1 arrest via inhibition of cyclin E and induction of apoptosis via activation of caspases-3 and -9 in human lung cancer A-549 cells. In Vivo 22: 215-221, 2008.
20. Pang, R.P., J.G. Zhou, Z.R. Zeng, X.Y. Li, W. Chen, M.H. Chen and P.J. Hu. Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway. Cancer Lett. 251: 268-277, 2007.
21. Park, E.K., E.J. Lee, S.H. Lee, K.H. Koo, J.Y. Sung, E.H. Hwang, J.H. Park, C.W. Kim, K.C. Joeng, B.K. Park and Y.N. Kim. Induction of apoptosis by the ginsenodide Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt. Br. J. Pharmacol. 160: 1212-1223, 2010.
22. Patil, J.B., J. Kim and G.K. Jayaprakasha. Berberine induces apoptosis in breast cancer cells (MCF-7 through mitochondrial-dependent pathway. Eur. J. Pharmacol. 645: 1-3, 2010.
23. Shibata, S. Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. J. Korean Med. Sci. 16: 28-37, 2001.
24. Singh, T., S.D. Sharma and S.K. Katiyar. Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo. PLos One 6: E27444, 2011.
25. Takahashi-Yanaga, F. and T. Sasaguri. Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: Inhibitors of the Wnt/beta-catenin signaling pathway as novel anticancer drugs. J. Pharmacol. Sci. 109: 179-183, 2009.
26. Tsutsumi, Y.M., R. Tsutsumi, K. Mawatari, Y. Nakaya, M. Kinoshita, K. Tanaka and S. Oshita. Compound K, a metabolite of ginsenosides, induced cardiac protection mediated nitric oxide via Akt/PI3K pathway. Life Sci. 88: 725-729, 2011.
27. Uddin, S., A.R. Hussain, K.A. AI-Hussein, P.S. Manogaran, A. Wickrema, M.I. Gutierrez and K.G. Bhatia. Inhibition of phosphatidylinositol 30-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells. Clin. Cancer Res. 11: 3102-3108, 2005.
28. Wang, C.Z., T. Calway and C.S. Yuan. Herbal medicines as adjuvants for cancer therapeutics. Am. J. Chin. Med. 40: 657-669, 2012.
29. Wang, H.Y., L.W. Qi, C.Z. Wang and P. Li. Bioactivity enhancement of herbal supplements by intestinal microbiota focusing on ginsenosides. Am. J. Chin. Med. 39: 1103-1115, 2011.
30. Wang, W., Y. Zhao, E.R. Rayburn, D.L. Hill, H. Wang and R. Zhang. In vitro anti-cancer activity and structure-Activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother. Pharmacol. 59: 589-601, 2007.
31. Wang, Z., Y. Li, A. Ahmad, A.S. Azmi, S. Banerjee, D. Kong and F.H. Sarkar. Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim. Biophys. Acta 1806: 258-267, 2010.
32. Wang, Z., K.S. Smith, M. Murphy, O. Piloto, T.C. Somervaille and M.L. Cleary. Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature 455: 1205-1209, 2008.
33. Wu, L.F., G.P. Li, J.L. Feng and Z.J. Pu. Molecular mechanisms of adenosine-induced apoptosis in human HepG2 cells. Acta. Pharmacol. Sin. 27; 477-484, 2006.
34. Xu, C., J. Teng, W. Chen, Q. Ge, Z. Yang, C. Yu, Z. Yang and W. Jia. 20(S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests. Prog. Neuropsychopharmacol. Biol. Psychiatry 34: 1402-1411, 2010.
35. Zhang, R., H.L. Xu, S.C. Qu, X.F. Yu, M.X. Chen and D.Y. Sui. Inhibition of 20 (S)-Protopanaxadiol on proliferation of lung cancer A549 cells and tumor growth of nude mice. Zhong Cao Yao 39: 1828-1841, 2008.
36. Zhang, R., H.L. Xu, X.F. Yu, S.C. Qu, M.X. Chen and D.Y. Sui. Effect of 20(S)-Protopanxadiol on SMMC-7721 human liver cancer in vivo and in vitro. Chin. Pharmacol. Bull. 24: 1504-1508, 2008b.