Roe of dynamics in the autoinhibition and activation of the hyperpolarization-activated cyclic nucleotide-modulated (HCN) ion channels

Journal of Biological Chemistry

Volumn 290, Issue 29, 2015, Pages 17642-17654

  Vanschouwen, Bryan ^a   Akimoto, Madoka ^a   Sayadi, Maryam ^a   Fogolari, Federico ^b   Melacini, Giuseppe ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF UDINE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR DYNAMICS; THERMODYNAMIC PROPERTIES;

CONFORMATIONAL CHANGE; CONFORMATIONAL ENSEMBLE; CYCLIC NUCLEOTIDE; LIMITED INFORMATION; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR DYNAMICS TRAJECTORIES; STRUCTURAL TRANSITIONS; THERMODYNAMIC CYCLE;

NUCLEOTIDES;

CYCLIC AMP; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; HCN4 PROTEIN, HUMAN; MUSCLE PROTEIN; POTASSIUM CHANNEL;

ARTICLE; BINDING AFFINITY; CALCULATION; CHANNEL GATING; HUMAN; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; THERMODYNAMICS; CHEMISTRY; METABOLISM; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION;

CYCLIC AMP; HUMANS; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; MOLECULAR DYNAMICS SIMULATION; MUSCLE PROTEINS; POTASSIUM CHANNELS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; THERMODYNAMICS;

EID: 84937509615     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.651877     Document Type: Article

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