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Volumn 303, Issue , 2015, Pages 422-432

Prolonged hyperglycemia & hyperinsulinemia increases BDNF mRNA expression in the posterior ventromedial hypothalamus and the dorsomedial hypothalamus of fed female rats

Author keywords

Brain derived neurotrophic factor (BDNF); Diazoxide; Glucose; Hyperglycemia; Hypothalamus; Insulin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DIAZOXIDE; ESTRADIOL; ESTROGEN; GLUCOSE; INSULIN; LEPTIN; LUTEINIZING HORMONE; MESSENGER RNA; NEUROTROPHIN; SODIUM CHLORIDE; GLUCOSE BLOOD LEVEL; PROGESTERONE; VASODILATOR AGENT;

EID: 84937469483     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.07.018     Document Type: Article
Times cited : (8)

References (72)
  • 1
    • 84880197109 scopus 로고    scopus 로고
    • PI3K: an attractive candidate for the central integration of metabolism and reproduction
    • Acosta-Martínez M. PI3K: an attractive candidate for the central integration of metabolism and reproduction. Front Endocrinol 2011, 2:110.
    • (2011) Front Endocrinol , vol.2 , pp. 110
    • Acosta-Martínez, M.1
  • 2
    • 34447554544 scopus 로고    scopus 로고
    • Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats
    • Acosta-Martínez M., Levine J.E. Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats. Am J Physiol Endocrinol Metab 2007, 292:E1801-E1807.
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , pp. E1801-E1807
    • Acosta-Martínez, M.1    Levine, J.E.2
  • 3
    • 0032788372 scopus 로고    scopus 로고
    • Molecular biology of adenosine triphosphate-sensitive potassium channels 1
    • Aguilar-Bryan L., Bryan J. Molecular biology of adenosine triphosphate-sensitive potassium channels 1. Endocr Rev 1999, 20:101-135.
    • (1999) Endocr Rev , vol.20 , pp. 101-135
    • Aguilar-Bryan, L.1    Bryan, J.2
  • 4
    • 0036302868 scopus 로고    scopus 로고
    • Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats
    • Alemzadeh R., Holshouser S., Massey P., Koontz J. Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats. Eur J Endocrinol 2002, 146:871-879.
    • (2002) Eur J Endocrinol , vol.146 , pp. 871-879
    • Alemzadeh, R.1    Holshouser, S.2    Massey, P.3    Koontz, J.4
  • 6
    • 0023911193 scopus 로고
    • Adenosine 5'-triphosphate-sensitive potassium channels
    • Ashcroft F.M. Adenosine 5'-triphosphate-sensitive potassium channels. Annu Rev Neurosci 1988, 11:97-118.
    • (1988) Annu Rev Neurosci , vol.11 , pp. 97-118
    • Ashcroft, F.M.1
  • 7
    • 0035783908 scopus 로고    scopus 로고
    • Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus
    • Berchtold N.C., Kesslak J.P., Pike C.J., Adlard P.A., Cotman C.W. Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus. Eur J Neurosci 2001, 14:1992-2002.
    • (2001) Eur J Neurosci , vol.14 , pp. 1992-2002
    • Berchtold, N.C.1    Kesslak, J.P.2    Pike, C.J.3    Adlard, P.A.4    Cotman, C.W.5
  • 8
    • 84869875771 scopus 로고    scopus 로고
    • Dorsomedial hypothalamic NPY and energy balance control
    • Bi S., Kim Y.J., Zheng F. Dorsomedial hypothalamic NPY and energy balance control. Neuropeptides 2012, 46:309-314.
    • (2012) Neuropeptides , vol.46 , pp. 309-314
    • Bi, S.1    Kim, Y.J.2    Zheng, F.3
  • 9
    • 0029969128 scopus 로고    scopus 로고
    • Distribution of brain-derived neurotrophic factor in the rat pituitary gland
    • Conner J.M., Yan Q., Varon S. Distribution of brain-derived neurotrophic factor in the rat pituitary gland. NeuroReport 1996, 7:1937.
    • (1996) NeuroReport , vol.7 , pp. 1937
    • Conner, J.M.1    Yan, Q.2    Varon, S.3
  • 10
    • 0021187646 scopus 로고
    • Intracellular ATP directly blocks K+ channels in pancreatic β-cells
    • Cook D.L., Hales C.N. Intracellular ATP directly blocks K+ channels in pancreatic β-cells. Nature 1984, 311:271-273.
    • (1984) Nature , vol.311 , pp. 271-273
    • Cook, D.L.1    Hales, C.N.2
  • 11
    • 0034867664 scopus 로고    scopus 로고
    • Immobilization stress rapidly and differentially modulates BDNF and TrkB mRNA expression in the pituitary gland of adult male rats
    • Givalois L., Marmigère F., Rage F., Ixart G., Arancibia S., Tapia-Arancibia L. Immobilization stress rapidly and differentially modulates BDNF and TrkB mRNA expression in the pituitary gland of adult male rats. Neuroendocrinology 2001, 74:148-159.
    • (2001) Neuroendocrinology , vol.74 , pp. 148-159
    • Givalois, L.1    Marmigère, F.2    Rage, F.3    Ixart, G.4    Arancibia, S.5    Tapia-Arancibia, L.6
  • 14
    • 77954947327 scopus 로고    scopus 로고
    • Lower brain-derived neurotrophic factor in patients with Prader-Willi syndrome compared to obese and lean control subjects
    • Han J.C., Muehlbauer M.J., Cui H.N., Newgard C.B., Haqq A.M. Lower brain-derived neurotrophic factor in patients with Prader-Willi syndrome compared to obese and lean control subjects. J Clin Endocrinol Metab 2010, 95:3532-3536.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3532-3536
    • Han, J.C.1    Muehlbauer, M.J.2    Cui, H.N.3    Newgard, C.B.4    Haqq, A.M.5
  • 15
    • 0033969423 scopus 로고    scopus 로고
    • Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats
    • Havel P.J., Hahn T.M., Sindelar D.K., Baskin D.G., Dallman M.F., Weigle D.S., Schwartz M.W. Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Diabetes 2000, 49:244-252.
    • (2000) Diabetes , vol.49 , pp. 244-252
    • Havel, P.J.1    Hahn, T.M.2    Sindelar, D.K.3    Baskin, D.G.4    Dallman, M.F.5    Weigle, D.S.6    Schwartz, M.W.7
  • 16
    • 40849094668 scopus 로고    scopus 로고
    • Neuroprotective effect of diazoxide on brain injury induced by cerebral ischemia/reperfusion during deep hypothermia
    • He X., Mo X., Gu H., Chen F., Gu Q., Peng W., Qi J., Shen L., Sun J., Zhang R., Yin K.J. Neuroprotective effect of diazoxide on brain injury induced by cerebral ischemia/reperfusion during deep hypothermia. J Neurol Sci 2008, 268:18-27.
    • (2008) J Neurol Sci , vol.268 , pp. 18-27
    • He, X.1    Mo, X.2    Gu, H.3    Chen, F.4    Gu, Q.5    Peng, W.6    Qi, J.7    Shen, L.8    Sun, J.9    Zhang, R.10    Yin, K.J.11
  • 17
    • 33745848775 scopus 로고    scopus 로고
    • Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
    • Herman M.A. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest 2006, 116:1767-1775.
    • (2006) J Clin Invest , vol.116 , pp. 1767-1775
    • Herman, M.A.1
  • 18
    • 45549104270 scopus 로고    scopus 로고
    • Hypothalamic pathways linking energy balance and reproduction
    • Hill J.W., Elmquist J.K., Elias C.F. Hypothalamic pathways linking energy balance and reproduction. Am J Physiol Endocrinol Metab 2008, 294:E827-E832.
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , pp. E827-E832
    • Hill, J.W.1    Elmquist, J.K.2    Elias, C.F.3
  • 19
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: roles in neuronal development and function
    • Huang E.J., Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001, 24:677-736.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 677-736
    • Huang, E.J.1    Reichardt, L.F.2
  • 20
    • 33845865582 scopus 로고    scopus 로고
    • Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase
    • Huang Q., Bu S., Yu Y., Guo Z., Ghatnekar G., Bu M., Yang L., Lu B., Feng Z., Liu S., Wang F. Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase. Endocrinology 2007, 148:81-91.
    • (2007) Endocrinology , vol.148 , pp. 81-91
    • Huang, Q.1    Bu, S.2    Yu, Y.3    Guo, Z.4    Ghatnekar, G.5    Bu, M.6    Yang, L.7    Lu, B.8    Feng, Z.9    Liu, S.10    Wang, F.11
  • 22
    • 84862488051 scopus 로고    scopus 로고
    • The role of brain-derived neurotrophic factor in the regulation of cell growth and gene expression in melanotrope cells of Xenopus laevis
    • Jenks B.G., Kuribara M., Kidane A.H., Kramer B.M.R., Roubos E.W., Scheenen W.J.J.M. The role of brain-derived neurotrophic factor in the regulation of cell growth and gene expression in melanotrope cells of Xenopus laevis. Gen Comp Endocrinol 2012, 177:315-321.
    • (2012) Gen Comp Endocrinol , vol.177 , pp. 315-321
    • Jenks, B.G.1    Kuribara, M.2    Kidane, A.H.3    Kramer, B.M.R.4    Roubos, E.W.5    Scheenen, W.J.J.M.6
  • 23
    • 55149094513 scopus 로고    scopus 로고
    • Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes
    • Kamboj S.S., Chopra K., Sandhir R. Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes. Metab Brain Dis 2008, 23:427-443.
    • (2008) Metab Brain Dis , vol.23 , pp. 427-443
    • Kamboj, S.S.1    Chopra, K.2    Sandhir, R.3
  • 24
    • 0036202956 scopus 로고    scopus 로고
    • Decreased serum brain-derived neurotrophic factor levels in major depressed patients
    • Karege F., Perret G., Bondolfi G., Schwald M., Bertschy G., Aubry J.-M. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 2002, 109:143-148.
    • (2002) Psychiatry Res , vol.109 , pp. 143-148
    • Karege, F.1    Perret, G.2    Bondolfi, G.3    Schwald, M.4    Bertschy, G.5    Aubry, J.-M.6
  • 25
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • Kernie S.G. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 2000, 19:1290-1300.
    • (2000) EMBO J , vol.19 , pp. 1290-1300
    • Kernie, S.G.1
  • 28
    • 77950219236 scopus 로고    scopus 로고
    • Increased food intake leads to obesity and insulin resistance in the Tg2576 Alzheimer's disease mouse model
    • Kohjima M., Sun Y., Chan L. Increased food intake leads to obesity and insulin resistance in the Tg2576 Alzheimer's disease mouse model. Endocrinology 2010, 151:1532-1540.
    • (2010) Endocrinology , vol.151 , pp. 1532-1540
    • Kohjima, M.1    Sun, Y.2    Chan, L.3
  • 29
    • 33646139871 scopus 로고    scopus 로고
    • Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus
    • Komori T., Morikawa Y., Nanjo K., Senba E. Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. Neuroscience 2006, 139:1107-1115.
    • (2006) Neuroscience , vol.139 , pp. 1107-1115
    • Komori, T.1    Morikawa, Y.2    Nanjo, K.3    Senba, E.4
  • 30
    • 0028007089 scopus 로고
    • Neurotrophins and their receptors in the rat pituitary gland: regulation of BDNF and trk B mRNA levels by adrenal hormones
    • Kononen J., Soinila S., Persson H., Honkaniemi J., Hökfelt T., Pelto-Huikko M. Neurotrophins and their receptors in the rat pituitary gland: regulation of BDNF and trk B mRNA levels by adrenal hormones. Mol Brain Res 1994, 27:347-354.
    • (1994) Mol Brain Res , vol.27 , pp. 347-354
    • Kononen, J.1    Soinila, S.2    Persson, H.3    Honkaniemi, J.4    Hökfelt, T.5    Pelto-Huikko, M.6
  • 31
    • 0027340688 scopus 로고
    • Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta-cells
    • Larsson O., Ammälä C., Bokvist K., Fredholm B., Rorsman P. Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta-cells. J Physiol 1993, 463:349-365.
    • (1993) J Physiol , vol.463 , pp. 349-365
    • Larsson, O.1    Ammälä, C.2    Bokvist, K.3    Fredholm, B.4    Rorsman, P.5
  • 33
    • 0036362471 scopus 로고    scopus 로고
    • CNS sensing and regulation of peripheral glucose levels
    • Levin B.E., Dunn-Meynell A.A., Routh V.H. CNS sensing and regulation of peripheral glucose levels. Int Rev Neurobiol 2002, 51:219-258.
    • (2002) Int Rev Neurobiol , vol.51 , pp. 219-258
    • Levin, B.E.1    Dunn-Meynell, A.A.2    Routh, V.H.3
  • 34
    • 79951490785 scopus 로고    scopus 로고
    • Functional identification of an aggression locus in the mouse hypothalamus
    • Lin D., Boyle M.P., Dollar P., Lee H., Lein E.S., Perona P., Anderson D.J. Functional identification of an aggression locus in the mouse hypothalamus. Nature 2011, 470:221-226.
    • (2011) Nature , vol.470 , pp. 221-226
    • Lin, D.1    Boyle, M.P.2    Dollar, P.3    Lee, H.4    Lein, E.S.5    Perona, P.6    Anderson, D.J.7
  • 35
    • 84880761558 scopus 로고    scopus 로고
    • Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat
    • Liu J., Feng L., Ma D., Zhang M., Gu J., Wang S., Fu Q., Song Y., Lan Z., Qu R., Ma S. Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. Neurosci Lett 2013, 549:63-68.
    • (2013) Neurosci Lett , vol.549 , pp. 63-68
    • Liu, J.1    Feng, L.2    Ma, D.3    Zhang, M.4    Gu, J.5    Wang, S.6    Fu, Q.7    Song, Y.8    Lan, Z.9    Qu, R.10    Ma, S.11
  • 36
    • 84898775542 scopus 로고    scopus 로고
    • Effects of energy status and diet on BDNF expression in the ventromedial hypothalamus of male and female rats
    • Liu X., Zhu Z., Kalyani M., Janik J.M., Shi H. Effects of energy status and diet on BDNF expression in the ventromedial hypothalamus of male and female rats. Physiol Behav 2014, 130:99-107.
    • (2014) Physiol Behav , vol.130 , pp. 99-107
    • Liu, X.1    Zhu, Z.2    Kalyani, M.3    Janik, J.M.4    Shi, H.5
  • 37
    • 84876072089 scopus 로고    scopus 로고
    • Interactions between estradiol, BDNF and dendritic spines in promoting memory
    • Luine V., Frankfurt M. Interactions between estradiol, BDNF and dendritic spines in promoting memory. Neuroscience 2013, 239:34-45.
    • (2013) Neuroscience , vol.239 , pp. 34-45
    • Luine, V.1    Frankfurt, M.2
  • 38
    • 34047095833 scopus 로고    scopus 로고
    • Effects of diazoxide on gene expression in rat pancreatic islets are largely linked to elevated glucose and potentially serve to enhance beta-cell sensitivity
    • Ma Z., Portwood N., Brodin D., Grill V., Björklund A. Effects of diazoxide on gene expression in rat pancreatic islets are largely linked to elevated glucose and potentially serve to enhance beta-cell sensitivity. Diabetes 2007, 56:1095-1106.
    • (2007) Diabetes , vol.56 , pp. 1095-1106
    • Ma, Z.1    Portwood, N.2    Brodin, D.3    Grill, V.4    Björklund, A.5
  • 39
    • 84904746043 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats
    • Maekawa F., Fujiwara K., Toriya M., Maejima Y., Nishio T., Toyoda Y., Nohara K., Yashiro T., Yada T. Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats. Front Synaptic Neurosci 2013, 5:7.
    • (2013) Front Synaptic Neurosci , vol.5 , pp. 7
    • Maekawa, F.1    Fujiwara, K.2    Toriya, M.3    Maejima, Y.4    Nishio, T.5    Toyoda, Y.6    Nohara, K.7    Yashiro, T.8    Yada, T.9
  • 40
    • 28444482143 scopus 로고    scopus 로고
    • Pharmacokinetics and effects of 17β-estradiol and progesterone implants in ovariectomized rats
    • Mannino C.A., South S.M., Inturrisi C.E., Quinones-Jenab V. Pharmacokinetics and effects of 17β-estradiol and progesterone implants in ovariectomized rats. J Pain 2005, 6:809-816.
    • (2005) J Pain , vol.6 , pp. 809-816
    • Mannino, C.A.1    South, S.M.2    Inturrisi, C.E.3    Quinones-Jenab, V.4
  • 41
    • 1842684425 scopus 로고    scopus 로고
    • Cerebral glucose metabolism in diabetes mellitus
    • McCall A.L. Cerebral glucose metabolism in diabetes mellitus. Eur J Pharmacol 2004, 490:147-158.
    • (2004) Eur J Pharmacol , vol.490 , pp. 147-158
    • McCall, A.L.1
  • 42
    • 33644696261 scopus 로고    scopus 로고
    • Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats
    • McCrimmon R.J., Evans M.L., Fan X., McNay E.C., Chan O., Ding Y., Zhu W., Gram D.X., Sherwin R.S. Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats. Diabetes 2005, 54:3169-3174.
    • (2005) Diabetes , vol.54 , pp. 3169-3174
    • McCrimmon, R.J.1    Evans, M.L.2    Fan, X.3    McNay, E.C.4    Chan, O.5    Ding, Y.6    Zhu, W.7    Gram, D.X.8    Sherwin, R.S.9
  • 46
    • 33645865261 scopus 로고    scopus 로고
    • Continuous i.c.v. infusion of brain-derived neurotrophic factor modifies hypothalamic-pituitary-adrenal axis activity, locomotor activity and body temperature rhythms in adult male rats
    • Naert G., Ixart G., Tapia-Arancibia L., Givalois L. Continuous i.c.v. infusion of brain-derived neurotrophic factor modifies hypothalamic-pituitary-adrenal axis activity, locomotor activity and body temperature rhythms in adult male rats. Neuroscience 2006, 139:779-789.
    • (2006) Neuroscience , vol.139 , pp. 779-789
    • Naert, G.1    Ixart, G.2    Tapia-Arancibia, L.3    Givalois, L.4
  • 49
    • 0032582853 scopus 로고    scopus 로고
    • Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus
    • Oliff H.S., Berchtold N.C., Isackson P., Cotman C.W. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain Res Mol Brain Res 1998, 61:147-153.
    • (1998) Brain Res Mol Brain Res , vol.61 , pp. 147-153
    • Oliff, H.S.1    Berchtold, N.C.2    Isackson, P.3    Cotman, C.W.4
  • 50
    • 0038522555 scopus 로고    scopus 로고
    • Specific and combined effects of insulin and glucose on functional pancreatic β-Cell mass in vivo in adult rats
    • Paris M., Bernard-Kargar C., Berthault M.-F., Bouwens L., Ktorza A. Specific and combined effects of insulin and glucose on functional pancreatic β-Cell mass in vivo in adult rats. Endocrinology 2003, 144:2717-2727.
    • (2003) Endocrinology , vol.144 , pp. 2717-2727
    • Paris, M.1    Bernard-Kargar, C.2    Berthault, M.-F.3    Bouwens, L.4    Ktorza, A.5
  • 52
    • 84873106561 scopus 로고    scopus 로고
    • BDNF and the central control of feeding: accidental bystander or essential player?
    • Rios M. BDNF and the central control of feeding: accidental bystander or essential player?. Trends Neurosci 2013, 36:83-90.
    • (2013) Trends Neurosci , vol.36 , pp. 83-90
    • Rios, M.1
  • 53
    • 0025677462 scopus 로고
    • Coupling of β-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats
    • Sako Y., Grill V.E. Coupling of β-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats. Diabetes 1990, 39:1580-1583.
    • (1990) Diabetes , vol.39 , pp. 1580-1583
    • Sako, Y.1    Grill, V.E.2
  • 54
    • 0026658679 scopus 로고
    • Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells
    • Schwanstecher C., Dickel C., Ebers I., Lins S., Zünkler B.J., Panten U. Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells. Br J Pharmacol 1992, 107:87-94.
    • (1992) Br J Pharmacol , vol.107 , pp. 87-94
    • Schwanstecher, C.1    Dickel, C.2    Ebers, I.3    Lins, S.4    Zünkler, B.J.5    Panten, U.6
  • 55
    • 0028924906 scopus 로고
    • Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression
    • Sipols A.J., Baskin D.G., Schwartz M.W. Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression. Diabetes 1995, 44:147-151.
    • (1995) Diabetes , vol.44 , pp. 147-151
    • Sipols, A.J.1    Baskin, D.G.2    Schwartz, M.W.3
  • 57
    • 0034093811 scopus 로고    scopus 로고
    • Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats
    • Standridge M., Alemzadeh R., Zemel M., Koontz J., Moustaid-Moussa N. Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats. FASEB J 2000, 14:455-460.
    • (2000) FASEB J , vol.14 , pp. 455-460
    • Standridge, M.1    Alemzadeh, R.2    Zemel, M.3    Koontz, J.4    Moustaid-Moussa, N.5
  • 58
    • 33745164834 scopus 로고    scopus 로고
    • Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus
    • Suwa M., Kishimoto H., Nofuji Y., Nakano H., Sasaki H., Radak Z., Kumagai S. Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. Metab Clin Exp 2006, 55:852-857.
    • (2006) Metab Clin Exp , vol.55 , pp. 852-857
    • Suwa, M.1    Kishimoto, H.2    Nofuji, Y.3    Nakano, H.4    Sasaki, H.5    Radak, Z.6    Kumagai, S.7
  • 59
    • 0033005143 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice
    • Tonra J.R., Ono M., Liu X., Garcia K., Jackson C., Yancopoulos G.D., Wiegand S.J., Wong V. Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice. Diabetes 1999, 48:588-594.
    • (1999) Diabetes , vol.48 , pp. 588-594
    • Tonra, J.R.1    Ono, M.2    Liu, X.3    Garcia, K.4    Jackson, C.5    Yancopoulos, G.D.6    Wiegand, S.J.7    Wong, V.8
  • 60
    • 33748454310 scopus 로고    scopus 로고
    • Diminished hypothalamic BDNF expression and impaired VMH function are associated with reduced SF-1 gene dosage
    • Tran P.V., Akana S.F., Malkovska I., Dallman M.F., Parada L.F., Ingraham H.A. Diminished hypothalamic BDNF expression and impaired VMH function are associated with reduced SF-1 gene dosage. J Comp Neurol 2006, 498:637-648.
    • (2006) J Comp Neurol , vol.498 , pp. 637-648
    • Tran, P.V.1    Akana, S.F.2    Malkovska, I.3    Dallman, M.F.4    Parada, L.F.5    Ingraham, H.A.6
  • 61
    • 37549055474 scopus 로고    scopus 로고
    • Selective deletion of BDNF in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
    • Unger T.J., Calderon G.A., Bradley L.C., Sena-Esteves M., Rios M. Selective deletion of BDNF in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 2007, 27:14265-14274.
    • (2007) J Neurosci , vol.27 , pp. 14265-14274
    • Unger, T.J.1    Calderon, G.A.2    Bradley, L.C.3    Sena-Esteves, M.4    Rios, M.5
  • 62
    • 84878792450 scopus 로고    scopus 로고
    • Molecular and neural bases underlying roles of BDNF in the control of body weight
    • Vanevski F., Xu B. Molecular and neural bases underlying roles of BDNF in the control of body weight. Front Neurosci 2013, 7:37.
    • (2013) Front Neurosci , vol.7 , pp. 37
    • Vanevski, F.1    Xu, B.2
  • 63
    • 34548381683 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reduces energy intake
    • Wang C., Bomberg E., Billington C., Levine A., Kotz C.M. Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reduces energy intake. Am J Physiol Regul Integr Comp Physiol 2007, 293:R1003-R1012.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293 , pp. R1003-R1012
    • Wang, C.1    Bomberg, E.2    Billington, C.3    Levine, A.4    Kotz, C.M.5
  • 64
    • 77952243631 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure
    • Wang C., Bomberg E., Billington C.J., Levine A.S., Kotz C.M. Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure. Brain Res 2010, 1336:66-77.
    • (2010) Brain Res , vol.1336 , pp. 66-77
    • Wang, C.1    Bomberg, E.2    Billington, C.J.3    Levine, A.S.4    Kotz, C.M.5
  • 65
    • 84863318618 scopus 로고    scopus 로고
    • Is BDNF biological link between depression and type 2 diabetes mellitus?
    • Wang J., Zhao X., He M. Is BDNF biological link between depression and type 2 diabetes mellitus?. Med Hypotheses 2012, 79:255-258.
    • (2012) Med Hypotheses , vol.79 , pp. 255-258
    • Wang, J.1    Zhao, X.2    He, M.3
  • 66
    • 68249117473 scopus 로고    scopus 로고
    • New insights into the role of brain-derived neurotrophic factor in synaptic plasticity
    • Waterhouse E.G., Xu B. New insights into the role of brain-derived neurotrophic factor in synaptic plasticity. Mol Cell Neurosci 2009, 42:81-89.
    • (2009) Mol Cell Neurosci , vol.42 , pp. 81-89
    • Waterhouse, E.G.1    Xu, B.2
  • 67
    • 33646813658 scopus 로고    scopus 로고
    • The neuroprotection conferred by activating the mitochondrial ATP-sensitive K+ channel is mediated by inhibiting the mitochondrial permeability transition pore
    • Wu L., Shen F., Lin L., Zhang X., Bruce I.C., Xia Q. The neuroprotection conferred by activating the mitochondrial ATP-sensitive K+ channel is mediated by inhibiting the mitochondrial permeability transition pore. Neurosci Lett 2006, 402:184-189.
    • (2006) Neurosci Lett , vol.402 , pp. 184-189
    • Wu, L.1    Shen, F.2    Lin, L.3    Zhang, X.4    Bruce, I.C.5    Xia, Q.6
  • 69
    • 84865803744 scopus 로고    scopus 로고
    • Iptakalim enhances adult mouse hippocampal neurogenesis via opening Kir6.1-composed K-ATP channels expressed in neural stem cells
    • Yang J.-Z., Huang X., Zhao F.-F., Xu Q., Hu G. Iptakalim enhances adult mouse hippocampal neurogenesis via opening Kir6.1-composed K-ATP channels expressed in neural stem cells. CNS Neurosci Ther 2012, 18:737-744.
    • (2012) CNS Neurosci Ther , vol.18 , pp. 737-744
    • Yang, J.-Z.1    Huang, X.2    Zhao, F.-F.3    Xu, Q.4    Hu, G.5
  • 72
    • 84875050347 scopus 로고    scopus 로고
    • Central expression and anorectic effect of brain-derived neurotrophic factor are regulated by circulating estradiol levels
    • Zhu Z., Liu X., Senthil Kumar S.P.D., Zhang J., Shi H. Central expression and anorectic effect of brain-derived neurotrophic factor are regulated by circulating estradiol levels. Horm Behav 2013, 63:533-542.
    • (2013) Horm Behav , vol.63 , pp. 533-542
    • Zhu, Z.1    Liu, X.2    Senthil Kumar, S.P.D.3    Zhang, J.4    Shi, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.