Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus

Molecular Brain Research

Volumn 61, Issue 1-2, 1998, Pages 147-153

  Oliff, Heather S ^a   Berchtold, Nicole C ^a   Isackson, Paul ^c   Cotman, Carl W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

Brain derived neurotrophic factor; Exercise; Exon; Hippocampus; Rat

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXERCISE; EXON; GENE INDUCTION; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSCRIPTION REGULATION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; EXERTION; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MALE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, INBRED F344; TIME FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0032582853     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00222-8     Document Type: Article

References (24)

1. N.C. Berchtold, H.S. Oliff, P. Isackson, C.W. Cotman, BDNF mRNA shows a diurnal regulation primarily in the exon III transcript, submitted.
2. Cosi C., Spoerri P.E., Comelli M.C., Guidolin D., Skaper S.D. Glucocorticoids depress activity-dependent expression of BDNF mRNA in hippocampal neurones. NeuroReport. 4:1993;527-530.
3. Dua J., Hargreaves L. Effect of aerobic exercise on negative effect, positive effect, stress and depression. Perceptual and Motor Skills. 75(2):1992;355-361.
4. Dustman R.E., Ruhling R.O., Russell E.M., Shearer D.E., Bonekat H.W., Shigeoka J.W., Wood J.S., Bradford D.C. Aerobic exercise training and improved neuropsychological function of older individuals. Neurobiol. Aging. 5:1984;35-42.
5. V.Y. Hayes, K.D. Murray, P.J. Isackson, Differential regulation of BDNF transcripts through a calcium/calmodulin dependent protein kinase pathway, Soc. Neurosci. Abstr., 21 (1995) 417.8.
6. Hill R.D., Storandt M., Malley M. The impact of long-term exercise training on psychological function in older adults. J. Gerontology. 48:1993;12-17.
7. Kokaia Z., Metsis M., Kokaia M., Bengzon J., Elmér E., Smith J.-L., Timmusk T., Seisjö B.K., Persson H., Kindvall O. Brain insults in rats induced increased expression of the BDNF gene through differential use of multiple promoters. Eur. J. Neurosci. 6:1994;587-596.
8. Kokaia M., Ferencz I., Leanza G., Elmér E., Metsis M., Kokaia Z., Wiley R.G., Lindvall O. Immunolesioning of basal forebrain cholinergic neurons facilitates hippocampal kindling and perturbs neurotrophin messenger RNA regulation. Neuroscience. 70:1996;313-327.
9. J.C. Lauterborn, C.T. Stinis, J.S. Wong, Z. Sun, P.J. Isackson, C.M. Gall, Adrenalectomy potentiates activity-dependent increases in BDNF exon I but not exon III mRNA expression, Soc. Neurosci. Abstr., 21 (1995) 126.3.
10. Lauterborn J.C., Poulsen F.R., Stinis C.T., Isackson P.J., Gall C.M. Transcript-specific effects of adrenalectomy on seizure-induced BDNF expression in rat hippocampus. Mol. Brain Res. 55:1998;81-91.
11. Lauterborn J.C., Rivera S., Stinis C.T., Hayes V.Y., Isackson P.J., Gall C.M. Differential effects of protein synthesis inhibition on the activity-dependent expression of BDNF transcripts: evidence for immediate-early gene responses from specific promoters. J. Neurosci. 16(23):1996;7428-7436.
12. Lindholm D., Dechant G., Heisenberg C.-P., Thoenen H. Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity. Eur. J. Neurosci. 5:1993;1455-1464.
13. Nakayama M., Gahara Y., Kitamura T., Osamu O. Distinctive four promoters collectively direct expression of brain-derived neurotrophic factor gene. Mol. Brain Res. 21:1994;206-218.
14. Neeper S.A., Gomez-Pinilla F., Choi J., Cotman C. Exercise and brain neurotrophins. Nature. 373:1995;109.
15. Neeper S.A., Gomez-Pinilla F., Choi J., Cotman C.W. Physical activity increases mRNA for nerve growth factor in rat brain. Brain Res. 726:1996;49-56.
16. Norris R., Carroll D., Cochrane R. The effects of physical activity and exercise training on psychological stress and well-being in an adolescent population. J. of Psychosomatic Res. 36(1):1992;55-65.
17. Patterson S.L., Abel T., Deuel T.A.S., Martin K.C., Rose J.C., Kandel E.R. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron. 16:1996;1137-1145.
18. Rejeski W.J., Thompson A., Brubaker P.H., Miller H.S. Acute exercise: buffering psychosocial stress responses in women. Health Psychology. 11(6):1992;355-362.
19. Rogers R.L., Meyer J.S., Mortel K.F. After reaching retirement age physical activity sustains cerebral perfusion and cognition. JAGS. 38:1990;123-128.
20. Shieh P.B., Hu S.-C., Bobb K., Timmusk T., Ghosh A. Identification of a signaling pathway involved in calcium regulation of BDNF expression. Neuron. 20:1998;727-740.
21. Smith M., Makino S., Kvetnansky R., Post R. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 in the hippocampus. J. Neurosci. 15:1995;1768-1777.
22. Stummer W., Weber K., Tranmer B., Baethmann A., Kempski O. Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia. Stroke. 25:1994;1862-1869.
23. 2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron. 20:1998;709-726.
24. Timmusk T., Palm K., Metsis M., Reintam T., Paalme V., Saarma M., Persson H. Multiple promoters direct tissue-specific expression of rat BDNF gene. Neuron. 10:1993;475-489.