Pharmacokinetics and effects of 17β-estradiol and progesterone implants in ovariectomized rats

Journal of Pain

Volumn 6, Issue 12, 2005, Pages 809-816

  Mannino, Christy A ^a   South, Samantha M ^a   Inturrisi, Charles E ^a   Quinones Jenab, Vanya ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

17 estradiol; Morphine ED50; Ovariectomized rat; Pharmacokinetics; Progesterone; Silastic implant; Tail flick latency

Indexed keywords

CHOLESTEROL; ESTRADIOL; MORPHINE SULFATE; PROGESTERONE; SILASTIC; BAYSILON; DIMETICONE; MORPHINE; SILICONE DERIVATIVE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG CLEARANCE; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENCY; DRUG RELEASE; FEMALE; HIGH TEMPERATURE; IMPLANT; NONHUMAN; OVARIECTOMY; RAT; STEADY STATE; TAIL FLICK TEST; ANIMAL; ARTIFICIAL MEMBRANE; BLOOD; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; HORMONE SUBSTITUTION; INFUSION PUMP; METABOLIC CLEARANCE RATE; METABOLISM; MICROCAPSULE; PAIN; PAIN THRESHOLD; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CAPSULES; DIMETHYLPOLYSILOXANES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; HORMONE REPLACEMENT THERAPY; INFUSION PUMPS, IMPLANTABLE; MEMBRANES, ARTIFICIAL; METABOLIC CLEARANCE RATE; MORPHINE; OVARIECTOMY; PAIN; PAIN THRESHOLD; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; SILICONES;

EID: 28444482143     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2005.07.007     Document Type: Article

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