Lower brain-derived neurotrophic factor in patients with Prader-Willi syndrome compared to obese and lean control subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 7, 2010, Pages 3532-3536

  Han, Joan C ^a   Muehlbauer, Michael J ^b   Cui, Huaxia N ^b   Newgard, Christopher B ^b   Haqq, Andrea M ^c  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLUCOSE; INSULIN; LEPTIN;

ADOLESCENT; ARTICLE; BODY MASS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENDER; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LEAN BODY WEIGHT; MALE; OBESITY; PRADER WILLI SYNDROME; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; SEX RATIO; ANALYSIS OF VARIANCE; BLOOD; INSULIN RESISTANCE;

ANALYSIS OF VARIANCE; BLOOD GLUCOSE; BODY MASS INDEX; BRAIN-DERIVED NEUROTROPHIC FACTOR; CROSS-SECTIONAL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; LEPTIN; MALE; OBESITY; PRADER-WILLI SYNDROME;

EID: 77954947327     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0127     Document Type: Article

References (20)

1. Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS 2002 Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med 8:643-644 (Pubitemid 34778697)
2. Haqq AM, Farooqi IS, O'Rahilly S, Stadler DD, Rosenfeld RG, Pratt KL, LaFranchi SH, Purnell JQ 2003 Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader- Willi syndrome. J Clin Endocrinol Metab 88:174-178 (Pubitemid 36115161)
3. Lindgren AC, Marcus C, Skwirut C, Elimam A, Hagenäs L, Schalling M, Anvret M, Lönnqvist F 1997 Increased leptin messenger RNA and serum leptin levels in children with Prader-Willi syndrome and nonsyndromal obesity. Pediatr Res 42:593-596 (Pubitemid 27459464)
4. Goldstone AP, Unmehopa UA, Bloom SR, Swaab DF 2002 Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects. J Clin Endocrinol Metab 87:927-937
5. Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF 2003 Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6:736-742 (Pubitemid 36792889)
6. Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M 2007 Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 27:14265-14274
7. Kernie SG, Liebl DJ, Parada LF 2000 BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19:1290-1300
8. Han JC, Liu QR, Jones M, Levinn RL, Menzie CM, Jefferson- George KS, Adler-Wailes DC, Sanford EL, Lacbawan FL, Uhl GR, Rennert OM, Yanovski JA 2008 Brain-derived neurotrophic factor and obesity in the WAGR syndrome. N Engl J Med 359:918-927
9. Gray J, Yeo GS, Cox JJ, Morton J, Adlam AL, Keogh JM, Yanovski JA, El Gharbawy A, Han JC, Tung YC, Hodges JR, Raymond FL, O'rahilly S, Farooqi IS 2006 Hyperphagia, severe obesity, impaired cognitive function and hyperactivity associated with functional loss of one copy of the BDNF gene. Diabetes 55:3366-3371
10. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419 (Pubitemid 15018832)
11. Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C, Fischer CP, Lindegaard B, Petersen AM, Taudorf S, Secher NH, Pilegaard H, Bruunsgaard H, Pedersen BK 2007 Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50:431-438
12. Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kambayashi J, Sun B, Tandon NN 2002 Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 87:728-734 (Pubitemid 34302963)
13. Pedersen BK, Pedersen M, Krabbe KS, Bruunsgaard H, Matthews VB, Febbraio MA 2009 Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals. Exp Physiol 94:1153-1160
14. Haqq AM, Muehlbauer M, Svetkey LP, Newgard CB, Purnell JQ, Grambow SC, Freemark MS 2007 Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones. Clin Endocrinol (Oxf) 67:944-951
15. Greenberg ME, Xu B, Lu B, Hempstead BL 2009 New insights in the biology of BDNF synthesis and release: implications in CNS function. J Neurosci 29:12764-12767
16. Cassidy SB, Driscoll DJ 2009 Prader-Willi syndrome. Eur J Hum Genet 17:3-13
17. Kuwako K, Hosokawa A, Nishimura I, Uetsuki T, Yamada M, Nada S, Okada M, Yoshikawa K 2005 Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. J Neurosci 25:7090-7099 (Pubitemid 41077018)
18. Tennese AA, Gee CB, Wevrick R 2008 Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons. Dev Dyn 237:1935-1943 (Pubitemid 351962469)
19. MacQueen GM, Ramakrishnan K, Croll SD, Siuciak JA, Yu G, Young LT, Fahnestock M 2001 Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression. Behav Neurosci 115:1145-1153 (Pubitemid 32906652)
20. Roth TL, Lubin FD, Funk AJ, Sweatt JD 2009 Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 65:760-769