The neuroprotection conferred by activating the mitochondrial ATP-sensitive K+ channel is mediated by inhibiting the mitochondrial permeability transition pore

Neuroscience Letters

Volumn 402, Issue 1-2, 2006, Pages 184-189

  Wu, Liping ^a   Shen, Fang ^a   Lin, Lin ^a   Zhang, Xiong ^a   Bruce, Iain C ^b   Xia, Qiang ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Brain; Ischemia and reperfusion injury; mitokatp; MPTP; Neuroprotection

Indexed keywords

ATRACTYLOSIDE; CYCLOSPORIN A; DIAZOXIDE; ESTER DERIVATIVE; POTASSIUM CHANNEL; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CONTROLLED STUDY; DRUG EFFECT; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE PERMEABILITY; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; SPECTROPHOTOMETRY;

ANIMALS; ATRACTYLOSIDE; BRAIN INFARCTION; CYCLOSPORINE; DIAZOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NEUROPROTECTIVE AGENTS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION; TIME FACTORS;

EID: 33646813658     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.04.001     Document Type: Article

References (24)

1. Andrabi S.A., Sayeed I., Siemen D., Wolf G., and Horn T.F. Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin. FASEB J. 18 (2004) 869-871
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
3. Clark J.B., and Nicklas W.J. The metabolism of rat brain mitochondria. Preparation and characterization. J. Biol. Chem. 245 (1970) 4724-4731
4. Crompton M., Barksby E., Johnson N., and Capano M. Mitochondrial intermembrane junctional complexes and their involvement in cell death. Biochimie 84 (2002) 143-152
5. Domanska-Janik K., Buzanska L., Dluzniewska J., Kozlowska H., Sarnowska A., and Zablocka B. Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm. Brain Res. Mol. Brain Res. 121 (2004) 50-59
6. Domoki F., Perciaccante J.V., Veltkamp R., Bari F., and Busija D.W. Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs. Stroke 30 (1999) 2713-2718
7. 2+-induced membrane transition in mitochondria. I. The protective mechanisms. Arch. Biochem. Biophys. 195 (1979) 453-459
8. Iwai T., Tanonaka K., Koshimizu M., and Takeo S. Preservation of mitochondrial function by diazoxide during sustained ischaemia in the rat heart. Br. J. Pharmacol. 129 (2000) 1219-1227
9. Khaspekov L., Friberg H., Halestrap A., Viktorov I., and Wieloch T. Cyclosporin A and its nonimmunosuppressive analogue N-Me-Val-4-cyclosporin A mitigate glucose/oxygen deprivation-induced damage to rat cultured hippocampal neurons. Eur. J. Neurosci. 11 (1999) 3194-3198
10. Li P.A., Kristian T., He Q.P., and Siesjo B.K. Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia. Exp. Neurol. 165 (2000) 153-163
11. 2+ release. J. Biol. Chem. 280 (2005) 715-721
12. Miura T., Liu Y., Kita H., Ogawa T., and Shimamoto K. Roles of mitochondrial ATP-sensitive K channels and PKC in anti-infarct tolerance afforded by adenosine A1 receptor activation. J. Am. Coll. Cardiol. 35 (2000) 238-245
13. Murata M., Akao M., O'Rourke B., and Marban E. Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection. Circ. Res. 89 (2001) 891-898
14. Nakai A., Shibazaki Y., Taniuchi Y., Miyake H., Oya A., and Takeshita T. Role of mitochondrial permeability transition in fetal brain damage in rats. Pediatr. Neurol. 30 (2004) 247-253
15. Rajapakse N., Shimizu K., Kis B., Snipes J., Lacza Z., and Busija D. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats. Neurosci. Lett. 327 (2002) 208-212
16. Rajesh K.G., Sasaguri S., Suzuki R., Xing Y., and Maeda H. Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channels. Int. J. Cardiol. 96 (2004) 41-49
17. Schmid-Elsaesser R., Zausinger S., Hungerhuber E., Baethmann A., and Reulen H.J. A critical reevaluation of the intraluminal thread model of focal cerebral ischemia: evidence of inadvertent premature reperfusion and subarachnoid hemorrhage in rats by laser-Doppler flowmetry. Stroke 29 (1998) 2162-2170
18. Seaton T.A., Cooper J.M., and Schapira A.H. Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins. Brain Res. 809 (1998) 12-17
19. Shiga Y., Onodera H., Matsuo Y., and Kogure K. Cyclosporin A protects against ischemia-reperfusion injury in the brain. Brain Res. 595 (1992) 145-148
20. Shimizu K., Lacza Z., Rajapakse N., Horiguchi T., Snipes J., and Busija D.W. MitoK(ATP) opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H1005-H1011
21. Teshima Y., Akao M., Li R.A., Chong T.H., Baumgartner W.A., Johnston M.V., and Marban E. Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress. Stroke 34 (2003) 1796-1802
22. Wang L., Cherednichenko G., Hernandez L., Halow J., Camacho S.A., Figueredo V., and Schaefer S. Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channels. Am. J. Physiol. Heart Circ. Physiol. 280 (2001) H2321-H2328
23. Wang G., Liem D.A., Vondriska T.M., Honda H.M., Korge P., Pantaleon D.M., Qiao X., Wang Y., Weiss J.N., and Ping P. Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. Am. J. Physiol. Heart Circ. Physiol. 288 (2005) H1290-H1295
24. Woodfield K., Ruck A., Brdiczka D., and Halestrap A.P. Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition. Biochem. J. 336 Part 2 (1998) 287-290