Effects of diazoxide on gene expression in rat pancreatic islets are largely linked to elevated glucose and potentially serve to enhance β-cell sensitivity

Diabetes

Volumn 56, Issue 4, 2007, Pages 1095-1106

  Ma, Zuheng ^a   Portwood, Neil ^a   Brodin, David ^b   Grill, Valdemar ^a,c,d   Björklund, Anneli ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Department of Biosciences ^*  (Sweden)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^d TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZOXIDE; GLUCOSE; LACTATE DEHYDROGENASE; TRANSCRIPTION FACTOR PDX 1; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL METABOLISM; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GENE EXPRESSION; INSULIN RELEASE; MALE; MICROARRAY ANALYSIS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT; UPREGULATION;

ANIMALS; DIAZOXIDE; GENE EXPRESSION REGULATION; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 34047095833     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0322     Document Type: Article

References (40)

1. Grill V, Björklund A: Overstimulation and beta cell function. Diabetes 50 (Suppl. 1):S122-S124, 2001
2. Lacy PE, Kostianovsky M: Method of the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35-39, 1967
3. Herbert V, Lau KS, Gottlieb CW, Bleicher SJ: Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25:1375-1384, 1965
4. Raz I, Eldor R, Naparstek Y: Immune modulation for prevention of type 1 diabetes mellitus (Review). Trends Biotechnol 23:128-134, 2005
5. Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patanè G, Laybutt R, Bonner-Weir S, Weir G: Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes. J Biol Chem 20:14112-14121, 1999
6. Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB: The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci 102:7297-7302, 2005
7. Björklund A, Grill V: B-cell insensitivity in vitro: reversal by diazoxide entails more than one event in stimulus-secretion coupling. Endocrinology 132:1319-1328, 1993
8. Harding HP, Ron D: Endoplasmatic reticulum stress and the development of diabetes: a review. Diabetes 51 (Suppl. 3):S455-S461, 2002
9. Ohsugi M, Cras-Meneur C, Zhou Y, Warren W, Bernal-Mizrachi E, Permutt MA: Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes. Diabetes 53:1496-1508, 2004
10. Leibiger IB, Leibiger B, Berggren PO: Insulin feedback action on pancreatic beta-cell function. FEBS Lett 532:1-6, 2002
11. Wicksteed B, Alarcon C, Briaud I, Lingohr MK, Rhodes CJ: Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem 278:42080-42090, 2003
12. Dzeja PP, Bast P, Ozcan C, Valverde A, Holmuhamedov EL, Van Wylen DG, Terzic A: Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection. Am J Physiol Heart Circ Physiol 284: H1048-H1056, 2003
13. Nagy K, Kis B, Rajapakse NC, Bari F, Busija DW: Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation. J Neurosci Res 76:697-704, 2004
14. Duchen MR: Roles of mitochondria in health and disease. Diabetes 53 (Suppl. 1):S96-S102, 2004
15. Grimmsmann T, Rustenbeck I: Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria. Br J Pharmacol 123:781-788, 1998
16. Kullin M, Li Z, Bondo Hansen J, Welsh N, Karlsson FA, Sandler S: Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1beta mediated suppression-possible involvement of the mitochondrial membrane potential. Diabetologia 46:80-88, 2003
17. Lenzen S, Panten U: Characterization of succinate dehydrogenase and alpha-glycerophosphate dehydrogenase in pancreatic islets. Biochem Med 30:349-356, 1983
18. Fridlyand LE, Philipson LH: Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells? Diabetes 53:1942-1948, 2004
19. Westermark PO, Lansner A: A model of phosphofructokinase and glycolytic oscillations in the pancreatic beta-cell. Biophys J 85:126-139, 2003
20. 2+ and insulin release in clonal insulin-secreting cells: a multiwell approach to oscillatory cell behaviour. J Biol Chem 276:36946-36950, 2001
21. Song SH, Rhodes CJ, Veldhuis JD, Butler PC: Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets. Endocrinology 144:3399-3405, 2003
22. Grill V, Qvigstad E: Fatty acids and insulin secretion. British J Nutr 83 (Suppl. 1):S79-S84, 2000
23. Youshikawa H, Ma Z, Björklund A, Grill V: Short-term intermittent exposure to diazoxide improves functional performance in β cells in a high-glucose environment. Am J Physiol 287:E1202-E1208, 2004
24. Mizuarai S, Miki S, Araki H, Takahashi K, Kotani H: Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. J Biol Chem 280:32434-32441, 2005
25. Gauthier BR, Brun T, Sarret EJ, Ishihara H, Schaad O, Descombes P, Wollheim CB: Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets. J Biol Chem 279:31121-31130, 2004
26. Larsson NG, Wang J, Wilhelmsson H, Oldfors A, Rustin P, Lewandoski M, Barsh GS, Clayton DA: Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet 18:231-236, 1999
27. Alcazar O, Tiedge M, Lenzen S: Importance of lactate dehydrogenase for the regulation of glycolytic flux and insulin secretion in insulin-producing cells. Biochem J 352:373-380, 2000
28. Zhou YP, Marlen K, Palma JF, Schweitzer A, Reilly L, Gregoire FM, Xu GG, Blume JE, Johnson JD: Overexpression of repressive cAMP response element modulators in high glucose and fatty acid-treated rat islets: a common mechanism for glucose toxicity and lipotoxicity? J Biol Chem 278:51316-51323, 2003
29. Li LX, Skorpen F, Egeberg K, Jorgensen IH, Grill V: Induction of uncoupling protein 2 mRNA in beta cells is stimulated by oxidation of fatty acids but not by nutrient oversupply. Endocrinology 143:1371-1377, 2002
30. Chan CB, Saleh MC, Koshkin V, Wheeler MB: Uncoupling protein 2 and islet function (Review). Diabetes 53 (Suppl. 1):S136-S142, 2004
31. Khaldi MZ, Guiot Y, Gilon P, Henquin JC, Jonas JC: Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose. Am J Physiol Endocrinol Metab 287:E207-E217, 2004
32. Bjork E, Kampe O, Andersson A, Karlsson FA: Expression of the 64 kDa/glutamic acid decarboxylase rat islet cell autoantigen is influenced by the rate of insulin secretion. Diabetologia 35:490-493, 1992
33. Velloso LA, Bjork E, Ballagi AE, Funa K, Andersson A, Kampe O, Karlsson FA, Eizirik DL: Regulation of GAD expression in islets of Langerhans occurs both at the mRNA and protein level. Mol Cell Endocrinol 102:31-37, 1994
34. Flodstrom M, Niemann A, Bedoya FJ, Morris SM Jr, Eizirik DL: Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic beta-cells: induction of argininosuccinate synthetase by cytokines. Endocrinology 136:3200-3206, 1995
35. Shimizu K, Kato Y, Shiratori K, Ding Y, Song Y, Furlanetto R, Chang TM, Watanabe S, Hayashi N, Kobayashi M, Chey WY: Evidence for the existence of CCK-producing cells in rat pancreatic islets. Endocrinology 139:389-396, 1998
36. Van de Casteele M, Kefas BA, Cai Y, Heimberg H, Scott DK, Henquin JC, Pipeleers D, Jonas JC: Prolonged culture in low glucose induces apoptosis of rat pancreatic β-cells through induction of c-myc. Biochem Biophys Res Commun 312:937-944, 2003
37. Hoorens A, Van de Casteele M, Klöppel G, Pipeleers D: Glucose promotes survival of rat pancreatic β cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98:1568-1574, 1996
38. Efanova IB, Zaitsev SV, Zhivotovsky B, Kohler M, Efendic S, Orrenius S, Berggren PO: Glucose and tolbutamide induce apoptosis in pancreatic beta-cells: a process dependent on intracellular Ca2+ concentration. J Biol Chem 273:33501-33507, 1998
39. Chen X, Ferry RJ Jr: Novel actions of IGFBP-3 on intracellular signaling pathways of insulin-secreting cells. Growth Horm IGF Res 16:41-48, 2006
40. Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF: Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol 25:3752-3762, 2005