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Volumn 23, Issue 4, 2008, Pages 427-443

Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes

Author keywords

Acetylcholinesterase; Antioxidants; Behavior; Diabetic encephalopathy; N acetylcysteine; Oxidative stress

Indexed keywords

ACETYLCHOLINESTERASE; ACETYLCYSTEINE; CATALASE; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; SUPEROXIDE DISMUTASE; THIOL;

EID: 55149094513     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-008-9104-7     Document Type: Article
Times cited : (66)

References (79)
  • 1
    • 0021318441 scopus 로고
    • Catalase in vitro
    • H Aebi 1984 Catalase in vitro Meth Enzymol 105 121 126
    • (1984) Meth Enzymol , vol.105 , pp. 121-126
    • Aebi, H.1
  • 2
    • 1842633820 scopus 로고    scopus 로고
    • The relationship between type 2 diabetes and cognitive dysfunction: Longitudinal studies and their methodological limitations
    • KV Allen BM Frier MWJ Strachan 2004 The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations Eur J Pharmacol 490 169 175
    • (2004) Eur J Pharmacol , vol.490 , pp. 169-175
    • Allen, K.V.1    Frier, B.M.2    Strachan, M.W.J.3
  • 4
    • 0033755119 scopus 로고    scopus 로고
    • Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats
    • M Aragno S Parola E Brignardello A Mauro E Tamagno R Manti O Danni G Boccuzzi 2000 Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats Diabetes 49 1924 1931
    • (2000) Diabetes , vol.49 , pp. 1924-1931
    • Aragno, M.1    Parola, S.2    Brignardello, E.3    Mauro, A.4    Tamagno, E.5    Manti, R.6    Danni, O.7    Boccuzzi, G.8
  • 5
    • 0034257193 scopus 로고    scopus 로고
    • Oxidative derangement in rat synaptosomes induced by hyperglycemia: Restorative effect of dehydroepiandrosterone treatment
    • M Aragno S Parola E Tamagno E Brignardello R Manti O Danni G Boccuzzi 2000 Oxidative derangement in rat synaptosomes induced by hyperglycemia: restorative effect of dehydroepiandrosterone treatment Biochem Pharmacol 60 389 395
    • (2000) Biochem Pharmacol , vol.60 , pp. 389-395
    • Aragno, M.1    Parola, S.2    Tamagno, E.3    Brignardello, E.4    Manti, R.5    Danni, O.6    Boccuzzi, G.7
  • 6
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • OI Aruoma B Halliwell BM Hoey J Butler 1989 The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid Free Radic Biol Med 6 593 597
    • (1989) Free Radic Biol Med , vol.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3    Butler, J.4
  • 8
    • 33747876619 scopus 로고    scopus 로고
    • N-Benzoyl-D-phenylalanine attenuates brain acetylcholinesterase in neonatal streptozotocin-diabetic rats
    • N Ashokkumar L Pari KM Ramkumar 2006 N-Benzoyl-D-phenylalanine attenuates brain acetylcholinesterase in neonatal streptozotocin-diabetic rats Basic Clin Pharmacol Toxicol 99 246 250
    • (2006) Basic Clin Pharmacol Toxicol , vol.99 , pp. 246-250
    • Ashokkumar, N.1    Pari, L.2    Ramkumar, K.M.3
  • 10
    • 0036255912 scopus 로고    scopus 로고
    • Comparative analysis of the protective effects of melatonin and vitamin e on streptozocin-induced diabetes mellitus
    • G Baydas H Canatan A Turkoglu 2002 Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus J Pineal Res 32 225 230
    • (2002) J Pineal Res , vol.32 , pp. 225-230
    • Baydas, G.1    Canatan, H.2    Turkoglu, A.3
  • 12
    • 13844265671 scopus 로고    scopus 로고
    • 2+ antagonist nimodipine on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats
    • 2+ antagonist nimodipine on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats Brain Res 1035 86 93
    • (2005) Brain Res , vol.1035 , pp. 86-93
    • Biessels, G.J.1    Ter Laak, M.P.2    Kamal, A.3    Gispen, W.H.4
  • 15
    • 0028960976 scopus 로고
    • Mesostriatal dopamine markers in aged Long-Evans rats with sensorimotor impairment
    • RD Burwell CP Lawler M Gallagher 1995 Mesostriatal dopamine markers in aged Long-Evans rats with sensorimotor impairment Neurobiol Aging 16 175 186
    • (1995) Neurobiol Aging , vol.16 , pp. 175-186
    • Burwell, R.D.1    Lawler, C.P.2    Gallagher, M.3
  • 17
    • 0042093769 scopus 로고    scopus 로고
    • New insights on oxidative stress and diabetic complications may lead to a causal antioxidant therapy
    • A Ceriello 2003 New insights on oxidative stress and diabetic complications may lead to a causal antioxidant therapy Diabetes Care 26 1589 1596
    • (2003) Diabetes Care , vol.26 , pp. 1589-1596
    • Ceriello, A.1
  • 18
    • 33748578688 scopus 로고    scopus 로고
    • Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes
    • A Ceriello 2006 Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes Curr Opin Lipidol 17 510 518
    • (2006) Curr Opin Lipidol , vol.17 , pp. 510-518
    • Ceriello, A.1
  • 19
    • 34347257435 scopus 로고    scopus 로고
    • Antioxidative and anti-inflammatory effects of four cysteine-containing agents in striatum of MPTP-treated mice
    • CM Chen MC Yin CC Hsu TC Liu 2007 Antioxidative and anti-inflammatory effects of four cysteine-containing agents in striatum of MPTP-treated mice Nutrition 23 589 597
    • (2007) Nutrition , vol.23 , pp. 589-597
    • Chen, C.M.1    Yin, M.C.2    Hsu, C.C.3    Liu, T.C.4
  • 21
    • 0032575363 scopus 로고    scopus 로고
    • Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury
    • S Demir M Inal-Erden 1998 Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury Clin Chim Acta 275 127 135
    • (1998) Clin Chim Acta , vol.275 , pp. 127-135
    • Demir, S.1    Inal-Erden, M.2
  • 23
    • 0021288821 scopus 로고
    • Assays of glutathione peroxidase
    • L Flohe WA Gunzler 1984 Assays of glutathione peroxidase Meth Enzymol 105 114 121
    • (1984) Meth Enzymol , vol.105 , pp. 114-121
    • Flohe, L.1    Gunzler, W.A.2
  • 24
    • 33747762642 scopus 로고    scopus 로고
    • Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice
    • AL Fu ZH Dong MJ Sun 2006 Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice Brain Res 1109 201 206
    • (2006) Brain Res , vol.1109 , pp. 201-206
    • Fu, A.L.1    Dong, Z.H.2    Sun, M.J.3
  • 25
    • 0035465325 scopus 로고    scopus 로고
    • G6PD deficiency: Its role in the high prevalence of hypertension and diabetes mellitus
    • RS Gaskin D Estwick R Peddi 2001 G6PD deficiency: Its role in the high prevalence of hypertension and diabetes mellitus Ethn Dis Fall 1 749 754
    • (2001) Ethn Dis Fall , vol.1 , pp. 749-754
    • Gaskin, R.S.1    Estwick, D.2    Peddi, R.3
  • 27
    • 41949116160 scopus 로고    scopus 로고
    • Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats
    • DA Ghareeb HM Hussen 2008 Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats Neurosci Lett 436 44 47
    • (2008) Neurosci Lett , vol.436 , pp. 44-47
    • Ghareeb, D.A.1    Hussen, H.M.2
  • 28
    • 0034333018 scopus 로고    scopus 로고
    • Cognition and synaptic plasticity in diabetes mellitus
    • WH Gispen GJ Biessels 2000 Cognition and synaptic plasticity in diabetes mellitus Trends Neurosci 23 542 549
    • (2000) Trends Neurosci , vol.23 , pp. 542-549
    • Gispen, W.H.1    Biessels, G.J.2
  • 29
    • 0032853995 scopus 로고    scopus 로고
    • Change in the lipid profile, lipogenic and related enzymes in the livers of experimental diabetic rats: Effect of insulin and vanadate
    • D Gupta J Raju J Prakash NZ Baquer 1999 Change in the lipid profile, lipogenic and related enzymes in the livers of experimental diabetic rats: Effect of insulin and vanadate Diabetes Res Clin Pract 46 1 7
    • (1999) Diabetes Res Clin Pract , vol.46 , pp. 1-7
    • Gupta, D.1    Raju, J.2    Prakash, J.3    Baquer, N.Z.4
  • 30
    • 0034725819 scopus 로고    scopus 로고
    • The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia
    • LL Guyot FG Diaz MH O'Regan D Song JW Phillis 2000 The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia Brain Res 872 29 36
    • (2000) Brain Res , vol.872 , pp. 29-36
    • Guyot, L.L.1    Diaz, F.G.2    O'Regan, M.H.3    Song, D.4    Phillis, J.W.5
  • 31
    • 0141727767 scopus 로고    scopus 로고
    • N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: Possible role of oxidative stress
    • CA Haber TK Lam Z Yu N Gupta T Goh E Bogdanovic 2003 N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress Am J Physiol Endocrinol Metab 285 744 753
    • (2003) Am J Physiol Endocrinol Metab , vol.285 , pp. 744-753
    • Haber, C.A.1    Lam, T.K.2    Yu, Z.3    Gupta, N.4    Goh, T.5    Bogdanovic, E.6
  • 32
    • 0026754574 scopus 로고
    • Reactive oxygen species and the central nervous system
    • B Halliwell 1992 Reactive oxygen species and the central nervous system J Neurochem 59 1609 1623
    • (1992) J Neurochem , vol.59 , pp. 1609-1623
    • Halliwell, B.1
  • 33
    • 0026012836 scopus 로고
    • Utility of an elevated plus maze for dissociation of amnesic and behavioural effects of drugs in mice
    • J Itoh T Nabeshima T Kameyama 1991 Utility of an elevated plus maze for dissociation of amnesic and behavioural effects of drugs in mice Eur J Pharmacol 1991 71 76
    • (1991) Eur J Pharmacol , vol.1991 , pp. 71-76
    • Itoh, J.1    Nabeshima, T.2    Kameyama, T.3
  • 34
    • 0036364935 scopus 로고    scopus 로고
    • Diabetes, the brain, and behavior: Is there a biological mechanism underlying the association between diabetes and depression?
    • AM Jacobson JA Samson K Weinger CM Ryan 2002 Diabetes, the brain, and behavior: is there a biological mechanism underlying the association between diabetes and depression? Int Rev Neurobiol 51 455 479
    • (2002) Int Rev Neurobiol , vol.51 , pp. 455-479
    • Jacobson, A.M.1    Samson, J.A.2    Weinger, K.3    Ryan, C.M.4
  • 35
    • 0025363792 scopus 로고
    • Regional brain glucose metabolism and blood flow in streptozotocin- induced diabetic rats
    • J Jakobsen M Nedergaard M Aarslew-Jensen NH Diemer 1990 Regional brain glucose metabolism and blood flow in streptozotocin-induced diabetic rats Diabetes 39 437 440
    • (1990) Diabetes , vol.39 , pp. 437-440
    • Jakobsen, J.1    Nedergaard, M.2    Aarslew-Jensen, M.3    Diemer, N.H.4
  • 36
    • 33645709875 scopus 로고    scopus 로고
    • Carbofuran-induced neurochemical and neurobehavioral alterations in rats: Attenuation by N-acetylcysteine
    • A Kamboj R Kiran R Sandhir 2006 Carbofuran-induced neurochemical and neurobehavioral alterations in rats: attenuation by N-acetylcysteine Exp Brain Res 170 567 575
    • (2006) Exp Brain Res , vol.170 , pp. 567-575
    • Kamboj, A.1    Kiran, R.2    Sandhir, R.3
  • 37
    • 2342562573 scopus 로고    scopus 로고
    • Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke
    • M Khan B Sekhon M Jatana S Giri AG Gilg C Sekhon I Singh AK Singh 2004 Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke J Neurosci Res 76 519 527
    • (2004) J Neurosci Res , vol.76 , pp. 519-527
    • Khan, M.1    Sekhon, B.2    Jatana, M.3    Giri, S.4    Gilg, A.G.5    Sekhon, C.6    Singh, I.7    Singh, A.K.8
  • 38
    • 1542330711 scopus 로고    scopus 로고
    • Apoptosis of vasopressinergic hypothalamic neurons in chronic diabetes mellitus
    • JP Klein BC Hains MJ Craner JA Black SG Waxman 2004 Apoptosis of vasopressinergic hypothalamic neurons in chronic diabetes mellitus Neurobiol Dis 15 221 228
    • (2004) Neurobiol Dis , vol.15 , pp. 221-228
    • Klein, J.P.1    Hains, B.C.2    Craner, M.J.3    Black, J.A.4    Waxman, S.G.5
  • 40
    • 0035872219 scopus 로고    scopus 로고
    • The potential mechanism of the diabetogenic action of streptozotocin: Inhibition of pancreatic β-cell O-GlcNAc-selective-N-acetyl-β-D- glucosaminidase
    • RJ Konrad I Mikolaenko JF Tolar K Liu JE Kudlow 2001 The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic β-cell O-GlcNAc-selective-N-acetyl-β-D-glucosaminidase Biochem J 356 31 41
    • (2001) Biochem J , vol.356 , pp. 31-41
    • Konrad, R.J.1    Mikolaenko, I.2    Tolar, J.F.3    Liu, K.4    Kudlow, J.E.5
  • 41
    • 0017804313 scopus 로고
    • Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase
    • Y Kono 1978 Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase Arch Biochem Biophys 186 189 195
    • (1978) Arch Biochem Biophys , vol.186 , pp. 189-195
    • Kono, Y.1
  • 42
    • 0034780525 scopus 로고    scopus 로고
    • Diabetes-induced changes in calcium homeostasis and the effects of calcium channel blockers in rat and mice nociceptive neurons
    • E Kostyuk N Voitenko I Kruglikov A Shmigol V Shishkin A Efimov P Kostyuk 2001 Diabetes-induced changes in calcium homeostasis and the effects of calcium channel blockers in rat and mice nociceptive neurons Diabetologia 44 1302 1309
    • (2001) Diabetologia , vol.44 , pp. 1302-1309
    • Kostyuk, E.1    Voitenko, N.2    Kruglikov, I.3    Shmigol, A.4    Shishkin, V.5    Efimov, A.6    Kostyuk, P.7
  • 44
    • 35348851411 scopus 로고    scopus 로고
    • Curcumin attenuates diabetic encephalopathy in rats:behavioral and biochemical evidences
    • A Kuhad K Chopra 2007 Curcumin attenuates diabetic encephalopathy in rats:behavioral and biochemical evidences Eur J Pharmacol 576 34 42
    • (2007) Eur J Pharmacol , vol.576 , pp. 34-42
    • Kuhad, A.1    Chopra, K.2
  • 45
    • 0030003540 scopus 로고    scopus 로고
    • Aldose reductase and sorbitol dehydrogenase activities in diabetic brain: In vivo kinetic studies using 19F 3-FDG NMR in rats
    • IL Kwee H Igarashi T Nakada 1996 Aldose reductase and sorbitol dehydrogenase activities in diabetic brain: in vivo kinetic studies using 19F 3-FDG NMR in rats Neuroreport 7 726 728
    • (1996) Neuroreport , vol.7 , pp. 726-728
    • Kwee, I.L.1    Igarashi, H.2    Nakada, T.3
  • 46
    • 0037118940 scopus 로고    scopus 로고
    • Hippocampal neuronal apoptosis in type 1 diabetes
    • ZG Li W Zhang G Grunberger AA Sima 2002 Hippocampal neuronal apoptosis in type 1 diabetes Brain Res 946 221 231
    • (2002) Brain Res , vol.946 , pp. 221-231
    • Li, Z.G.1    Zhang, W.2    Grunberger, G.3    Sima, A.A.4
  • 47
    • 0038491473 scopus 로고    scopus 로고
    • Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics
    • R Liu IY Liu X Bi RF Thompson SR Doctrow B Malfroy M Baudry 2003 Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics Proc Natl Acad Sci USA 100 8526 8531
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8526-8531
    • Liu, R.1    Liu, I.Y.2    Bi, X.3    Thompson, R.F.4    Doctrow, S.R.5    Malfroy, B.6    Baudry, M.7
  • 48
    • 0030961020 scopus 로고    scopus 로고
    • The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy
    • PA Low KK Nickander HJ Tritschler 1997 The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy Diabetes 46 38 42
    • (1997) Diabetes , vol.46 , pp. 38-42
    • Low, P.A.1    Nickander, K.K.2    Tritschler, H.J.3
  • 50
    • 0029831258 scopus 로고    scopus 로고
    • Alterations in tissue glutathione antioxidant system in streptozotocin - Induced diabetic rats
    • DHF Mak SP Ip PC Li MKT Poon KM Ko 1996 Alterations in tissue glutathione antioxidant system in streptozotocin - induced diabetic rats Mol Cell Biochem 162 153 158
    • (1996) Mol Cell Biochem , vol.162 , pp. 153-158
    • Mak, D.H.F.1    Ip, S.P.2    Li, P.C.3    Poon, M.K.T.4    Ko, K.M.5
  • 51
    • 0037459810 scopus 로고    scopus 로고
    • Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin- diabetic rats
    • SM Manschot GJ Biessels NE Cameron MA Cotter A Kamal LJ Kappelle WH Gispen 2003 Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin- diabetic rats Brain Res 966 274 282
    • (2003) Brain Res , vol.966 , pp. 274-282
    • Manschot, S.M.1    Biessels, G.J.2    Cameron, N.E.3    Cotter, M.A.4    Kamal, A.5    Kappelle, L.J.6    Gispen, W.H.7
  • 52
    • 0343049023 scopus 로고    scopus 로고
    • N-acetylcysteine delays age-associated memory impairment in mice: Role in synaptic mitochondria
    • M Martinez AI Hernandez N Martinez 2000 N-acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria Brain Res 855 100 106
    • (2000) Brain Res , vol.855 , pp. 100-106
    • Martinez, M.1    Hernandez, A.I.2    Martinez, N.3
  • 53
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • H Ohkawa N Ohishi K Yagi 1979 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 351 358
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 55
    • 0035046295 scopus 로고    scopus 로고
    • High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF - Beta 1
    • SH Park HJ Choi JH Lee CH Woo JH Kim HJ Han 2001 High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF - beta 1 Kidney Int 59 1695 1705
    • (2001) Kidney Int , vol.59 , pp. 1695-1705
    • Park, S.H.1    Choi, H.J.2    Lee, J.H.3    Woo, C.H.4    Kim, J.H.5    Han, H.J.6
  • 57
    • 0027284337 scopus 로고
    • The importance of sample preparation and storage in glutathione analysis
    • JC Roberts DJ Francetic 1993 The importance of sample preparation and storage in glutathione analysis Anal Biochem 211 183 187
    • (1993) Anal Biochem , vol.211 , pp. 183-187
    • Roberts, J.C.1    Francetic, D.J.2
  • 58
    • 0028296692 scopus 로고
    • Lipoperoxidative damage on lead exposure in rat brain and its implications on membrane bound enzymes
    • R Sandhir D Julka KD Gill 1994 Lipoperoxidative damage on lead exposure in rat brain and its implications on membrane bound enzymes Pharmacol Toxicol 74 66 71
    • (1994) Pharmacol Toxicol , vol.74 , pp. 66-71
    • Sandhir, R.1    Julka, D.2    Gill, K.D.3
  • 59
    • 0019961923 scopus 로고
    • Changes of glutathione and protein bound SH-groups concentration in rat adrenals under acute and repeated stress
    • J Sedlak L Hanus 1982 Changes of glutathione and protein bound SH-groups concentration in rat adrenals under acute and repeated stress Endocrinol Exp 16 103 109
    • (1982) Endocrinol Exp , vol.16 , pp. 103-109
    • Sedlak, J.1    Hanus, L.2
  • 60
    • 11844290703 scopus 로고    scopus 로고
    • Clinical trials update from the American Heart Association meeting: ACORN-CSD, primary care trial of chronic disease management, PEACE, CREATE, SHIELD, A-HeFT, GEMINI, vitamin e metaanalysis, ESCAPE, CARP, and SCD-HeFT cost-effectiveness study
    • RJ Shelton P Velavan NP Nikitin AP Coletta AL Clark AS Rigby 2005 Clinical trials update from the American Heart Association meeting: ACORN-CSD, primary care trial of chronic disease management, PEACE, CREATE, SHIELD, A-HeFT, GEMINI, vitamin E metaanalysis, ESCAPE, CARP, and SCD-HeFT cost-effectiveness study Eur J Heart Fail 7 127 135
    • (2005) Eur J Heart Fail , vol.7 , pp. 127-135
    • Shelton, R.J.1    Velavan, P.2    Nikitin, N.P.3    Coletta, A.P.4    Clark, A.L.5    Rigby, A.S.6
  • 61
    • 1842785176 scopus 로고    scopus 로고
    • Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes
    • AAF Sima H Kamiya ZG Li 2004 Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes Eur J Pharmacol 490 187 197
    • (2004) Eur J Pharmacol , vol.490 , pp. 187-197
    • Sima, A.A.F.1    Kamiya, H.2    Li, Z.G.3
  • 63
    • 0347758406 scopus 로고    scopus 로고
    • Evidence that glutathione depletion is a mechanism responsible for the anti - Inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide- stimulated RAW 264.7 cells
    • M Song JA Kellum H Kaldas MP Fink 2004 Evidence that glutathione depletion is a mechanism responsible for the anti - inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells J Pharmacol Exp Ther 308 307 316
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 307-316
    • Song, M.1    Kellum, J.A.2    Kaldas, H.3    Fink, M.P.4
  • 64
    • 0030838053 scopus 로고    scopus 로고
    • Antioxidant inhibition of protein kinase C-signaled increases in transforming growth factor-beta in mesangial cells
    • RK Studer PA Craven FR De Rubertis 1997 Antioxidant inhibition of protein kinase C-signaled increases in transforming growth factor-beta in mesangial cells Metabolism 46 918 925
    • (1997) Metabolism , vol.46 , pp. 918-925
    • Studer, R.K.1    Craven, P.A.2    De Rubertis, F.R.3
  • 66
    • 0033042041 scopus 로고    scopus 로고
    • Detection of cell death of cultured mouse mesangial cells induced by oxidized low-density lipoprotein
    • K Tashiro Y Makita T Shike I Shirato T Sato O Cynshi Y Tomino 1999 Detection of cell death of cultured mouse mesangial cells induced by oxidized low-density lipoprotein Nephron 82 51 58
    • (1999) Nephron , vol.82 , pp. 51-58
    • Tashiro, K.1    Makita, Y.2    Shike, T.3    Shirato, I.4    Sato, T.5    Cynshi, O.6    Tomino, Y.7
  • 68
    • 1842785174 scopus 로고    scopus 로고
    • Hippocampal synaptic plasticity and glutamate receptor regulation: Influences of diabetes mellitus
    • F Trudeaua S Gagnonb G Massicotte 2004 Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus Eur J Pharmacol 490 177 186
    • (2004) Eur J Pharmacol , vol.490 , pp. 177-186
    • Trudeaua, F.1    Gagnonb, S.2    Massicotte, G.3
  • 69
    • 0035972093 scopus 로고    scopus 로고
    • Effects of L-phenylalanine on acetylcholinesterase and Na (+), K (+)-ATPase activities in adult and aged rat brain
    • S Tsakiris 2001 Effects of L-phenylalanine on acetylcholinesterase and Na (+), K (+)-ATPase activities in adult and aged rat brain Mech Ageing Dev 122 491 501
    • (2001) Mech Ageing Dev , vol.122 , pp. 491-501
    • Tsakiris, S.1
  • 70
    • 33646161716 scopus 로고    scopus 로고
    • Effect of melatonin and vitamin e on diabetes-induced learning and memory impairment in rats
    • M Tuzcu G Baydas 2006 Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats Eur J Pharmacol 537 106 110
    • (2006) Eur J Pharmacol , vol.537 , pp. 106-110
    • Tuzcu, M.1    Baydas, G.2
  • 71
    • 0037409980 scopus 로고    scopus 로고
    • Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: Effects of stobadine and vitamin e
    • NN Ulusu M Sahilli A Avci O Canbolat G Ozansoy N Ari M Bali M Stefek S Stolc A Gajdosik C Karasu 2003 Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effects of stobadine and vitamin E Neurochem Res 28 815 823
    • (2003) Neurochem Res , vol.28 , pp. 815-823
    • Ulusu, N.N.1    Sahilli, M.2    Avci, A.3    Canbolat, O.4    Ozansoy, G.5    Ari, N.6    Bali, M.7    Stefek, M.8    Stolc, S.9    Gajdosik, A.10    Karasu, C.11
  • 73
    • 33745351101 scopus 로고    scopus 로고
    • N-acetylcysteine does not protect against type II cell injury after prolonged exposure to hyperoxia in rats
    • RJ van Klaveren D Dinsdale JL Pype M Demedts B Nemery 1997 N-acetylcysteine does not protect against type II cell injury after prolonged exposure to hyperoxia in rats Am J Physiol 273 548 555
    • (1997) Am J Physiol , vol.273 , pp. 548-555
    • Van Klaveren, R.J.1    Dinsdale, D.2    Pype, J.L.3    Demedts, M.4    Nemery, B.5
  • 76
    • 0035720552 scopus 로고    scopus 로고
    • Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway
    • WA Wilmer CL Dixon C Hebert 2001 Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway Kidney Int 60 858 871
    • (2001) Kidney Int , vol.60 , pp. 858-871
    • Wilmer, W.A.1    Dixon, C.L.2    Hebert, C.3
  • 77
    • 0024990024 scopus 로고
    • Hippocampal and prefrontal cortex contributions to learning and memory: Analysis of lesion and aging effects on maze learning in rats
    • G Winocur M Moscovitch 1990 Hippocampal and prefrontal cortex contributions to learning and memory: analysis of lesion and aging effects on maze learning in rats Behav Neurosci 104 544 551
    • (1990) Behav Neurosci , vol.104 , pp. 544-551
    • Winocur, G.1    Moscovitch, M.2
  • 78
    • 33746647309 scopus 로고    scopus 로고
    • Antioxidant N-acetylcysteine restores myocardial Mn-SOD activity and attenuates myocardial dysfunction in diabetic rats
    • Z Xia Z Guo PR Nagareddy V Yuen E Yeung JH McNeill 2006 Antioxidant N-acetylcysteine restores myocardial Mn-SOD activity and attenuates myocardial dysfunction in diabetic rats Eur J Pharmacol 544 118 125
    • (2006) Eur J Pharmacol , vol.544 , pp. 118-125
    • Xia, Z.1    Guo, Z.2    Nagareddy, P.R.3    Yuen, V.4    Yeung, E.5    McNeill, J.H.6
  • 79
    • 33846880290 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates PKCbeta2 over expression and myocardial hypertrophy in streptozotocin-induced diabetic rats
    • Z Xia KH Kuo PR Nagareddy F Wang Z Guo T Guo J Jiang JH McNeill 2007 N-acetylcysteine attenuates PKCbeta2 over expression and myocardial hypertrophy in streptozotocin-induced diabetic rats Cardiovasc Res 73 770 782
    • (2007) Cardiovasc Res , vol.73 , pp. 770-782
    • Xia, Z.1    Kuo, K.H.2    Nagareddy, P.R.3    Wang, F.4    Guo, Z.5    Guo, T.6    Jiang, J.7    McNeill, J.H.8


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