Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat

Neuroscience Letters

Volumn 549, Issue , 2013, Pages 63-68

  Liu, Jiping ^a,c   Feng, Liang ^b   Ma, Dongying ^a   Zhang, Minghua ^b   Gu, Junfei ^b   Wang, Shuyuan ^a   Fu, Qiang ^a   Song, Yu ^a   Lan, Zhou ^a   Qu, Rong ^d   Ma, Shiping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

^c SHAANXI UNIVERSITY OF CHINESE MEDICINE   (China)

^d NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Anti apoptosis; Cognition deficits; Diabetic encephalopathy; Neuropathological changes; Paeonol

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CHOLINE ACETYLTRANSFERASE; PEONOL; SOMATOMEDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; COGNITIVE DEFECT; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC ENCEPHALOPATHY; ENZYME ACTIVITY; LATENT PERIOD; MALE; MAZE TEST; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES;

ACETYLCHOLINESTERASE; ACHE; AMYLOID BETA; ANTI-APOPTOSIS; AΒ; BDNF; BRAIN DERIVED NEUROTROPHIC FACTOR; CHAT; CHOLINE ACETYLTRANSFERASE; COGNITION DEFICITS; DE; DIABETIC ENCEPHALOPATHY; HGF; HIGH-GLUCOSE-FAT DIET; IGF; INSULIN-LIKE GROWTH FACTORS; NA(+)-K(+)-ADENOSINE TRIPHOSPHATASE; NA(+)-K(+)-ATPASE; NEUROPATHOLOGICAL CHANGES; PAEONOL; STREPTOZOTOCIN; STZ; Β-AMYLOID;

ACETOPHENONES; ACETYLCHOLINESTERASE; ANIMALS; APOPTOSIS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CEREBRAL CORTEX; COGNITION; COGNITION DISORDERS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; HIPPOCAMPUS; INSULIN-LIKE GROWTH FACTOR I; MALE; MAZE LEARNING; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84880761558     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.06.002     Document Type: Article

References (22)

1. Aliaga E., Silhol M., Bonneau N., Maurice T., Arancibia S., Tapia-Arancibia L. Dual response of BDNF to sublethal concentrations of beta-amyloid peptides in cultured cortical neurons. Neurobiol. Dis. 2010, 37:208-217.
2. Bhutada P., Mundhada Y., Humane V., Rahigude A., Deshmukh P., Latad S., Jain K. Agmatine, an endogenous ligand of imidazoline receptor protects against memory impairment and biochemical alterations in streptozotocin-induced diabetic rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 2012, 37:96-105.
3. Biessels G.J., Kamal A., Urban I.J., Spruijt B.M., Erkelens D.W., Gispen W.H. Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment. Brain Res. 1998, 800:125-135.
4. Catalano S.M., Dodson E.C., Henze D.A., Joyce J.G., Krafft G.A., Kinney G.G. The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease. Curr. Top. Med. Chem. 2006, 6:597-608.
5. Duarte J.M., Oses J.P., Rodrigues R.J., Cunha R.A. Modification of purinergic signaling in the hippocampus of streptozotocin-induced diabetic rats. Neuroscience 2007, 149:382-391.
6. Fazeli S.A. Neuroprotection in diabetic encephalopathy. Neurodegener. Dis. 2009, 6:213-218.
7. Forlenza O.V., Diniz B.S., Teixeira A.L., Ojopi E.B., Talib L.L., Mendonça V.A., Izzo G., Gattaz W.F. Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment. World J. Biol. Psychiatry 2010, 1:774-780.
8. Javier Miguel-Hidalgo J., Paul I.A., Wanzo V., Banerjee P.K. Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β(1-40). Eur. J. Pharmacol. 2012, 692:38-45.
9. Jeremias I.C., Scaini G., Constantino L., Vuolo F., Ferreira A.K., Scherer E.B., Kolling J., da Silva Dornelles A., de Souza Wyse A.T., Bogo M.R., Dal-Pizzol F., Streck E.L. The decrease on Na(+), K (+)-ATPase activity in the cortex, but not in hippocampus, is reverted by antioxidants in an animal model of sepsis. Mol. Neurobiol. 2012, 10.1007/s12035-012-8297-2.
10. Kamboj S.S., Chopra K., Sandhir R. Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes. Metab. Brain Dis. 2008, 23:427-443.
11. Kamboj S.S., Chopra K., Sandhir R. Hyperglycemia-induced alterations in synaptosomal membrane fluidity and activity of membrane bound enzymes: beneficial effect of N-acetylcysteine supplementation. Neuroscience 2009, 162:349-358.
12. Kim D.S., Kim J.Y., Han Y. Curcuminoids in neurodegenerative diseases. Recent Pat. CNS Drug Discov. 2012, 3:184-204.
13. Lesné S., Koh M.T., Kotilinek L., Kayed R., Glabe C.G., Yang A., Gallagher M., Ashe K.H. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006, 440:352-357.
14. Lin B. Polyphenols and neuroprotection against ischemia and neurodegeneration. Mini Rev. Med. Chem. 2011, 11:1222-1238.
15. Mastrocola R., Restivo F., Vercellinatto I., Danni O., Brignardello E., Aragno M., Boccuzzi G. Oxidative and nitrosative stress in brain mitochondria of diabetic rats. J. Endocrinol. 2005, 187:37-44.
16. Reijmer Y.D., van den Berg E., de Bresser J., Kessels R.P., Kappelle L.J., Algra A., Biessels G.J., Utrecht Diabetic Encephalopathy Study Group Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors. Diabetes Metab. Res. Rev. 2011, 27:195-202.
17. Renic M., Kumar S.N., Gebremedhin D., Florence M.A., Gerges N.Z., Falck J.R., Harder D.R., Roman R.J. Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures. Am. J. Physiol. Heart Circ. Physiol. 2012, 302:H1285-H1293.
18. Robert A., Jirounek P. Axonal and glial currents activated during the post-tetanic hyperpolarization in non-myelinated nerve. Pflugers Arch. 1998, 436:529-537.
19. Su S.Y., Cheng C.Y., Tsai T.H., Hsieh C.L. Paeonol protects memory after ischemic stroke via inhibiting β-secretase and apoptosis. Evid. Based Complement Alternat. Med. 2012, 2012:932823.
20. Uematsu N., Matsukawa N., Kanamori T., Arai Y., Sagisaka T., Toyoda T., Yoshida M., Ojika K. Overexpression of hippocampal cholinergic neurostimulating peptide in heterozygous transgenic mice increases the amount of ChAT in the medial septal nucleus. Brain Res. 2009, 1305:150-157.
21. Wu J.B., Song N.N., Wei X.B., Guan H.S., Zhang X.M. Protective effects of paeonol on cultured rat hippocampal neurons against oxygen-glucose deprivation-induced injury. J. Neurol. Sci. 2008, 264:50-55.
22. Zhong S.Z., Ge Q.H., Qu R., Li Q., Ma S.P. Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. J. Neurol. Sci. 2009, 277:58-64.