Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 13, 2015, Pages 3163-3174

  Magoulas, George E ^a   Kostopoulou, Ourania N ^b,c   Garnelis, Thomas ^a   Athanassopoulos, Constantinos M ^a   Kournoutou, Georgia G ^b   Leotsinidis, Michael ^b   Dinos, George P ^b   Papaioannou, Dionissios ^a   Kalpaxis, Dimitrios L ^b  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antibacterial activity; Chloramphenicol; Polyamine conjugates; Polyamine uptake system; Polyamines

Indexed keywords

ANTIINFECTIVE AGENT; N [1,3 DIHYDROXY 1 (4 NITROPHENYL)PROPAN 2 YL] 1H 1,2,4 TRIAZOLE 3 CARBOXAMIDE; N [3 [1,3 DIHYDROXY 1 (4 NITROPHENYL)PROPAN 2 YLAMINO] 3 OXO PROPYL] 1H 1,2,4 TRIAZOLE 3 CARBOXAMIDE; N [3 [4 (3 AMINOPROPYLAMINO)BUTYLAMINO]PROPYL] 2 (2,2 DICHLOROACETAMIDO) 3 HYDROXY 3 (4 NITROPHENYL)PROPANAMIDE; N1 (4 AMINOBUTYL) N1 (3 AMINOPROPYL) N4 [1,3 DIHYDROXY 1 (4 NITROPHENYL)PROPAN 2 YL]SUCCINAMIDE; N1 (4 AMINOBUTYL) N2 [1,3 DIHYDROXY 1 (4 NITRONITROPHENYL)PROPAN 2 YL]PHTHALAMIDE; N1 (4 AMINOBUTYL) N4 [1,3 DIHYDROXY 1 (4 NITROPHENYLPROPAN 2 YL)SUCCINAMIDE]; N1 [(3 AMINOPROPYL) N1 (4 DIBENZYLAMINO)BUTYL] N4 [1,3 DIHYDROXY 1 (4 NITROPHENYL)PROPAN 2 YL]SUCCINAMIDE; N1 [3 [4 (3 AMINOPROPYLAMINO)BUTYLAMINO]PROPYL] N4 [1,3 DIHYDROXY 1 (4 NITROPHENYL)PROPAN 2 YL]SUCCINAMIDE; N1 [3 [4 (DIBENZYLAMINO)BUTYLAMINO]PROPYL] N4 [1,3 DIHYDROXY 1 (4 NITROPHENYL) PROPAN 2 YL]SUCCINAMIDE; PHTHALIC ANHYDRIDE; SUCCINIC ANHYDRIDE; UNCLASSIFIED DRUG; ACYLTRANSFERASE; BACTERIAL PROTEIN; CHLORAMPHENICOL; SPERMIDINE;

ACYLATION; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; CAT GENE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; ESCHERICHIA COLI; GENE EXPRESSION; GROWTH INHIBITION; IC50; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; WILD TYPE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYME ASSAY; GENETICS; GROWTH, DEVELOPMENT AND AGING; KINETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MUTATION; SYNTHESIS;

ESCHERICHIA COLI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

ACETYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CHLORAMPHENICOL; ENZYME ASSAYS; ESCHERICHIA COLI; GENE EXPRESSION; KINETICS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MUTATION; PHTHALIC ANHYDRIDES; SPERMIDINE; SUCCINIC ANHYDRIDES;

EID: 84937424261     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.04.069     Document Type: Article

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