Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 11, 2009, Pages 3810-3817

  Yang, Kanghui ^a   Wang, Qiang ^a   Su, Li ^a   Fang, Hao ^a   Wang, Xuejian ^a   Gong, Jianzhi ^a   Wang, Binghe ^b   Xu, Wenfang ^a  

^a SHANDONG UNIVERSITY   (China)

^b GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Aminopeptidase N; Chloramphenicol amine; Inhibitor; QSAR; Synthesis

Indexed keywords

2 [2 [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPANAMIDO) 3 PHENYLPROPANAMIDO] 3 PHENYLPROPANOIC ACID; 2 [2 [2 AMINO 3 HYDROXY 3 (4 NITROPHENYL)PROPANAMIDO] 4 METHYLPENTANAMIDO] 3 PHENYLPROPANOIC ACID; 2 AMINO 1 (4 NITROPHENYL)PROPANE 1,3 DIOL; AMINE; BESTATIN; CHLORAMPHENICOL DERIVATIVE; MICROSOMAL AMINOPEPTIDASE; PROPANE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HL 60; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50;

AMINES; ANTIGENS, CD13; CATALYTIC DOMAIN; CHLORAMPHENICOL; DRUG DESIGN; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LEUCINE; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PROTEASE INHIBITORS;

EID: 65549122879     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.038     Document Type: Article

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