A new era of secreted phospholipase A2

Journal of Lipid Research

Volumn 56, Issue 7, 2015, Pages 1248-1261

  Murakami, Makoto ^a,b   Sato, Hiroyasu ^a   Miki, Yoshimi ^a   Yamamoto, Kei ^a   Taketomi, Yoshitaka ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Eicosanoids; Fatty acid; Immunology; Inflammation; Lipidomics; Lysophospholipid; Membranes; Obesity; Phospholipids metabolism; Supplementary arachidonic acid

Indexed keywords

ASPARTIC ACID; CALCIUM; HISTIDINE; LIPID; PHOSPHOLIPASE A2; PHOSPHOLIPID; SECRETED PHOSPHOLIPASE A2; UNCLASSIFIED DRUG; PHOSPHOLIPASE A2 RECEPTOR; SECRETORY PHOSPHOLIPASE A2;

CELLULAR DISTRIBUTION; ENZYME ACTIVITY; HUMAN; IN VIVO STUDY; KNOCKOUT MOUSE; LIPID COMPOSITION; LIPID DEGRADATION; LIPIDOMICS; MEMBRANE; MOLECULAR WEIGHT; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; TISSUE DISTRIBUTION; TRANSGENIC MOUSE; ANIMAL; CHEMISTRY; CLASSIFICATION; METABOLISM;

ANIMALS; HUMANS; PHOSPHOLIPASES A2, SECRETORY; RECEPTORS, PHOSPHOLIPASE A2;

EID: 84937127077     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R058123     Document Type: Review

References (165)

1. 2 Annu. Rev. Biochem. 77: 495-520.
2. 2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem. Rev. 111: 6130-6185.
3. 2 research: from cells to animals to humans. Prog. Lipid Res. 50: 152-192.
4. 2 enzymes: Lessons from transgenic and knockout mice. Biochimie. 92: 561-582.
5. 2 revisited. J. Biochem. 150: 233-255.
6. rd edition. Biochimie. 107: 105-113.
7. 2 from human pancreas. Biochim. Biophys. Acta. 747: 93-99.
8. 2: isolation of the human gene and cDNAs from porcine pancreas and human lung. DNA. 5: 519-527.
9. 2 J. Biol. Chem. 264: 5768-5775.
10. 2 present in rheumatoid arthritic synovial fluid. J. Biol. Chem. 264: 5335-5338.
11. 2 J. Biol. Chem. 269: 2365-2368.
12. 2 genes are linked and map to homologous chromosome regions in mouse and human. Genomics. 32: 328-333.
13. 2 J. Biol. Chem. 272: 15745-15752.
14. 2 with homology to the group III bee venom enzyme. J. Biol. Chem. 275: 7492-7496.
15. 2 J. Biol. Chem. 275: 39823-39826.
16. 2 lacking enzymatic activity. Biochemistry. 42: 11494-11503.
17. 2 from bacteria to human. Comp. Biochem. Physiol. Part D Genomics Proteomics. 7: 340-350.
18. 2 Proc. Natl. Acad. Sci. USA. 95: 15345-15350.
19. Zhao, X., H. Yang, E. N. Yamoah, and Y. W. Lundberg. 2007. Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrix. Dev. Biol. 304: 508-524.
20. 2 from inflammatory exudate. Science. 254: 1007-1010.
21. 2 Electrostatically neutral interfacial surface targets zwitterionic membranes. J. Biol. Chem. 277: 29086-29093.
22. 2 Biochim. Biophys. Acta. 1394: 57-64.
23. 2 J. Biol. Chem. 273: 14411-14423.
24. 2s (groups III and XII). J. Biol. Chem. 278: 10657-10667.
25. 2 Biochim. Biophys. Acta. 1736: 38-50.
26. 2s act on distinct cellular phospholipid molecular species. Biochim. Biophys. Acta. 1771: 1389-1396.
27. 2 and its zymogen induced by submicellar concentrations of negatively charged detergents. Biochemistry. 22: 5347-5353.
28. 2exacerbates diet-induced obesity and insulin resistance in mice. Int. J. Obes. (Lond). 35: 877-881.
29. 2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate. J. Clin. Invest. 97: 2233-2241.
30. 2 Arterioscler. Thromb. Vasc. Biol. 19: 1284-1290.
31. 2 against Staphylococcus aureus. J. Immunol. 162: 7402-7408.
32. 2 to Escherichia coli infection. Infect. Immun. 68: 87-92.
33. 2 in skin results in abnormal epidermis and increased sensitivity to chemical carcinogenesis. Oncogene. 22: 1936-1944.
34. 2 in mice leads to neonatal lethality because of lung dysfunction. J. Biol. Chem. 281: 36420-36433.
35. 2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology. J. Biol. Chem. 283: 21640-21648.
36. 2 in mouse skin. J. Biol. Chem. 286: 11616-11631.
37. 2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis. J. Biol. Chem. 283: 33483-33497.
38. 2 transgenic mice spontaneously develop inflammation. Biochem. J. 421: 17-27.
39. 2-deficient mice. Am. J. Physiol. Endocrinol. Metab. 283: E994-E1001.
40. 2-mediated lysophospholipid absorption directly contributes to postprandial hyperglycemia. Diabetes. 55: 935-941.
41. 2 and diet-induced obesity. FASEB J. 24: 2516-2524.
42. 2 deficiency protects against diet-induced hyperlipidemia in mice. J. Lipid Res. 52: 2005-2011.
43. 2 inactivation suppresses atherosclerosis and metabolic diseases in LDL receptor-deficient mice. Atherosclerosis. 234: 377-380.
44. 2 inhibitor methyl indoxam suppresses diet-induced obesity and glucose intolerance in mice. Br. J. Pharmacol. 157: 1263-1269.
45. Wilson, S. G., G. Adam, M. Langdown, R. Reneland, A. Braun, T. Andrew, G. L. Surdulescu, M. Norberg, F. Dudbridge, P. W. Reed, et al. 2006. Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort. Eur. J. Hum. Genet. 14: 340-348.
46. 2-a mediator between proximal and distal effectors of inflammation. Immunol. Today. 12: 143-146.
47. 2 gene in inbred mouse strains. J. Biol. Chem. 270: 22378-22385.
48. Min-induced intestinal neoplasia. Cell. 81: 957-966.
49. 2 J. Clin. Invest. 102: 633-638.
50. 2 J. Biol. Chem. 277: 5849-5857.
51. 2 in concert with polymorphonuclear leukocytes. J. Biol. Chem. 269: 26331-26337.
52. 2 against Staphylococcus aureus. J. Biol. Chem. 277: 47636-47644.
53. 2 against experimental anthrax. J. Immunol. 175: 6786-6791.
54. 2: role of Streptococcus pyogenes sortase A. J. Immunol. 187: 6437-6446.
55. Pernet, E., L. Guillemot, P. R. Burgel, C. Martin, G. Lambeau, I. Sermet-Gaudelus, D. Sands, D. Leduc, P. C. Morand, L. Jeammet, et al. 2014. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat. Commun. 5: 5105.
56. 2 expression by alveolar macrophages. PLoS Pathog. 3: e187.
57. Cormier, R. T., K. H. Hong, R. B. Halberg, T. L. Hawkins, P. Richardson, R. Mulherkar, W. F. Dove, and E. S. Lander. 1997. Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat. Genet. 17: 88-91.
58. 2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc. Natl. Acad. Sci. USA. 99: 16203-16208.
59. 2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours. Ann. Hum. Genet. 60: 369-376.
60. 2 increases with prostate tumor grade. Clin. Cancer Res. 7: 3857-3861.
61. 2 enzymes in cancer. Biochimie. 92: 601-610.
62. Brglez, V., G. Lambeau, and T. Petan. 2014. Secreted phospholipases A2 in cancer: diverse mechanisms of action. Biochimie. 107: 114-123.
63. 2 in immune complex-mediated arthritis. EMBO Mol. Med. 2: 172-187.
64. 2 to promote inflammation. Blood. 124: 2173-2183.
65. Boilard, E., P. A. Nigrovic, K. Larabee, G. F. Watts, J. S. Coblyn, M. E. Weinblatt, E. M. Massarotti, E. Remold-O'Donnell, R. W. Farndale, J. Ware, et al. 2010. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science. 327: 580-583.
66. 2IIa: results from the UDACS study. Hum. Mol. Genet. 15: 355-361.
67. 2 predict coronary events in patients with coronary artery disease. Circulation. 100: 1280-1284.
68. 2 increases atherosclerotic lesion formation in LDL receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 23: 263-268.
69. 2 J. Biol. Chem. 274: 19152-19160.
70. 2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators. J. Exp. Med. 210: 1217-1234.
71. + regulatory T cells. Proc. Natl. Acad. Sci. USA. 106: 11673-11678.
72. 2-IID is associated with body weight loss in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 172: 1097-1104.
73. 2 Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes. J. Biol. Chem. 274: 31195-31202.
74. Sato, H., Y. Taketomi, A. Ushida, Y. Isogai, T. Kojima, T. Hirabayashi, Y. Miki, K. Yamamoto, Y. Nishito, T. Kobayashi, et al. 2014. The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity. Cell Metab. 20: 119-132.
75. Yang, S. K., M. Hong, W. Zhao, Y. Jung, N. Tayebi, B. D. Ye, K. J. Kim, S. H. Park, I. Lee, H. D. Shin, et al. 2013. Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians. Inflamm. Bowel Dis. 19: 954-966.
76. 2s containing 16 cysteines. J. Biol. Chem. 269: 23018-23024.
77. Zeissig, S., K. Murata, L. Sweet, J. Publicover, Z. Hu, A. Kaser, E. Bosse, J. Iqbal, M. M. Hussain, K. Balschun, et al. 2012. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat. Med. 18: 1060-1068.
78. 2 mRNA to meiotic cells in the mouse. J. Cell. Biochem. 64: 369-375.
79. 2 and the epidermal barrier. Biochim. Biophys. Acta. 1841: 416-421.
80. Man, M. Q., T. K. Lin, J. L. Santiago, A. Celli, L. Zhong, Z. M. Huang, T. Roelandt, M. Hupe, J. P. Sundberg, K. A. Silva, et al. 2014. Basis for enhanced barrier function of pigmented skin. J. Invest. Dermatol. 134: 2399-2407.
81. 2 J. Biol. Chem. 274: 11881-11888.
82. 2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. J. Biol. Chem. 279: 16488-16494.
83. 2 contributes to LPS-induced leukocyte recruitment. J. Cell. Physiol. 224: 127-134.
84. 2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice. J. Immunol. 179: 4800-4807.
85. 2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 296: L879-L887.
86. 2 causes lung inflammation and acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 304: L689-L700.
87. 2 in allergic response and parturition. Nature. 390: 618-622.
88. 2αactivation. Blood. 110: 561-567.
89. 2s. J. Immunol. 182: 3877-3883.
90. 2 enzymes present in P388D1 macrophages. J. Biol. Chem. 271: 6758-6765.
91. 2 expression and function by proinflammatory stimuli. Eur. J. Biochem. 263: 826-835.
92. 2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. J. Immunol. 190: 5927-5938.
93. 2 is upregulated by IL-4 in human macrophages and mediates phagocytosis via hydrolysis of ethanolamine phospholipids. J. Immunol. 194: 3327-3339.
94. 2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling. PLoS ONE. 8: e56172.
95. 2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function. J. Immunol. 185: 4430-4438.
96. 2 modulates phagosome maturation and regulates the innate immune response against Candida albicans. J. Immunol. 182: 4891-4898.
97. 2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia. J. Biol. Chem. 286: 35650-35662.
98. 2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation. Arterioscler. Thromb. Vasc. Biol. 24: 762-767.
99. 2 promotes atherosclerosis: evidence from genetically altered mice. Arterioscler. Thromb. Vasc. Biol. 27: 600-606.
100. -/- mouse LDL in vitro predicts its atherogenic role in vivo. Arterioscler. Thromb. Vasc. Biol. 29: 532-538.
101. 2 plays a pathogenic role in myocardial ischaemia-reperfusion injury. Cardiovasc. Res. 90: 335-343.
102. 2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice. Am. J. Pathol. 181: 1088-1098.
103. Nicholls, S. J., J. J. Kastelein, G. G. Schwartz, D. Bash, R. S. Rosenson, M. A. Cavender, D. M. Brennan, W. Koenig, J. W. Jukema, V. Nambi, et al.; VISTA-16 Investigators. 2014. Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial. JAMA. 311: 252-262.
104. 2-IIA: results from the UDACS study. Hum. Mol. Genet. 16: 1437-1444.
105. 2 group V of lipoproteins in diabetic dyslipidaemia. J. Intern. Med. 264: 155-165.
106. 2, cause benign fleck retina. Am. J. Hum. Genet. 89: 782-791.
107. Friedman, J. S., B. Chang, D. S. Krauth, I. Lopez, N. H. Waseem, R. E. Hurd, K. L. Feathers, K. E. Branham, M. Shaw, G. E. Thomas, et al. 2010. Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice. Proc. Natl. Acad. Sci. USA. 107: 15523-15528.
108. 2 J. Biol. Chem. 280: 23203-23214.
109. 2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells. J. Biol. Chem. 286: 36509-36521.
110. 2 but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells. J. Biol. Chem. 275: 3179-3191.
111. 2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. J. Biol. Chem. 276: 10083-10096.
112. 2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J. Exp. Med. 204: 865-877.
113. 2 inhibitor. J. Biol. Chem. 286: 28049-28055.
114. 2 group X. J. Biol. Chem. 285: 41491-41500.
115. 2 group X in asthma. Am. J. Respir. Crit. Care Med. 188: 42-50.
116. 2 increases survival following pandemic H1N1 influenza infection. Virology. 454-455: 78-92.
117. 2 groups IIA and X in the airways and asthma severity. Clin. Exp. Allergy. 41: 801-810.
118. 2-deficient mice. Circulation. 117: 2977-2985.
119. 2 augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice. Atherosclerosis. 214: 58-64.
120. 2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice. Am. J. Physiol. Heart Circ. Physiol. 302: H95-H104.
121. 2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. J. Biol. Chem. 286: 11632-11648.
122. 2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands. J. Biol. Chem. 285: 20031-20039.
123. 2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism. J. Biol. Chem. 289: 27410-27417.
124. 2 limits the development of atherosclerosis in LDL receptor-null mice. Arterioscler. Thromb. Vasc. Biol. 33: 466-473.
125. 2 group X gene: relevance to coronary artery disease. J. Mol. Med. (Berl). 87: 723-733.
126. 2 activity and coronary heart disease risk. Circ. Cardiovasc. Genet. Epub ahead of print. January 12, 2015; doi:10.1161/CIRCGENETICS.114.000633.
127. 2 enhances TLR4 signaling in macrophages. J. Immunol. 187: 482-489.
128. 2 negatively regulates adipogenesis in murine models. FASEB J. 24: 4313-4324.
129. Mazmanian, S. K., C. H. Liu, A. O. Tzianabos, and D. L. Kasper. 2005. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 122: 107-118.
130. Ley, R. E., F. Backhed, P. Turnbaugh, C. A. Lozupone, R. D. Knight, and J. I. Gordon. 2005. Obesity alters gut microbial ecology. Proc. Natl. Acad. Sci. USA. 102: 11070-11075.
131. Tremaroli, V., and F. Backhed. 2012. Functional interactions between the gut microbiota and host metabolism. Nature. 489: 242-249.
132. 2 is released during sperm acrosome reaction and controls fertility outcome in mice. J. Clin. Invest. 120: 1415-1428.
133. 2 J. Biol. Chem. 280: 24987-24998.
134. 2-DP1 receptor paracrine axis. Nat. Immunol. 14: 554-563.
135. 2 regulates epididymal sperm maturation and fertility in mice. J. Clin. Invest. 120: 1400-1414.
136. 2-III as a biomarker candidate. Br. J. Cancer. 98: 587-595.
137. Hoeft, B., J. Linseisen, L. Beckmann, K. Muller-Decker, F. Canzian, A. Husing, R. Kaaks, U. Vogel, M. U. Jakobsen, K. Overvad, et al. 2010. Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk. Carcinogenesis. 31: 466-472.
138. 2 gene family polymorphisms and AIDS progression using the SNPlex method. Biomed. Pharmacother. 62: 31-40.
139. Martínez-García, A., I. Sastre, M. Recuero, J. Aldudo, E. Vilella, I. Mateo, P. Sanchez-Juan, T. Vargas, E. Carro, F. Bermejo-Pareja, et al. 2010. PLA2G3, a gene involved in oxidative stress induced death, is associated with Alzheimer's disease. J. Alzheimers Dis. 22: 1181-1187.
140. Kim, J., J. E. Lee, S. Heynen-Genel, E. Suyama, K. Ono, K. Lee, T. Ideker, P. Aza-Blanc, and J. G. Gleeson. 2010. Functional genomic screen for modulators of ciliogenesis and cilium length. Nature. 464: 1048-1051.
141. 2 against Helicobacter pylori in vitro. APMIS. 114: 127-130.
142. 2 Mol. Cell. Biol. 25: 3608-3619.
143. 2 XIIA in the brain and its role in lipid metabolism and cognition. Mol. Neurobiol. 50: 60-75.
144. Wang, V. M., R. B. Rosen, C. B. Meyerle, S. K. Kurup, D. Ardeljan, E. Agron, K. Tai, M. Pomykala, E. Y. Chew, C. C. Chan, et al. 2012. Suggestive association between PLA2G12A single nucleotide polymorphism rs2285714 and response to anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration. Mol. Vis. 18: 2578-2585.
145. 2 GXIIB. Hepatology. 53: 458-466.
146. 2 to the mouse M-type receptor. Biochemistry. 46: 1647-1662.
147. 2 receptor. J. Biol. Chem. 269: 5897-5904.
148. 2 J. Biol. Chem. 269: 1575-1578.
149. 2 Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. J. Biol. Chem. 270: 8963-8970.
150. 2 receptor-deficient mice. J. Biol. Chem. 272: 32792-32797.
151. 2 receptor exacerbates oval-bumin-induced lung inflammation. J. Immunol. 191: 1021-1028.
152. 2 receptor increases susceptibility to cardiac rupture after myocardial infarction. Circ. Res. 114: 493-504.
153. Augert, A., C. Payre, Y. de Launoit, J. Gil, G. Lambeau, and D. Bernard. 2009. The M-type receptor PLA2R regulates senescence through the p53 pathway. EMBO Rep. 10: 271-277.
154. Augert, A., D. Vindrieux, C. A. Girard, B. Le Calve, B. Gras, M. Ferrand, B. P. Bouchet, A. Puisieux, Y. de Launoit, H. Simonnet, et al. 2013. PLA2R1 kills cancer cells by inducing mitochondrial stress. Free Radic. Biol. Med. 65: 969-977.
155. Vindrieux, D., A. Augert, C. A. Girard, D. Gitenay, H. Lallet-Daher, C. Wiel, B. Le Calve, B. Gras, M. Ferrand, S. Verbeke, et al. 2013. PLA2R1 mediates tumor suppression by activating JAK2. Cancer Res. 73: 6334-6345.
156. 2 receptor as target antigen in idiopathic membranous nephropathy. N. Engl. J. Med. 361: 11-21.
157. Stanescu, H. C., M. Arcos-Burgos, A. Medlar, D. Bockenhauer, A. Kottgen, L. Dragomirescu, C. Voinescu, N. Patel, K. Pearce, M. Hubank, et al. 2011. Risk HLA-DQA1 and PLA2R1 alleles in idiopathic membranous nephropathy. N. Engl. J. Med. 364: 616-626.
158. 2 and peroxisome proliferator-activated receptor α activation. J. Biol. Chem. 278: 29799-29812.
159. 2 J. Biol. Chem. 271: 250-257.
160. Geijtenbeek, T. B., and S. I. Gringhuis. 2009. Signalling through C-type lectin receptors: shaping immune responses. Nat. Rev. Immunol. 9: 465-479.
161. Takeuchi, O., and S. Akira. 2010. Pattern recognition receptors and inflammation. Cell. 140: 805-820.
162. Ip, W. K., K. Takahashi, K. J. Moore, L. M. Stuart, and R. A. Ezekowitz. 2008. Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome. J. Exp. Med. 205: 169-181.
163. Gantner, B. N., R. M. Simmons, S. J. Canavera, S. Akira, and D. M. Underhill. 2003. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J. Exp. Med. 197: 1107-1117.
164. Sato, K., X. L. Yang, T. Yudate, J. S. Chung, J. Wu, K. Luby-Phelps, R. P. Kimberly, D. Underhill, P. D. Cruz, Jr., and K. Ariizumi. 2006. Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J. Biol. Chem. 281: 38854-38866.
165. 2 generation in mouse bone marrow culture-derived mast cells in a strain-dependent manner. Biochim. Biophys. Acta. 1761: 1489-1497.