PLA2R1 kills cancer cells by inducing mitochondrial stress

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 969-977

  Augert, Arnaud ^a,b,c,d   Vindrieux, David ^a,b,c   Girard, Christophe A ^e   Le Calvé, Benjamin ^a,b,c   Gras, Baptiste ^a,b,c   Ferrand, Mylène ^a,b,c   Bouchet, Benjamin P ^a,b,c   Puisieux, Alain ^a,b,c   De Launoit, Yvan ^d   Simonnet, Hélène ^a,b,c   Lambeau, Gérard ^e   Bernard, David ^a,b,c  

^a CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^b CENTRE LÉON BÉRARD   (France)

^c UNIVERSITÉ DE LYON   (France)

^d INSTITUT DE BIOLOGIE DE LILLE   (France)

^e INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Cell death; Free radicals; Mitochondria; PLA2R1; ROS; Senescence

Indexed keywords

PHOSPHOLIPASE A2 RECEPTOR; PHOSPHOLIPASE A2 RECEPTOR 1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; MULTIENZYME COMPLEX; PLA2R1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY CHAIN; SENESCENCE; CELL PROLIFERATION; DNA FRAGMENTATION; GENE EXPRESSION; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA FRAGMENTATION; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; GENE EXPRESSION; HUMANS; MITOCHONDRIA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTORS, PHOSPHOLIPASE A2;

EID: 84884389665     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.08.177     Document Type: Article

References (28)

1. P. Ancian, G. Lambeau, and M. Lazdunski Multifunctional activity of the extracellular domain of the M-type (180 kDa) membrane receptor for secretory phospholipases A2 Biochemistry 34 1995 13146 13151
2. M. Rouault, C. Le Calvez, E. Boilard, F. Surrel, A. Singer, F. Ghomashchi, S. Bezzine, S. Scarzello, J. Bollinger, M.H. Gelb, and G. Lambeau Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor Biochemistry 46 2007 1647 1662
3. G. Lambeau, P. Ancian, J. Barhanin, and M. Lazdunski Cloning and expression of a membrane receptor for secretory phospholipases A2 J. Biol. Chem. 269 1994 1575 1578 (Pubitemid 24035339)
4. M. Murakami, Y. Taketomi, C. Girard, K. Yamamoto, and G. Lambeau Emerging roles of secreted phospholipase A2 enzymes: lessons from transgenic and knockout mice Biochimie 92 2010 561 582
5. A. Augert, C. Payre, Y. de Launoit, J. Gil, G. Lambeau, and D. Bernard The M-type receptor PLA2R regulates senescence through the p53 pathway EMBO Rep. 10 2009 271 277
6. F. Debacq-Chainiaux, J.D. Erusalimsky, J. Campisi, and O. Toussaint Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo Nat. Protoc. 4 2009 1798 1806
7. E. Giaime, H. Yamaguchi, C.A. Gautier, T. Kitada, and J. Shen Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening PLoS One 7 2012 e40501
8. C. Ferlini, and G. Scambia Assay for apoptosis using the mitochondrial probes, Rhodamine123 and 10-N-nonyl acridine orange Nat. Protoc. 2 2007 3111 3114
9. J.P. Nicolas, G. Lambeau, and M. Lazdunski Identification of the binding domain for secretory phospholipases A2 on their M-type 180-kDa membrane receptor J. Biol. Chem 270 1995 28869 28873
10. S.M. Deneke Thiol-based antioxidants Curr. Top. Cell Regul. 36 2000 151 180
11. D. Salvemini, and R. Botting Modulation of platelet function by free radicals and free-radical scavengers Trends Pharmacol. Sci. 14 1993 36 42 (Pubitemid 23049338)
12. D.A. Mickle, and R.D. Weisel Future directions of vitamin E and its analogues in minimizing myocardial ischemia-reperfusion injury Can. J. Cardiol. 9 1993 89 93
13. L. Raj, T. Ide, A.U. Gurkar, M. Foley, M. Schenone, X. Li, N.J. Tolliday, T.R. Golub, S.A. Carr, A.F. Shamji, A.M. Stern, A. Mandinova, S.L. Schreiber, and S.W. Lee Selective killing of cancer cells by a small molecule targeting the stress response to ROS Nature 475 2011 231 234
14. L.H. Beck Jr, R.G. Bonegio, G. Lambeau, D.M. Beck, D.W. Powell, T.D. Cummins, J.B. Klein, and D.J. Salant M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy N. Engl. J. Med. 361 2009 11 21
15. H. Debiec, and P. Ronco PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy N. Engl. J. Med. 364 2011 689 690
16. D. Trachootham, Y. Zhou, H. Zhang, Y. Demizu, Z. Chen, H. Pelicano, P.J. Chiao, G. Achanta, R.B. Arlinghaus, J. Liu, and P. Huang Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate Cancer Cell 10 2006 241 252 (Pubitemid 44311067)
17. D. Trachootham, J. Alexandre, and P. Huang Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat. Rev. Drug Discovery 8 2009 579 591
18. N. Li, K. Ragheb, G. Lawler, J. Sturgis, B. Rajwa, J.A. Melendez, and J.P. Robinson Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production J. Biol. Chem. 278 2003 8516 8525 (Pubitemid 36800604)
19. R. Zhou, A.S. Yazdi, P. Menu, and J. Tschopp A role for mitochondria in NLRP3 inflammasome activation Nature 469 2011 221 225
20. G. Tettamanti, D. Malagoli, E. Ottaviani, and E.M. de Oligomycin A and the IPLB-LdFB insect cell line: actin and mitochondrial responses Cell Biol. Int. 32 2008 287 292
21. J. Gil, S. Almeida, C.R. Oliveira, and A.C. Rego Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis Free Radic. Biol. Med. 35 2003 1500 1514 (Pubitemid 37452475)
22. L. Karawajew, P. Rhein, G. Czerwony, and W.D. Ludwig Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species Blood 105 2005 4767 4775 (Pubitemid 40807302)
23. +-ATP synthase Carcinogenesis 27 2006 925 935
24. +-ATP-synthase, suppresses the TNF-induced apoptosis Oncogene 21 2002 8149 8157 (Pubitemid 35454417)
25. 2+ depletion and cell death in leukemia cells Mol. Pharmacol 70 2006 1424 1434 (Pubitemid 44435995)
26. T. Finkel Signal transduction by mitochondrial oxidants J. Biol. Chem. 287 2012 4434 4440
27. T. Finkel Signal transduction by reactive oxygen species J. Cell Biol. 194 2011 7 15
28. M. Lacroix, R.A. Toillon, and G. Leclercq p53 and breast cancer, an update Endocr. Relat. Cancer 13 2006 293 325 (Pubitemid 43886660)