Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase a to promote inflammation

Blood

Volumn 124, Issue 14, 2014, Pages 2173-2183

  Boudreau, Luc H ^a   Duchez, Anne Claire ^a   Cloutier, Nathalie ^a   Soulet, Denis ^a   Martin, Nicolas ^b   Bollinger, James ^c   Paré, Alexandre ^a   Rousseau, Matthieu ^a   Naika, Gajendra S ^c   Lévesque, Tania ^a   Laflamme, Cynthia ^a   Marcoux, Geneviève ^a   Lambeau, Gérard ^d   Farndale, Richard W ^e   Pouliot, Marc ^a   Hamzeh Cognasse, Hind ^f   Cognasse, Fabrice ^f   Garraud, Olivier ^f   Nigrovic, Peter A ^g   Guderley, Helga ^b   Lacroix, Steve ^a   Thibault, Louis ^h   Semple, John W ⁱ   Gelb, Michael H ^c   Boilard, Eric ^a   more..

^a UNIVERSITÉ LAVAL   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITY OF WASHINGTON   (United States)

^d CNRS   (France)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITÉ DE LYON   (France)

^g HARVARD MEDICAL SCHOOL   (United States)

^h Research and Development   (Canada)

ⁱ ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; LYSOPHOSPHOLIPID; MITOCHONDRIAL DNA; PHOSPHOLIPASE A2 GROUP II; PHOSPHOLIPASE A2 GROUP IIA; THROMBOCYTE CONCENTRATE; UNCLASSIFIED DRUG; PLA2G2A PROTEIN, HUMAN; PLA2G2A PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; BACTERICIDAL ACTIVITY; BLOOD TRANSFUSION; CARDIOVASCULAR DISEASE; CELL ADHESION; CELL INTERACTION; CONTROLLED STUDY; ENZYME RELEASE; FLUORESCENCE MICROSCOPY; HUMAN; HYPOTHESIS; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE ACTIVATION; MALE; MEMBRANE MICROPARTICLE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NEUTROPHIL; NONHUMAN; PROTEIN HYDROLYSIS; PROTEOBACTERIA; RESPIRATORY SYSTEM; SKIN MANIFESTATION; THROMBOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; FLOW CYTOMETRY; METABOLISM; RICKETTSIA PROWAZEKII; THROMBOCYTE; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD PLATELETS; DNA, MITOCHONDRIAL; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; GROUP II PHOSPHOLIPASES A2; HUMANS; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; PLATELET ACTIVATION; RICKETTSIA PROWAZEKII;

EID: 84907693658     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-05-573543     Document Type: Article

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