Blockade of human group X secreted phospholipase A 2 (GX-sPLA 2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA 2 inhibitor

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 28049-28055

  Henderson Jr , William R ^a   Oslund, Rob C ^a   Bollinger, James G ^a   Ye, Xin ^a   Tien, Ying Tzang ^a   Xue, Jun ^a   Gelb, Michael H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIRWAY INFLAMMATION; ARACHIDONIC ACIDS; ASTHMA MODELS; EICOSANOIDS; HYPERSECRETION; IN-VITRO; IN-VIVO; INFLAMMATORY CELLS; INHIBITOR CONCENTRATION; LARGE GROUPS; METHACHOLINE; MOUSE MODELS; PHARMACOLOGICAL BLOCKADE; PHOSPHOLIPASE A; PHOSPHOLIPASES; POTENTIAL UTILITY; THERAPEUTIC INTERVENTION;

ALLERGIES; DISEASES; PATHOLOGY; PATIENT TREATMENT; PLANTS (BOTANY);

MAMMALS;

ALLERGEN; GROUP X SECRETED PHOSPHOLIPASE A2; METHACHOLINE; PHOSPHOLIPASE A2 INHIBITOR; RO 061606; SECRETORY PHOSPHOLIPASE A2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; TRANSGENIC MOUSE;

ALLERGENS; ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GENE KNOCK-IN TECHNIQUES; GROUP X PHOSPHOLIPASES A2; HUMANS; INFLAMMATION; MICE; MICE, KNOCKOUT; MUCUS;

MUS;

EID: 80051536995     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.235812     Document Type: Article

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