Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells

Virology

Volumn 485, Issue , 2015, Pages 1-15

  Iordanskiy, Sergey ^a   Van Duyne, Rachel ^a,b   Sampey, Gavin C ^a   Woodson, Caitlin M ^a   Fry, Kelsi ^a   Saifuddin, Mohammed ^a   Guo, Jia ^a   Wu, Yuntao ^a   Romerio, Fabio ^c   Kashanchi, Fatah ^a  

^a GEORGE MASON UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; CD4+ T cells; HIV 1 latency; HIV 1 reactivation; Humanized mice; Irradiation; Monocytes; Transcription; X ray

Indexed keywords

BRYOSTATIN 1; HISTONE DEACETYLASE 1; METHYLTRANSFERASE; METHYLTRANSFERASE SUV39H1; PROTEIN P53; RNA POLYMERASE II; UNCLASSIFIED DRUG; VIRUS RNA; VORINOSTAT; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BRYOSTATIN; GREEN FLUORESCENT PROTEIN; HDAC1 PROTEIN, HUMAN; REPRESSOR PROTEIN; SUV39H1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL DEATH; CELL LEVEL; CELL VIABILITY; CELLULAR STRESS SIGNAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; LYMPHOBLASTOID CELL; MALE; MONOCYTE; MOUSE; NEWBORN; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; VIRAL CLEARANCE; VIRUS REACTIVATION; VIRUS REPLICATION; X IRRADIATION; AGONISTS; ANIMAL; CELL SURVIVAL; GAMMA RADIATION; GENETIC TRANSCRIPTION; GENETICS; HIV INFECTIONS; METABOLISM; PHYSIOLOGY; REPORTER GENE; THERAPEUTIC USE; TUMOR CELL LINE; VIROLOGY; VIRUS ACTIVATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; MUS;

ANIMALS; ANTI-HIV AGENTS; APOPTOSIS; BRYOSTATINS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; GAMMA RAYS; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HISTONE DEACETYLASE 1; HIV INFECTIONS; HIV-1; HUMANS; MALE; METHYLTRANSFERASES; MICE; MONOCYTES; REPRESSOR PROTEINS; RNA POLYMERASE II; RNA, VIRAL; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; VIRUS ACTIVATION; VIRUS REPLICATION;

EID: 84937060496     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2015.06.021     Document Type: Article

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