DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition

Retrovirology

Volumn 10, Issue 1, 2013, Pages

  Koyama, Takayoshi ^a   Sun, Binlian ^b   Tokunaga, Kenzo ^c   Tatsumi, Masashi ^c   Ishizaka, Yukihito ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

DNA damage; HIV 1; Integrase inhibitor; Integration; Resting macrophages; Vpr

Indexed keywords

ANTIRETROVIRUS AGENT; ATAXIA TELANGIECTASIA MUTATED PROTEIN INHIBITOR; ATM PROTEIN; BLEOMYCIN; DOUBLE STRANDED DNA; ELVITEGRAVIR; ENDONUCLEASE; ENFUVIRTIDE; ETOPOSIDE; INTEGRASE; RALTEGRAVIR; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS RNA; ZIDOVUDINE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE TARGETING; GENE TRANSFER; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MACROPHAGE; NONHUMAN; PROGENY; PROVIRUS; REGULATOR GENE; VIRUS DNA CELL DNA INTERACTION; VIRUS GENE; VIRUS INFECTIVITY; VIRUS REPLICATION; VIRUS RESISTANCE; VIRUS STRAIN;

CELL CYCLE PROTEINS; CELL LINE; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA-BINDING PROTEINS; DRUG RESISTANCE, VIRAL; HEK293 CELLS; HIV INTEGRASE; HIV-1; HUMANS; INTEGRASE INHIBITORS; MACROPHAGES; PROTEIN-SERINE-THREONINE KINASES; PYRROLIDINONES; TUMOR SUPPRESSOR PROTEINS; VIRUS INTEGRATION; VPR GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

ATAXIA TELANGIECTASIA; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84874005275     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-10-21     Document Type: Article

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