Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones

Virology

Volumn 277, Issue 2, 2000, Pages 278-295

  Deng, Longwen ^a   De la Fuente, Cynthia ^a   Fu, Peng ^a   Wang, Lai ^a   Donnelly, Robert ^a   Wade, John D ^b   Lambert, Paul ^c   Li, Hong ^a   Lee, Chee Gun ^a   Kashanchi, Fatah ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c FLINDERS UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HISTONE; HISTONE ACETYLTRANSFERASE; LYSINE; PEPTIDE; PROTEIN P300; TRANSACTIVATOR PROTEIN; VIRUS DNA; VIRUS PROTEIN;

ACETYLATION; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROVIRUS; RNA BINDING; STOP CODON; VIRUS GENOME; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

EID: 0034715791     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0593     Document Type: Article

References (73)

1. Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoterproximal transcripts
2. Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A
3. The CBP co-activator is a histone acetyltransferase
4. Activation of integrated provirus requires histone acetyltransferase, p300 and P/CAF are coactivators for HLV-1 Tat
5. Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription
6. The histone acetylase PCAF is a nuclear receptor coactivator
7. Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300
8. A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity
9. Nuclear factor I-mediated repression of the mouse mammary tumor virus promoter is abrogated by the coactivators p300/CBP and SRC-1
10. Specific interaction of Tat with the human but not rodent P-TEFb complex mediates the species-specific Tat activation of HIV-1 transcription
11. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
12. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
13. Phosphorylated CREB binds specifically to the nuclear protein CBR
14. Control of the histone-apetyltransferase activity of Tip60 by the HIV-1 transactivator protein Tat
15. The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme
16. Molecular cloning and functional analysis of the denovirus E1A-associated 300-kD protein (p300/reveals a protein with properties of a transcriptional adaptor
17. Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter
18. Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator
19. Routine identification of proteins from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) gels or polyvinyl difluoride membranes using matrix assisted laser desorption/ionization-time of flight-mass spectrometry (MALDFTOF-MS)
20. The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat
21. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein
22. Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HW-1 transcription
23. Upregulation of cyclin T1/CDK9 complexes during T cell activation
24. The multifunctional role of the co-activator CBP in transcriptional regulation
25. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
26. Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase
27. Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein
28. Altered replication of human immunodeficiency virus type 1 (HIV-1) in T cell lines retrovirally transduced to express herpesvirus saimiri proteins StpC and/or Tip
29. Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: Candidate for a Tat cofactor
30. Interaction of human immuno-deficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein
31. Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300
32. SWI/SNF complexes and facilitation of TATA binding protein: Nucleosome interactions
33. Acetylation of general transcription factors by histone acetyltransferases
34. Factors involved in specific transcription by mammalian RNA polymerase II. Purification and functional analysis of general transcription factor IIE
35. Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation
36. Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation
37. In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor
38. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 tat transactivator
39. Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product
40. Electroporation of viral transactivator proteins into lymphocyte suspension cells
41. Direct interaction of human TFIID with the HIV-1 transactivator tat
42. Second-site long terminal repeat (LTR) revertants of replication-defective human immunodeficiency virus: Effects of revertant TATA box motifs on virus infectivity, LTR-directed expression, in vitro RNA synthesis, and binding of basal transcription factors TFIID and TFIIA
43. The coactivator CBP stimulates human T-cell lymphotrophic virus type 1 Tax transactivation in vitro
44. Cell cycle-regulated transcription by the human immunodeficieney virus type 1 Tat transactivator
45. HIV-1 Tat transcriptional activity is regulated by acetylation
46. Conditional modulation of glucocorticoid receptor activities by CREB-binding protein (CBP) and p300
47. Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations
48. Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP
49. Recruitment of the TATA-binding protein to the HIV-1 promoter is a limiting step for Tat transactivation
50. The acetyltransferase activity of CBP stimulates transcription
51. HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter
52. Human immunodeficiency virus type 1 and 2 Tat proteins specifically interact with RNA polymerase II
53. The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity
54. Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription
55. Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity
56. Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain
57. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter
58. The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300
59. Transcription of the human T-cell lymphotropic virus type I promoter by an alpha-amanitin-resistant polymerase
60. Human and rodent transcription elongation factor P-TEFb: Interactions with human immunodeficiency virus type 1 tat and carboxy-terminal domain substrate
61. Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression
62. Induction of developmentally programmed cell death and activation of HIV by sodium butyrate
63. Roles of p300, pocket proteins, and hTBP in E1A-mediated transcriptional regulation and inhibition of p53 transactivation activity
64. A new procedure for purifying histone pairs H2A + H2B and H3 + H4 from chromatin using hydroxylapatite
65. The p300/CBP family: Integrating signals with transcription factors and chromatin
66. Reconstitution of chromatin from purified components
67. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation
68. DNase I-hypersensitive sites are associated with both long terminal repeats and with the intragenic enhancer of integrated human immunodeficiency virus type 1
69. Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo
70. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
71. Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b
72. The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function
73. Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases