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Volumn 86, Issue 1, 2012, Pages 114-120

Latent HIV-1 infection of resting CD4+ T Cells in the humanized Rag2 -/- γ c -/- mouse

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; EMTRICITABINE; ENFUVIRTIDE; INTEGRASE INHIBITOR; L 870812; RAG2 PROTEIN; TENOFOVIR; UNCLASSIFIED DRUG;

EID: 84863393573     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05590-11     Document Type: Article
Times cited : (71)

References (38)
  • 1
    • 79955402159 scopus 로고    scopus 로고
    • Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells
    • Anderson JA, et al. 2011. Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells. J. Virol. 85:5220-5223.
    • (2011) J. Virol. , vol.85 , pp. 5220-5223
    • Anderson, J.A.1
  • 2
    • 50949131800 scopus 로고    scopus 로고
    • Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells
    • Archin NM, et al. 2008. Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells. AIDS 22:1131-1135.
    • (2008) AIDS , vol.22 , pp. 1131-1135
    • Archin, N.M.1
  • 3
    • 60849127627 scopus 로고    scopus 로고
    • Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid
    • Archin NM, et al. 2009. Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid. AIDS Res. Hum. Retroviruses 25:207-212.
    • (2009) AIDS Res. Hum. Retroviruses , vol.25 , pp. 207-212
    • Archin, N.M.1
  • 4
    • 33750436225 scopus 로고    scopus 로고
    • Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/-mice
    • Baenziger S, et al. 2006. Disseminated and sustained HIV infection in CD34+cord blood cell-transplanted Rag2-/-gamma c-/- mice. Proc. Natl. Acad. Sci. U. S. A. 103:15951-15956.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 15951-15956
    • Baenziger, S.1
  • 5
    • 33745245733 scopus 로고    scopus 로고
    • Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells
    • Bailey JR, et al. 2006. Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells. J. Virol. 80:6441-6457.
    • (2006) J. Virol. , vol.80 , pp. 6441-6457
    • Bailey, J.R.1
  • 6
    • 73949142803 scopus 로고    scopus 로고
    • Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year
    • Berges BK, Akkina SR, Remling L, Akkina R. 2010. Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year. Virology 397:100-103.
    • (2010) Virology , vol.397 , pp. 100-103
    • Berges, B.K.1    Akkina, S.R.2    Remling, L.3    Akkina, R.4
  • 7
    • 33751003823 scopus 로고    scopus 로고
    • HIV 1 infection and CD4 T cell depletion in the humanized Rag2-/-gammac-/- (RAG-hu) mouse model
    • Berges BK, Wheat WH, Palmer BE, Connick E, Akkina R. 2006. HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model. Retrovirology 3:76.
    • (2006) Retrovirology , vol.3 , pp. 76
    • Berges, B.K.1    Wheat, W.H.2    Palmer, B.E.3    Connick, E.4    Akkina, R.5
  • 8
    • 0033779574 scopus 로고    scopus 로고
    • Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells
    • Bieniasz PD, Cullen BR. 2000. Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells. J. Virol. 74:986-9877.
    • (2000) J. Virol. , vol.74 , pp. 9868-9877
    • Bieniasz, P.D.1    Cullen, B.R.2
  • 9
    • 0141567539 scopus 로고    scopus 로고
    • Molecular characterization, reactivation, and depletion of latent HIV
    • Brooks DG, et al. 2003. Molecular characterization, reactivation, and depletion of latent HIV. Immunity 19:413-423.
    • (2003) Immunity , vol.19 , pp. 413-423
    • Brooks, D.G.1
  • 11
    • 79952653986 scopus 로고    scopus 로고
    • HIV 1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells
    • Carter CC, et al. 2011. HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells. Cell Host Microbe 9:223-234.
    • (2011) Cell Host Microbe , vol.9 , pp. 223-234
    • Carter, C.C.1
  • 13
    • 0032555117 scopus 로고    scopus 로고
    • Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection
    • Chun TW, et al. 1998. Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. Proc. Natl. Acad. Sci. U. S. A. 95:8869-8873.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 8869-8873
    • Chun, T.W.1
  • 14
    • 0032490570 scopus 로고    scopus 로고
    • Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines
    • Chun TW, Engel D, Mizell SB, Ehler LA, Fauci AS. 1998. Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines. J. Exp. Med. 188:83-91.
    • (1998) J. Exp. Med. , vol.188 , pp. 83-91
    • Chun, T.W.1    Engel, D.2    Mizell, S.B.3    Ehler, L.A.4    Fauci, A.S.5
  • 15
    • 78549235738 scopus 로고    scopus 로고
    • Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication
    • Chun TW, et al. 2010. Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication. AIDS 24:2803-2808.
    • (2010) AIDS , vol.24 , pp. 2803-2808
    • Chun, T.W.1
  • 16
    • 27644524761 scopus 로고    scopus 로고
    • HIV infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    • Chun TW, et al. 2005. HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J. Clin. Invest. 115:3250-3255.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3250-3255
    • Chun, T.W.1
  • 17
    • 40549092339 scopus 로고    scopus 로고
    • Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy
    • Chun TW, et al. 2008. Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy. J. Infect. Dis. 197: 714-720.
    • (2008) J. Infect. Dis. , vol.197 , pp. 714-720
    • Chun, T.W.1
  • 18
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    • Chun TW, et al. 1997. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acad. Sci. U. S. A. 94:13193-13197.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 13193-13197
    • Chun, T.W.1
  • 19
    • 69449083091 scopus 로고    scopus 로고
    • A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy
    • Dinoso JB, et al. 2009. A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy. J. Virol. 83:9247-9257.
    • (2009) J. Virol. , vol.83 , pp. 9247-9257
    • Dinoso, J.B.1
  • 20
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi D, et al. 1997. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278:1295-1300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1
  • 21
    • 0032533253 scopus 로고    scopus 로고
    • The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein
    • Garber ME, et al. 1998. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. Genes Dev. 12:3512-3527.
    • (1998) Genes Dev , vol.12 , pp. 3512-3527
    • Garber, M.E.1
  • 22
    • 0038468339 scopus 로고    scopus 로고
    • Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo
    • Hermankova M, et al. 2003. Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo. J. Virol. 77:7383-7392.
    • (2003) J. Virol. , vol.77 , pp. 7383-7392
    • Hermankova, M.1
  • 23
    • 15744378284 scopus 로고    scopus 로고
    • Persistence of replication-competent HIV in the central nervous system despite long-term effective highly active antiretroviral therapy
    • Lambotte O, et al. 2005. Persistence of replication-competent HIV in the central nervous system despite long-term effective highly active antiretroviral therapy. AIDS 19:217-218.
    • (2005) AIDS , vol.19 , pp. 217-218
    • Lambotte, O.1
  • 24
    • 0034068397 scopus 로고    scopus 로고
    • A block to human immunodeficiency virus type 1 assembly in murine cells
    • Mariani R, et al. 2000. A block to human immunodeficiency virus type 1 assembly in murine cells. J. Virol. 74:3859-3870.
    • (2000) J. Virol. , vol.74 , pp. 3859-3870
    • Mariani, R.1
  • 25
    • 33750705617 scopus 로고    scopus 로고
    • Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1
    • Melkus MW, et al. 2006. Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nat. Med. 12:1316-1322.
    • (2006) Nat. Med. , vol.12 , pp. 1316-1322
    • Melkus, M.W.1
  • 26
    • 19644365063 scopus 로고    scopus 로고
    • An improvement in virologic response to highly active antiretroviral therapy in clinical practice from 1996 through 2002
    • Moore RD, Keruly JC, Gebo KA, Lucas GM. 2005. An improvement in virologic response to highly active antiretroviral therapy in clinical practice from 1996 through 2002. J. Acquir. Immune Defic. Syndr. 39: 195-198.
    • (2005) J. Acquir. Immune Defic. Syndr. , vol.39 , pp. 195-198
    • Moore, R.D.1    Keruly, J.C.2    Gebo, K.A.3    Lucas, G.M.4
  • 27
    • 13844274980 scopus 로고    scopus 로고
    • Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART
    • Nettles RE, et al. 2005. Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART. JAMA 293:817-829.
    • (2005) JAMA , vol.293 , pp. 817-829
    • Nettles, R.E.1
  • 28
    • 41649083599 scopus 로고    scopus 로고
    • Low level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
    • Palmer S, et al. 2008. Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy. Proc. Natl. Acad. Sci. U. S. A. 105:3879-3884.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 3879-3884
    • Palmer, S.1
  • 29
    • 0027538456 scopus 로고
    • HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
    • Pantaleo G, et al. 1993. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362: 355-358.
    • (1993) Nature , vol.362 , pp. 355-358
    • Pantaleo, G.1
  • 30
    • 0036340605 scopus 로고    scopus 로고
    • Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection
    • Pierson TC, et al. 2002. Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection. J. Virol. 76: 8518-8531.
    • (2002) J. Virol. , vol.76 , pp. 8518-8531
    • Pierson, T.C.1
  • 31
    • 77954892271 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy potently suppresses HIV infection in humanized Rag2-/-gammac-/- mice
    • Sango K, et al. 2010. Highly active antiretroviral therapy potently suppresses HIV infection in humanized Rag2-/-gammac-/- mice. AIDS Res. Hum. Retroviruses 26:735-746.
    • (2010) AIDS Res. Hum. Retroviruses , vol.26 , pp. 735-746
    • Sango, K.1
  • 32
    • 0345578685 scopus 로고    scopus 로고
    • Resting CD4+ T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus-Macaca nemestrina model of human immunodeficiency virus type 1-infected patients on highly active antiretroviral therapy
    • Shen A, et al. 2003. Resting CD4+ T lymphocytes but not thymocytes provide a latent viral reservoir in a simian immunodeficiency virus-Macaca nemestrina model of human immunodeficiency virus type 1-infected patients on highly active antiretroviral therapy. J. Virol. 77: 4938-4949.
    • (2003) J. Virol. , vol.77 , pp. 4938-4949
    • Shen, A.1
  • 33
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano JD, et al. 2003. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat. Med. 9:727-728.
    • (2003) Nat. Med. , vol.9 , pp. 727-728
    • Siliciano, J.D.1
  • 34
    • 20244376915 scopus 로고    scopus 로고
    • Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1
    • Strain MC, et al. 2005. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. J. Infect. Dis. 191:1410-1418.
    • (2005) J. Infect. Dis. , vol.191 , pp. 1410-1418
    • Strain, M.C.1
  • 35
    • 1842588698 scopus 로고    scopus 로고
    • Development of a human adaptive immune system in cord blood cell-transplanted mice
    • Traggiai E, et al. 2004. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 304:104-107.
    • (2004) Science , vol.304 , pp. 104-107
    • Traggiai, E.1
  • 36
    • 0029085036 scopus 로고
    • Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors
    • Uberla K, et al. 1995. Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors. Proc. Natl. Acad. Sci. U. S. A. 92:8210-8214.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 8210-8214
    • Uberla, K.1
  • 37
    • 33846809447 scopus 로고    scopus 로고
    • Primitive hematopoietic cells resist HIV-1 infection via p21
    • Zhang J, Scadden DT, Crumpacker CS. 2007. Primitive hematopoietic cells resist HIV-1 infection via p21. J. Clin. Invest. 117:473-481.
    • (2007) J. Clin. Invest. , vol.117 , pp. 473-481
    • Zhang, J.1    Scadden, D.T.2    Crumpacker, C.S.3
  • 38
    • 33947596455 scopus 로고    scopus 로고
    • HIV 1 infection and pathogenesis in a novel humanized mouse model
    • Zhang L, Kovalev GI, Su L. 2007. HIV-1 infection and pathogenesis in a novel humanized mouse model. Blood 109:2978-2981.
    • (2007) Blood , vol.109 , pp. 2978-2981
    • Zhang, L.1    Kovalev, G.I.2    Su, L.3


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