Generalized portrait of cancer metabolic pathways inferred from a list of genes overexpressed in cancer

Genetics Research International

Volumn 2014, Issue , 2014, Pages

  Poliakov, Eugenia ^a   Managadze, David ^b   Rogozin, Igor B ^b  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; AMINOACYL TRANSFER RNA; ANTIOXIDANT; CYSTEINE; CYTOCHROME P450; GLYCAN; GLYCEROLIPID; HISTIDINE; LACTIC ACID; MANNOSE; METHIONINE; PHENYLALANINE; PYRUVIC ACID; TYROSINE;

AMINO ACID METABOLISM; ARTICLE; CITRIC ACID CYCLE; EXPRESSED SEQUENCE TAG; FATTY ACID METABOLISM; FOLATE METABOLISM; FRUCTOSE METABOLISM; GENE OVEREXPRESSION; GLUCONEOGENESIS; GLYCOLYSIS; HUMAN; METABOLISM; NEOPLASM; OXIDATIVE PHOSPHORYLATION; PENTOSE PHOSPHATE CYCLE; PROTEIN EXPRESSION; PROTEIN PROCESSING; PURINE METABOLISM; PURINE SYNTHESIS; PYRIMIDINE METABOLISM; PYRIMIDINE SYNTHESIS; STEROIDOGENESIS;

EID: 84937029527     PISSN: 20903154     EISSN: 20903162     Source Type: Journal    
DOI: 10.1155/2014/646193     Document Type: Article

References (60)

1. O. Warburg, "On the origin of cancer cells," Science, vol. 123, no. 3191, pp. 309-314, 1956.
2. O. Warburg, F. Wind, and E. Negelein, "The metabolism of tumors in the body," The Journal of General Physiology, vol. 8, no. 6, pp. 519-530, 1927.
3. L. Jiang and R. J. Deberardinis, "Cancer metabolism: when more is less," Nature, vol. 489, no.7417, pp. 511-512, 2012.
4. L. Tasselli and K. F. Chua, "Cancer: metabolism in 'the driver's seat," Nature, vol. 492, no. 7429, pp. 362-363, 2012.
5. M. G. V. Heiden, L. C. Cantley, and C. B. Thompson, "Understanding the warburg effect: the metabolic requirements of cell proliferation," Science, vol. 324, no. 5930, pp. 1029-1033, 2009.
6. W. Kowalski, D. Nocon, A. Gamian, J. Kolodziej, and D. Rakus, "Association of C-terminal region of phosphoglycerate mutase with glycolytic complex regulates energy production in cancer cells," Journal of Cellular Physiology, vol. 227, no. 6, pp. 2613-2621, 2012.
7. M. G. V. Heiden, J. W. Locasale, K. D. Swanson et al., "Evidence for an alternative glycolytic pathway in rapidly proliferating cells," Science, vol. 329, no. 5998, pp. 1492-1499, 2010.
8. M. G. H. Chun and R. J. Shaw, "Cancer metabolism in breadth and depth," Nature Biotechnology, vol. 31, no. 6, pp. 505-507, 2013.
9. J. Hu, J. W. Locasale, J. H. Bielas et al., "Heterogeneity of tumor induced gene expression changes in the human metabolic network," Nature Biotechnology, vol. 31, no. 6, pp. 522-529, 2013.
10. J. Son, C. A. Lyssiotis, H. Ying et al., "Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway," Nature, vol. 496, no. 7443, pp. 101-105, 2013.
11. M. Jain, R. Nilsson, S. Sharma et al., "Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation," Science, vol. 336, no. 6084, pp. 1040-1044, 2012.
12. T. Santarius, J. Shipley, D. Brewer, M. R. Stratton, and C. S. Cooper, "A census of amplified and overexpressed human cancer genes," Nature Reviews Cancer, vol. 10, no. 1, pp. 59-64, 2010.
13. E. Wang, "Understanding genomic alterations in cancer genomes using an integrative network approach," Cancer Letters, vol. 340, no. 2, pp. 261-269, 2013.
14. E. Wang, N. Zaman, S. McGee, J. S. Milanese, A. Masoudi-Nejad, and M. O'Connor-McCourt, "Predictive genomics: a cancer hallmark network framework for predicting tumor clinical phenotypes using genome sequencing data," Seminars in Cancer Biology, 2014.
15. K. R. Kampen, "Membrane proteins: the key players of a cancer cell," Journal of Membrane Biology, vol. 242, no. 2, pp. 69-74, 2011.
16. A. Aouacheria, V. Navratil, A. Barthelaix, D. Mouchiroud, and C. Gautier, "Bioinformatic screening of human ESTs for differentially expressed genes in normal and tumor tissues," BMC Genomics, vol. 7, article 94, 2006.
17. M. Kanehisa, S. Goto, Y. Sato, M. Kawashima, M. Furumichi, and M. Tanabe, "Data, information, knowledge and principle: back to metabolism in KEGG," Nucleic Acids Research, vol. 42, Database issue, pp. D199-D205, 2014.
18. N. Kondoh, M. Shuda, K. Tanaka, T. Wakatsuki, A. Hada, and M. Yamamoto, "Enhanced expression of S8, L12, L23a, L27 and L30 ribosomal protein mRNAs in human hepatocellular carcinoma," Anticancer Research, vol. 21, no. 4, pp. 2429-2433, 2001.
19. M. Stoneley and A. E. Willis, "Aberrant regulation of translation initiation in tumorigenesis," Current Molecular Medicine, vol.3, no. 7, pp. 597-603, 2003.
20. M. J. Clemens, "Targets and mechanisms for the regulation of translation in malignant transformation, "Oncogene, vol. 23, no. 18, pp. 3180-3188, 2004.
21. M. Lai and J. Xu, "Ribosomal proteins and colorectal cancer," Current Genomics, vol. 8, no. 1, pp. 43-49, 2007.
22. H. R. Christofk, M. G. Vander Heiden, M. H. Harris et al., "The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth," Nature, vol. 452, no. 7184, pp. 230-233, 2008.
23. S. Mazurek, C. B. Boschek, F. Hugo, and E. Eigenbrodt, "Pyruvate kinase type M2 and its role in tumor growth and spreading," Seminars in Cancer Biology, vol. 15, no. 4, pp. 300-308, 2005.
24. C. Frezza, L. Zheng, D. A. Tennant et al., "Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival," PLoS ONE, vol. 6, no. 9, Article ID e24411, 2011.
25. P. Sonveaux, F. Végran, T. Schroeder et al., "Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice," Journal of Clinical Investigation, vol. 118, no. 12, pp. 3930-3942, 2008.
26. O. Feron, "Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells," Radiotherapy and Oncology, vol. 92, no. 3, pp. 329-333, 2009.
27. S. J. Nelson, J. Kurhanewicz, D. B. Vigneron et al., "Metabolic imaging of patients with prostate cancer using hyperpolarized [1-13C]pyruvate," Science Translational Medicine, vol. 5, no. 198, Article ID 198ra108, 2013.
28. M. L. McCleland, A. S. Adler, Y. Shang et al., "An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer," Cancer Research, vol. 72, no. 22, pp. 5812-5823, 2012.
29. S. A. Marchitti, D. J. Orlicky, C. Brocker, and V. Vasiliou, "Aldehyde dehydrogenase 3B1 (ALDH3B1): immunohistochemical tissue distribution and cellular-specific localization in normal and cancerous human tissues," Journal of Histochemistry & Cytochemistry, vol. 58, no. 9, pp. 765-783, 2010.
30. T. Matsunaga, A. Hojo, Y. Yamane, S. Endo, O. El-Kabbani, and A. Hara, "Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers," Chemico-Biological Interactions, vol. 202, no. 1-3, pp. 234-242, 2013.
31. N. Shafqat, J. Shafqat, G. Eissner et al., "Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue," Cellular and Molecular Life Sciences, vol. 63, no. 10, pp. 1205-1213, 2006.
32. H. Liu, D. Huang, D. L. McArthur, L. G. Boros, N. Nissen, and A. P. Heaney, "Fructose induces transketolase flux to promote pancreatic cancer growth," Cancer Research, vol. 70, no. 15, pp. 6368-6376, 2010.
33. A. M. Port, M. R. Ruth, and N. W. Istfan, "Fructose consumption and cancer: is there a connection?" Current Opinion in Endocrinology, Diabetes and Obesity, vol. 19, no. 5, pp. 367-374, 2012.
34. B. E. Baysal, R. E. Ferrell, J. E. Willett-Brozick et al., "Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma," Science, vol. 287, no. 5454, pp. 848-851, 2000.
35. A. Schulze and A. L. Harris, "How cancer metabolism is tuned for proliferation and vulnerable to disruption," Nature, vol. 491, no. 7424, pp. 364-373, 2012.
36. N. Raimundo, B. E. Baysal, and G. S. Shadel, "Revisiting the TCA cycle: signaling to tumor formation," Trends in Molecular Medicine, vol. 17, no. 11, pp. 641-649, 2011.
37. R. J. DeBerardinis, A. Mancuso, E. Daikhin et al., "Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis," Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 49, pp. 19345-19350, 2007.
38. M. Hassanein, M. D. Hoeksema, M. Shiota et al., "SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival," Clinical Cancer Research, vol. 19, no. 3, pp. 560-570, 2013.
39. P. M. C. Smith and C. A. Atkins, "Purine biosynthesis. Big in cell division, even bigger in nitrogen assimilation," Plant Physiology, vol. 128, no. 3, pp. 793-802, 2002.
40. A. C. Racanelli, S. B. Rothbart, C. L. Heyer, and R. G. Moran, "Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition," Cancer Research, vol. 69, no. 13, pp. 5467-5474, 2009.
41. I. B. Spurr, C. N. Birts, F. Cuda, S. J. Benkovic, J. P. Blaydes, and A. Tavassoli, "Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization," ChemBioChem, vol. 13, no. 11, pp. 1628-1634, 2012.
42. Y. I. Pavlov, P. V. Shcherbakova, and I. B. Rogozin, "Roles of DNA polymerases in replication, repair, and recombination in eukaryotes," International Review of Cytology, vol. 255, pp. 41-132, 2006.
43. U. V. Roongta, J. G. Pabalan, X. Wang et al., "Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy," Molecular Cancer Research, vol. 9, no. 11, pp. 1551-1561, 2011.
44. P. Mason, B. Liang, L. Li et al., "SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids," PLoS ONE, vol. 7, no. 3, Article ID e33823, 2012.
45. R. A. Igal, "Stearoyl-coa desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer," Carcinogenesis, vol. 31, no. 9, pp. 1509-1515, 2010.
46. A. Gupta, P. Kessler, J. Rawwas, and B. R. G. Williams, "Regulation of CRABP-II expression by MycN in Wilms tumor," Experimental Cell Research, vol. 314, no. 20, pp. 3663-3668, 2008.
47. Y. Zhao, M. Takahashi, J. Gu et al., "Functional roles of N-glycans in cell signaling and cell adhesion in cancer," Cancer Science, vol. 99, no. 7, pp. 1304-1310, 2008.
48. K. S. Lau and J. W. Dennis, "N-Glycans in cancer progression," Glycobiology, vol. 18, no. 10, pp. 750-760, 2008.
49. B. Blomme, F. Heindryckx, J. M. Stassen, A. Geerts, I. Colle, and H. Van Vlierberghe, "Serum protein N-glycan alterations of diethylnitrosamine-induced hepatocellular carcinoma mice and their evolution after inhibition of the placental growth factor," Molecular and Cellular Biochemistry, vol. 372, no. 1-2, pp. 199-210, 2013.
50. M. V. Trivedi, J. S. Laurence, and T. J. Siahaan, "The role of thiols and disulfides on protein stability," Current Protein and Peptide Science, vol. 10, no. 6, pp. 614-625, 2009.
51. E. Chevet, D. Fessart, F. Delom et al., "Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development," Oncogene, vol. 32, no. 20, pp. 2499-2509, 2013.
52. T. A. Gray, N. J. MacLaine, C. O. Michie et al., "Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models," Journal of Immunological Methods, vol. 378, no. 1-2, pp. 20-32, 2012.
53. T. Ilani, A. Alon, I. Grossman et al., "A secreted disulfide catalyst controls extracellular matrix composition and function," Science, vol. 341, no. 6141, pp. 74-76, 2013.
54. J. M. Pare, P. LaPointe, and T. C. Hobman, "Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells," Molecular Biology of the Cell, vol. 24, no. 15, pp. 2303-2310, 2013.
55. N. J. Martinez, H. M. Chang, R. Borrajo Jde, and R. I. Gregory, "The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly," RNA, vol. 19, pp. 1583-1593, 2013.
56. P. Khatri, M. Sirota, and A. J. Butte, "Ten years of pathway analysis: current approaches and outstanding challenges," PLoS Computational Biology, vol. 8, no. 2, Article ID e1002375, 2012.
57. D. W. Huang, B. T. Sherman, and R. A. Lempicki, "Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources," Nature Protocols, vol. 4, no. 1, pp. 44-57, 2009.
58. P. A. Futreal, L. Coin, M. Marshall et al., "A census of human cancer genes," Nature Reviews Cancer, vol. 4, no. 3, pp. 177-183, 2004.
59. V. N. Babenko, M. K. Basu, F. A. Kondrashov, I. B. Rogozin, and E. V. Koonin, "Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis," BMC Cancer, vol. 6, article 36, 2006.
60. I. P. Gorlov, C. J. Logothetis, S. Fang, O. Y. Gorlova, and C. Amos, "Building a statistical model for predicting cancer genes," PLoS ONE, vol. 7, no. 11, Article ID e49175, 2012.