Fructose induces transketolase flux to promote pancreatic cancer growth

Cancer Research

Volumn 70, Issue 15, 2010, Pages 6368-6376

  Liu, Haibo ^a   Huang, Danshan ^a   McArthur, David L ^a   Boros, Laszlo G ^b   Nissen, Nicholas ^c   Heaney, Anthony P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SIDMAP LLC   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSE; GLUCOSE; NUCLEIC ACID; PENTOSE PHOSPHATE; THIAMINE; TRANSKETOLASE; URIC ACID;

ARTICLE; CANCER CELL; CANCER GROWTH; CELL METABOLISM; CELL PROLIFERATION; FRUCTOSE METABOLISM; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; METABOLOMICS; NUCLEIC ACID SYNTHESIS; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN TRANSPORT; PURINE SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CELL GROWTH PROCESSES; CELL LINE, TUMOR; ENZYME INDUCTION; FRUCTOSE; GLUCOSE; HEPATOBLASTOMA; HUMANS; LIVER NEOPLASMS; NUCLEIC ACIDS; PANCREATIC NEOPLASMS; PENTOSE PHOSPHATE PATHWAY; PURINES; TRANSKETOLASE;

EID: 77955408416     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-4615     Document Type: Article

References (29)

1. Warburg O, Posener K, Negelein E. On the metabolism of cancer cells. Biochem Z 1924;152:319-44.
2. Boros LG, Puigjaner J, Cascante M, et al. Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Res 1997;57:4242-8.
3. Xu X, Hausen AZ, Coy JF, Lochelt M. Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. In J cancer 2009;124:1330-7.
4. Staiger WI, Coy JF, Grobholz R, et al. Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer. Oncol Rep 2006;16:657-61.
5. National Institutes of Health: National Institute of Diabetes, Digestive and Kidney Diseases. "Statistics related to overweight and obesity: the economic costs." Available from: http://www.win.niddk.nih.gov/statistics/ index.htm.
6. Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR, Flegal KM. Prevalence of overweight and obesity among U.S. children, adolescents, and adults, 1999-2002. JAMA 2004;291:2847-50.
7. Calle EE, Thun MJ. Obesity and cancer. Oncogene 2004;23:6365-78.
8. Kaaks R, Lukanova A. Effects of weight control and physical activity in cancer prevention. International agency for research on cancer. Ann N Y Acad Sci 2002;963:268-81.
9. Park YK, Yetley EA. Intakes and food sources of fructose in the United States. Am J Clin Nutr 1993;58:737-47S.
10. Bray GA, Nielson SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004;79:537-43.
11. Michaud DS, Liu S, Giovannucci E, et al. Dietary sugar, glycemic load, and pancreatic cancer risk in a prospective study. J Natl Cancer Inst 2002;94:1293-300.
12. Larsson SC, Bergkvist L, Wolk A. Consumption of sugar and sugarsweetened foods and the risk of pancreatic cancer in a prospective study. Am J Clin Nutr 2006;84:1171-6.
13. Kim JW, Dang CV. Cancer's molecule sweet tooth and the Warburg effect. Cancer Res 2006;66:8927-30.
14. Hui H, McArthur D, Nissen N, Heaney AP. Direct spectrophotometric determination of serum fructose in pancreatic cancer patients. Pancreas 2009;38:706-12.
15. Ouyang H, Mou LJ, Luk C, et al. Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype. Am J Pathol 2000;157:1623-31.
16. Shiota M, Galassetti P, Monohan M, et al. Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Diabetes 1998;47:867-73.
17. Sucha R, Ulcova-Gallova Z, Pavelkova-Seifertova P, et al. Fructose and glucose in follicular fluid and serum of women undergoing stimulation in an in vitro fertilization program. Ceska Gynekol 2002;67:144-8.
18. Richthoff J, Spano M, Giwercman YL, et al. The impact of testicular and accessory sex gland function on sperm chromatin integrity as assessed by the sperm chromatin structure assay (SCSA). Hum Reprod 2002;17:3162-9.
19. Cascante M, Boros LG, Comin B, Atauri P, Centelles JJ, Lee PW. Metabolic control analysis in drug discovery and disease. Nat Biotechnol 2002;20:246-9.
20. Boros LG, Cascante M, Lee WN. Metabolic profiling of cell growth and death in cancer: applications in drug discovery. Drug Discov Today 2002;7:364-72.
21. 2]glucose. Am J Physiol 1998;274:E843-51.
22. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis. Nat Rev Cancer 2004;4:891-9.
23. Eigenbrodt E. Glycolysis: one of the keys to cancer? Trends Pharmacol Sci 1980;1:240-5.
24. Nakagawa T, Tuttle KR, Short RA, Johnson RJ. Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat Clin Pract Nephrol 2005;1:80-6.
25. Tobey TA, Mondon CE, Zavaroni I, Reaven GM. Mechanism of insulin resistance in fructose-fed rats. Metabolism 1982;31:608-12.
26. Koh ET, Mueller J, Osilesi O, Knehans A, Reiser S. Effects of fructose feeding on lipid parameter in lean, diabetic and nondiabetic Zucker rats. J Nutr 1985;115:1274-84.
27. Putnam JJ, Allshouse JE. Food consumption, prices, and expenditures, 1970-97. Washington (DC): Economic Research Service, U.S. Department of Agriculture; 1999.
28. Bardeesy N, DePinho RA. Pancreatic cancer biology and genetics. Nat Rev Cancer 2002;2:897-909.
29. 13C isotopic tracers for metabolic flux analysis in mammalian cells. J Biotechnol 2009;144:167-74.